Camilla Muccini, Trevor A Crowell, Suteeraporn Pinyakorn, Eugène Kroon, Carlo Sacdalan, Jintanat Ananworanich, Sandhya Vasan, Nittaya Phanuphak, Donn J Colby, ,
<h4>Background</h4>Syphilis has been increasing in the past years, especially among men who have sex with men (MSM). The aim of the study was to assess syphilis prevalence and incidence and changes in CD4 count and viremia in the RV254 cohort of persons living with HIV who initiated antiretroviral therapy during ... Read more >>
J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2021, 86(2):219-223]
Cited: 0 times
Catherine W Cai, Suteeraporn Pinyakorn, Eugène Kroon, Mark de Souza, Donn J Colby, Tippawan Pankam, Supanit Pattanachaiwit, Sasiwimol Ubolyam, Adam Rupert, Perrine Lallemand, Robin Dewar, Helene C Highbarger, Jintanat Ananworanich, Sandhya Vasan, Irini Sereti,
Persistent viral activity may cause enduring seropositivity and inflammation in treated people with HIV (PWH). We compared inflammatory biomarkers between early treated PWH who remained seronegative or seroconverted and found similar levels of D-dimer, soluble cluster of differentiation 14, C-reactive protein, and interleukin-6, indicating that seronegativity does not affect chronic ... Read more >>
Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(9):ofaa383]
Cited: 1 time
Catherine W Cai, Suteeraporn Pinyakorn, Eugène Kroon, Mark de Souza, Donn J Colby, Tippawan Pankam, Supanit Pattanachaiwit, Sasiwimol Ubolyam, Adam Rupert, Perrine Lallemand, Robin Dewar, Helene C Highbarger, Jintanat Ananworanich, Sandhya Vasan, Irini Sereti,
Abstract Persistent viral activity may cause enduring seropositivity and inflammation in treated people with HIV (PWH). We compared inflammatory biomarkers between early treated PWH who remained seronegative or seroconverted and found similar levels of D-dimer, soluble cluster of differentiation 14, C-reactive protein, and interleukin-6, indicating that seronegativity does not affect ... Read more >>
Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(9):]
Cited: 0 times
Tanyaporn Wansom, Suteeraporn Pinyakorn, Christy J Kolsteeg, Eugene Kroon, Carlo P Sacdalan, Nitiya Chomchey, Jintanat Ananworanich, Sandhya Vasan, Nittaya Phanuphak, Donn J Colby,
BACKGROUND:Increased rates of hepatitis C virus (HCV) infection among HIV-infected men who have sex with men (MSM) and who deny injecting drugs have been reported in resource-rich settings. SETTING:We measured HCV prevalence and incidence in a predominantly MSM cohort with acute HIV infection in Bangkok, Thailand. METHODS:In 2009-2018, participants with ... Read more >>
J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2020, 84(4):331-335]
Cited: 0 times
Joanna Hellmuth, Camilla Muccini, Donn J Colby, Eugène Kroon, Mark de Souza, Trevor A Crowell, Phillip Chan, Carlo Sacdalan, Jintana Intasan, Khunthalee Benjapornpong, Somporn Tipsuk, Suwanna Puttamaswin, Nitiya Chomchey, Victor Valcour, Michal Sarnecki, Frank Tomaka, Shelly J Krebs, Bonnie M Slike, Linda L Jagodzinski, Netsiri Dumrongpisutikul, Napapon Sailasuta, Vishal Samboju, Nelson L Michael, Merlin L Robb, Sandhya Vasan, Jintanat Ananworanich, Praphan Phanuphak, Nittaya Phanuphak, Robert Paul, Serena Spudich,
<h4>Background</h4>The central nervous system (CNS) is a likely reservoir of HIV, vulnerable to viral rebound, inflammation, and clinical changes upon stopping antiretroviral therapy (ART). It is critical to evaluate the CNS safety of studies using analytic treatment interruption (ATI) to assess HIV remission.<h4>Methods</h4>Thirty participants who started ART during acute HIV ... Read more >>
Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]
Cited: 0 times
Eugène D M B Kroon, Jintanat Ananworanich, Amélie Pagliuzza, Ajantha Rhodes, Nittaya Phanuphak, Lydie Trautmann, Julie L Mitchell, Michelle Chintanaphol, Jintana Intasan, Suteeraporn Pinyakorn, Khuntalee Benjapornpong, J Judy Chang, Donn J Colby, Nitiya Chomchey, James L K Fletcher, Keith Eubanks, Hua Yang, John Kapson, Ashanti Dantanarayana, Surekha Tennakoon, Robert J Gorelick, Frank Maldarelli, Merlin L Robb, Jerome H Kim, Serena Spudich, Nicolas Chomont, Praphan Phanuphak, Sharon R Lewin, Mark S de Souza, ,
<h4>Objective and design</h4>A randomized, open-label pilot study in individuals treated with antiretroviral therapy (ART) since acute HIV infection (AHI) with a regimen including a histone deacetylase inhibitor to induce HIV from latency and control HIV replication during subsequent treatment interruption (TI).<h4>Methods</h4>Fifteen participants who initiated ART at AHI were randomized to ... Read more >>
J Virus Erad (Journal of virus eradication)
[2020, 6(3):100004]
Cited: 0 times
Win M Han, Donn J Colby, Apichaya Khlaiphuengsin, Tanakorn Apornpong, Stephen J Kerr, Sasiwimol Ubolyam, Eugène Kroon, Nittaya Phanuphak, Sandhya Vasan, Gail V Matthews, Anchalee Avihingsanon, Kiat Ruxrungtham, Praphan Phanuphak, Pisit Tangkijvanich,
A rapidly emerging and highly concentrated hepatitis C virus (HCV) outbreak has recently been observed among both acute and chronic HIV-positive men who have sex with men (MSM) in Bangkok, Thailand. NS5B regions of the HCV genome were amplified using nested PCR and sequenced. Phylogenetic inference was constructed by Maximum ... Read more >>
Liver Int (Liver international : official journal of the International Association for the Study of the Liver)
[2020, 40(9):2104-2109]
Cited: 0 times
Evan M Cale, Hongjun Bai, Meera Bose, Michael A Messina, Donn J Colby, Eric Sanders-Buell, Bethany Dearlove, Yifan Li, Emily Engeman, Daniel Silas, Anne Marie O'Sullivan, Brendan Mann, Suteeraporn Pinyakorn, Jintana Intasan, Khunthalee Benjapornpong, Carlo Sacdalan, Eugène Kroon, Nittaya Phanuphak, Robert Gramzinski, Sandhya Vasan, Merlin L Robb, Nelson L Michael, Rebecca M Lynch, Robert T Bailer, Amélie Pagliuzza, Nicolas Chomont, Amarendra Pegu, Nicole A Doria-Rose, Lydie Trautmann, Trevor A Crowell, John R Mascola, Jintanat Ananworanich, Sodsai Tovanabutra, Morgane Rolland, ,
Infusion of the broadly neutralizing antibody VRC01 has been evaluated in individuals chronically infected with HIV-1. Here, we studied how VRC01 infusions affected viral rebound after cessation of antiretroviral therapy (ART) in 18 acutely treated and durably suppressed individuals. Viral rebound occurred in all individuals, yet VRC01 infusions modestly delayed ... Read more >>
J Clin Invest (The Journal of clinical investigation)
[2020, 130(6):3299-3304]
Cited: 0 times
Julie L Mitchell, Hiroshi Takata, Roshell Muir, Donn J Colby, Eugène Kroon, Trevor A Crowell, Carlo Sacdalan, Suteeraporn Pinyakorn, Suwanna Puttamaswin, Khunthalee Benjapornpong, Rapee Trichavaroj, Randall L Tressler, Lawrence Fox, Victoria R Polonis, Diane L Bolton, Frank Maldarelli, Sharon R Lewin, Elias K Haddad, Praphan Phanuphak, Merlin L Robb, Nelson L Michael, Mark de Souza, Nittaya Phanuphak, Jintanat Ananworanich, Lydie Trautmann, ,
Plasmacytoid dendritic cells (pDCs) are robust producers of IFNα and one of the first immune cells to respond to SIV infection. To elucidate responses to early HIV-1 replication, we studied blood pDCs in 29 HIV-infected participants who initiated antiretroviral therapy during acute infection and underwent analytic treatment interruption (ATI). We ... Read more >>
J Clin Invest (The Journal of clinical investigation)
[2020, 130(6):2845-2858]
Cited: 0 times
Donn J Colby, Michal Sarnecki, Dan H Barouch, Somporn Tipsuk, Daniel J Stieh, Eugène Kroon, Alexandra Schuetz, Jintana Intasan, Carlo Sacdalan, Suteeraporn Pinyakorn, Pornsuk Grandin, Hongshuo Song, Sodsai Tovanabutra, Zhanna Shubin, Dohoon Kim, Dominic Paquin-Proulx, Michael A Eller, Rasmi Thomas, Mark de Souza, Lindsay Wieczorek, Victoria R Polonis, Amélie Pagliuzza, Nicolas Chomont, Lauren Peter, Joseph P Nkolola, Johan Vingerhoets, Carla Truyers, Maria G Pau, Hanneke Schuitemaker, Nittaya Phanuphak, Nelson Michael, Merlin L Robb, Frank L Tomaka, Jintanat Ananworanich,
We administered Ad26, modified vaccinia Ankara vectors containing mosaic HIV-1 antigens or placebo in 26 individuals who initiated antiretroviral therapy during acute human immunodeficiency virus infection as an exploratory study to determine the safety and duration of viremic control after treatment interruption. The vaccine was safe and generated robust immune ... Read more >>
Nat Med (Nature medicine)
[2020, 26(4):498-501]
Cited: 1 time
Michelle Chintanaphol, Carlo Sacdalan, Suteeraporn Pinyakorn, Rungsun Rerknimitr, Wiriyaporn Ridtitid, Piyapan Prueksapanich, Irini Sereti, Alexandra Schuetz, Trevor A Crowell, Donn J Colby, Merlin L Robb, Nittaya Phanuphak, Jintanat Ananworanich, Serena S Spudich, Eugène Kroon,
Background:The gut-associated lymphoid tissue (GALT) is a major reservoir of HIV-1 established early in acute HIV-1 infection (AHI). Sampling tissue from GALT can provide information about viral reservoirs and immune responses but may be complicated during AHI for reasons such as high viral replication, CD4 T cell depletion and immune ... Read more >>
J Virus Erad (Journal of virus eradication)
[2020, 6(1):7-10]
Cited: 0 times
Michael J Peluso, Donn J Colby, Suteeraporn Pinyakorn, Sasiwimol Ubolyam, Jintana Intasan, Rapee Trichavaroj, Nitiya Chomchey, Peeriya Prueksakaew, Bonnie M Slike, Shelly J Krebs, Ningbo Jian, Merlin L Robb, Praphan Phanuphak, Nittaya Phanuphak, Serena Spudich, Jintanat Ananworanich, Eugène Kroon, ,
<h4>Introduction</h4>Liver disease is a common cause of non-AIDS morbidity and mortality in people living with HIV (PLHIV), but the prevalence and significance of liver function test (LFT) abnormalities in early HIV infection is unknown. This study aimed to characterize LFTs in a large cohort of participants with acute HIV infection ... Read more >>
J Int AIDS Soc (Journal of the International AIDS Society)
[2020, 23(1):e25444]
Cited: 1 time
Phillip Chan, Netsiri Dumrongpisutikul, Caroline Subra, Donn J Colby, Eugène Kroon, James Fletcher, Carlo Sacdalan, Nittaya Phanuphak, Victor Valcour, Jintanat Ananworanich, Lydie Trautmann, Serena Spudich,
J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2019, 82(2):e34-e37]
Cited: 0 times
Sodsai Tovanabutra, Rujipas Sirijatuphat, Phuc T Pham, Lydia Bonar, Elizabeth A Harbolick, Meera Bose, Hongshuo Song, David Chang, Celina Oropeza, Anne Marie O'Sullivan, Joyce Balinang, Eugene Kroon, Donn J Colby, Carlo Sacdalan, Joanna Hellmuth, Phillip Chan, Peeriya Prueksakaew, Suteeraporn Pinyakorn, Linda L Jagodzinski, Duanghathai Sutthichom, Suwanna Pattamaswin, Mark de Souza, Robert A Gramzinski, Jerome H Kim, Nelson L Michael, Merlin L Robb, Nittaya Phanuphak, Jintanat Ananworanich, Victor Valcour, Gustavo H Kijak, Eric Sanders-Buell, Serena Spudich, , ,
HIV-1 disseminates to a broad range of tissue compartments during acute HIV-1 infection (AHI). The central nervous system (CNS) can serve as an early and persistent site of viral replication, which poses a potential challenge for HIV-1 remission strategies that target the HIV reservoir. CNS compartmentalization is a key feature ... Read more >>
Cells (Cells)
[2019, 8(8):]
Cited: 0 times
Linda L Jagodzinski, Mark M Manak, Holly R Hack, Ying Liu, Jennifer A Malia, Joanna Freeman, Nittaya Phanuphak, Mark de Souza, Eugène D Kroon, Donn J Colby, Nitiya Chomchey, Michelle A Lally, Nelson L Michael, Jintanat Ananworanich, Sheila A Peel, ,
The Roche Cobas AmpliPrep/Cobas TaqMan HIV-1 test, v2.0 (the CAP/CTM assay), was used to quantify cell-associated HIV-1 (CAH) nucleic acid in peripheral blood mononuclear cells (PBMC) from well-characterized clinical specimens from HIV-1-infected individuals on antiretroviral therapy (ART). Chronically infected individuals on ART with no detectable plasma HIV-1 RNA demonstrated average ... Read more >>
J Clin Microbiol (Journal of clinical microbiology)
[2019, 57(5):]
Cited: 3 times
Trevor A Crowell, Donn J Colby, Suteeraporn Pinyakorn, Carlo Sacdalan, Amélie Pagliuzza, Jintana Intasan, Khunthalee Benjapornpong, Kamonkan Tangnaree, Nitiya Chomchey, Eugène Kroon, Mark S de Souza, Sodsai Tovanabutra, Morgane Rolland, Michael A Eller, Dominic Paquin-Proulx, Diane L Bolton, Andrey Tokarev, Rasmi Thomas, Hiroshi Takata, Lydie Trautmann, Shelly J Krebs, Kayvon Modjarrad, Adrian B McDermott, Robert T Bailer, Nicole Doria-Rose, Bijal Patel, Robert J Gorelick, Brandie A Fullmer, Alexandra Schuetz, Pornsuk V Grandin, Robert J O'Connell, Julie E Ledgerwood, Barney S Graham, Randall Tressler, John R Mascola, Nicolas Chomont, Nelson L Michael, Merlin L Robb, Nittaya Phanuphak, Jintanat Ananworanich, ,
<h4>Background</h4>HIV-1-specific broadly neutralising antibodies such as VRC01 could promote HIV remission by halting viral replication and clearing infected cells. We investigated whether VRC01 could promote sustained viral control off antiretroviral therapy (ART) in adults who initiated ART during acute HIV infection.<h4>Methods</h4>We did a randomised, double-blind, placebo-controlled trial at the Thai ... Read more >>
Lancet HIV (The lancet. HIV)
[2019, 6(5):e297-e306]
Cited: 12 times
Gail E Henderson, Margaret Waltz, Karen Meagher, R Jean Cadigan, Thidarat Jupimai, Sinéad Isaacson, Nuchanart Q Ormsby, Donn J Colby, Eugène Kroon, Nittaya Phanuphak, Jintanat Ananworanich, Holly L Peay,
<h4>Introduction</h4>The South East Asia Research Collaboration in HIV (SEARCH) RV411 clinical trial in Thailand was a systematic investigation of analytic treatment interruption (ATI) in individuals diagnosed and treated since Fiebig stage I acute HIV infection. Here, we explore decision-making processes and perceptions of trial participation in a phase I trial ... Read more >>
J Int AIDS Soc (Journal of the International AIDS Society)
[2019, 22(3):e25260]
Cited: 4 times
Todd M Pollack, Hao T Duong, Thuy T Pham, Thang D Nguyen, Howard Libman, Long Ngo, James H McMahon, Julian H Elliott, Cuong D Do, Donn J Colby,
<h4>Introduction</h4>HIV viral load (VL) testing is recommended by the WHO as the preferred method for monitoring patients on antiretroviral therapy (ART). However, evidence that routine VL (RVL) monitoring improves clinical outcomes is lacking.<h4>Methods</h4>We conducted a prospective, randomized controlled trial of RVL monitoring every six months versus a targeted VL (TVL) ... Read more >>
J Int AIDS Soc (Journal of the International AIDS Society)
[2019, 22(3):e25258]
Cited: 1 time
Kathryn E Lancaster, Angela Hetrick, Antoine Jaquet, Adebola Adedimeji, Lukoye Atwoli, Donn J Colby, Angel M Mayor, Angela Parcesepe, Jennifer Syvertsen,
As universal testing and treatment for HIV, or 'treat all', expands across sub-Saharan Africa (SSA), substance use will likely have a negative impact on the success of scale-up efforts for antiretroviral treatment (ART). Overwhelming evidence highlights the negative impact of substance use on HIV care and treatment outcomes. Yet, as ... Read more >>
J Virus Erad (Journal of virus eradication)
[2018, 4(Suppl 2):26-32]
Cited: 5 times
David Chang, Eric Sanders-Buell, Meera Bose, Anne Marie O'Sullivan, Phuc Pham, Eugene Kroon, Donn J Colby, Rujipas Sirijatuphat, Erik Billings, Suteeraporn Pinyakorn, Nitiya Chomchey, Wiriya Rutvisuttinunt, Gustavo Kijak, Mark de Souza, Jean-Louis Excler, Praphan Phanuphak, Nittaya Phanuphak, Robert J O'Connell, Jerome H Kim, Merlin L Robb, Nelson L Michael, Jintanat Ananworanich, Sodsai Tovanabutra, ,
<h4>Introduction</h4>Thailand plays a substantial role in global HIV-1 transmission of CRF01_AE. Worldwide, men who have sex with men (MSM) are at elevated risk for HIV-1 infection. Hence, understanding HIV-1 diversity in a primarily Thai MSM cohort with acute infection, and its connections to the broader HIV-1 transmission network in Asia ... Read more >>
J Int AIDS Soc (Journal of the International AIDS Society)
[2018, 21(11):e25204]
Cited: 1 time
Michelle Chintanaphol, Carlo Sacdalan, Suthat Chottanapund, Suteeraporn Pinyakorn, Supranee Buranapraditkun, Trevor A Crowell, Eugene Kroon, Sopark Manasnayakorn, Jeffrey G Chipman, Timothy W Schacker, Nelson Michael, Nittaya Phanuphak, Serena S Spudich, Donn J Colby, Jintanat Ananworanich,
<h4>Introduction</h4>Latent HIV reservoirs are rapidly established in lymphoid tissues during acute HIV infection (AHI). Sampling these tissues provides important information about HIV pathogenesis. This period is associated with viral replication and immune activation that may affect procedure-related adverse events (AEs). We examined the safety and tolerability of inguinal lymph node ... Read more >>
J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2018, 79(2):244-248]
Cited: 3 times
Eugène Kroon, Phuc T Pham, Sunee Sirivichayakul, Rapee Trichavaroj, Donn J Colby, Suteeraporn Pinyakorn, Nittaya Phanuphak, Eric Sanders-Buell, Frits van Griensven, Gustavo H Kijak, Jerome H Kim, Nelson L Michael, Merlin L Robb, Jintanat Ananworanich, Mark S De Souza, Sodsai Tovanabutra, ,
<h4>Objective</h4>To assess transmission characteristics in a predominantly MSM cohort initiating antiretroviral therapy (ART) immediately following diagnosis of acute HIV-1infection (AHI).<h4>Methods</h4>A longitudinal study (2009-2017) was performed in participants with AHI (n = 439) attending a single clinic in Bangkok. Plasma samples obtained prior to ART were used to obtain HIV-1 pol sequences and ... Read more >>
AIDS (AIDS (London, England))
[2018, 32(16):2373-2381]
Cited: 2 times
Donn J Colby, Eugene Kroon, Carlo Sacdalan, Monica Gandhi, Robert M Grant, Praphan Phanuphak, Jintanat Ananworanich, Merlin L Robb, Nittaya Phanuphak,
We report a case indicating that acquisition of multidrug-resistant human immunodeficiency (HIV) virus type 1 during preexposure prophylaxis with combination tenofovir disoproxil fumarate and emtricitabine or evolution of resistance after HIV seroconversion remains a risk. ... Read more >>
Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2018, 67(6):962-964]
Cited: 3 times
Phillip Chan, Payal Patel, Joanna Hellmuth, Donn J Colby, Eugène Kroon, Carlo Sacdalan, Suteeraporn Pinyakorn, Linda Jagodzinski, Shelly Krebs, Jintanat Ananworanich, Victor Valcour, Serena Spudich, ,
Background:Human immunodeficiency virus (HIV) ribonucleic acid (RNA) levels in the plasma and cerebrospinal fluid (CSF) are correlated in chronic HIV infection, but their dynamics have not been characterized during acute infection. Methods:This study analyzed predictors of CSF HIV RNA and relative degree of CNS viral transmigration expressed as plasma minus ... Read more >>
J Infect Dis (The Journal of infectious diseases)
[2018, 218(6):937-945]
Cited: 1 time
Donn J Colby, Nawarat Posuwan, Eugene Kroon, Nittaya Phanuphak, Jintanat Ananworanich, Merlin L Robb, Praphan Phanuphak, Yong Poovorawan, ,
J Infect Dis (The Journal of infectious diseases)
[2018, 218(3):505-507]
Cited: 1 time