Full Text Journal Articles by
Author Don Sharkey


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Characteristics and outcomes of neonatal SARS-CoV-2 infection in the UK: a prospective national cohort study using active surveillance.

Chris Gale, Maria A Quigley, Anna Placzek, Marian Knight, Shamez Ladhani, Elizabeth S Draper, Don Sharkey, Cora Doherty, Helen Mactier, Jennifer J Kurinczuk,

BACKGROUND:Babies differ from older children with regard to their exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, data describing the effect of SARS-CoV-2 in this group are scarce, and guidance is variable. We aimed to describe the incidence, characteristics, transmission, and outcomes of SARS-CoV-2 infection in neonates who ... Read more >>

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, :]

Cited: 0 times

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Finding Comfortable Routes for Ambulance Transfers of Newborn Infants.

Tom J Partridge, David E Morris, Roger A Light, Andrew Leslie, Don Sharkey, John A Crowe, Donal S McNally,

Early inter-hospital ambulance transport of premature babies is associated with more severe brain injury. The mechanism is unclear, but they are exposed to excessive noise and vibration. Smart-routing may help minimise these exposure levels and potentially improve outcomes.An app for Android smartphones was developed to collect vibration, noise and location ... Read more >>

Annu Int Conf IEEE Eng Med Biol Soc (Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference)
[2020, 2020:5905-5908]

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Early childhood respiratory morbidity and antibiotic use in ex-preterm infants: a primary care population-based cohort study.

Shin Tan, Lisa Szatkowski, William Moreton, Linda Fiaschi, Tricia McKeever, Jack Gibson, Don Sharkey,

BACKGROUND:Globally, bronchopulmonary dysplasia (BPD) continues to increase in preterm infants. Recent studies exploring subsequent early childhood respiratory morbidity have been small or focused on hospital admissions. AIMS:To examine early childhood rates of primary care consultations for respiratory tract infections (RTI), lower respiratory tract infections (LRTI), wheeze and antibiotic prescriptions in ... Read more >>

Eur Respir J (The European respiratory journal)
[2020, 56(1):]

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National active surveillance to understand and inform neonatal care in COVID-19.

Chris Gale, Marian Knight, Shamez Ladhani, Elizabeth S Draper, Don Sharkey, Cora Doherty, Helen Mactier, Jennifer J Kurinczuk, ,

Arch Dis Child Fetal Neonatal Ed (Archives of disease in childhood. Fetal and neonatal edition)
[2020, 105(4):346-347]

Cited: 0 times

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Accurate neonatal heart rate monitoring using a new wireless, cap mounted device.

Caroline Henry, Lara Shipley, Carole Ward, Siavash Mirahmadi, Chong Liu, Steve Morgan, John Crowe, James Carpenter, Barrie Hayes-Gill, Don Sharkey,

AIM:A device for newborn heart rate (HR) monitoring at birth that is compatible with delayed cord clamping and minimises hypothermia risk could have advantages over current approaches. We evaluated a wireless, cap mounted device (fhPPG) for monitoring neonatal HR. METHODS:A total of 52 infants on the neonatal intensive care unit ... Read more >>

Acta Paediatr. (Acta paediatrica (Oslo, Norway : 1992))
[2020, :]

Cited: 1 time

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Improving newborn heart rate assessment using a simple visual timer.

Caroline Henry, David E Morris, Sophie Coleman, Andrea Pereira, Christian Tamakloe, Peter Blanchfield, Don Sharkey,

Objective:Newborn resuscitation relies on accurate heart rate (HR) assessment, which, during auscultation, is prone to error. We investigated if a 6 s visual timer (VT) could improve HR assessment accuracy during newborn simulation. Design:Prospective observational study of newborn healthcare professionals. Setting:Three-phase developmental approach: phase I: HR auscultation during newborn simulation ... Read more >>

BMJ Paediatr Open (BMJ paediatrics open)
[2020, 4(1):e000638]

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Hospital-Acquired Viral Respiratory Tract Infections in the Neonatal Unit: A Comparison with Other Inpatient Groups.

Chiara Taylor, Shin Tan, Rebecca McClaughry, Don Sharkey,

Hospital-acquired viral respiratory tract infections (VRTIs) cause significant morbidity and mortality in neonatal patients. This includes escalation of respiratory support, increased length of hospital stay, and need for home oxygen, as well as higher healthcare costs. To date, no studies have compared population rates of VRTIs across age groups. Quantify ... Read more >>

Neonatology (Neonatology)
[2020, :1-4]

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The authors reply.

Don Sharkey, Lara Shipley, Jon Dorling, Laila J Tata, Lisa Szatkowski,

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2020, 21(3):300-301]

Cited: 0 times

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Risk of Severe Intraventricular Hemorrhage in the First Week of Life in Preterm Infants Transported Before 72 Hours of Age.

Lara Shipley, Timea Gyorkos, Jon Dorling, Laila J Tata, Lisa Szatkowski, Don Sharkey,

OBJECTIVES:Evaluate the risk of severe intraventricular hemorrhage, in the first week of life, in preterm infants undergoing early interhospital transport. DESIGN:Retrospective cohort study. SETTING:Tertiary neonatal centers of the Trent Perinatal Network in the United Kingdom. PATIENTS:Preterm infants less than 32 weeks gestation, who were either born within and remained at ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2019, 20(7):638-644]

Cited: 0 times

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Neurocritical care of high-risk infants during inter-hospital transport.

Neelam Gupta, Lara Shipley, Nitin Goel, Kathryn Browning Carmo, Andrew Leslie, Don Sharkey,

The centralisation of neonatal intensive care in recent years has improved mortality, particularly of extremely preterm infants, but similar improvements in morbidity, such as neurodevelopmental impairment, have not been seen. Integral to the success of centralisation are specialised neonatal transport teams who provide intensive care prior to and during retrieval ... Read more >>

Acta Paediatr (Acta paediatrica (Oslo, Norway : 1992))
[2019, 108(11):1965-1971]

Cited: 0 times

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Development of a Clinical Interface for a Novel Newborn Resuscitation Device: Human Factors Approach to Understanding Cognitive User Requirements.

Laura Pickup, Alexandra Lang, Lara Shipley, Caroline Henry, James Carpenter, Damon McCartney, Matthew Butler, Barrie Hayes-Gill, Don Sharkey,

BACKGROUND:A novel medical device has been developed to address an unmet need of standardizing and facilitating heart rate recording during neonatal resuscitation. In a time-critical emergency resuscitation, where failure can mean death of an infant, it is vital that clinicians are provided with information in a timely, precise, and clear ... Read more >>

JMIR Hum Factors (JMIR human factors)
[2019, 6(2):e12055]

Cited: 0 times

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Postnatal gestational age estimation of newborns using Small Sample Deep Learning.

Mercedes Torres Torres, Michel Valstar, Caroline Henry, Carole Ward, Don Sharkey,

A baby's gestational age determines whether or not they are premature, which helps clinicians decide on suitable post-natal treatment. The most accurate dating methods use Ultrasound Scan (USS) machines, but these are expensive, require trained personnel and cannot always be deployed to remote areas. In the absence of USS, the ... Read more >>

Image Vis Comput (Image and vision computing)
[2019, 83-84:87-99]

Cited: 0 times

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Restricted visiting reduces nosocomial viral respiratory tract infections in high-risk neonates.

Lisa Szatkowski, Rebecca McClaughry, Martin Clarkson, Don Sharkey,

Eur Respir J (The European respiratory journal)
[2019, 53(3):]

Cited: 1 time

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Early Life Incidence of Gastrointestinal and Respiratory Infections in Children With Gastroschisis: A Cohort Study.

Jessica Bannister, Lisa Szatkowski, Don Sharkey, Shin Tan, Linda Fiaschi, Lu Ban,

OBJECTIVES:Survival in infants with gastroschisis is increasing although little is known about early childhood morbidity. In the context of a hypothesized link between the gastrointestinal (GI) tract and immune function, this study explores rates of GI and respiratory infections in children with gastroschisis. METHODS:We conducted a population-based retrospective cohort study ... Read more >>

J Pediatr Gastroenterol Nutr (Journal of pediatric gastroenterology and nutrition)
[2018, 67(5):580-585]

Cited: 0 times

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Variation in Visiting and Isolation Policies in Neonatal Units: A U.K. Nationwide Survey.

Shin Tan, Martin Clarkson, Don Sharkey,

Global pandemics, such as H1N1, are a major risk for neonatal patients. We surveyed U.K. tertiary and district neonatal units about visiting and infection control policies relating to viral respiratory infections. There was marked variation with visiting policies, tertiary units being more restrictive. Isolation, screening, and outbreak management of infected ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2018, 37(1):e20-e22]

Cited: 1 time

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Glucocorticoids modulate human brown adipose tissue thermogenesis in vivo.

Hannah Scotney, Michael E Symonds, James Law, Helen Budge, Don Sharkey, Konstantinos N Manolopoulos,

Brown adipose tissue (BAT) is a thermogenic organ with substantial metabolic capacity and has important roles in the maintenance of body weight and metabolism. Regulation of BAT is primarily mediated through the β-adrenoceptor (β-AR) pathway. The in vivo endocrine regulation of this pathway in humans is unknown. The objective of ... Read more >>

Metab. Clin. Exp. (Metabolism: clinical and experimental)
[2017, 70:125-132]

Cited: 19 times

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Outcomes of Nosocomial Viral Respiratory Infections in High-Risk Neonates.

Shairbanu Zinna, Arthi Lakshmanan, Shin Tan, Rebecca McClaughry, Martin Clarkson, Shiu Soo, Lisa Szatkowski, Don Sharkey,

BACKGROUND AND OBJECTIVE:Neonatal respiratory disease, particularly bronchopulmonary dysplasia, remains one of the leading causes of morbidity and mortality in newborn infants. Recent evidence suggests nosocomially acquired viral respiratory tract infections (VRTIs) are not uncommon in the NICU. The goal of this study was to assess the association between nosocomial VRTIs, ... Read more >>

Pediatrics (Pediatrics)
[2016, 138(5):]

Cited: 10 times

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Newborn radiographic clues for undiagnosed posterior urethral valves.

Lisa Barker, Judith Grant, Stephen P Wardle, Don Sharkey,

J Pediatr (The Journal of pediatrics)
[2013, 162(1):213-213.e1]

Cited: 0 times

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Using serial oxygenation index as an objective predictor of survival for antenatally diagnosed congenital diaphragmatic hernia.

Yew-Wei Tan, Louise Adamson, Christopher Forster, Brian Davies, Don Sharkey,

INTRODUCTION: Best oxygenation index on day 1 (BOId1) had been shown to predict survival in congenital diaphragmatic hernia (CDH). Serial oxygenation index (OI) may enable better assessment of response to cardiorespiratory support than BOId1. METHODS: All antenatally diagnosed CDH from one tertiary neonatal unit were retrospectively reviewed. Oxygenation index at ... Read more >>

J Pediatr Surg (Journal of pediatric surgery)
[2012, 47(11):1984-1989]

Cited: 3 times

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Thermal imaging to assess age-related changes of skin temperature within the supraclavicular region co-locating with brown adipose tissue in healthy children.

Michael E Symonds, Katrina Henderson, Lindsay Elvidge, Conrad Bosman, Don Sharkey, Alan C Perkins, Helen Budge,

OBJECTIVE: To establish the feasibility of infrared thermal imaging as a reproducible, noninvasive method for assessing changes in skin temperature within the supraclavicular region in vivo. STUDY DESIGN: Thermal imaging was used to assess the effect of a standard cool challenge (by placement of the participant's feet or hand in ... Read more >>

J Pediatr (The Journal of pediatrics)
[2012, 161(5):892-898]

Cited: 68 times

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Marked variation in newborn resuscitation practice: a national survey in the UK.

Chantelle Mann, Carole Ward, Mark Grubb, Barrie Hayes-Gill, John Crowe, Neil Marlow, Don Sharkey,

BACKGROUND:Although international newborn resuscitation guidance has been in force for some time, there are no UK data on current newborn resuscitation practices. OBJECTIVE:Establish delivery room (DR) resuscitation practices in the UK, and identify any differences between neonatal intensive care units (NICU), and other local neonatal services. METHODS:We conducted a structured ... Read more >>

Resuscitation (Resuscitation)
[2012, 83(5):607-611]

Cited: 16 times

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Correct positioning for hip radiographs allows reliable measurement of hip displacement in cerebral palsy.

Lucy Cliffe, Don Sharkey, Grace Charlesworth, Jill Minford, Simon Elliott, Richard E Morton,

AIM: The pelvic radiograph in children with cerebral palsy (CP) can inform the degree of hip displacement by calculation of the migration percentage. However, concerns have arisen about the reliability of this measurement. The present study examined the reliability of radiographic assessment of displacement and the importance of positioning and ... Read more >>

Dev Med Child Neurol (Developmental medicine and child neurology)
[2011, 53(6):549-552]

Cited: 4 times

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The early programming of metabolic health: is epigenetic setting the missing link?

Sylvain Sebert, Don Sharkey, Helen Budge, Michael E Symonds,

Adult health is dependent, in part, on maternal nutrition and growth during early life, which may independently affect insulin sensitivity, body composition, and overall energy homeostasis. Since the publication of the "thrifty phenotype hypothesis" by Hales and Barker (Diabetologia 1992;35:595-601), animal experiments have focused on establishing the mechanisms involved, which ... Read more >>

Am. J. Clin. Nutr. (The American journal of clinical nutrition)
[2011, 94(6 Suppl):1953S-1958S]

Cited: 47 times

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A green light for improved resuscitation.

Carole Ward, Jeremy Teoh, John Crowe, Don Sharkey, Mark Grubb, Neil Marlow, Barrie Hayes-Gill,

Midwives (Midwives)
[2010, :34-36]

Cited: 0 times

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Maternal nutrient restriction during early fetal kidney development attenuates the renal innate inflammatory response in obese young adult offspring.

Don Sharkey, David S Gardner, Michael E Symonds, Helen Budge,

Obesity is an independent risk factor for developing chronic kidney disease. Toll-like receptor 4 (TLR4), interleukin (IL)-18, and uncoupling protein 2 (UCP2) are important components of the innate immune system mediating inflammatory renal damage. Early to midgestation maternal nutrient restriction appears to protect the kidney from the deleterious effects of ... Read more >>

Am. J. Physiol. Renal Physiol. (American journal of physiology. Renal physiology)
[2009, 297(5):F1199-207]

Cited: 7 times

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