Full Text Journal Articles by
Author Douglas J Morrison

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Glucose and Fructose Hydrogel Enhances Running Performance, Exogenous Carbohydrate Oxidation, and Gastrointestinal Tolerance.

Joshua T Rowe, Roderick F G J King, Andy J King, Douglas J Morrison, Thomas Preston, Oliver J Wilson, John P O'Hara,

<h4>Purpose</h4>Beneficial effects of carbohydrate (CHO) ingestion on exogenous CHO oxidation and endurance performance require a well-functioning gastrointestinal (GI) tract. However, GI complaints are common during endurance running. This study investigated the effect of a CHO solution-containing sodium alginate and pectin (hydrogel) on endurance running performance, exogenous and endogenous CHO oxidation, ... Read more >>

Med Sci Sports Exerc (Medicine and science in sports and exercise)
[2022, 54(1):129-140]

Cited: 0 times

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Understanding the role of the gut in undernutrition: what can technology tell us?

Alex J Thompson, Claire D Bourke, Ruairi C Robertson, Nirupama Shivakumar, Christine A Edwards, Tom Preston, Elaine Holmes, Paul Kelly, Gary Frost, Douglas J Morrison, ,

Gut function remains largely underinvestigated in undernutrition, despite its critical role in essential nutrient digestion, absorption and assimilation. In areas of high enteropathogen burden, alterations in gut barrier function and subsequent inflammatory effects are observable but remain poorly characterised. Environmental enteropathy (EE)-a condition that affects both gut morphology and function ... Read more >>

Gut (Gut)
[2021, :]

Cited: 0 times

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Carbohydrate Supplementation and the Influence of Breakfast on Fuel Use in Hypoxia.

Alex Griffiths, Kevin Deighton, Christopher J Boos, Joshua Rowe, Douglas J Morrison, Tom Preston, Roderick King, John P O'Hara,

<h4>Purpose</h4>This study investigated the effect of carbohydrate supplementation on substrate oxidation during exercise in hypoxia after preexercise breakfast consumption and omission.<h4>Methods</h4>Eleven men walked in normobaric hypoxia (FiO2 ~11.7%) for 90 min at 50% of hypoxic V˙O2max. Participants were supplemented with a carbohydrate beverage (1.2 g·min-1 glucose) and a placebo beverage ... Read more >>

Med Sci Sports Exerc (Medicine and science in sports and exercise)
[2021, 53(4):785-795]

Cited: 0 times

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Impact of the source of fermentable carbohydrate on SCFA production by human gut microbiota in vitro - a systematic scoping review and secondary analysis.

Hannah C Harris, Douglas J Morrison, Christine A Edwards,

Short chain fatty acids (SCFA) are produced by bacterial fermentation of non-digestible carbohydrates (NDC) and have many potential tissue and SCFA specific actions, from providing fuel for colonic cells to appetite regulation. Many studies have described the fermentation of different carbohydrates, often using in vitro batch culture. As evidence-based critical evaluation ... Read more >>

Crit Rev Food Sci Nutr (Critical reviews in food science and nutrition)
[2021, 61(22):3892-3903]

Cited: 2 times

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Mycoprotein as a possible alternative source of dietary protein to support muscle and metabolic health.

Mariana O C Coelho, Alistair J Monteyne, Mandy V Dunlop, Hannah C Harris, Douglas J Morrison, Francis B Stephens, Benjamin T Wall,

The world's population is expanding, leading to an increased global requirement for dietary protein to support health and adaptation in various populations. Though a strong evidence base supports the nutritional value of animal-derived dietary proteins, mounting challenges associated with sustainability of these proteins have led to calls for the investigation ... Read more >>

Nutr Rev (Nutrition reviews)
[2020, 78(6):486-497]

Cited: 3 times

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Dietary Fibres Differentially Impact on the Production of Phenolic Acids from Rutin in an In Vitro Fermentation Model of the Human Gut Microbiota.

Jaroslav Havlik, Vittoria Marinello, Andrew Gardyne, Min Hou, William Mullen, Douglas J Morrison, Thomas Preston, Emilie Combet, Christine A Edwards,

Polyphenols are often ingested alongside dietary fibres. They are both catabolised by, and may influence, the intestinal microbiota; yet, interactions between them and the impact on their resultant microbial products are poorly understood. Dietary fibres (inulin, pectin, psyllium, pyrodextrin, wheat bran, cellulose-three doses) were fermented in vitro with human faeces ... Read more >>

Nutrients (Nutrients)
[2020, 12(6):]

Cited: 3 times

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Moderate intensity exercise training combined with inulin-propionate ester supplementation increases whole body resting fat oxidation in overweight women.

Dalia Malkova, Thelma Polyviou, Eleni Rizou, Konstantinos Gerasimidis, Edward S Chambers, Tom Preston, M Catriona Tedford, Gary Frost, Douglas J Morrison,

<h4>Background</h4>Our previous work has shown that oral supplementation with inulin propionate ester (IPE) reduces intra-abdominal fat and prevents weight gain and that oral propionate intake enhances resting fat oxidation. The effects of IPE combined with exercise training on energy substrate utilisation are unknown. The aim of this study was to ... Read more >>

Metabolism (Metabolism: clinical and experimental)
[2020, 104:154043]

Cited: 3 times

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Fuel Use during Exercise at Altitude in Women with Glucose-Fructose Ingestion.

John P O'Hara, Lauren Duckworth, Alistair Black, David R Woods, Adrian Mellor, Christopher Boos, Liam Gallagher, Costas Tsakirides, Nicola C Arjomandkhah, Douglas J Morrison, Thomas Preston, Roderick F G J King,

<h4>Purpose</h4>This study compared the coingestion of glucose and fructose on exogenous and endogenous substrate oxidation during prolonged exercise at terrestrial high altitude (HA) versus sea level, in women.<h4>Method</h4>Five women completed two bouts of cycling at the same relative workload (55% Wmax) for 120 min on acute exposure to HA (3375 ... Read more >>

Med Sci Sports Exerc (Medicine and science in sports and exercise)
[2019, 51(12):2586-2594]

Cited: 5 times

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Short Chain Fatty Acid Production from Mycoprotein and Mycoprotein Fibre in an In Vitro Fermentation Model.

Hannah C Harris, Christine A Edwards, Douglas J Morrison,

Dietary mycoprotein (marketed as Quorn<sup>TM</sup>) has many health benefits, including reductions in energy intake. The majority of studies evaluating mycoprotein focus on the protein content and very few consider the fibre content. Fibre consumption is also associated with decreased energy intake, which is partly attributed to short chain fatty acids ... Read more >>

Nutrients (Nutrients)
[2019, 11(4):]

Cited: 0 times

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Liver and muscle glycogen oxidation and performance with dose variation of glucose-fructose ingestion during prolonged (3 h) exercise.

Andy J King, John P O'Hara, Nicola C Arjomandkhah, Josh Rowe, Douglas J Morrison, Thomas Preston, Roderick F G J King,

<h4>Purpose</h4>This study investigated the effect of small manipulations in carbohydrate (CHO) dose on exogenous and endogenous (liver and muscle) fuel selection during exercise.<h4>Method</h4>Eleven trained males cycled in a double-blind randomised order on 4 occasions at 60% [Formula: see text] for 3 h, followed by a 30-min time-trial whilst ingesting either 80 g h<sup>-1</sup> ... Read more >>

Eur J Appl Physiol (European journal of applied physiology)
[2019, 119(5):1157-1169]

Cited: 6 times

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Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: a randomised cross-over trial.

Edward S Chambers, Claire S Byrne, Douglas J Morrison, Kevin G Murphy, Tom Preston, Catriona Tedford, Isabel Garcia-Perez, Sofia Fountana, Jose Ivan Serrano-Contreras, Elaine Holmes, Catherine J Reynolds, Jordie F Roberts, Rosemary J Boyton, Daniel M Altmann, Julie A K McDonald, Julian R Marchesi, Arne N Akbar, Natalie E Riddell, Gareth A Wallis, Gary S Frost,

<h4>Objective</h4>To investigate the underlying mechanisms behind changes in glucose homeostasis with delivery of propionate to the human colon by comprehensive and coordinated analysis of gut bacterial composition, plasma metabolome and immune responses.<h4>Design</h4>Twelve non-diabetic adults with overweight and obesity received 20 g/day of inulin-propionate ester (IPE), designed to selectively deliver propionate to ... Read more >>

Gut (Gut)
[2019, 68(8):1430-1438]

Cited: 56 times

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Effects of Inulin Propionate Ester Incorporated into Palatable Food Products on Appetite and Resting Energy Expenditure: A Randomised Crossover Study.

Claire S Byrne, Edward S Chambers, Tom Preston, Catriona Tedford, Jerusa Brignardello, Isabel Garcia-Perez, Elaine Holmes, Gareth A Wallis, Douglas J Morrison, Gary S Frost,

Supplementation with inulin-propionate ester (IPE), which delivers propionate to the colon, suppresses ad libitum energy intake and stimulates the release of satiety hormones acutely in humans, and prevents weight gain. In order to determine whether IPE remains effective when incorporated into food products (FP), IPE needs to be added to ... Read more >>

Nutrients (Nutrients)
[2019, 11(4):]

Cited: 4 times

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Role of Gut Microbiota-Generated Short-Chain Fatty Acids in Metabolic and Cardiovascular Health.

Edward S Chambers, Tom Preston, Gary Frost, Douglas J Morrison,

<h4>Purpose of this review</h4>This review assesses the latest evidence linking short-chain fatty acids (SCFA) with host metabolic health and cardiovascular disease (CVD) risk and presents the latest evidence on possible biological mechanisms.<h4>Recent findings</h4>SCFA have a range of effects locally in the gut and at both splanchnic and peripheral tissues which ... Read more >>

Curr Nutr Rep (Current nutrition reports)
[2018, 7(4):198-206]

Cited: 130 times

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The effect of L-rhamnose on intestinal transit time, short chain fatty acids and appetite regulation: a pilot human study using combined 13CO2/H2 breath tests.

Claire S Byrne, Tom Preston, Jerusa Brignardello, Isabel Garcia-Perez, Elaine Holmes, Gary S Frost, Douglas J Morrison,

<h4>Background</h4>The appetite-regulating effects of non-digestible carbohydrates (NDC) have in part previously been attributed to their effects on intestinal transit rates as well as microbial production of short chain fatty acids (SCFA). Increased colonic production of the SCFA propionate has been shown to reduce energy intake and stimulate gut hormone secretion ... Read more >>

J Breath Res (Journal of breath research)
[2018, 12(4):046006]

Cited: 2 times

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The effects of dietary supplementation with inulin and inulin-propionate ester on hepatic steatosis in adults with non-alcoholic fatty liver disease.

Edward S Chambers, Claire S Byrne, Annette Rugyendo, Douglas J Morrison, Tom Preston, Catriona Tedford, Jimmy D Bell, Louise Thomas, Arne N Akbar, Natalie E Riddell, Rohini Sharma, Mark R Thursz, Pinelopi Manousou, Gary Frost,

The short chain fatty acid (SCFA) propionate, produced through fermentation of dietary fibre by the gut microbiota, has been shown to alter hepatic metabolic processes that reduce lipid storage. We aimed to investigate the impact of raising colonic propionate production on hepatic steatosis in adults with non-alcoholic fatty liver disease ... Read more >>

Diabetes Obes Metab (Diabetes, obesity & metabolism)
[2019, 21(2):372-376]

Cited: 16 times

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Acute oral sodium propionate supplementation raises resting energy expenditure and lipid oxidation in fasted humans.

Edward S Chambers, Claire S Byrne, Karen Aspey, Yanjie Chen, Saadiyah Khan, Douglas J Morrison, Gary Frost,

Short-chain fatty acids (SCFAs), produced from fermentation of dietary fibre by the gut microbiota, have been suggested to modulate energy metabolism. Previous work using rodent models has demonstrated that oral supplementation of the SCFA propionate raises resting energy expenditure (REE) by promoting lipid oxidation. The objective of the present study ... Read more >>

Diabetes Obes Metab (Diabetes, obesity & metabolism)
[2018, 20(4):1034-1039]

Cited: 23 times

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Carbohydrate dose influences liver and muscle glycogen oxidation and performance during prolonged exercise.

Andy J King, John P O'Hara, Douglas J Morrison, Tom Preston, Roderick F G J King,

This study investigated the effect of carbohydrate (CHO) dose and composition on fuel selection during exercise, specifically exogenous and endogenous (liver and muscle) CHO oxidation. Ten trained males cycled in a double-blind randomized order on 5 occasions at 77% V˙O2max for 2 h, followed by a 30-min time-trial (TT) while ingesting ... Read more >>

Physiol Rep (Physiological reports)
[2018, 6(1):]

Cited: 8 times

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Stable Isotope Techniques for the Assessment of Host and Microbiota Response During Gastrointestinal Dysfunction.

Ross N Butler, Margaret Kosek, Nancy F Krebs, Cornelia U Loechl, Alexander Loy, Victor O Owino, Michael B Zimmermann, Douglas J Morrison,

The International Atomic Energy Agency convened a technical meeting on environmental enteric dysfunction (EED) in Vienna (October 28-30, 2015; https://nucleus.iaea.org/HHW/Nutrition/EED_Technical_Meeting/index.html) to bring together international experts in the fields of EED, nutrition, and stable isotope technologies. Advances in stable isotope-labeling techniques open up new possibilities to improve our understanding of gastrointestinal ... Read more >>

J Pediatr Gastroenterol Nutr (Journal of pediatric gastroenterology and nutrition)
[2017, 64(1):8-14]

Cited: 5 times

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A comparison of substrate oxidation during prolonged exercise in men at terrestrial altitude and normobaric normoxia following the coingestion of 13C glucose and 13C fructose.

John P O'Hara, David R Woods, Adrian Mellor, Christopher Boos, Liam Gallagher, Costas Tsakirides, Nicola C Arjomandkhah, David A Holdsworth, Carlton B Cooke, Douglas J Morrison, Thomas Preston, Roderick Fgj King,

This study compared the effects of coingesting glucose and fructose on exogenous and endogenous substrate oxidation during prolonged exercise at altitude and sea level, in men. Seven male British military personnel completed two bouts of cycling at the same relative workload (55% W<sub>max</sub>) for 120 min on acute exposure to altitude ... Read more >>

Physiol Rep (Physiological reports)
[2017, 5(1):]

Cited: 5 times

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The diet-derived short chain fatty acid propionate improves beta-cell function in humans and stimulates insulin secretion from human islets in vitro.

Attilio Pingitore, Edward S Chambers, Thomas Hill, Inmaculada Ruz Maldonado, Bo Liu, Gavin Bewick, Douglas J Morrison, Tom Preston, Gareth A Wallis, Catriona Tedford, Ramón Castañera González, Guo C Huang, Pratik Choudhary, Gary Frost, Shanta J Persaud,

<h4>Aims</h4>Diet-derived short chain fatty acids (SCFAs) improve glucose homeostasis in vivo, but the role of individual SCFAs and their mechanisms of action have not been defined. This study evaluated the effects of increasing colonic delivery of the SCFA propionate on β-cell function in humans and the direct effects of propionate ... Read more >>

Diabetes Obes Metab (Diabetes, obesity & metabolism)
[2017, 19(2):257-265]

Cited: 57 times

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Impact of Glycosidic Bond Configuration on Short Chain Fatty Acid Production from Model Fermentable Carbohydrates by the Human Gut Microbiota.

Hannah C Harris, Christine A Edwards, Douglas J Morrison,

Short chain fatty acids (SCFA) are the major products of carbohydrate fermentation by gut bacteria. Different carbohydrates are associated with characteristic SCFA profiles although the mechanisms are unclear. The individual SCFA profile may determine any resultant health benefits. Understanding determinants of individual SCFA production would enable substrate choice to be ... Read more >>

Nutrients (Nutrients)
[2017, 9(1):]

Cited: 12 times

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Increased colonic propionate reduces anticipatory reward responses in the human striatum to high-energy foods.

Claire S Byrne, Edward S Chambers, Habeeb Alhabeeb, Navpreet Chhina, Douglas J Morrison, Tom Preston, Catriona Tedford, Julie Fitzpatrick, Cherag Irani, Albert Busza, Isabel Garcia-Perez, Sofia Fountana, Elaine Holmes, Anthony P Goldstone, Gary S Frost,

<h4>Background</h4>Short-chain fatty acids (SCFAs), metabolites produced through the microbial fermentation of nondigestible dietary components, have key roles in energy homeostasis. Animal research suggests that colon-derived SCFAs modulate feeding behavior via central mechanisms. In humans, increased colonic production of the SCFA propionate acutely reduces energy intake. However, evidence of an effect ... Read more >>

Am J Clin Nutr (The American journal of clinical nutrition)
[2016, 104(1):5-14]

Cited: 46 times

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Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism.

Douglas J Morrison, Tom Preston,

The formation of SCFA is the result of a complex interplay between diet and the gut microbiota within the gut lumen environment. The discovery of receptors, across a range of cell and tissue types for which short chain fatty acids SCFA appear to be the natural ligands, has led to ... Read more >>

Gut Microbes (Gut microbes)
[2016, 7(3):189-200]

Cited: 607 times

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Control of appetite and energy intake by SCFA: what are the potential underlying mechanisms?

Edward S Chambers, Douglas J Morrison, Gary Frost,

In recent years, there has been a renewed interest in the role of dietary fibre in obesity management. Much of this interest stems from animal and human studies which suggest that an increased intake of fermentable fibre can suppress appetite and improve weight management. A growing number of reports have ... Read more >>

Proc Nutr Soc (The Proceedings of the Nutrition Society)
[2015, 74(3):328-336]

Cited: 72 times

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Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults.

Edward S Chambers, Alexander Viardot, Arianna Psichas, Douglas J Morrison, Kevin G Murphy, Sagen E K Zac-Varghese, Kenneth MacDougall, Tom Preston, Catriona Tedford, Graham S Finlayson, John E Blundell, Jimmy D Bell, E Louise Thomas, Shahrul Mt-Isa, Deborah Ashby, Glen R Gibson, Sofia Kolida, Waljit S Dhillo, Stephen R Bloom, Wayne Morley, Stuart Clegg, Gary Frost,

<h4>Objective</h4>The colonic microbiota ferment dietary fibres, producing short chain fatty acids. Recent evidence suggests that the short chain fatty acid propionate may play an important role in appetite regulation. We hypothesised that colonic delivery of propionate would increase peptide YY (PYY) and glucagon like peptide-1 (GLP-1) secretion in humans, and ... Read more >>

Gut (Gut)
[2015, 64(11):1744-1754]

Cited: 340 times

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