Full Text Journal Articles by
Author Dominic P J Howard

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Risk of stroke in relation to degree of asymptomatic carotid stenosis: a population-based cohort study, systematic review, and meta-analysis.

Dominic P J Howard, Liam Gaziano, Peter M Rothwell, ,

<h4>Background</h4>There is uncertainty around which patients with asymptomatic carotid stenosis should be offered surgical intervention. Although stroke rates were unrelated to the degree of stenosis in the medical-treatment-only groups in previous randomised trials, this could simply reflect recruitment bias and there has been no systematic analysis of a stenosis-risk association ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2021, 20(3):193-202]

Cited: 0 times

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Malperfusion following repair of a type I aortic dissection.

Mirko Muretti, Renata Greco, Dominic P J Howard, Raman Uberoi, Ediri Sideso, Mario Petrou,

J Card Surg (Journal of cardiac surgery)
[2018, 33(12):857-858]

Cited: 0 times

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Editor's Choice - Influence of Proximal Aortic Neck Diameter on Durability of Aneurysm Sealing and Overall Survival in Patients Undergoing Endovascular Aneurysm Repair. Real World Data from the Gore Global Registry for Endovascular Aortic Treatment (GREAT).

Dominic P J Howard, Conor D Marron, Ediri Sideso, Phillip J Puckridge, Eric L G Verhoeven, James I Spark, ,

OBJECTIVES:Aortic neck diameter is an independent anatomical feature that is poorly understood, yet potentially linked to proximal seal failure and adverse outcome following standard EVAR. The aim of this study was to assess whether large proximal aortic neck (LAN) diameter is associated with adverse outcome using prospectively collected individual patient ... Read more >>

Eur J Vasc Endovasc Surg (European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery)
[2018, 56(2):189-199]

Cited: 3 times

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Hospital and Institutionalisation Care Costs after Limb and Visceral Ischaemia Benchmarked Against Stroke: Long-Term Results of a Population Based Cohort Study.

Ramon Luengo-Fernandez, Dominic P J Howard, Kathleen G Nichol, Emily Dobell, Peter M Rothwell, ,

<h4>Objective/background</h4>There are few published data on the acute care or long-term costs after acute/critical limb or visceral ischaemia (ACLVI) events. Using data from patients with acute events in a population based incidence study (Oxford Vascular Study), the present study aimed to determine the long-term costs after an ACLVI event.<h4>Methods</h4>All patients ... Read more >>

Eur J Vasc Endovasc Surg (European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery)
[2018, 56(2):271-281]

Cited: 2 times

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Recent time trends in incidence, outcome and premorbid treatment of atrial fibrillation-related stroke and other embolic vascular events: a population-based study.

Gabriel S C Yiin, Dominic P J Howard, Nicola L M Paul, Linxin Li, Ziyah Mehta, Peter M Rothwell, ,

BACKGROUND:Prevalence of atrial fibrillation (AF) is increasing, due partly to the ageing population. The Birmingham Atrial Fibrillation Treatment of the Aged (BAFTA) Trial, published in 2007, provided strong evidence of the effectiveness of warfarin at age≥80 years, but the impact on incidence of AF-related stroke and peripheral embolic vascular events is ... Read more >>

J Neurol Neurosurg Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2017, 88(1):12-18]

Cited: 10 times

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Population-Based Study of Incidence, Risk Factors, Outcome, and Prognosis of Ischemic Peripheral Arterial Events: Implications for Prevention.

Dominic P J Howard, Amitava Banerjee, Jack F Fairhead, Linda Hands, Louise E Silver, Peter M Rothwell, ,

<h4>Background</h4>There are few published data on the incidence and long-term outcomes of critical limb ischemia, acute limb ischemia, or acute visceral ischemia with which to inform health service planning, to monitor prevention, and to enable risk prediction.<h4>Methods and results</h4>In a prospective population-based study (Oxfordshire, UK; 2002-2012), we determined the incidence ... Read more >>

Circulation (Circulation)
[2015, 132(19):1805-1815]

Cited: 25 times

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Population-Based Study of Incidence of Acute Abdominal Aortic Aneurysms With Projected Impact of Screening Strategy.

Dominic P J Howard, Amitava Banerjee, Jack F Fairhead, Ashok Handa, Louise E Silver, Peter M Rothwell, ,

<h4>Background</h4>Current abdominal aortic aneurysm (AAA) screening in men age 65 might have limited impact on overall AAA death rates if incidence is moving to older ages. Up-to-date population-based studies of age-specific incidence, risk factors, and outcome of acute AAA are needed to inform screening policy.<h4>Methods and results</h4>In a prospective, population-based ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2015, 4(8):e001926]

Cited: 4 times

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Type 2 diabetes is not associated with an altered plaque phenotype among patients undergoing carotid revascularization. A histological analysis of 1455 carotid plaques.

Vincent P W Scholtes, Wouter Peeters, Guus W van Lammeren, Dominic P J Howard, Jean-Paul P M de Vries, Gert Jan de Borst, Jessica N Redgrave, Hans Kemperman, Casper G Schalkwijk, Hester M den Ruijter, Dominique P V de Kleijn, Frans L Moll, Peter M Rothwell, Gerard Pasterkamp,

<h4>Aims</h4>Diabetes accelerates progression of atherosclerotic disease, but data on associations between diabetes and advanced atherosclerotic plaque composition are scarce.<h4>Methods and results</h4>We used one of the largest biobanks, the Athero-Express study (n=1455) at carotid endarterectomy (CEA). All plaques were subjected to histological analysis to assess lipid core size, collagen, macrophages, smooth ... Read more >>

Atherosclerosis (Atherosclerosis)
[2014, 235(2):418-423]

Cited: 9 times

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Age-specific incidence, outcome, cost, and projected future burden of atrial fibrillation-related embolic vascular events: a population-based study.

Gabriel S C Yiin, Dominic P J Howard, Nicola L M Paul, Linxin Li, Ramon Luengo-Fernandez, Linda M Bull, Sarah J V Welch, Sergei A Gutnikov, Ziyah Mehta, Peter M Rothwell, ,

<h4>Background</h4>Prevalence of atrial fibrillation (AF) is >10% at age ≥80 years, but the impact of population aging on rates of AF-related ischemic events is uncertain.<h4>Methods and results</h4>We studied age-specific incidence, outcome, and cost of all AF-related incident strokes and systemic emboli from 2002 to 2012 in the Oxford Vascular Study ... Read more >>

Circulation (Circulation)
[2014, 130(15):1236-1244]

Cited: 51 times

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Histological features of carotid plaque in patients with ocular ischemia versus cerebral events.

Dominic P J Howard, Guus W van Lammeren, Jessica N Redgrave, Frans L Moll, Jean-Paul P M de Vries, Dominique P V de Kleijn, Gert Jan de Borst, Gerard Pasterkamp, Peter M Rothwell,

<h4>Background and purpose</h4>Patients with carotid artery stenosis and ocular ischemic events have a much lower risk of future ipsilateral ischemic stroke on medical treatment and lower procedural risks for endarterectomy and stenting than patients with cerebral ischemic events, and are closer in risk to patients with asymptomatic stenosis. The reasons ... Read more >>

Stroke (Stroke)
[2013, 44(3):734-739]

Cited: 18 times

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Incidence, risk factors, outcome and projected future burden of acute aortic dissection.

Dominic P J Howard, Ediri Sideso, Ashok Handa, Peter M Rothwell,

Ann Cardiothorac Surg (Annals of cardiothoracic surgery)
[2014, 3(3):278-284]

Cited: 13 times

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Population-based study of incidence and outcome of acute aortic dissection and premorbid risk factor control: 10-year results from the Oxford Vascular Study.

Dominic P J Howard, Amitava Banerjee, Jack F Fairhead, Jeremy Perkins, Louise E Silver, Peter M Rothwell, ,

<h4>Background</h4>Acute aortic dissection is a preventable life-threatening condition. However, there have been no prospective population-based studies of incidence or outcome to inform an understanding of risk factors, strategies for prevention, or projections for future clinical service provision.<h4>Methods and results</h4>We prospectively determined incidence and outcomes of all acute aortic dissections in ... Read more >>

Circulation (Circulation)
[2013, 127(20):2031-2037]

Cited: 148 times

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Harry Potter casts a spell on accident prone children.

Stephen Gwilym, Dominic P J Howard, Nev Davies, Keith Willett,

BMJ (BMJ (Clinical research ed.))
[2005, 331(7531):1505-1506]

Cited: 0 times

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Acute thromboembolism in medical inpatients: the need for a focus on prevention rather than cure.

Dominic P J Howard,

Clin Med (Lond) (Clinical medicine (London, England))
[2006, 6(1):117-118]

Cited: 0 times

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Basolateral adrenoceptor activation mediates noradrenaline-induced Cl- secretion in M-1 mouse cortical collecting duct cells.

John E Cuffe, Dominic P J Howard, Marko Bertog, Christoph Korbmacher,

Noradrenaline (NA) released from efferent renal sympathetic nerves may directly affect renal tubular transport. Here we examined the effect of NA on transepithelial ion transport of cultured M-1 mouse cortical collecting duct cells using equivalent short-circuit current ( I(SC)) measurements. Steady-state I(SC) averaged 87.5+/-2.9 microA cm(-2) (n=185) and was reduced ... Read more >>

Pflugers Arch (Pflugers Archiv : European journal of physiology)
[2002, 445(3):381-389]

Cited: 8 times

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