Full Text Journal Articles by
Author Dominique Singer

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Adults Born Preterm: Long-Term Health Risks of Former Very Low Birth Weight Infants.

Dominique Singer, Luise Pauline Thiede, Anna Perez,

<h4>Background</h4>Advances in neonatology now enable increasing numbers of very low birth weight neonates (<1500 g) to survive into early adulthood and beyond. What are the implications for their long-term care?<h4>Methods</h4>Selective literature search on the outcome of very low birth weight neonates in adulthood ("adults born preterm").<h4>Results</h4>Robust data are available on ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Mucha-Habermann disease: a pediatric case report and proposal of a risk score.

Martin Ernst Blohm, Chinedu Ulrich Ebenebe, Cornelius Rau, Carolin Escherich, Jessika Johannsen, Gabriele Escherich, Joenna Driemeyer, Philipp Daniel Nagel, Robin Kobbe, Marc Lütgehetmann, Maximilian Lennartz, Nina Booken, Stefan Werner Schneider, Dominique Singer,

Febrile ulceronecrotic Mucha-Habermann disease (FUMHD) is a rare inflammatory dermatological disease. A case of a 13-year-old boy with FUMHD possibly triggered by mycoplasma infection is presented. Based on FUMHD cases identified in a MEDLINE literature search, demographic, treatment, and outcome data were analyzed. An FUMHD mortality risk score is proposed ... Read more >>

Int J Dermatol (International journal of dermatology)
[2021, :]

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Intravenous fluids: issues warranting concern.

Friedrich Mertzlufft, Franz Brettner, George J Crystal, Markus W Hollmann, Anton Kasatkin, Per-Arne Lönnqvist, Dominique Singer, Robert Sümpelmann, Volker Wenzel, Rolf Zander, Thomas Ziegenfuß,

Eur J Anaesthesiol (European journal of anaesthesiology)
[2021, :]

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Fatal COVID-19 in a Child with Persistence of SARS-CoV-2 Despite Extensive Multidisciplinary Treatment: A Case Report.

Sofia Apostolidou, Theresa Harbauer, Peter Lasch, Daniel Biermann, Maja Hempel, Marc Lütgehetmann, Susanne Pfefferle, Jochen Herrmann, André Rüffer, Konrad Reinshagen, Rainer Kozlik-Feldmann, Anna Gieras, Inga Kniep, Jun Oh, Dominique Singer, Chinedu Ulrich Ebenebe, Robin Kobbe,

Critical Coronavirus disease 2019 (COVID-19) developed in a 7-year-old girl with a history of dystrophy, microcephaly, and central hypothyroidism. Starting with gastrointestinal symptoms, the patient developed severe myocarditis followed by progressive multiple organ failure complicated by <i>Pseudomonas aeruginosa</i> bloodstream infection. Intensive care treatment consisting of invasive ventilation, drainage of pleural ... Read more >>

Children (Basel) (Children (Basel, Switzerland))
[2021, 8(7):]

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Whole-Exome Sequencing in Critically Ill Neonates and Infants: Diagnostic Yield and Predictability of Monogenic Diagnosis.

Tasja Scholz, Martin Ernst Blohm, Fanny Kortüm, Tatjana Bierhals, Davor Lessel, Amelie T van der Ven, Jasmin Lisfeld, Theresia Herget, Katja Kloth, Dominique Singer, Anna Perez, Nadia Obi, Jessika Johannsen, Jonas Denecke, René Santer, Christian Kubisch, Philipp Deindl, Maja Hempel,

<h4>Introduction</h4>Monogenic diseases play an important role in critically ill neonates and infants treated in the intensive care unit. This study aimed to determine the diagnostic yield of whole-exome sequencing (WES) for monogenic diseases and identify phenotypes more likely associated with a genetic etiology.<h4>Methods</h4>From March 2017 to 2020, a comprehensive diagnostic ... Read more >>

Neonatology (Neonatology)
[2021, :1-8]

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Perinatalmedizin – ein weibliches Fach wird „weiblicher“.

Dominique Singer,

Z Geburtshilfe Neonatol (Zeitschrift fur Geburtshilfe und Neonatologie)
[2021, 225(2):97]

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[Correction: Effects of Obstetric Analgesia with Systemic Opioids on the Newborn - A Review].

Berenike Seiler, Philipp Deindl, Thierry Somville, Chinedu Ulrich Ebenebe, Kurt Hecher, Dominique Singer,

Z Geburtshilfe Neonatol (Zeitschrift fur Geburtshilfe und Neonatologie)
[2021, :]

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Reference ranges for sphingosine-1-phosphate in neonates.

Chinedu Ulrich Ebenebe, Mirjam von Lucadou, Eileen Moritz, Edzard Schwedhelm, Guenter Daum, Dominique Singer, Phillip Deindl, Martin Sebastian Winkler,

<h4>Objectives</h4>Sphingosine-1-phosphate (S1P) is a signalling lipid involved in embryonic development, physiological homeostasis, and pathogenic processes in multiple organ systems. Disturbance of S1P homeostasis has been associated with various human diseases in which the immune response and vascular integrity are severely compromised. Up-to-date, no study has analyzed S1P levels in neonates. ... Read more >>

J Perinat Med (Journal of perinatal medicine)
[2021, :]

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[Effects of Obstetric Analgesia with Systemic Opioids on the Newborn - A Review].

Berenike Seiler, Philipp Deindl, Thierry Somville, Chinedu Ulrich Ebenebe, Kurt Hecher, Dominique Singer,

<h4>Introduction</h4>Three-quarters of all women receive analgesia during labor. There are regional and systemic analgesia procedures available. In this review, we investigate the impact of obstetric analgesia using systemic opioids on neonatal outcomes.<h4>Methods</h4>We searched the PubMed and Cochrane Library databases using the following search terms: "meptazinol", "meptide", "analgesia", "painkiller", "pain reliever", ... Read more >>

Z Geburtshilfe Neonatol (Zeitschrift fur Geburtshilfe und Neonatologie)
[2021, :]

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The Impact of a Dedicated Sedation Team on the Incidence of Complications in Paediatric Procedural Analgosedation

Sofia Apostolidou, Mirna Kintscher, Gerhard Schoen, Dominique Singer, Chinedu Ulrich Ebenebe, Hans-Jürgen Bartz, Christian Zöllner, Katharina Roeher,

Demands in procedural sedation and analgesia in children are growing as the number of diagnostic and minor therapeutic procedures performed on paediatric patients outside the operating room setting has increased. We established a specialized interdisciplinary team of paediatric anaesthesiologists and paediatric intensivists (Children’s Analgosedation Team, CAST) for diagnostic and therapeutic ... Read more >>

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Prediction of Nociception in Children Using the Nociceptive Flexion Reflex Threshold and the Bispectral Index-A Prospective Exploratory Observational Study.

Maximilian D Mauritz, Felix Uhlenberg, Dario Bashir-Elahi, Tobias Werther, Urda Gottschalk, Chinedu Ulrich Ebenebe, Marlies Bergers, Vito Giordano, Eik Vettorazzi, Dominique Singer, Philipp Deindl,

<h4>Objectives</h4>The prediction of patient responses to potentially painful stimuli remains a challenge in PICUs. We investigated the ability of the paintracker analgesia monitor (Dolosys GmbH, Berlin, Germany) measuring the nociceptive flexion reflex threshold, the cerebral sedation monitor bispectral index (Medtronic, Dublin, Ireland), the COMFORT Behavior, and the modified Face, Legs, ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2021, :]

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Neues Cover-Design, fortgesetzte Mindestmengen-Diskussion.

Dominique Singer,

Z Geburtshilfe Neonatol (Zeitschrift fur Geburtshilfe und Neonatologie)
[2021, 225(1):5]

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A first-in-human clinical study of a new SP-B and SP-C enriched synthetic surfactant (CHF5633) in preterm babies with respiratory distress syndrome: two-year outcomes.

David G Sweet, Mark Turner, Zbynek Straňák, Richard Plavka, Paul Clarke, Ben Stenson, Dominique Singer, Rangmar Goelz, Laura Fabbri, Guido Varoli, Annalisa Piccinno, Debora Santoro, Dorothea Del Buono, Christian P Speer,

<h4>Objective</h4>To assess at 24 months corrected age (CA) the neurological, respiratory, and general health status of children born prematurely from 27<sup>+0</sup> to 33<sup>+6</sup> weeks' gestation who were treated in a first-in-human study with a new fully synthetic surfactant (CHF5633) enriched with SP-B and SP-C proteins.<h4>Outcome measures</h4>Children were assessed using Bayley Scales ... Read more >>

J Matern Fetal Neonatal Med (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2020, :1-5]

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Lost in Transition: Health Care Experiences of Adults Born Very Preterm-A Qualitative Approach.

Anna Perez, Luise Thiede, Daniel Lüdecke, Chinedu Ulrich Ebenebe, Olaf von dem Knesebeck, Dominique Singer,

<b>Introduction:</b> Adults Born Very Preterm (ABP) are an underperceived but steadily increasing patient population. It has been shown that they face multiple physical, mental and emotional health problems as they age. Very little is known about their specific health care needs beyond childhood and adolescence. This article focuses on their ... Read more >>

Front Public Health (Frontiers in public health)
[2020, 8:605149]

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[Surviving the Lack: Natural Adaptations in Newborns].

Dominique Singer,

Newborns are equipped with a number of natural adaptation mechanisms preventing them from impaired energy supply, despite their elevated (size-related) metabolic rate. These include the diving response known from aquatic mammals, which - being composed of apnea, bradycardia, and vasoconstriction - ensures an economical use of O<sub>2</sub> reserves and results ... Read more >>

Z Geburtshilfe Neonatol (Zeitschrift fur Geburtshilfe und Neonatologie)
[2021, 225(3):203-215]

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T cell cytokines in the diagnostic of early-onset sepsis.

Glenn Malin Froeschle, Tanja Bedke, Michael Boettcher, Samuel Huber, Dominique Singer, Chinedu Ulrich Ebenebe,

<h4>Background</h4>Early-onset sepsis (EOS) remains a substantial cause of morbidity and mortality among neonates. Yet, currently available biological parameters have not proven to be accurate enough to predict EOS reliably. This study aimed to determine serum concentrations of 13 cytokines in umbilical cord blood and evaluate their diagnostic value for EOS.<h4>Methods</h4>A ... Read more >>

Pediatr Res (Pediatric research)
[2020, :]

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Treatment of refractory acute myeloid leukaemia during pregnancy with venetoclax, high-dose cytarabine and mitoxantrone.

Panagiotis Karagiannis, Winfried Alsdorf, Ann-Christin Tallarek, Martin E Blohm, Jennyfer Oelrich, Jonas S Waizenegger, Christine Wolschke, Kurt Hecher, Dominique Singer, Carsten Bokemeyer, Walter Fiedler,

Br J Haematol (British journal of haematology)
[2021, 192(2):e60-e63]

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Kollodium-Baby.

Theresa Harbauer, Peter Höger, Maike Thayssen, Dominique Singer,

Z Geburtshilfe Neonatol (Zeitschrift fur Geburtshilfe und Neonatologie)
[2020, 224(6):407-408]

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Von der Quantifizierung des Qualitativen.

Dominique Singer,

Z Geburtshilfe Neonatol (Zeitschrift fur Geburtshilfe und Neonatologie)
[2020, 224(5):237]

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Application of two different nasal CPAP levels for the treatment of respiratory distress syndrome in preterm infants-"The OPTTIMMAL-Trial"-Optimizing PEEP To The IMMAture Lungs: study protocol of a randomized controlled trial.

Markus Waitz, Corinna Engel, Rolf Schloesser, Ulrich Rochwalsky, Sascha Meyer, Alexander Larsen, Paul Hoffmann, Michael Zemlin, Bettina Bohnhorst, Corinna Peter, Marc Hoppenz, Thomas Pabst, Klaus-Peter Zimmer, Axel R Franz, Christoph Haertel, Eric Frieauff, Julia Sandkötter, Katja Masjosthusmann, Philipp Deindl, Dominique Singer, Melanie Heidkamp, Annesuse Schmidt, Harald Ehrhardt,

<h4>Background</h4>Nasal continuous positive airway pressure (CPAP) applies positive end-expiratory pressure (PEEP) and has been shown to reduce the need for intubation and invasive mechanical ventilation in very low birth weight infants with respiratory distress syndrome. However, CPAP failure rates of 50% are reported in large randomized controlled trials. A possible ... Read more >>

Trials (Trials)
[2020, 21(1):822]

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Intravesical monitoring of intra-abdominal pressure after renal transplantation in children: A safety and feasibility study.

Jula Wagner, Uta Herden, Lutz Fischer, Raphael Schild, Eik Vettorazzi, Jochen Herrmann, Chinedu Ulrich Ebenebe, Dominique Singer, Philipp Deindl,

IAH after RTX can threaten graft viability. This study aimed to assess the feasibility and safety of longitudinal IAP measurements as an IAH screening method in children after RTX. A cohort of eight children with a mean ± SD [range] age 9.6 ± 6.2 [2-17] years who underwent RTX and 18 control patients were ... Read more >>

Pediatr Transplant (Pediatric transplantation)
[2020, 24(7):e13781]

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Ein aktueller Schwerpunkt, eine gute Neuigkeit und ein dankbares „Adieu“.

Dominique Singer,

Z Geburtshilfe Neonatol (Zeitschrift fur Geburtshilfe und Neonatologie)
[2020, 224(4):173-174]

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A prospective observational trial evaluating factors predictive of accurate endotracheal tube positioning in neonates and small infants.

Chinedu Ulrich Ebenebe, Philipp Deindl, Monika Wolf, Matthias Jahn, Dominique Singer, Martin Ernst Blohm,

<h4>Background</h4>There is a high incidence of endotracheal tube malposition in neonates and small infants. Yet, verification of accurate endotracheal tube location via radiographic imaging involves radiation exposure.<h4>Aims</h4>This study aimed to identify demographic and clinical parameters associated with accurate endotracheal tube positioning.<h4>Methods</h4>We conducted a prospective single-center study with term and preterm ... Read more >>

Paediatr Anaesth (Paediatric anaesthesia)
[2020, 30(8):922-927]

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Zur Akademisierung des Hebammenberufs.

Dominique Singer,

Z Geburtshilfe Neonatol (Zeitschrift fur Geburtshilfe und Neonatologie)
[2020, 224(3):117]

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„Die einzige Art, gegen die Pest zu kämpfen, ist die Ehrlichkeit“ (A. Camus).

Dominique Singer,

Z Geburtshilfe Neonatol (Zeitschrift fur Geburtshilfe und Neonatologie)
[2020, 224(2):53]

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