Full Text Journal Articles by
Author Donia Ounissi

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Clinicopathological characteristics and mutational profile of KRAS and NRAS in Tunisian patients with sporadic colorectal cancer.

Donia Ounissi, Marwa Weslati, Rahma Boughriba, Meriam Hazgui, Saadia Bouraoui,

BACKGROUND/AIM:Colorectal cancer (CRC) is a major public health problem worldwide and in Tunisia due to its increasing incidence. KRAS and NRAS mutations have become a pivotal part of CRC diagnosis, given their association to treatment resistance with anti-epidermal growth factor receptor (EGFR) monoclonal antibodies. We aim to screen for mutations ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2020, :]

Cited: 0 times

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MUC1 and MUC5AC implication in Tunisian colorectal cancer patients.

Meriam Hazgui, Marwa Weslati, Rahma Boughriba, Donia Ounissi, Dhouha Bacha, Saadia Bouraoui,

BACKGROUND/AIM:Mucins such as MUC1 and MUC5AC are known for their protective and moisturizing role of the intestinal epithelium. Their expression is tightly controlled given their essential role in the normal tissue homeostasis, whereas their deregulation leads to chronic inflammation and even cancer. This study aims to assess the expression profiles ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2020, :]

Cited: 0 times

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Stromal cell derived factor-1 and CXCR4 expression in colorectal cancer promote liver metastasis.

Sameh Amara, Ines Chaar, Meriem Khiari, Donia Ounissi, Marwa Weslati, Rahma Boughriba, Abdelmajid B Hmida, Saadia Bouraoui,

Recent studies suggest that SDF-1 and CXCR4 are expressed in certain cancer cells, and malignant cells use this chemokine/receptor system to promote tumor progression and metastasis. However, the pathophysiological significance of their expression in colorectal cancer (CRC) tissue has not been fully elucidated.The purpose of this study was to assess ... Read more >>

Cancer Biomark (Cancer biomarkers : section A of Disease markers)
[2015, 15(6):869-879]

Cited: 11 times

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Relationship between SDF-1G801A polymorphism and its expression in Tunisian patients with colorectal cancer.

Sameh Amara, Ines Chaar, Meriem Khiari, Donia Ounissi, Abdelmajid B Hmida, Sabeh Regaya Mzabi, Saadia Bouraoui,

The aim was to evaluate the relationship between SDF-1G801A polymorphism and its immunohistochemical expression in colorectal cancer tissues in the Tunisian cohort. The molecular and immunohistochemical analysis showed that SDF-1G801A polymorphic variant was higher in CRC patients with TNM stage II and III, the SDF-1 expression was significantly increased from ... Read more >>

J Immunoassay Immunochem (Journal of immunoassay & immunochemistry)
[2015, 36(2):182-194]

Cited: 4 times

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Implication of K-ras and p53 in colorectal cancer carcinogenesis in Tunisian population cohort.

Chaar Ines, Ounissi Donia, Boughriba Rahma, Azza Ben Ammar, Amara Sameh, Taher Khalfallah, Ben Hmida Abdelmajid, Mzabi Sabeh, Bouraoui Saadia,

According to the multistep route of genetic alterations in the colorectal adenoma-carcinoma sequence, the complex K-ras/p53 mutation is one of the first alterations to occur and represent an important genetic event in colorectal cancer (CRC). An evaluation of the mutation spectra in K-ras and p53 gene was effected in 167 ... Read more >>

Tumour Biol. (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine)
[2014, 35(7):7163-7175]

Cited: 4 times

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Biological significance of promoter hypermethylation of p14/ARF gene: relationships to p53 mutational status in Tunisian population with colorectal carcinoma.

Ines Chaar, Sameh Amara, Olfa Elhadj Elamine, Mariem Khiari, Donia Ounissi, Taher Khalfallah, Abdelmajid Ben Hmida, Sabeh Mzabi, Saadia Bouraoui,

One of the most important pathways which are frequently affected in colorectal cancer is p53/ (MDM2)/p14ARF pathway. We aim to determine the methylation pattern of p14/ARF in relation to mutation of p53. This correlation was studied to investigate whether their alterations could be considered as a predictor factor of prognosis ... Read more >>

Tumour Biol. (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine)
[2014, 35(2):1439-1449]

Cited: 12 times

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Relationship between MDM2 and p53 alterations in colorectal cancer and their involvement and prognostic value in the Tunisian population.

Ines Chaar, Sameh Amara, Mariem Khiari, Donia Ounissi, Monia Dhraif, Abd E M Ben Hamida, Lassad Gharbi, Sabeh Mzabi, Saadia Bouraoui,

The prevalence of p53 mutations in colorectal cancer could reach 90%. The most important regulator of this protein that was identified originally was the Murine Double Minute2 (MDM2) oncoprotein, by which the levels of p53 were fixed through an autoregulatory feedback loop. In cancer cases, the overexpression of MDM2 deregulates ... Read more >>

Appl. Immunohistochem. Mol. Morphol. (Applied immunohistochemistry & molecular morphology : AIMM)
[2013, 21(3):228-236]

Cited: 2 times

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