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The Role of Mannose-binding Lectin in Infectious Complications of Pediatric Hemato-Oncologic Diseases.

Marianna Dobi, Ágnes Szilágyi, Dorottya Csuka, Lilian Varga, Zoltán Prohászka, Csaba Bereczki, Gábor Kovács, Ferenc Fekete,

The complement system is essential for protection against infections in oncologic patients because of the chemotherapy-induced immunosuppression. One of the key elements in the activation of the complement system via the lectin pathway is the appropriate functioning of mannose-binding lectin (MBL) and mannose-binding lectin-associated serine protease 2 (MASP2) complex. The ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(2):154-158]

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Deciphering the Genetics of Primary Angioedema with Normal Levels of C1 Inhibitor.

Gedeon Loules, Faidra Parsopoulou, Maria Zamanakou, Dorottya Csuka, Maria Bova, Teresa González-Quevedo, Fotis Psarros, Fotis Psarros, Gregor Porebski, Matthaios Speletas, Davide Firinu, Stefano Del Giacco, Chiara Suffritti, Michael Makris, Sofia Vatsiou, Andrea Zanichelli, Henriette Farkas, Anastasios E Germenis,

The genetic alteration underlying the great majority of primary angioedema with normal C1 inhibitor (nl-C1-INH-HAE) cases remains unknown. To search for variants associated with nl-C1-INH-HAE, we genotyped 133 unrelated nl-C1-INH-HAE patients using a custom next-generation sequencing platform targeting 55 genes possibly involved in angioedema pathogenesis. Patients already diagnosed with <i>F12</i> ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(11):]

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Deep Intronic SERPING1 Gene Variants: Ending One Odyssey and Starting Another?

Anastasios E Germenis, Sofia Vatsiou, Dorottya Csuka, Maria Zamanakou, Henriette Farkas,

J Clin Immunol (Journal of clinical immunology)
[2020, :]

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The Importance of Complement Testing in Acquired Angioedema Related to Angiotensin-Converting Enzyme Inhibitors.

Zsuzsanna Balla, Zsuzsanna Zsilinszky, Zsófia Pólai, Noémi Andrási, Kinga Viktória Kőhalmi, Dorottya Csuka, Lilian Varga, Henriette Farkas,

<h4>Background</h4>Angiotensin-converting enzyme inhibitors may cause angioedema. Currently, no laboratory method is available for identifying acquired angioedema related to angiotensin-converting enzyme inhibitors. However, establishing the diagnosis is possible from the medical history and the preexisting angiotensin-converting enzyme inhibitor therapy, as well as by excluding other angioedema types.<h4>Objective</h4>To evaluate the results of ... Read more >>

J Allergy Clin Immunol Pract (The journal of allergy and clinical immunology. In practice)
[2020, :]

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CFHR5 Genetic Variations and Serum Levels in Patients with Immune-Complex-Mediated Membranoproliferative Glomerulonephritis and C3-Glomerulopathy

Nóra Garam, Marcell Cserhalmi, Zoltán Prohászka, Ágnes Szilágyi, Nóra Veszeli, Edina Szabó, Barbara Uzonyi, Attila Iliás, Christof Aigner, Alice Schmidt, Martina Gaggl, Gere Sunder-Plassmann, Dóra Bajcsi, Jürgen Brunner, Alexandra Dumfarth, Daniel Cejka, Stefan Flaschberger, Hana Flögelova, Ágnes Haris, Ágnes Hartmann, Andreas Heilos, Thomas Mueller, Krisztina Rusai, Klaus Arbeiter, Johannes Hofer, Dániel Jakab, Mária Sinkó, Erika Szigeti, Csaba Bereczki, Viktor Janko, Kata Kelen, György Reusz, Attila Szabó, Nóra Klenk, Krisztina Kóbor, Nika Kojc, Maarten Knechtelsdorfer, Mario Laganovic, Adrian Catalin Lungu, Anamarija Meglic, Rina Rus, Tanja Kersnik-Levart, Ernesta Macioniene, Marius Miglinas, Anna Pawłowska, Tomasz Stompór, Ludmila Podracka, Michael Rudnicki, Gert Mayer, Romana Rysava, Jana Reiterova, Marijan Saraga, Tomáš Seeman, Jakub Zieg, Eva Sládková, Natasa Stajic, Tamás Szabó, Andrei Capitanescu, Simona Stancu, Miroslav Tisljar, Kresimir Galesic, András Tislér, Inga Vainumäe, Martin Windpessl, Tomas Zaoral, Galia Zlatanova, Mihály Józsi, Dorottya Csuka,

<h4>Background: </h4> Factor H-related-5 (FHR-5) is a member of the complement Factor H protein family. Due to the homology to Factor H, the main complement regulator of the alternative pathway, it may also be implicated in pathomechanism of kidney diseases where Factor H and alternative pathway dysregulation play a role. ... Read more >>

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Associations between serum L-arginine and ficolins in the early phase of acute ischemic stroke - A pilot study.

Tihamer Molnar, Dorottya Csuka, Gabriella Pusch, Lajos Nagy, Peter Garred, Zsolt Illes,

<h4>Introduction</h4>Activation of both the L-arginine and the lectin pathway contributes to the pathophysiology and the outcome of acute ischemic stroke (AIS). However, the interplay between the two systems has not yet been examined.<h4>Methods</h4>A total of 44 patients with AIS were recruited into this study. Serial measurement of serum L-arginine, asymmetric ... Read more >>

J Stroke Cerebrovasc Dis (Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association)
[2020, 29(8):104951]

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Molecular basis and outcomes of atypical haemolytic uraemic syndrome in Czech children.

Šárka Štolbová, Martin Bezdíčka, Zoltán Prohászka, Dorottya Csuka, Ingrid Hrachovinová, Jan Burkert, Naděžda Šimánková, Štěpánka Průhová, Jakub Zieg,

Atypical haemolytic uraemic syndrome is an ultra-rare, life-threatening disease. Causative variants in genes that encode complement factors can be identified in 40-70% of cases. We performed genetic analysis of 21 Czech children with atypical haemolytic uraemic syndrome. Genetic or acquired predisposition to the disease was identified in the majority of ... Read more >>

Eur J Pediatr (European journal of pediatrics)
[2020, 179(11):1739-1750]

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Sex Differences in Clinical Presentation and Outcomes among Patients with Complement-Gene-Variant-Mediated Thrombotic Microangiopathy.

Christof Aigner, Martina Gaggl, Renate Kain, Zoltán Prohászka, Nóra Garam, Dorottya Csuka, Raute Sunder-Plassmann, Leah Charlotte Piggott, Natalja Haninger-Vacariu, Alice Schmidt, Gere Sunder-Plassmann,

Sex differences among patients with complement-gene-variant-mediated thrombotic microangiopathy (cTMA) are not well established. We examined demographic and clinical data from female and male patients with a history of cTMA enrolled in the Vienna thrombotic microangiopathy (TMA) cohort. Follow-up was three years after first presentation with cTMA. In this single-center study, ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(4):]

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Definition, aims, and implementation of GA2 LEN/HAEi Angioedema Centers of Reference and Excellence.

Marcus Maurer, Werner Aberer, Rosana Agondi, Mona Al-Ahmad, Maryam Ali Al-Nesf, Ignacio Ansotegui, Rand Arnaout, Luisa Karla Arruda, Riccardo Asero, Emel Aygören-Pürsün, Aleena Banerji, Andrea Bauer, Moshe Ben-Shoshan, Alejandro Berardi, Jonathan A Bernstein, Stephen Betschel, Carsten Bindslev-Jensen, Mojca Bizjak, Isabelle Boccon-Gibod, Konrad Bork, Laurence Bouillet, Henrik Balle Boysen, Nicholas Brodszki, Sigurd Broesby-Olsen, Paula Busse, Thomas Buttgereit, Anette Bygum, Teresa Caballero, Régis A Campos, Mauro Cancian, Ivan Cherrez-Ojeda, Danny M Cohn, Célia Costa, Timothy Craig, Paulo Ricardo Criado, Roberta F Criado, Dorottya Csuka, Joachim Dissemond, Aurélie Du-Thanh, Luis Felipe Ensina, Ragıp Ertaş, José E Fabiani, Claudio Fantini, Henriette Farkas, Silvia Mariel Ferrucci, Ignasi Figueras-Nart, Natalia L Fili, Daria Fomina, Atsushi Fukunaga, Asli Gelincik, Ana Giménez-Arnau, Kiran Godse, Mark Gompels, Margarida Gonçalo, Maia Gotua, Richard Gower, Anete S Grumach, Guillermo Guidos-Fogelbach, Michihiro Hide, Natalia Ilina, Naoko Inomata, Thilo Jakob, Dario O Josviack, Hye-Ryun Kang, Allen Kaplan, Alicja Kasperska-Zając, Constance Katelaris, Aharon Kessel, Andreas Kleinheinz, Emek Kocatürk, Mitja Košnik, Dorota Krasowska, Kanokvalai Kulthanan, M Sendhil Kumaran, José Ignacio Larco Sousa, Hilary J Longhurst, William Lumry, Andrew MacGinnitie, Markus Magerl, Michael P Makris, Alejandro Malbrán, Alexander Marsland, Inmaculada Martinez-Saguer, Iris V Medina, Raisa Meshkova, Martin Metz, Iman Nasr, Jan Nicolay, Chikako Nishigori, Isao Ohsawa, Kemal Özyurt, Nikolaos G Papadopoulos, Claudio A S Parisi, Jonathan Grant Peter, Wolfgang Pfützner, Todor Popov, Nieves Prior, German D Ramon, Adam Reich, Avner Reshef, Marc A Riedl, Bruce Ritchie, Heike Röckmann-Helmbach, Michael Rudenko, Andaç Salman, Mario Sanchez-Borges, Peter Schmid-Grendelmeier, Faradiba S Serpa, Esther Serra-Baldrich, Farrukh R Sheikh, William Smith, Angèle Soria, Petra Staubach, Urs C Steiner, Marcin Stobiecki, Gordon Sussman, Anna Tagka, Simon Francis Thomsen, Regina Treudler, Solange Valle, Martijn van Doorn, Lilian Varga, Daniel O Vázquez, Nicola Wagner, Liangchun Wang, Christina Weber-Chrysochoou, Young-Min Ye, Anna Zalewska-Janowska, Andrea Zanichelli, Zuotao Zhao, Yuxiang Zhi, Torsten Zuberbier, Ricardo D Zwiener, Anthony Castaldo,

Allergy (Allergy)
[2020, 75(8):2115-2123]

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A novel deep intronic SERPING1 variant as a cause of hereditary angioedema due to C1-inhibitor deficiency.

Sofia Vatsiou, Maria Zamanakou, Gedeon Loules, Fotis Psarros, Faidra Parsopoulou, Dorottya Csuka, Anna Valerieva, Maria Staevska, Grzegorz Porebski, Krystyna Obtulowicz, Markus Magerl, Marcus Maurer, Matthaios Speletas, Henriette Farkas, Anastasios E Germenis,

BACKGROUND:In about 5% of patients with hereditary angioedema due to C1-inhibitor deficiency (C1-INH-HAE) no mutation in the SERPING1 gene is detected. METHODS:C1-INH-HAE cases with no mutation in the coding region of SERPING1 after conventional genotyping were examined for defects in the intronic or untranslated regions of the gene. Using a ... Read more >>

Allergol Int (Allergology international : official journal of the Japanese Society of Allergology)
[2020, 69(3):443-449]

Cited: 1 time

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Preemptive plasma therapy prevents atypical hemolytic uremic syndrome relapse in kidney transplant recipients.

Christof Aigner, Georg A Böhmig, Farsad Eskandary, Harald Herkner, Zoltán Prohászka, Dorottya Csuka, Renate Kain, Martina Gaggl, Raute Sunder-Plassmann, Thomas Müller-Sacherer, André Oszwald, Gottfried Fischer, Alice Schmidt, Gere Sunder-Plassmann,

<h4>Background</h4>Atypical hemolytic uremic syndrome (aHUS) frequently leads to renal failure, and kidney transplantation bears a high risk of disease recurrence and graft loss.<h4>Methods</h4>Patients who received a kidney graft in our center were retrospectively identified using our Vienna Thrombotic Microangiopathy Cohort. Since 2005, the majority of aHUS patients received perioperative plasma ... Read more >>

Eur J Intern Med (European journal of internal medicine)
[2020, 73:51-58]

Cited: 1 time

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C4 nephritic factor in patients with immune-complex-mediated membranoproliferative glomerulonephritis and C3-glomerulopathy.

Nóra Garam, Zoltán Prohászka, Ágnes Szilágyi, Christof Aigner, Alice Schmidt, Martina Gaggl, Gere Sunder-Plassmann, Dóra Bajcsi, Jürgen Brunner, Alexandra Dumfarth, Daniel Cejka, Stefan Flaschberger, Hana Flögelova, Ágnes Haris, Ágnes Hartmann, Andreas Heilos, Thomas Mueller, Krisztina Rusai, Klaus Arbeiter, Johannes Hofer, Dániel Jakab, Mária Sinkó, Erika Szigeti, Csaba Bereczki, Viktor Janko, Kata Kelen, György S Reusz, Attila J Szabó, Nóra Klenk, Krisztina Kóbor, Nika Kojc, Maarten Knechtelsdorfer, Mario Laganovic, Adrian Catalin Lungu, Anamarija Meglic, Rina Rus, Tanja Kersnik-Levart, Ernesta Macioniene, Marius Miglinas, Anna Pawłowska, Tomasz Stompór, Ludmila Podracka, Michael Rudnicki, Gert Mayer, Romana Rysava, Jana Reiterova, Marijan Saraga, Tomáš Seeman, Jakub Zieg, Eva Sládková, Tamás Szabó, Andrei Capitanescu, Simona Stancu, Miroslav Tisljar, Kresimir Galesic, András Tislér, Inga Vainumäe, Martin Windpessl, Tomas Zaoral, Galia Zlatanova, Dorottya Csuka,

BACKGROUND:Acquired or genetic abnormalities of the complement alternative pathway are the primary cause of C3glomerulopathy(C3G) but may occur in immune-complex-mediated membranoproliferative glomerulonephritis (IC-MPGN) as well. Less is known about the presence and role of C4nephritic factor(C4NeF) which may stabilize the classical pathway C3-convertase. Our aim was to examine the presence ... Read more >>

Orphanet J Rare Dis (Orphanet journal of rare diseases)
[2019, 14(1):247]

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International Consensus on the Use of Genetics in the Management of Hereditary Angioedema.

Anastasios E Germenis, Maurizio Margaglione, João Bosco Pesquero, Henriette Farkas, Sven Cichon, Dorottya Csuka, Alberto López Lera, Matija Rijavec, Stephen Jolles, Agnes Szilagyi, Margarita López Trascasa, Camila Lopes Veronez, Christian Drouet, Maria Zamanakou, ,

Hereditary angioedema (HAE) is becoming much more genetically complex than was initially considered. Thus, the role of HAE genetics is expanding beyond research laboratories, and the genotyping of subjects suffering from HAE has become diagnostically indispensable in clinical practice. The synthesis and interpretation of the clinical and biochemical analyses to ... Read more >>

J Allergy Clin Immunol Pract (The journal of allergy and clinical immunology. In practice)
[2020, 8(3):901-911]

Cited: 2 times

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[Community-acquired bacterial infections among type 2 diabetic and non-diabetic patients hospitalized on a general medical ward: a clinical comparison].

László József Barkai, Emese Sipter, Dorottya Csuka, Tímea Baló, Zsuzsa Nébenführer, András Máthé, István Karádi, Pál Pánczél, Zoltán Prohászka, Nóra Hosszúfalusi,

<i>Introduction:</i> Previous data showed bacterial infections among diabetic patients to be more serious and frequent, with higher mortality rates in comparison with non-diabetics. Recent investigations, however, are contradictory. <i>Aim:</i> The goal of our prospective, observational study was to compare patients hospitalized on a general medical ward due to community-acquired bacterial ... Read more >>

Orv Hetil (Orvosi hetilap)
[2019, 160(41):1623-1632]

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Validation of distinct pathogenic patterns in a cohort of membranoproliferative glomerulonephritis patients by cluster analysis.

Nóra Garam, Zoltán Prohászka, Ágnes Szilágyi, Christof Aigner, Alice Schmidt, Martina Gaggl, Gere Sunder-Plassmann, Dóra Bajcsi, Jürgen Brunner, Alexandra Dumfarth, Daniel Cejka, Stefan Flaschberger, Hana Flögelova, Ágnes Haris, Ágnes Hartmann, Andreas Heilos, Thomas Mueller, Krisztina Rusai, Klaus Arbeiter, Johannes Hofer, Dániel Jakab, Mária Sinkó, Erika Szigeti, Csaba Bereczki, Viktor Janko, Kata Kelen, György S Reusz, Attila J Szabó, Nóra Klenk, Krisztina Kóbor, Nika Kojc, Maarten Knechtelsdorfer, Mario Laganovic, Adrian Catalin Lungu, Anamarija Meglic, Rina Rus, Tanja Kersnik-Levart, Ernesta Macioniene, Marius Miglinas, Anna Pawłowska, Tomasz Stompór, Ludmila Podracka, Michael Rudnicki, Gert Mayer, Romana Rysava, Jana Reiterova, Marijan Saraga, Tomáš Seeman, Jakub Zieg, Eva Sládková, Tamás Szabó, Andrei Capitanescu, Simona Stancu, Miroslav Tisljar, Kresimir Galesic, András Tislér, Inga Vainumäe, Martin Windpessl, Tomas Zaoral, Galia Zlatanova, Dorottya Csuka,

Background:A novel data-driven cluster analysis identified distinct pathogenic patterns in C3-glomerulopathies and immune complex-mediated membranoproliferative glomerulonephritis. Our aim was to replicate these observations in an independent cohort and elucidate disease pathophysiology with detailed analysis of functional complement markers. Methods:A total of 92 patients with clinical, histological, complement and genetic data ... Read more >>

Clin Kidney J (Clinical kidney journal)
[2020, 13(2):225-234]

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Decreased Ficolin-3-mediated Complement Lectin Pathway Activation and Alternative Pathway Amplification During Bacterial Infections in Patients With Type 2 Diabetes Mellitus.

László József Barkai, Emese Sipter, Dorottya Csuka, Zoltán Prohászka, Katrine Pilely, Peter Garred, Nóra Hosszúfalusi,

Bacterial infections are frequent and severe in patients with diabetes mellitus. Whether diabetes <i>per se</i> induces functional alterations in the complement system hampering activation during infection is unknown. We investigated key elements of the complement system during bacterial infections in patients with type 2 diabetes mellitus (T2DM) and compared them ... Read more >>

Front Immunol (Frontiers in immunology)
[2019, 10:509]

Cited: 3 times

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Elevated Systemic Pentraxin-3 Is Associated With Complement Consumption in the Acute Phase of Thrombotic Microangiopathies.

Eszter Trojnar, Mihály Józsi, Zsóka Szabó, Marienn Réti, Péter Farkas, Kata Kelen, George S Reusz, Attila J Szabó, Nóra Garam, Bálint Mikes, György Sinkovits, Blanka Mező, Dorottya Csuka, Zoltán Prohászka,

Pentraxin-3 (PTX3) and C-reactive protein (CRP) have been shown to regulate complement activation <i>in vitro</i>, but their role has not been investigated in complement consumption <i>in vivo</i>. Thrombotic microangiopathies (TMA) are often accompanied by complement overactivation and consumption, therefore we analyzed the relation of the systemic pentraxin levels to the ... Read more >>

Front Immunol (Frontiers in immunology)
[2019, 10:240]

Cited: 1 time

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A case report of a child with sepsis induced multiorgan failure and massive complement consumption treated with a short course of Eculizumab: A case of crosstalk between coagulation and complement?

Slobodan Galic, Dorottya Csuka, Zoltán Prohászka, Daniel Turudic, Petra Dzepina, Danko Milosevic,

<h4>Rationale</h4>This article describes a child with a life-threatening multiorgan failure with disseminated intravascular coagulation (DIC) and massive complement consumption. To our knowledge this therapeutic approach was for the first time effectively applied in a pediatric patient.<h4>Patient concerns</h4>A 14-month-old boy was presented with a severe, rapidly progressing, life-threatening disease because of ... Read more >>

Medicine (Baltimore) (Medicine)
[2019, 98(4):e14105]

Cited: 3 times

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Antibody-mediated inhibition of FXIIa blocks downstream bradykinin generation.

Helen Cao, Mark Biondo, Hadi Lioe, Samantha Busfield, Veronika Rayzman, Bernhard Nieswandt, Konrad Bork, Leonard C Harrison, Priscilla Auyeung, Henriette Farkas, Dorottya Csuka, Matthias Pelzing, Steve Dower, Michael J Wilson, Andrew Nash, Marc W Nolte, Con Panousis,

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2018, 142(4):1355-1358]

Cited: 3 times

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Idiopathic Nonhistaminergic Acquired Angioedema Versus Hereditary Angioedema.

Noémi Andrási, Nóra Veszeli, Kinga Viktória Kőhalmi, Dorottya Csuka, György Temesszentandrási, Lilian Varga, Henriette Farkas,

BACKGROUND:The mechanism of idiopathic nonhistaminergic acquired angioedema (InH-AAE) has not yet been precisely elucidated. This condition is characterized by recurrent angioedema without wheals. OBJECTIVE:To study the clinical features of InH-AAE, and to make, for the first time, independent comparisons with hereditary angioedema of unknown origin (U-HAE), as well as with hereditary ... Read more >>

J Allergy Clin Immunol Pract (The journal of allergy and clinical immunology. In practice)
[2018, 6(4):1205-1208]

Cited: 1 time

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Targeted next-generation sequencing for the molecular diagnosis of hereditary angioedema due to C1-inhibitor deficiency.

Gedeon Loules, Maria Zamanakou, Faidra Parsopoulou, Sofia Vatsiou, Fotis Psarros, Dorottya Csuka, Grzegorz Porebski, Krystyna Obtulowicz, Anna Valerieva, Maria Staevska, Alberto López-Lera, Margarita López-Trascasa, Dumitru Moldovan, Markus Magerl, Marcus Maurer, Matthaios Speletas, Henriette Farkas, Anastasios E Germenis,

SERPING1 genotyping of subjects suspicious for hereditary angioedema due to C1-INH deficiency (C1-INH-HAE) is important for clinical practice as well as for research reasons. Conventional approaches towards the detection of C1-INH-HAE-associated SERPING1 variants are cumbersome and time-demanding with many pitfalls. To take advantage of the benefits of next-generation sequencing (NGS) ... Read more >>

Gene (Gene)
[2018, 667:76-82]

Cited: 3 times

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Early Increase in Complement Terminal Pathway Activation Marker sC5b-9 Is Predictive for the Development of Thrombotic Microangiopathy after Stem Cell Transplantation.

Orsolya Horváth, Krisztián Kállay, Dorottya Csuka, Blanka Mező, György Sinkovits, Csaba Kassa, Anita Stréhn, Katalin Csordás, János Sinkó, Zoltán Prohászka, Gergely Kriván,

Hematopoietic stem cell transplantation (HSCT)-associated thrombotic microangiopathy (TA-TMA) is a multifactorial complication, and its prediction is largely unresolved. Our aim was to analyze changes of complement profile after HSCT to identify potential markers of TA-TMA development. Thirty-three consecutive pediatric patients (9.6 ± 4.4 years old) who underwent allogeneic HSCT due to malignant ... Read more >>

Biol Blood Marrow Transplant (Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation)
[2018, 24(5):989-996]

Cited: 3 times

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Maternal and Fetal Outcomes of Pregnancies in Women with Atypical Hemolytic Uremic Syndrome.

Martina Gaggl, Christof Aigner, Dorottya Csuka, Ágnes Szilágyi, Zoltán Prohászka, Renate Kain, Natalja Haninger, Maarten Knechtelsdorfer, Raute Sunder-Plassmann, Gere Sunder-Plassmann, Alice Schmidt,

Atypical HUS (aHUS) is a disorder most commonly caused by inherited defects of the alternative pathway of complement, or the proteins that regulate this pathway, and life-threatening episodes of aHUS can be provoked by pregnancy. We retrospectively and prospectively investigated 27 maternal and fetal pregnancy outcomes in 14 women with ... Read more >>

J Am Soc Nephrol (Journal of the American Society of Nephrology : JASN)
[2018, 29(3):1020-1029]

Cited: 16 times

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Functional Characterization of the Disease-Associated N-Terminal Complement Factor H Mutation W198R.

Marcell Cserhalmi, Barbara Uzonyi, Nicolas S Merle, Dorottya Csuka, Edgar Meusburger, Karl Lhotta, Zoltán Prohászka, Mihály Józsi,

Dysregulation of the complement alternative pathway is involved in the pathogenesis of several diseases, including the kidney diseases atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G). In a patient, initially diagnosed with chronic glomerulonephritis, possibly C3G, and who 6 years later had an episode of aHUS, a heterozygous missense mutation ... Read more >>

Front Immunol (Frontiers in immunology)
[2017, 8:1800]

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Genetic Determinants of C1 Inhibitor Deficiency Angioedema Age of Onset.

Panagiota Gianni, Gedeon Loules, Maria Zamanakou, Maria Kompoti, Dorottya Csuka, Fotis Psarros, Markus Magerl, Dimitru Moldovan, Marcus Maurer, Matthaios G Speletas, Henriette Farkas, Anastasios E Germenis,

<h4>Background</h4>In view of the large heterogeneity in the clinical presentation of hereditary angioedema due to C1 inhibitor deficiency (C1-INH-HAE), great efforts are being made towards detecting measurable biological determinants of disease severity that can help to improve the management of the disease. Considering the central role that plasma kallikrein plays ... Read more >>

Int Arch Allergy Immunol (International archives of allergy and immunology)
[2017, 174(3-4):200-204]

Cited: 4 times

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