Full Text Journal Articles by
Author Dorothy Scott

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Thrombin generation test based on a 96-channel pipettor for evaluation of FXIa procoagulant activity in pharmaceuticals.

Leonid A Parunov, Maria E Shea, Yideng Liang, Stepan S Surov, Maitreyi Chattopadhyay, Timothy K Lee, Dorothy E Scott, Mikhail V Ovanesov,

Thrombin generation (TG) assays are used widely to investigate both diseases and drugs that impact thrombosis and bleeding. TG assays were also instrumental in the identification of thrombogenic impurities in immune globulin products, which were associated with thrombotic adverse events in patients. TG assays are therefore now used by quality ... Read more >>

Nat Protoc (Nature protocols)
[2021, 16(8):3981-4003]

Cited: 0 times

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Detecting factor XIa in immune globulin products: Commutability of international reference materials for traditional and global hemostasis assays.

Yideng Liang, Joseph W Jackson, Samuel A Woodle, Stepan S Surov, Leonid A Parunov, Dorothy E Scott, Mark Weinstein, Timothy K Lee, Mikhail V Ovanesov,

<h4>Background</h4>Activated coagulation factor XIa (FXIa) is an impurity and primary source of procoagulant activity in thrombosis-implicated immune globulin (IG) products. Several assays, of varying quality and precision are used to assess FXIa-like procoagulant activity in units relevant to their respective principles.<h4>Objectives</h4>To advance unified reporting, we sought to employ the World ... Read more >>

Res Pract Thromb Haemost (Research and practice in thrombosis and haemostasis)
[2021, 5(1):211-222]

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Combined thrombogenic effects of vessel injury, pregnancy and procoagulant immune globulin administration in mice.

Yanqun Xu, Yideng Liang, Leonid Parunov, Daryl Despres, Michael Eckhaus, Dorothy Scott, Mikhail Ovanesov, Evi B Struble,

<h4>Background</h4>Pregnant women are at increased risk of thrombotic adverse events. Plasma derived immune globulin (IG) products, which are used in pregnancy for various indications, may contain procoagulant impurity activated coagulation factor XI (FXIa). Procoagulant IG products have been associated with increased thrombogenicity but their effect in pregnancy is unknown.<h4>Methods</h4>Late pregnant ... Read more >>

Thromb J (Thrombosis journal)
[2020, 18(1):32]

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Foster and kinship carer survey: Accessing health services for children in out-of-home care.

Karen McLean, Harriet Hiscock, Dorothy Scott, Sharon Goldfeld,

<h4>Aim</h4>To explore the experiences of Victorian foster and kinship carers in accessing health services for children in their care and to quantify the frequency of potential barriers to health care.<h4>Methods</h4>On-line survey co-designed with the Foster Care Association of Victoria measuring carer-reported health service engagement by a child/young person in their ... Read more >>

J Paediatr Child Health (Journal of paediatrics and child health)
[2021, 57(1):132-139]

Cited: 0 times

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Health needs and timeliness of assessment of Victorian children entering out-of-home care: An audit of a multidisciplinary assessment clinic.

Karen McLean, Keriann Little, Harriet Hiscock, Dorothy Scott, Sharon Goldfeld,

<h4>Aim</h4>To describe the health needs identified in children attending a comprehensive health assessment at a tertiary hospital, multidisciplinary clinic for children following entry to out-of-home care and timeliness of referral and assessment compared with national recommendations.<h4>Methods</h4>This was a retrospective audit of all the children who attended the Pathway to Good ... Read more >>

J Paediatr Child Health (Journal of paediatrics and child health)
[2019, 55(12):1470-1475]

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S27 of IFNα1 Contributes to Its Low Affinity for IFNAR2 and Weak Antiviral Activity.

Nikunj Sharma, Anya J O'Neal, Christian Gonzalez, Megen Wittling, Erisa Gjinaj, Lisa M Parsons, Debasis Panda, Alexey Khalenkov, Dorothy Scott, Saurav Misra, Ronald L Rabin,

Type I interferons (IFNs) signal by forming a high affinity IFN-IFNAR2 dimer, which subsequently recruits IFNAR1 to form a ternary complex that initiates JAK/STAT signaling. Among the 12 IFNα subtypes, IFNα1 has a uniquely low affinity for IFNAR2 (<100 × of the other IFNα subtypes) and commensurately weak antiviral activity, suggesting an ... Read more >>

J Interferon Cytokine Res (Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research)
[2019, 39(5):283-292]

Cited: 2 times

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Assuring immune globulin potency in a world of changing pathogen challenges.

Dorothy E Scott,

Transfusion (Transfusion)
[2018, 58 Suppl 3:3121-3124]

Cited: 0 times

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What is the timeliness and extent of health service use of Victorian (Australia) children in the year after entry to out-of-home care? Protocol for a retrospective cohort study using linked administrative data.

Karen McLean, Harriet Hiscock, Dorothy Scott, Sharon Goldfeld,

Introduction:Children entering out-of-home care have high rates of health needs across all domains of health. To identify these needs early and optimise long-term outcomes, routine health assessment on entry to care is recommended by child health experts and included in policy in many jurisdictions. If effective, this ought to lead ... Read more >>

BMJ Paediatr Open (BMJ paediatrics open)
[2019, 3(1):e000400]

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Immune globulin potency: challenges and opportunities.

Dorothy E Scott,

Transfusion (Transfusion)
[2018, 58 Suppl 3:3051-3053]

Cited: 1 time

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Vitamin K5 is an efficient photosensitizer for ultraviolet A light inactivation of bacteria.

Fei Xu, Ying Li, Justen Ahmad, Yonggang Wang, Dorothy E Scott, Jaroslav G Vostal,

Photodynamic treatment combining light and a photosensitizer molecule can be an effective method to inactivate pathogenic bacteria. This study identified vitamin K5 as an efficient photosensitizer for ultraviolet light A (UVA)-induced bacterial inactivation. Six bacterial species, Bacillus cereus (vegetative form), Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis, Klebsiella pneumoniae, ... Read more >>

FEMS Microbiol Lett (FEMS microbiology letters)
[2018, 365(4):]

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Characterization of source plasma from self-identified vaccinated or convalescent donors during the 2009 H1N1 pandemic.

Alexey Khalenkov, Yong He, Jennifer L Reed, Thomas R Kreil, John McVey, Malgorzata Norton, John Scott, Dorothy E Scott,

BACKGROUND:Influenza immune globulin, manufactured from plasma of convalescent or vaccinated donors has been proposed as a potential therapy for severe influenza. In 2009, a program was initiated to collect plasma from donors who self-identified as having had H1N1 influenza or having received the H1N1 pandemic vaccine. The goal of this ... Read more >>

Transfusion (Transfusion)
[2018, 58(5):1108-1116]

Cited: 3 times

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Binding and neutralizing anti-cytomegalovirus activities in immune globulin products.

Xiao Wang, Yanqun Xu, Dorothy E Scott, Haruhiko Murata, Evi B Struble,

Congenital infection as well as infection of immunocompromised individuals by cytomegalovirus (CMV) can be associated with significant morbidity, mortality, and long-term adverse health outcomes. Assessment of anti-viral activity using appropriate assays is essential for ensuring safe and efficacious use of therapeutic CMV immune globulin (IG) products. In this study, we ... Read more >>

Biologicals (Biologicals : journal of the International Association of Biological Standardization)
[2017, 50:35-41]

Cited: 3 times

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Serotherapy for patients with severe influenza.

Dorothy Scott, Jay S Epstein, Frederick G Hayden,

Lancet Respir Med (The Lancet. Respiratory medicine)
[2017, 5(6):462-464]

Cited: 0 times

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Association of immune globulin intravenous and thromboembolic adverse events.

Mikhail V Ovanesov, Mikhail D Menis, Dorothy E Scott, Richard Forshee, Steven Anderson, Wilson Bryan, Basil Golding,

Am J Hematol (American journal of hematology)
[2017, 92(4):E44-E45]

Cited: 6 times

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Meeting Report: 2015 PDA Virus & TSE Safety Forum.

Hannelore Willkommen, Johannes Blümel, Kurt Brorson, Dayue Chen, Qi Chen, Albrecht Gröner, Thomas R Kreil, Michel Ruffing, Sol Ruiz, Dorothy Scott, Glenda Silvester,

The report provides a summary of the presentations at the Virus & TSE Safety Forum 2015 organized by the Parenteral Drug Association (PDA) and held in Cascais, Portugal, from 9 to 11 June, 2015. As with previous conferences of this series, the PDA Virus & TSE Safety Forum 2015 provided ... Read more >>

PDA J Pharm Sci Technol (PDA journal of pharmaceutical science and technology)
[2016, 70(2):177-188]

Cited: 1 time

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Serum Samples From Middle-aged Adults Vaccinated Annually with Seasonal Influenza Vaccines Cross-neutralize Some Potential Pandemic Influenza Viruses.

Wei Wang, Esmeralda Alvarado-Facundo, Qiong Chen, Christine M Anderson, Dorothy Scott, Russell Vassell, Carol D Weiss,

We examined serum samples from adults ages 48-64 who received multiple seasonal influenza vaccines from 2004 to 2009 for cross-neutralizing antibodies to potential pandemic strains. Using pseudoviruses bearing various hemagglutinins (HA-pseudoviruses), we found serum neutralization titers (≥160) in 100% against A/Japan/305/1957 (H2N2), 53% against A/Hong Kong/1073/99 (H9N2), 56% against the ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2016, 213(3):403-406]

Cited: 6 times

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Safeguarding immune globulin recipients against hemolysis: what do we know and where do we go?

Dorothy E Scott, Jay S Epstein,

Transfusion (Transfusion)
[2015, 55 Suppl 2:S122-6]

Cited: 3 times

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Hemolytic adverse events with immune globulin products: product factors and patient risks.

Dorothy E Scott, Jay S Epstein,

Transfusion (Transfusion)
[2015, 55 Suppl 2:S2-5]

Cited: 2 times

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Meeting Report: 2013 PDA Virus & TSE Safety Forum.

Hannelore Willkommen, Johannes Blümel, Kurt Brorson, Dayue Chen, Qi Chen, Albrecht Gröner, Brian R Hubbard, Thomas R Kreil, Michel Ruffing, Sol Ruiz, Dorothy Scott, Glenda Silvester,

The report provides a summary of the presentations and discussions at the Virus & TSE Safety Forum 2013 organized by the Parenteral Drug Association (PDA) and held in Berlin, Germany, from June 4 to 6, 2013. The conference was accompanied by a workshop, "Virus Spike Preparations and Virus Removal by ... Read more >>

PDA J Pharm Sci Technol (PDA journal of pharmaceutical science and technology)
[2014, 68(3):193-214]

Cited: 1 time

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Hyperimmune globulins and same-day thrombotic adverse events as recorded in a large healthcare database during 2008-2011.

Mikhail Menis, Gayathri Sridhar, Nandini Selvam, Mikhail V Ovanesov, Hozefa A Divan, Yideng Liang, Dorothy Scott, Basil Golding, Richard Forshee, Robert Ball, Steven A Anderson, Hector S Izurieta,

Thrombotic events (TEs) are rare serious complications following administration of hyperimmune globulin (HIG) products. Our retrospective claims-based study assessed occurrence of same-day TEs following administration of HIGs during 2008-2011 and examined potential risk factors using HealthCore's Integrated Research Database (HIRD(SM) ) and laboratory testing of products' procoagulant Factor XIa activity ... Read more >>

Am J Hematol (American journal of hematology)
[2013, 88(12):1035-1040]

Cited: 24 times

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Cytosolic, autocrine alpha-1 proteinase inhibitor (A1PI) inhibits caspase-1 and blocks IL-1β dependent cytokine release in monocytes.

Yonggang Wang, Yong He, Bindu Abraham, Farshid N Rouhani, Mark L Brantly, Dorothy E Scott, Jennifer L Reed,

<h4>Rationale</h4>Activation state-dependent secretion of alpha-1 proteinase inhibitor (A1PI) by monocytes and macrophages was first reported in 1985. Since then, monocytes and tissue macrophages have emerged as key sentinels of infection and tissue damage via activation of self-assembling pattern recognition receptors (inflammasomes), which trigger inflammation and cell death in a caspase-1 ... Read more >>

PLoS One (PloS one)
[2012, 7(11):e51078]

Cited: 12 times

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Immune globulins and thrombotic adverse events as recorded in a large administrative database in 2008 through 2010.

Gregory W Daniel, Mikhail Menis, Gayathri Sridhar, Dorothy Scott, Anna E Wallace, Mikhail V Ovanesov, Basil Golding, Steven A Anderson, Jay Epstein, David Martin, Robert Ball, Hector S Izurieta,

BACKGROUND: Thrombotic events (TEs) are rare but often serious adverse events that could occur after administration of immune globulin (IG) products. Our study objective was to assess occurrence of recorded TEs after administration of different US-licensed IG products and investigate potential risk factors using a large administrative database. STUDY DESIGN ... Read more >>

Transfusion (Transfusion)
[2012, 52(10):2113-2121]

Cited: 30 times

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Eczema vaccinatum.

Jennifer L Reed, Dorothy E Scott, Mike Bray,

Eczema vaccinatum (EV) is a complication of smallpox vaccination that can occur in persons with eczema/atopic dermatitis (AD), in which vaccinia virus disseminates to cause an extensive rash and systemic illness. Because persons with eczema are deferred from vaccination, only a single, accidentally transmitted case of EV has been described ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2012, 54(6):832-840]

Cited: 22 times

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Nanoparticle-based biosensor for the detection of emerging pandemic influenza strains.

Tracy L Kamikawa, Malgorzata G Mikolajczyk, Michael Kennedy, Pei Zhang, Wei Wang, Dorothy E Scott, Evangelyn C Alocilja,

Electrically active magnetic (EAM) nanoparticles, consisting of aniline monomer polymerized around gamma iron(III) oxide (γ-Fe(2)O(3)) cores, serve as the basis of a direct-charge transfer biosensor developed for detection of surface glycoprotein hemagglutinin (HA) from the Influenza A virus (FLUAV) H5N1 (A/Vietnam/1203/04). H5N1 preferentially binds α2,3-linked host glycan receptors. EAM nanoparticles ... Read more >>

Biosens Bioelectron (Biosensors & bioelectronics)
[2010, 26(4):1346-1352]

Cited: 19 times

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Investigation of whether the acute hemolysis associated with Rh(o)(D) immune globulin intravenous (human) administration for treatment of immune thrombocytopenic purpura is consistent with the acute hemolytic transfusion reaction model.

Ann Reed Gaines, Hallie Lee-Stroka, Karen Byrne, Dorothy E Scott, Lynne Uhl, Ellen Lazarus, David F Stroncek,

<h4>Background</h4>Immune thrombocytopenic purpura and secondary thrombocytopenia patients treated with Rh(o)(D) immune globulin intravenous (human; anti-D IGIV) have experienced acute hemolysis, which is inconsistent with the typical presentation of extravascular hemolysis -- the presumed mechanism of action of anti-D IGIV. Although the mechanism of anti-D-IGIV-associated acute hemolysis has not been established, ... Read more >>

Transfusion (Transfusion)
[2009, 49(6):1050-1058]

Cited: 6 times

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