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Author Dong Hoon Shin

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Phylogenetic Positioning of a Strongyloides stercoralis Isolate Recovered from a Korean Patient and Comparison with Other Asian Isolates.

Jaeho Bae, Mi Jin Jeong, Dong Hoon Shin, Hyun Woo Kim, Sung Ho Ahn, Jun Ho Choi, Hak Sun Yu,

Strongyloidiasis is caused by Strongyloides stercoralis and is one of the most neglected tropical diseases in tropical and subtropical regions. Although several strongyloidiasis cases have been reported in Korea, genetic analysis of Korean isolates is still incomplete. In this study, a parasite was isolated from a 61-year-old man diagnosed with ... Read more >>

Korean J Parasitol (The Korean journal of parasitology)
[2020, 58(6):689-694]

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Effectiveness of Albumin-bilirubin Score as a Predictor of Post-hepatectomy Liver Failure in Patients with Hepatocellular Carcinoma.

Hyun Joon Park, Kwang Il Seo, Sung Jun Kim, Sang Uk Lee, Byung Cheol Yun, Byung Hoon Han, Dong Hoon Shin, Young Il Choi, Hyung Hwan Moon,

<h4>Backgrounds/aims</h4>Post-hepatectomy liver failure (PHLF) is a major concern for patients with hepatocellular carcinoma (HCC) who have undergone liver resection. The albumin-bilirubin (ALBI) score is a novel model for assessing liver function. We aimed to investigate the effectiveness of the ALBI score as a predictor of PHLF in HCC patients who ... Read more >>

Korean J Gastroenterol (The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi)
[2021, 77(3):115-122]

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Comorbidity index for predicting mortality at 6 months after reperfusion therapy.

Hyo Suk Nam, Young Dae Kim, Joonsang Yoo, Hyungjong Park, Byung Moon Kim, Oh Young Bang, Hyeon Chang Kim, Euna Han, Dong Joon Kim, Joonyung Heo, Minyoung Kim, Jin Kyo Choi, Kyung-Yul Lee, Hye Sun Lee, Dong Hoon Shin, Hye-Yeon Choi, Sung-Il Sohn, Jeong-Ho Hong, Jong Yun Lee, Jang-Hyun Baek, Gyu Sik Kim, Woo-Keun Seo, Jong-Won Chung, Seo Hyun Kim, Tae-Jin Song, Sang Won Han, Joong Hyun Park, Jinkwon Kim, Yo Han Jung, Han-Jin Cho, Seong Hwan Ahn, Sung Ik Lee, Kwon-Duk Seo, Ji Hoe Heo,

The eligibility of reperfusion therapy has been expanded to increase the number of patients. However, it remains unclear the reperfusion therapy will be beneficial in stroke patients with various comorbidities. We developed a reperfusion comorbidity index for predicting 6-month mortality in patients with acute stroke receiving reperfusion therapy. The 19 ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):5963]

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Automated assessment of the substantia nigra on susceptibility map-weighted imaging using deep convolutional neural networks for diagnosis of Idiopathic Parkinson's disease.

Dong Hoon Shin, Hwan Heo, Soohwa Song, Na-Young Shin, Yoonho Nam, Sang-Won Yoo, Joong-Seok Kim, Jung Han Yoon, Seon Heui Lee, Young Hee Sung, Eung Yeop Kim,

<h4>Objectives</h4>Despite its use in determining nigrostriatal degeneration, the lack of a consistent interpretation of nigrosome 1 susceptibility map-weighted imaging (SMwI) limits its generalized applicability. To implement and evaluate a diagnostic algorithm based on convolutional neural networks for interpreting nigrosome 1 SMwI for determining nigrostriatal degeneration in idiopathic Parkinson's disease (IPD).<h4>Methods</h4>In ... Read more >>

Parkinsonism Relat Disord (Parkinsonism & related disorders)
[2021, 85:84-90]

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Optimal ICG dosage of preoperative colonoscopic tattooing for fluorescence-guided laparoscopic colorectal surgery.

Hong-Min Ahn, Gyung Mo Son, In Young Lee, Dong-Hoon Shin, Tae Kyun Kim, Su Bum Park, Hyung Wook Kim,

<h4>Background</h4>Indocyanine green (ICG) is a multifunctional dye used in tumor localization, tissue perfusion, and lymph node (LN) mapping during fluorescence-guided laparoscopic colorectal surgery.<h4>Purpose</h4>This study aimed to establish the optimal protocol for preoperative endoscopic submucosal ICG injection to perform fluorescence lymph node mapping (FLNM), along with undisturbed fluorescent tumor localization and ... Read more >>

Surg Endosc (Surgical endoscopy)
[2021, :]

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Increased risk of herpes zoster in gynecological cancer patients receiving radiotherapy combined with chemotherapy: a need for paying attention to vaccines.

Dong Hoon Shin, Kyoung Ho Song,

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(2):e35]

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Semiconductor-less vertical transistor with ION/IOFF of 106.

Jun-Ho Lee, Dong Hoon Shin, Heejun Yang, Nae Bong Jeong, Do-Hyun Park, Kenji Watanabe, Takashi Taniguchi, Eunah Kim, Sang Wook Lee, Sung Ho Jhang, Bae Ho Park, Young Kuk, Hyun-Jong Chung,

Semiconductors have long been perceived as a prerequisite for solid-state transistors. Although switching principles for nanometer-scale devices have emerged based on the deployment of two-dimensional (2D) van der Waals heterostructures, tunneling and ballistic currents through short channels are difficult to control, and semiconducting channel materials remain indispensable for practical switching. ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):1000]

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Genetic variants of TLR9 Gene and Chronic Kidney Disease Susceptibility

Jin Ho Kwak, Gyeong Im Yu, Woo Yeong Park, Jin Hyuk Paek, Yaerim Kim, Dong Hoon Shin, Kyubok Jin,

<h4>Objectives: </h4> Chronic kidney disease (CKD) is a common condition that can lead to renal dysfunction and is closely in relation to an increased cardiovascular risk and mortality risk. CKD is an important public health issue, and recent genetic studies have verified common CKD susceptibility variants. In this research, we ... Read more >>

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The longitudinal associations between trajectory of and quantity of alcohol consumption and subsequent changes in blood pressure levels among non-hypertensive adults.

Sukyoung Jung, Mi Kyung Kim, Jinho Shin, Bo Youl Choi, Young-Hoon Lee, Dong Hoon Shin, Min-Ho Shin,

Given the dynamic characteristic of an individual's drinking behaviors, comprehensive consideration of alcohol consumption variation using repeated measures may improve insight into the nature of its association with blood pressure (BP) change. We examined the association between longitudinal alcohol consumption (trajectory and quantity) and changes in BP and pulse pressure ... Read more >>

Br J Nutr (The British journal of nutrition)
[2021, :1-26]

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Identification of the CFAP410 Pathogenic Variants in a Korean Patient with Autosomal Recessive Retinitis Pigmentosa and Skeletal Anomalies.

Dong Hoon Shin, Ah Reum Kim, Hye In Woo, Ja-Hyun Jang, Woong-Yang Park, Byoung Joon Kim, Sang Jin Kim,

Korean J Ophthalmol (Korean journal of ophthalmology : KJO)
[2020, 34(6):500-502]

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Oseltamivir and the Risk of Neuropsychiatric Events: A National, Population-based Study.

Kyungmin Huh, Minsun Kang, Dong Hoon Shin, Jinwook Hong, Jaehun Jung,

<b>Background: </b>Reports of serious neuropsychiatric events (NPEs), specifically suicide/suicide attempts, following the use of oseltamivir have led to public concerns. Our aim in this study was to determine whether an association exists between oseltamivir use and NPEs.<br><br><b>Method: </b>This study was a population-based, retrospective, cohort study on a random sample of ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, 71(9):e409-e414]

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Metagonimus yokogawai Ancient DNA Recovered from 16th- to 17th-Century Korean Mummy Feces of the Joseon Dynasty.

Jong Ha Hong, Min Seo, Chang Seok Oh, Jong-Yil Chai, Dong Hoon Shin,

Metagonimiasis is foodborne intestinal parasitism occurring by the definitive hosts' ingestion of raw or undercooked fish, mostly commonly sweetfish. Most Metagonimus infection is caused by Metagonimus yokogawai but also rarely by Metagonimus takahashii as well as Metagonimus miyatai. Despite recent molecular work on Metagonimus spp., there are still insufficient data ... Read more >>

J Parasitol (The Journal of parasitology)
[2020, 106(6):802-808]

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A call for antimicrobial stewardship in patients with COVID-19: a nationwide cohort study in Korea.

Dong Hoon Shin, Minsun Kang, Kyoung-Ho Song, Jaehun Jung, Eu Suk Kim, Hong Bin Kim,

Clin Microbiol Infect (Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases)
[2021, 27(4):653-655]

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Factors predicting metastasis in patients with 10–20-mm sized rectal neuroendocrine tumor 

Byung-Soo Park, Sung Hwan Cho, Gyung Mo Son, Hyun Sung Kim, Su Jin Kim, Su Bum Park, Cheol Woong Choi, Hyung Wook Kim, Dong Hoon Shin,

<h4>Background: </h4> Rectal neuroendocrine tumors (NET) <10 mm are typically treated with endoscopic resection, while those >20 mm should be treated with radical surgical resection. However, the proper treatment methodology for 10-20-mm sized rectal NETs remains controversial. The purpose of this study was to investigate the appropriate treatment strategy for ... Read more >>

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Short course of voriconazole therapy as a risk factor for relapse of invasive pulmonary aspergillosis.

Dong Hoon Shin, Seung-Jin Yoo, Kang Il Jun, Hyungjin Kim, Chang Kyung Kang, Kyoung-Ho Song, Pyoeng Gyun Choe, Wan Beom Park, Ji-Hwan Bang, Eu Suk Kim, Sang Won Park, Hong Bin Kim, Nam-Joong Kim, Myoung-Don Oh,

To investigate associations of the duration of voriconazole treatment and radiological response with relapse of invasive pulmonary aspergillosis (IPA) in immunocompromised patients, we explored the risk factors for IPA relapse after successful initial treatment. All patients with proven or probable IPA who had finished voriconazole treatment between 2005 and 2019 ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):16078]

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1147. Short Course of Voriconazole Therapy as a Risk Factor for Relapse of Invasive Pulmonary Aspergillosis

Dong Hoon Shin, Seung-Jin Yoo, Jongtak Jung, Kang Il Jun, Hyungjin Kim, Chang Kyung Kang, Kyung Ho Song, Pyoeng Gyun Choe, Wan Beom Park, Ji-Hwan Bang, Eu Suk Kim, Sang Won Park, Hong Bin Kim, Nam-Joong Kim, Myoung-don Oh,

Abstract <h4>Background</h4> Invasive pulmonary aspergillosis (IPA) is a life-threatening opportunistic infection which usually occurs in immunocompromised patients. Recommended duration of voriconazole therapy is a minimum of 6-12 weeks for IPA, despite the lack of any firm evidence. In addition, risk factors for relapse of IPA are still unclear. Here, we ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(Suppl 1):S600-S601]

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Unilateral synchronous papillary renal neoplasm with reverse polarity and clear cell renal cell carcinoma: a case report with KRAS and PIK3CA mutations.

Hyun Jung Lee, Dong Hoon Shin, Joon Young Park, So Young Kim, Chung Su Hwang, Jung Hee Lee, Jee Yeon Kim, Mee Young Sol, Jong Kil Nam,

<h4>Background</h4>The presence of histologically different neoplasms in the same organ is rare in pathologic practice. We report the first case of synchronous clear cell renal cell carcinoma (clear cell RCC) and papillary renal neoplasm with reverse polarity (PRNRP) with comprehensive immunohistochemical and molecular characterization using next-generation sequencing (NGS).<h4>Case presentation</h4>A 61-year-old ... Read more >>

Diagn Pathol (Diagnostic pathology)
[2020, 15(1):123]

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Unilateral synchronous papillary renal neoplasm with reverse polarity and clear cell renal cell carcinoma: a case report with KRAS and PIK3CA mutations

Hyun Jung Lee, Dong Hoon Shin, Joon Young Park, So Young Kim, Chung Su Hwang, Jung Hee Lee, Jee Yeon Kim, Mee Young Sol, Jong Kil Nam,

<h4>Background: </h4> The presence of histologically different neoplasms in the same organ is rare in pathologic practice. We report the first case of synchronous clear cell renal cell carcinoma (clear cell RCC) and papillary renal neoplasm with reverse polarity (PRNRP) with comprehensive immunohistochemical and molecular characterization using next-generation sequencing (NGS). ... Read more >>

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Chronic activation of 4-1BB signaling induces granuloma development in tumor-draining lymph nodes that is detrimental to subsequent CD8+ T cell responses.

Seon-Hee Kim, Rohit Singh, Chungyong Han, Eunjung Cho, Yu I Kim, Don G Lee, Young H Kim, Sang Soo Kim, Dong Hoon Shin, Hye Jin You, Hyeon-Woo Lee, Byoung S Kwon, Beom K Choi,

The antitumor capabilities of agonistic anti-4-1BB mAbs have made them an attractive target for tumor immunotherapy. However, the adverse side effects associated with agonist antibodies have hindered their clinical development. Here, we aimed to study the immune-related adverse events of repeated doses and long-term use of agonistic anti-4-1BB mAbs. We ... Read more >>

Cell Mol Immunol (Cellular & molecular immunology)
[2020, :]

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Midkine Is a Potential Therapeutic Target of Tumorigenesis, Angiogenesis, and Metastasis in Non-Small Cell Lung Cancer.

Dong Hoon Shin, Jeong Yeon Jo, Sun Ha Kim, Minyoung Choi, Chungyong Han, Beom K Choi, Sang Soo Kim,

Hypoxia-inducible factors (HIFs) induced by reduced O<sub>2</sub> availability activate the transcription of target genes encoding proteins that play important roles in communication between cancer and stromal cells. Cancer cells were incubated under hypoxic conditions: H1299, A549 (NSCLC); Hep3B, HepG2 (HCC); HCT116, CT26 (Colon cancer); MCF-7, MDAMB231 (Breast cancer); MKN1, MKN5 ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(9):]

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Identification of MYC as an antinecroptotic protein that stifles RIPK1-RIPK3 complex formation.

Daehyeon Seong, Manhyung Jeong, Jinho Seo, Ji-Yoon Lee, Chi Hyun Hwang, Ho-Chul Shin, Jeong Yoon Shin, Young Woo Nam, Jeong Yeon Jo, Haeseung Lee, Hye-Jung Kim, Hwa-Ryeon Kim, Ji Hoon Oh, Sang-Jun Ha, Seung Jun Kim, Jae-Seok Roe, Wankyu Kim, June-Won Cheong, Kwang-Hee Bae, Sang Chul Lee, Andrew Oberst, Peter Vandenabeele, Dong Hoon Shin, Eun-Woo Lee, Jaewhan Song,

The underlying mechanism of necroptosis in relation to cancer is still unclear. Here, MYC, a potent oncogene, is an antinecroptotic factor that directly suppresses the formation of the RIPK1-RIPK3 complex. Gene set enrichment analyses reveal that the MYC pathway is the most prominently down-regulated signaling pathway during necroptosis. Depletion or ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2020, 117(33):19982-19993]

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Vasodilatory Effect of Phellinus linteus Extract in Rat Mesenteric Arteries.

Youngin Kwon, Chae Eun Haam, Seonhee Byeon, Soo Jung Choi, Dong-Hoon Shin, Soo-Kyoung Choi, Young-Ho Lee,

<i>Phellinus linteus</i> is a well-known medicinal mushroom that is widely used in Asian countries. In several experimental models, <i>Phellinus linteus</i> extracts were reported to have various biological effects, including anti-inflammatory, anti-cancer, hepatoprotective, anti-diabetic, neuroprotective, and anti-angiogenic activity. In the present study, several bioactive compounds, including palmitic acid ethyl ester and ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2020, 25(14):]

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Clinical manifestations of cuticular drusen in Korean patients.

Dong Hoon Shin, Mingui Kong, Gyule Han, Jong Chul Han, Don-Il Ham,

Cuticular drusen show some similarities to and differences from soft drusen in age-related macular degeneration (AMD) and might thus be a unique AMD subtype. Previous studies on cuticular drusen were performed mainly in white ethnic groups, but AMD shows ethnic differences. We investigated clinical manifestations of cuticular drusen in Korean ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):11469]

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Bicarbonate permeation through anion channels: its role in health and disease.

Dong Hoon Shin, Minjae Kim, Yonjung Kim, Ikhyun Jun, Jinsei Jung, Joo Hyun Nam, Mary Hongying Cheng, Min Goo Lee,

Many anion channels, frequently referred as Cl- channels, are permeable to different anions in addition to Cl-. As the second-most abundant anion in the human body, HCO3- permeation via anion channels has many important physiological roles. In addition to its classical role as an intracellular pH regulator, HCO3- also controls ... Read more >>

Pflugers Arch (Pflugers Archiv : European journal of physiology)
[2020, 472(8):1003-1018]

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Risk factors for and clinical outcomes of carbapenem non-susceptible gram negative bacilli bacteremia in patients with acute myelogenous leukemia.

Dong Hoon Shin, Dong-Yeop Shin, Chang Kyung Kang, Suhyeon Park, Jieun Park, Kang Il Jun, Taek Soo Kim, Youngil Koh, Jun Shik Hong, Pyoeng Gyun Choe, Wan Beom Park, Nam-Joong Kim, Sung-Soo Yoon, Inho Kim, Myoung-Don Oh,

<h4>Background</h4>Carbapenem is frequently used when gram negative bacilli (GNB) bacteremia is detected especially in neutropenic patients. Consequently, appropriate treatment could be delayed in GNB bacteremia cases involving organisms which are not susceptible to carbapenem (carba-NS), resulting in a poor clinical outcomes. Here, we explored risk factors for carba-NS GNB bacteremia ... Read more >>

BMC Infect Dis (BMC infectious diseases)
[2020, 20(1):404]

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