Full Text Journal Articles by
Author Dominique Paquette

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Cerebrospinal Fluid Characterization in Cynomolgus Monkeys, Beagle Dogs, and Göttingen Minipigs.

Cristina Ballesteros, Mylène Pouliot, Rémi Froment, Mohamed Said Maghezzi, Camille St-Jean, Christian Li, Dominique Paquette, Simon Authier,

Intrathecal administration is an important route for drug delivery, and in pharmacology and toxicology studies, cerebrospinal fluid (CSF) collection and analysis is required for evaluating blood-brain barrier penetration and central nervous system exposure. The characteristics of CSF in commonly used nonrodent models are lacking. The purpose of this study is ... Read more >>

Int. J. Toxicol. (International journal of toxicology)
[2020, 39(2):124-130]

Cited: 0 times

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Characterization of EEG morphologies during drug-induced seizures and Peri-ictal changes in non-clinical species.

Simon Authier, Mylene Pouliot, Dominique Paquette, Michelle Dubuc-Mageau, Audrey Sanfacon, Wendy Tan, Michael Accardi,

J Pharmacol Toxicol Methods (Journal of pharmacological and toxicological methods)
[2019, 99:106595]

Cited: 0 times

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Reprint of "EEG: Characteristics of drug-induced seizures in rats, dogs and non-human primates".

Simon Authier, Joseph Arezzo, Mylène Pouliot, Michael V Accardi, Emmanuel Boulay, Eric Troncy, Michelle Dubuc Mageau, Wendy Tan, Audrey Sanfacon, Stephanie Mignault Goulet, Dominique Paquette,

Seizures are amongst the most frequent neurological issues encountered in pre-clinical safety testing. The objective was to characterize EEG morphologies and premonitory signs in drug-induced seizures in preclinical species. A comparative (inter-species) retrospective analysis for drug-induced seizures recorded by video-telemetry was conducted in rats (n = 53), dogs (n = 195), and non-human primates ... Read more >>

J Pharmacol Toxicol Methods (Journal of pharmacological and toxicological methods)
[2019, 99:106611]

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EEG: Characteristics of drug-induced seizures in rats, dogs and non-human primates.

Simon Authier, Joseph Arezzo, Mylène Pouliot, Michael V Accardi, Emmanuel Boulay, Eric Troncy, Michelle Dubuc Mageau, Wendy Tan, Audrey Sanfacon, Stephanie Mignault Goulet, Dominique Paquette,

Seizures are amongst the most frequent neurological issues encountered in pre-clinical safety testing. The objective was to characterize EEG morphologies and premonitory signs in drug-induced seizures in preclinical species. A comparative (inter-species) retrospective analysis for drug-induced seizures recorded by video-telemetry was conducted in rats (n = 53), dogs (n = 195), and non-human primates ... Read more >>

J Pharmacol Toxicol Methods (Journal of pharmacological and toxicological methods)
[2019, 97:52-58]

Cited: 0 times

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Functional neurotoxicity evaluation of noribogaine using video-EEG in cynomolgus monkeys.

Simon Authier, Michael V Accardi, Dominique Paquette, Mylène Pouliot, Joseph Arezzo, R John Stubbs, Ronald J Gerson, Lawrence T Friedhoff, Holger Weis,

Continuous video-electroencephalographic (EEG) monitoring remains the gold standard for seizure liability assessments in preclinical drug safety assessments. EEG monitored by telemetry was used to assess the behavioral and EEG effects of noribogaine hydrochloride (noribogaine) in cynomolgus monkeys. Noribogaine is an iboga alkaloid being studied for the treatment of opioid dependence.Six ... Read more >>

J Pharmacol Toxicol Methods (Journal of pharmacological and toxicological methods)
[2016, 81:306-312]

Cited: 2 times

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Safety pharmacology investigations on the nervous system: An industry survey.

Simon Authier, Joseph Arezzo, Marcus S Delatte, Mary-Jeanne Kallman, Carrie Markgraf, Dominique Paquette, Michael K Pugsley, Sian Ratcliffe, William S Redfern, Joanne Stevens, Jean-Pierre Valentin, Hugo M Vargas, Michael J Curtis,

The Safety Pharmacology Society (SPS) conducted an industry survey in 2015 to identify industry practices as they relate to central, peripheral and autonomic nervous system ('CNS') drug safety testing. One hundred fifty-eight (158) participants from Asia (16%), Europe (20%) and North America (56%) responded to the survey. 52% of participants ... Read more >>

J Pharmacol Toxicol Methods (Journal of pharmacological and toxicological methods)
[2016, 81:37-46]

Cited: 5 times

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Reprint of "Effects of amphetamine, diazepam and caffeine on polysomnography (EEG, EMG, EOG)-derived variables measured using telemetry in Cynomolgus monkeys".

Simon Authier, Leanne Bassett, Mylene Pouliot, Adeline Rachalski, Eric Troncy, Dominique Paquette, Valérie Mongrain,

INTRODUCTION: Medication-induced sleep disturbances are a major concern in drug development as a multitude of prescription drugs alter sleep patterns, often negatively. Polysomnography is used in clinical diagnostics but is also applicable to animal models. Rodent sleep architecture (nocturnal) differs from larger diurnal mammals, including humans, increasing the translational potential ... Read more >>

J Pharmacol Toxicol Methods (Journal of pharmacological and toxicological methods)
[2014, 70(3):287-294]

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Telemetry video-electroencephalography (EEG) in rats, dogs and non-human primates: methods in follow-up safety pharmacology seizure liability assessments.

Leanne Bassett, Eric Troncy, Mylene Pouliot, Dominique Paquette, Alexis Ascah, Simon Authier,

INTRODUCTION: Non-clinical seizure liability studies typically aim to: 1) confirm the nature of EEG activity during abnormal clinical signs, 2) identify premonitory clinical signs, 3) measure plasma levels at seizure onset, 4) demonstrate that drug-induced seizures are self-limiting, 5) confirm that conventional drugs (e.g. diazepam) can treat drug-induced seizures and ... Read more >>

J Pharmacol Toxicol Methods (Journal of pharmacological and toxicological methods)
[2014, 70(3):230-240]

Cited: 5 times

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Effects of amphetamine, diazepam and caffeine on polysomnography (EEG, EMG, EOG)-derived variables measured using telemetry in Cynomolgus monkeys.

Simon Authier, Leanne Bassett, Mylene Pouliot, Adeline Rachalski, Eric Troncy, Dominique Paquette, Valérie Mongrain,

INTRODUCTION: Medication-induced sleep disturbances are a major concern in drug development as a multitude of prescription drugs alter sleep patterns, often negatively. Polysomnography is used in clinical diagnostics but is also applicable to animal models. Rodent sleep architecture (nocturnal) differs from larger diurnal mammals, including humans, increasing the translational potential ... Read more >>

J Pharmacol Toxicol Methods (Journal of pharmacological and toxicological methods)
[2014, 70(1):86-93]

Cited: 6 times

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A L2HGDH initiator methionine codon mutation in a Yorkshire terrier with L-2-hydroxyglutaric aciduria.

Fabiana H G Farias, Rong Zeng, Gary S Johnson, G D Shelton, Dominique Paquette, Dennis P O'Brien,

BACKGROUND: L-2-hydroxyglutaric aciduria is a metabolic repair deficiency characterized by elevated levels of L-2-hydroxyglutaric acid in urine, blood and cerebrospinal fluid. Neurological signs associated with the disease in humans and dogs include seizures, ataxia and dementia. CASE PRESENTATION: Here we describe an 8 month old Yorkshire terrier that presented with ... Read more >>

BMC Vet. Res. (BMC veterinary research)
[2012, 8:124]

Cited: 4 times

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Comparison of susceptibility to antimicrobials of bacterial isolates from companion animals in a veterinary diagnostic laboratory in Canada between 2 time points 10 years apart.

Simon Authier, Dominique Paquette, Olivia Labrecque, Serge Messier,

The susceptibility to antimicrobials of bacterial species most frequently isolated from companion animals in a veterinary teaching diagnostic laboratory was evaluated retrospectively. A significant decrease between 1990-1992 and 2002-2003 was noted in the susceptibility of dog isolates to the following antimicrobials: Escherichia coli to cephalothin (86% to 61%, P < ... Read more >>

Can. Vet. J. (The Canadian veterinary journal = La revue veterinaire canadienne)
[2006, 47(8):774-778]

Cited: 18 times

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