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Efficacy and safety of Chinese patent medicine (Kang-ai injection) as an adjuvant in the treatment of patients with hepatocellular carcinoma: a meta-analysis.

Chuihua Sun, Fang Dong, Ting Xiao, Wenni Gao,

<h4>Context</h4>Kang-ai injection (KAI) is an authorized herbal medicine used in cancer treatment. However, its clinical efficacy in hepatocellular carcinoma (HCC) has not been investigated thoroughly.<h4>Objective</h4>To systematically evaluate the efficacy and safety of KAI in patients with HCC.<h4>Materials and methods</h4>The Web of Science, PubMed, Cochrane Library, EMBASE, CBM, CNKI, VIP and ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):472-483]

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Cytoskeleton-associated protein 2 (CKAP2) is regulated by vascular endothelial growth factor and p53 in retinal capillary endothelial cells under high-glucose conditions.

Xiangting Chen, Jie Xie, Ying Cui, Liang Zhang, Honghua Yu, Jing Chen, Mengxia He, Shuangxin Liu, Tian Huang, Lu Chen, Dong Fang, Ying Zhu, Shaochong Zhang, Qianli Meng,

<h4>Purpose</h4>We previously found the mutation frequency of cytoskeleton-associated protein 2 (CKAP2) was significantly increased in proliferative diabetic retinopathy (PDR) patients through whole exome sequencing. The present study was conducted to explore the expression and possible mechanism of CKAP2 in PDR patients and human retinal capillary endothelial cells (HRCECs) under high-glucose ... Read more >>

Mol Cell Endocrinol (Molecular and cellular endocrinology)
[2021, 535:111378]

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Hypervirulent Klebsiella pneumoniae Infections in Pediatric Populations in Beijing (2017-2019): Clinical Characteristics, Molecular Epidemiology and Antimicrobial Susceptibility.

Yue Li, Limin Dong, Wei Gao, Jinghui Zhen, Fang Dong, Kaihu Yao,

<h4>Background</h4>Hypervirulent variants of Klebsiella pnuemoniae (hvKp) are emerging globally causing life-threatening infectious diseases; however, comprehensive studies on pediatric hvKp strains and related infections are still lacking.<h4>Methods</h4>Clinical data were collected from medical records. Genotype (multilocus sequence typing), capsular serotype, virulence gene profile and carbapenemase of the isolates were determined by PCR ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, :]

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Breast cancer cell-derived extracellular vesicles transfer miR-182-5p and promote breast carcinogenesis via the CMTM7/EGFR/AKT axis.

Chong Lu, Yu Zhao, Jing Wang, Wei Shi, Fang Dong, Yue Xin, Xiangwang Zhao, Chunping Liu,

<h4>Background</h4>Extracellular vesicles (EVs) derived from tumor cells are implicated in the progression of malignancies through the transfer of molecular cargo microRNAs (miRNAs or miRs). We aimed to explore the role of EVs derived from breast cancer cells carrying miR-182-5p in the occurrence and development of breast cancer.<h4>Methods</h4>Differentially expressed miRNAs and ... Read more >>

Mol Med (Molecular medicine (Cambridge, Mass.))
[2021, 27(1):78]

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Abnormal resting-state EEG power and impaired inhibition control in young smokers.

Fang Dong, Xiaojian Li, Yunmiao Zhang, Shaodi Jia, Shidi Zhang, Ting Xue, Yan Ren, Xiaoqi Lv, Kai Yuan, Dahua Yu,

Exposure to nicotine during adolescence may cause neurophysiological changes and increase the risks of developing nicotine dependence; it can even lead to lifelong smoking. The intake of nicotine may also lead to abnormal patterns of oscillatory brain activity and inhibition control deficits. However, little is known about the specific relationship ... Read more >>

Neurosci Lett (Neuroscience letters)
[2021, :136120]

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WDR82-binding long non-coding RNA lncEry controls mouse erythroid differentiation and maturation

Shangda Yang, Guohuan Sun, Peng Wu, Cong Chen, Yijin Kuang, Zhaofeng Zheng, Yicheng He, Quan Gu, Ting Lu, Caiying Zhu, Fengjiao Wang, Fanglin Gou, Zining Yang, Xiangnan Zhao, Shiru Yuan, Liu Yang, Shihong Lu, Yapu Li, Xue Lv, Fang Dong, Yanni Ma, Jia Yu, Lai Guan Ng, Lihong Shi, Jing Liu, Hui Cheng, Tao Cheng,

<h4>ABSTRACT</h4> Hematopoietic differentiation is controlled by both genetic and epigenetic regulators. Long non-coding RNAs (lncRNAs) have been demonstrated to be important for normal hematopoiesis, but their function in erythropoiesis needs to be further explored. We profiled the transcriptomes of 16 murine hematopoietic cell populations by deep RNA-sequencing and identified a ... Read more >>

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The basis of α-hemolysis Negative Methicillin-resistant Staphylococcus Aureus Isolates from Beijing Children’s Hospital

Lijuan Wang, Chen Sun, Suyun Qian, Yingchao Liu, Kaihu Yao, Fang Dong, Wenqi Song,

<h4>Background: </h4> Methicillin-resistant Staphylococcus aureus (MRSA) Clonal Complex 59 (CC59) clone has spread among Chinese children, resulting in many Staphylococcus aureus infections. α-hemolysin (Hlα) is an important virulence factor of Staphylococcus aureus , but little research has been done on CC59 isolates with negative α-hemolysis. <h4>Results: </h4>. During the 4 ... Read more >>

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Intraoperative choroidal detachment during small-gauge vitrectomy: analysis of causes, anatomic, and visual outcomes.

Ting Zhang, Yantao Wei, Zhaotian Zhang, Wei Chi, Lujia Feng, Wu Xiang, Li Wang, Dong Fang, Yunhong Shi, Shaochong Zhang,

<h4>Introduction</h4>To investigate the incidence and causes of intraoperative choroidal detachment (CD) during small-gauge vitrectomy, as well as the anatomic and visual outcomes.<h4>Methods</h4>We retrospectively reviewed the medical records of 1026 consecutive patients who underwent small-gauge vitrectomy from June 2017 to December 2018 at Zhongshan Ophthalmic Centre, Guangzhou, China. Data on the ... Read more >>

Eye (Lond) (Eye (London, England))
[2021, :]

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The impact of chronic diseases on psychological distress among the older adults: the mediating and moderating role of activities of daily living and perceived social support.

Shujuan Xiao, Lei Shi, Fang Dong, Xiao Zheng, Yaqing Xue, Jiachi Zhang, Benli Xue, Huang Lin, Ping Ouyang, Chichen Zhang,

<h4>Objectives</h4>Previous literature has shown that chronic diseases and psychological distress are correlated. However, the mediating and moderating mechanisms underlying this relationship have not been sufficiently studied. The purpose of this study was to explore the role played by activities of daily living (ADL) and perceived social support.<h4>Method</h4>Face-to-face questionnaire-based surveys were ... Read more >>

Aging Ment Health (Aging & mental health)
[2021, :1-7]

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Comprehensive analysis of suppressor of cytokine signaling proteins in human breast Cancer.

Mingyu Sun, Chuangang Tang, Jun Liu, Wenli Jiang, Haifeng Yu, Fang Dong, Caiguo Huang, Youlutuziayi Rixiati,

<h4>Background</h4>Abnormal expression of suppressor of cytokine signaling (SOCS) proteins regulates tumor angiogenesis and development in cancers. In this study, we aimed to perform a comprehensive bioinformatic analysis of SOCS proteins in breast invasive carcinoma (BRCA).<h4>Methods</h4>The gene expression, methylation level, copy number, protein expression and patient survival data related to SOCS ... Read more >>

BMC Cancer (BMC cancer)
[2021, 21(1):696]

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The Epidemiological Characteristics of Pediatric Streptococcus Pneumoniae Isolated From Inpatients And Outpatients At Beijing Children’s Hospital

Shuang Lyu, Wei Shi, Fang Dong, Baoping Xu, Gang Liu, Quan Wang, Kaihu Yao, Yong Hong Yang,

<h4>Background: </h4> The epidemiological data of Streptococcus pneumoniae isolates are important for the practice of treatment and prevention. This research aimed to explore the epidemiological characteristics of pediatric S. pneumoniae isolated from outpatients and inpatients. <h4>Methods: </h4>: S. pneumoniae were isolated from unsterile samples of inpatients and outpatients younger than ... Read more >>

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A Cloud Computing Platform for Scalable Relative and Absolute Binding Free Energy Predictions: New Opportunities and Challenges for Drug Discovery.

Zhixiong Lin, Junjie Zou, Shuai Liu, Chunwang Peng, Zhipeng Li, Xiao Wan, Dong Fang, Jian Yin, Gianpaolo Gobbo, Yongpan Chen, Jian Ma, Shuhao Wen, Peiyu Zhang, Mingjun Yang,

Free energy perturbation (FEP) has become widely used in drug discovery programs for binding affinity prediction between candidate compounds and their biological targets. However, limitations of FEP applications also exist, including, but not limited to, high cost, long waiting time, limited scalability, and breadth of application scenarios. To overcome these ... Read more >>

J Chem Inf Model (Journal of chemical information and modeling)
[2021, 61(6):2720-2732]

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The H3K36me2 methyltransferase NSD1 modulates H3K27ac at active enhancers to safeguard gene expression.

Yuan Fang, Yin Tang, Yanjun Zhang, Yixin Pan, Junqi Jia, Zhongxing Sun, Weiwu Zeng, Jiaqi Chen, Ying Yuan, Dong Fang,

Epigenetics, especially histone marks, functions beyond the DNA sequences to regulate gene expression. Depletion of NSD1, which catalyzes H3K36me2, leads to both up- and down-regulation of gene expression, indicating NSD1 is associated with both active and repressed gene expression. It's known that NSD1 regulates the deposition and expansion of H3K27me3, ... Read more >>

Nucleic Acids Res (Nucleic acids research)
[2021, 49(11):6281-6295]

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Mechanistic Insights into Substrate Recognition and Catalysis of a New Ulvan Lyase of Polysaccharide Lyase Family 24.

Fei Xu, Fang Dong, Xiao-Hui Sun, Hai-Yan Cao, Hui-Hui Fu, Chun-Yang Li, Xi-Ying Zhang, Andrew McMinn, Yu-Zhong Zhang, Peng Wang, Xiu-Lan Chen,

Ulvan is an important marine polysaccharide. Bacterial ulvan lyases play important roles in ulvan degradation and marine carbon cycling. Until now, only a small number of ulvan lyases have been characterized. Here, a new ulvan lyase, Uly1, belonging to polysaccharide lyase family 24 (PL24) from the marine bacterium Catenovulum maritimum, ... Read more >>

Appl Environ Microbiol (Applied and environmental microbiology)
[2021, 87(12):e0041221]

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Scaffold Hopping Transformations Using Auxiliary Restraints for Calculating Accurate Relative Binding Free Energies.

Junjie Zou, Zhipeng Li, Shuai Liu, Chunwang Peng, Dong Fang, Xiao Wan, Zhixiong Lin, Tai-Sung Lee, Daniel P Raleigh, Mingjun Yang, Carlos Simmerling,

<i>In silico</i> screening of drug-target interactions is a key part of the drug discovery process. Changes in the drug scaffold via contraction or expansion of rings, the breaking of rings, and the introduction of cyclic structures from acyclic structures are commonly applied by medicinal chemists to improve binding affinity and ... Read more >>

J Chem Theory Comput (Journal of chemical theory and computation)
[2021, 17(6):3710-3726]

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Case Report: A Novel Compound Heterozygous Mutation in IL-10RA in a Chinese Child With Very Early-Onset Inflammatory Bowel Disease.

Fang Dong, Fangfei Xiao, Ting Ge, Xiaolu Li, Wuhen Xu, Shengnan Wu, Ting Zhang, Yizhong Wang,

Very early-onset inflammatory bowel disease (VEO-IBD) is defined as IBD diagnosed in children younger than 6 years of age. VEO-IBD is often associated with a monogenic etiology or primary immune deficiency. Here, we report the case of a 7-month-old Chinese girl diagnosed with VEO-IBD who had a variant in the ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2021, 9:678390]

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Arylazo-1,2,3-Triazoles: “Clicked” Photoswitches for Versatile Functionalization and Electronic Decoupling

Dong Fang, Zhao-Yang Zhang, Tao LI,

The development of light-responsive chemical systems often relies on the rational design and suitable incorporation of molecular photoswitches such as azobenzenes. Linking a photoswitch core with another π-conjugated molecular entity may give rise to intramolecular electronic coupling, which can dramatically impair the photoswitch function. Decoupling strategies have been developed based ... Read more >>

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Radiation-induced bystander effects impair transplanted human hematopoietic stem cells via oxidative DNA damage.

Linping Hu, Xiuxiu Yin, Yawen Zhang, Aiming Pang, Xiaowei Xie, Shangda Yang, Caiying Zhu, Yapu Li, Biao Zhang, Yaojin Huang, Yunhong Tian, Mei Wang, Wenbin Cao, Shulian Chen, Yawei Zheng, Shihui Ma, Fang Dong, Sha Hao, Sizhou Feng, Yongxin Ru, Hui Cheng, Erlie Jiang, Tao Cheng,

Total body irradiation (TBI) is commonly used in host conditioning regimens for human hematopoietic stem cell (HSC) transplantation to treat various hematological disorders. Exposure to TBI not only induces acute myelosuppression and immunosuppression, but also injures the various components of the HSC niche in recipients. Our previous study demonstrated that ... Read more >>

Blood (Blood)
[2021, 137(24):3339-3350]

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Granulocyte colony-stimulating factor directly acts on mouse lymphoid-biased but not myeloid-biased hematopoietic stem cells.

Miner Xie, Shanshan Zhang, Fang Dong, Qingyun Zhang, Jinhong Wang, Chenchen Wang, Caiying Zhu, Sen Zhang, Bingqing Luo, Peng Wu, Hideo Ema,

Granulocyte colony-stimulating factor (G-CSF) is widely used in clinical settings to mobilize hematopoietic stem cells (HSCs) into the circulation for HSC harvesting and transplantation. However, whether G-CSF directly stimulates HSCs to change their cell cycle state and fate is controversial. HSCs are a heterogeneous population consisting of different types of ... Read more >>

Haematologica (Haematologica)
[2021, 106(6):1647-1658]

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Single Hormone Receptor-Positive Metaplastic Breast Cancer: Similar Outcome as Triple-Negative Subtype.

Jinqian Mao, Jin Hu, Yanting Zhang, Jian Shen, Fang Dong, Ximeng Zhang, Jie Ming, Tao Huang, Xiaoqin Run,

<h4>Background</h4>Metaplastic breast cancer (MBC) is a rare and aggressive subtype of the breast. To understand the characteristics and prognosis of single hormone receptor-positive (HR+) MBC (estrogen receptor-positive [ER+]/progesterone receptor-negative [PR-] and ER-/PR+), we compared these tumors to double HR+ tumors as well as HR- tumors.<h4>Patients and methods</h4>The Surveillance, Epidemiology, and ... Read more >>

Front Endocrinol (Lausanne) (Frontiers in endocrinology)
[2021, 12:628939]

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Gene knockout in highly purified mouse hematopoietic stem cells by CRISPR/Cas9 technology.

Yan Dong, Haitao Bai, Fang Dong, Xiao-Bing Zhang, Hideo Ema,

The CRISPR/Cas9 system has been used for genome editing of human and mouse cells. In this study, we established a protocol for gene knockout (KO) in mouse hematopoietic stem cells (HSCs). HSCs were highly purified from the bone marrow of tamoxifen-treated Cas9-EGFP/Cre-ER transgenic mice, maintained in serum-free polyvinyl alcohol culture ... Read more >>

J Immunol Methods (Journal of immunological methods)
[2021, 495:113070]

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Correction to: The Impact of Smoking, Sex, Infection, and Comedication Administration on Oral Olanzapine: A Population Pharmacokinetic Model in Chinese Psychiatric Patients.

Yan-Nan Zang, Fang Dong, An-Ning Li, Chuan-Yue Wang, Gui-Xin Guo, Qian Wang, Yan-Fang Zhang, Lei Zhang, Jose de Leon, Can-Jun Ruan,

Eur J Drug Metab Pharmacokinet (European journal of drug metabolism and pharmacokinetics)
[2021, 46(3):373-374]

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Genome profiling of mismatch repair genes in eight types of tumors.

Siqi Wang, Gefei Guan, Cunyi Zou, Qing Guo, Wen Cheng, Shuai Shen, Fang Dong, Anhua Wu, Guang Li, Chen Zhu,

Mismatch repair (MMR) plays an important role in the occurrence and development of tumors. At present, it is widely believed that MMR is a protective mechanism of tumors that plays a critical role in the progresses of cancer. In this study, 34 genes related to MMR selected from Gene Ontology ... Read more >>

Cell Cycle (Cell cycle (Georgetown, Tex.))
[2021, 20(11):1091-1106]

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Alleviation of neurological disease by RNA editing.

Shaochong Zhang, Lu Chen, Yining Zhang, Dong Fang,

The development of CRISPR/Cas genome editing tools has revolutionized the life sciences by providing transformative applications in many biological fields, including the field of neurological disorders. Compared with previous CRISPR-Cas systems targeting DNA, a new field of RNA editing using CRISPR-Cas13 systems is gaining immense popularity. CRISPR-Cas13 is a robust, ... Read more >>

Methods (Methods (San Diego, Calif.))
[2021, :]

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Antibiotics prescription for targeted therapy of pediatric invasive pneumococcal diseases in China: a multicenter retrospective study

Tian-ming Chen, Wen-hui Li, Fang Wang, Kun Tan, Qing-xiong Zhu, Kai Zhou, Shi-hua Liu, Jing Liu, Jing Bi, Hui-ling Deng, Xue-xia Chen, Juan Li, Yu-min Wang, Qing Zhao, Liang Zhu, Hui-xuan Ma, Zhi Li, Ji-kui Deng, Chun-hui Zhu, Kang-kang Wu, Ai-wei Lin, Shuang-jie Li, Dong-meng Wang, Hui-jun Cai, Shi-yong Zhao, Xu-dong Lu, Lan Ye, Fang Dong, Wen-shuang Zhang, Yong-hong Yang, Gang Liu,

<h4>Background: </h4> Streptococcus pneumoniae ( S. pneumoniae ) is a major cause of bacterial meningitis, septicemia and pneumonia in children. Inappropriate choice of antibiotic can have important adverse consequences for both the individual and the community. <h4>Objective: </h4> To evaluate antibiotics therapy for children with IPD (invasive pneumococcal diseases) in ... Read more >>

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