Full Text Journal Articles by
Author Doralina L Anghelescu

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Prospective randomized trial of interventions for vincristine-related neuropathic pain.

Doralina L Anghelescu, Jessica Michala Tesney, Sima Jeha, Becky B Wright, Luis Trujillo, John T Sandlund, Jennifer Pauley, Cheng Cheng, Deqing Pei, Ching-Hon Pui,

BACKGROUND:To evaluate the efficacy of gabapentin at 20 mg/kg per day in the treatment of vincristine-related neuropathic pain. PROCEDURE:Children aged 1-18 years who developed vincristine-induced neuropathy on a St Jude frontline acute lymphoblastic leukemia trial were prospectively enrolled on a randomized, double-blind, placebo-controlled, phase II trial with two treatment arms: gabapentin plus ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2020, :e28539]

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Anesthesia Exposure during Therapy Predicts Neurocognitive Outcomes in Survivors of Childhood Medulloblastoma.

Lisa M Jacola, Doralina L Anghelescu, Lacey Hall, Kathryn Russell, Hui Zhang, Fang Wang, Joanna B Peters, Michael Rossi, Jane E Schreiber, Amar Gajjar,

OBJECTIVE:To examine the contribution of anesthesia exposure during treatment for childhood medulloblastoma to neurocognitive outcomes 3 years after tumor diagnosis. STUDY DESIGN:In this retrospective study, anesthesia data were abstracted from medical records for 111 patients treated with risk-adapted protocol therapy at St Jude Children's Research Hospital. Neurocognitive testing data were obtained ... Read more >>

J. Pediatr. (The Journal of pediatrics)
[2020, :]

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Propofol Total Intravenous Anesthesia as an Intervention for Severe Radiation-Induced Phantosmia in an Adolescent with Ependymoma.

Kavitha C Raghavan, Angela S Camfield, John Lucas, Yousef Ismael, Michael G Rossi, Doralina L Anghelescu,

Radiation-induced phantosmia has been reported both in children and adults. A fraction of these patients have nausea and vomiting triggered by phantosmia. Radiation-induced phantosmia, although transient, can be distressing enough to prevent a patient from staying still during radiation therapy. To date, specific interventions for radiation-induced phantosmia, including anesthesia, have ... Read more >>

J Adolesc Young Adult Oncol (Journal of adolescent and young adult oncology)
[2020, 9(2):299-302]

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Ketamine and lidocaine infusions decrease opioid consumption during vaso-occlusive crisis in adolescents with sickle cell disease.

Latika Puri, Kyle J Morgan, Doralina L Anghelescu,

PURPOSE OF REVIEW:Recurrent exposure to opioids can lead to development of opioid tolerance and opioid-induced hyperalgesia through activation of N-methyl-D-aspartate receptors. N-methyl-D-aspartate receptor antagonists ketamine and lidocaine can modulate development of opioid tolerance and OIH. This study evaluated the utility of ketamine and/or lidocaine in decreasing opioid consumption during acute ... Read more >>

Curr Opin Support Palliat Care (Current opinion in supportive and palliative care)
[2019, 13(4):402-407]

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A Quality Improvement Intervention to Decrease Postoperative Opioid Prescriptions in Pediatric Oncology Patients.

Sara A Mansfield, Yousef El Gohary, Amy Kimble, Lynn Wynn, Elizabeth A Hall, Doralina L Anghelescu, Andrew M Davidoff, Andrew J Murphy,

PURPOSE:This quality improvement initiative aimed to minimize opioid prescribing after oncologic pediatric surgery. METHODS:Retrospective surgical data collected at a pediatric cancer hospital from July 2016 to June 2018 included hospitalization details, oral morphine equivalents prescribed, unplanned visits/calls because of pain, and parental/patient satisfaction with pain control. The quality improvement initiative ... Read more >>

J. Pediatr. Hematol. Oncol. (Journal of pediatric hematology/oncology)
[2020, 42(4):e207-e212]

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Adult Cancer Pain, Version 3.2019, NCCN Clinical Practice Guidelines in Oncology.

Robert A Swarm, Judith A Paice, Doralina L Anghelescu, Madhuri Are, Justine Yang Bruce, Sorin Buga, Marcin Chwistek, Charles Cleeland, David Craig, Ellin Gafford, Heather Greenlee, Eric Hansen, Arif H Kamal, Mihir M Kamdar, Susan LeGrand, Sean Mackey, M Rachel McDowell, Natalie Moryl, Lisle M Nabell, Suzanne Nesbit, , Nina O'Connor, Michael W Rabow, Elizabeth Rickerson, Rebecca Shatsky, Jill Sindt, Susan G Urba, Jeanie M Youngwerth, Lydia J Hammond, Lisa A Gurski,

In recent years, the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Adult Cancer Pain have undergone substantial revisions focusing on the appropriate and safe prescription of opioid analgesics, optimization of nonopioid analgesics and adjuvant medications, and integration of nonpharmacologic methods of cancer pain management. This selection highlights some ... Read more >>

J Natl Compr Canc Netw (Journal of the National Comprehensive Cancer Network : JNCCN)
[2019, 17(8):977-1007]

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Association Between Anesthesia Exposure and Neurocognitive and Neuroimaging Outcomes in Long-term Survivors of Childhood Acute Lymphoblastic Leukemia.

Pia Banerjee, Michael G Rossi, Doralina L Anghelescu, Wei Liu, Ashley M Breazeale, Wilburn E Reddick, John O Glass, Nicholas S Phillips, Lisa M Jacola, Noah D Sabin, Hiroto Inaba, Deokumar Srivastava, Leslie L Robison, Ching-Hon Pui, Melissa M Hudson, Kevin R Krull,

Importance:Limited studies have reported associations between anesthesia and neurocognitive and neuroimaging outcomes, particularly in pediatric patients who undergo multiple exposures to anesthesia as part of chronic disease management. Objective:To investigate whether general anesthesia is associated with neurocognitive impairment and neuroimaging abnormalities in long-term survivors of childhood acute lymphoblastic leukemia. Design, ... Read more >>

JAMA Oncol (JAMA oncology)
[2019, :]

Cited: 1 time

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Desmoplastic Small Round Cell Tumor: Long-Term Complications After Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy.

Zachary E Stiles, Andrew J Murphy, Doralina L Anghelescu, Christina-Lin Brown, Andrew M Davidoff, Paxton V Dickson, Evan S Glazer, Michael W Bishop, Wayne L Furman, Alberto S Pappo, John T Lucas, Jeremiah L Deneve,

BACKGROUND:Desmoplastic small round cell tumor (DSRCT) is a rare intra-abdominal soft tissue sarcoma affecting adolescents and young adults. Cytoreduction, hyperthermic intraperitoneal chemotherapy (CRS/HIPEC), and adjuvant radiotherapy may improve local control. We review our experience with patients who undergo CRS/HIPEC and adjuvant radiotherapy for DSRCT. METHODS:A retrospective review was performed for ... Read more >>

Ann. Surg. Oncol. (Annals of Surgical Oncology)
[2020, 27(1):171-178]

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Neuropathic Pain in Pediatric Oncology: A Clinical Decision Algorithm.

Doralina L Anghelescu, Jessica Michala Tesney,

Neuropathic pain in pediatric oncology can be caused by distinct lesions or disease processes affecting the somatosensory system, including chemotherapy-related neuronal injury, solid tumor-related involvement of neural structures, post-surgical neuropathic pain-including phantom limb pain and pain after limb-sparing surgery-and the complex circumstances of neuropathic pain at the end of life. ... Read more >>

Paediatr Drugs (Paediatric drugs)
[2019, 21(2):59-70]

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Reducing pain in children with cancer: Methodology for the development of a clinical practice guideline.

Erik A H Loeffen, Leontien C M Kremer, Marianne D van de Wetering, Renée L Mulder, Anna Font-Gonzalez, Lee L Dupuis, Fiona Campbell, Wim J E Tissing, ,

Although pain is one of the most prevalent and bothersome symptoms children with cancer experience, evidence-based guidance regarding assessment and management is lacking. With 44 international, multidisciplinary healthcare professionals and nine patient representatives, we aimed to develop a clinical practice guideline (following GRADE methodology), addressing assessment and pharmacological, psychological, and ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2019, 66(6):e27698]

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Provision of Adequate Pain Management to a Young Adult Oncology Patient Presenting with Aberrant Opioid-Associated Behavior: A Case Study.

Kelly R Peck, Jennifer L Harman, Doralina L Anghelescu,

Pain and emotional distress are relevant risk factors as clinicians assess for aberrant opioid-associated behavior and provide adequate and responsible pain relief to patients who engage in behaviors that may be interpreted as drug seeking in nature. The present case illustrates how undertreated pain and treatment-related anxiety affected the opioid ... Read more >>

J Adolesc Young Adult Oncol (Journal of adolescent and young adult oncology)
[2019, 8(2):221-224]

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Anesthesia and Pain Management for Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Desmoplastic Small Round Cell Tumors in Children, Adolescents, and Young Adults.

Doralina L Anghelescu, Christina-Lin Brown, Andrew J Murphy, Andrew M Davidoff, Paxton V Dickson, Evan S Glazer, Zachary E Stiles, Michael W Bishop, Luke Douthitt, Jeremiah L Deneve,

BACKGROUND:Desmoplastic small round cell tumor (DSRCT) is a rare, aggressive sarcoma. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) may improve survival. METHODS:A retrospective review of anesthetic management and postoperative pain control strategies after CRS/HIPEC for DSRCT from 2013 to 2017 was performed. RESULTS:The review analyzed 10 CRS/HIPEC procedures performed ... Read more >>

Ann. Surg. Oncol. (Annals of surgical oncology)
[2019, 26(1):131-138]

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Methadone for Pain Management in Children with Cancer.

Catherine Habashy, Erin Springer, Elizabeth A Hall, Doralina L Anghelescu,

Methadone is a synthetic opioid with unique pharmacodynamic and pharmacokinetic properties. It is effective in treating both nociceptive and neuropathic pain, which commonly co-exist in children with cancer. Upon reviewing the literature describing the use of methadone in pediatric oncology patients, publications are limited in number and low in quality ... Read more >>

Paediatr Drugs (Paediatric drugs)
[2018, 20(5):409-416]

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Pain Outcomes After Celiac Plexus Block in Children and Young Adults with Cancer.

Doralina L Anghelescu, Andy Guo, Kyle J Morgan, Michael Frett, Hasmukh Prajapati, Robert Gold, Sara M Federico,

Purpose: The use of celiac plexus block (CPB) for abdominal pain has been extensively reported in adults. However, pediatric literature is limited to three single case reports and a series of three cases. This study evaluated the effectiveness of CPB in children and young adults (aged 8-20 years) with abdominal ... Read more >>

J Adolesc Young Adult Oncol (Journal of adolescent and young adult oncology)
[2018, 7(6):666-672]

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Bisphosphonate Use in Pediatric Oncology for Pain Management.

Doralina L Anghelescu, Varayini Pankayatselvan, Rosa Nguyen, Deborah Ward, Jianrong Wu, Huiyun Wu, Denaya D Edwards, Wayne Furman,

The use of bisphosphonates for pain control in children with cancer is not extensively studied. We retrospectively evaluated 35 children with cancer treated with intravenous bisphosphonates for pain management at a single institution from 1998 through 2015. We analyzed pain scores and opioid and adjuvant medication consumption before bisphosphonate administration, ... Read more >>

Am J Hosp Palliat Care (The American journal of hospice & palliative care)
[2019, 36(2):138-142]

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Role of Amputation in Improving Mobility, Pain Outcomes, and Emotional and Psychological Well-Being in Children With Metastatic Osteosarcoma.

Sebastian Gil, Israel Fernandez-Pineda, Bhaskar Rao, Michael D Neel, Justin N Baker, Huiyun Wu, Jianrong Wu, Doralina L Anghelescu,

BACKGROUND::Few studies have analyzed the benefit of limb amputations in children with metastatic osteosarcoma and limited life span. OBJECTIVE::We studied outcomes of limb amputations in children with metastatic osteosarcoma. DESIGN::We performed a retrospective review of patients who underwent limb amputations (January 1995-June 2015) and died within 1 year of surgery. ... Read more >>

Am J Hosp Palliat Care (The American journal of hospice & palliative care)
[2019, 36(2):105-110]

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Parent perspectives and preferences for strategies regarding nonsedated MRI scans in a pediatric oncology population.

Breya Walker, Heather M Conklin, Doralina L Anghelescu, Lacey P Hall, Wilburn E Reddick, Robert Ogg, Lisa M Jacola,

PURPOSE:Children with cancer frequently require MRI scans for clinical purposes. Sedation with general anesthesia (GA) is often used to promote compliance, reduce motion, and alleviate anxiety. The use of GA for MRI scans is costly in terms of time, personnel, and medications. In addition, prominent risks are associated with anesthesia ... Read more >>

Support Care Cancer (Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer)
[2018, 26(6):1815-1824]

Cited: 1 time

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State of the Art Management of Acute Vaso-occlusive Pain in Sickle Cell Disease.

Latika Puri, Kerri A Nottage, Jane S Hankins, Doralina L Anghelescu,

Acute vaso-occlusive crisis (VOC) is a hallmark of sickle cell disease (SCD). Multiple complex pathophysiological processes can result in pain during a VOC. Despite significant improvements in the understanding and management of SCD, little progress has been made in the management of pain in SCD, although new treatments are being ... Read more >>

Paediatr Drugs (Paediatric drugs)
[2018, 20(1):29-42]

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Family and Peer-Group Substance Abuse as a Risk-Factor for Opioid Misuse Behaviors for a Young Adult with Cancer-Related Pain-A Case Study.

Kelly R Peck, Jennifer L Harman, Doralina L Anghelescu,

The purpose of this report is to illustrate the importance of assessing for family, peer, and personal substance abuse risk factors in the case of a young adult with cancer-related pain and behaviors potentially indicative of opioid misuse (OM). A thorough clinical interview and an OM screening measure revealed important ... Read more >>

J Adolesc Young Adult Oncol (Journal of adolescent and young adult oncology)
[2018, 7(1):137-140]

Cited: 0 times

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A Review of Adult and Pediatric Neuropathic Pain Assessment Tools.

Kyle J Morgan, Doralina L Anghelescu,

To identify and summarize the tools currently available for diagnosing and assessing neuropathic pain (NP) in adults and children and to identify areas where further research is required to address deficiencies in the existing tools.A review of journal articles pertaining to the diagnosis and assessment of NP was conducted.We identified ... Read more >>

Clin J Pain (The Clinical journal of pain)
[2017, 33(9):844-852]

Cited: 4 times

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Erratum to: Emergence Delirium in Pediatric Anesthesia.

Arthura D Moore, Doralina L Anghelescu,

Paediatr Drugs (Paediatric drugs)
[2017, 19(3):267]

Cited: 1 time

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Palliative Sedation With Propofol for an Adolescent With a DNR Order.

Liza-Marie Johnson, Joel Frader, Joanne Wolfe, Justin N Baker, Doralina L Anghelescu, John D Lantos,

Death from cancer is often painful. Usually, the pain can be relieved in ways that allow patients to remain awake and alert until the end. Sometimes, however, the only way to relieve pain is to sedate patients until they are unconscious. This method has been called palliative sedation therapy. Palliative ... Read more >>

Pediatrics (Pediatrics)
[2017, 140(2):]

Cited: 2 times

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The role of the pediatric anesthesiologist in relieving suffering at the end of life: when is palliative sedation appropriate in pediatrics?

Doralina L Anghelescu, Esther Knapp, Liza-Marie Johnson, Justin N Baker,

Paediatr Anaesth (Paediatric anaesthesia)
[2017, 27(4):443-444]

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Emergence Delirium in Pediatric Anesthesia.

Arthura D Moore, Doralina L Anghelescu,

Emergence delirium (ED) is a complex of perceptual disturbances and psychomotor agitation that occurs most commonly in preschool-aged children in the early postanesthetic period. The incidence of ED varies between 10 and 80% in children and is perceived as a troublesome clinical situation by 42% of pediatric anesthesiologists. Although these ... Read more >>

Paediatr Drugs (Paediatric drugs)
[2017, 19(1):11-20]

Cited: 11 times

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Prospective study of neuropathic pain after definitive surgery for extremity osteosarcoma in a pediatric population.

Doralina L Anghelescu, Brenda D Steen, Huiyun Wu, Jianrong Wu, Najat C Daw, Bhaskar N Rao, Michael D Neel, Fariba Navid,

Neuropathic pain (NP) after definitive surgery for extremity osteosarcoma (OS) has not been previously characterized. This study prospectively investigates the incidence, duration, and treatment of NP in limb sparing surgery and amputation groups.In patients treated for OS on a chemotherapy and definitive surgery (limb sparing vs. amputation) protocol (OS08), we ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2017, 64(3):]

Cited: 2 times

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