Full Text Journal Articles by
Author Dominic J Abrams

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Clinical and Genetic Findings in Children Presenting With Ventricular Fibrillation as the First Manifestation of Cardiovascular Disease.

Robyn J Hylind, Stephanie F Chandler, Virginie Beausejour Ladouceur, Shelina M Jamal, Mark E Alexander, Douglas Y Mah, Emily A Phaneuf, Elizabeth S DeWitt, Vassilios J Bezzerides, Dominic J Abrams,

J Am Heart Assoc (Journal of the American Heart Association)
[2020, 9(10):e016322]

Cited: 0 times

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Value of provocative electrophysiology testing in the management of pediatric patients after congenital heart surgery.

Audrey Dionne, John N Kheir, Kimberlee Gauvreau, John K Triedman, Dominic J Abrams, Mark E Alexander, Elizabeth S DeWitt, Douglas Y Mah, Edward P Walsh, Vassilios J Bezzerides,

OBJECTIVE:To determine the impact of provocative electrophysiology testing in post-operative congenital heart disease (CHD) patients on the management of supraventricular tachycardia (SVT) and clinical outcomes. METHODS:This is a retrospective study including patients < 18 years of age with surgery for CHD who had post-operative SVT between 2006-2017. Post-operative outcomes were ... Read more >>

Pacing Clin Electrophysiol (Pacing and clinical electrophysiology : PACE)
[2020, :]

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Predicting Heart Failure in Arrhythmogenic Right Ventricular Cardiomyopathy.

Robyn J Hylind, Dominic J Abrams,

J Am Heart Assoc (Journal of the American Heart Association)
[2020, 9(3):e015702]

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Adverse event rate during inpatient sotalol initiation for the management of supraventricular and ventricular tachycardia in the pediatric and young adult population.

Stephanie F Chandler, Esther Chu, Robert D Whitehill, Laura M Bevilacqua, Vassilios J Bezzerides, Elizabeth S DeWitt, Mark E Alexander, Dominic J Abrams, John K Triedman, Edward P Walsh, Douglas Y Mah,

BACKGROUND:Sotalol is an important antiarrhythmic drug in the pediatric population. Given the risk of proarrhythmia, sotalol is initiated in inpatient settings, with adult studies as recent as 2015 supporting this practice. OBJECTIVE:The purpose of this study was to determine the frequency of adverse events (AEs) during sotalol initiation for the ... Read more >>

Heart Rhythm (Heart rhythm)
[2020, 17(6):984-990]

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An International Multicenter Evaluation of Type 5 Long QT Syndrome: A Low Penetrant Primary Arrhythmic Condition.

Jason D Roberts, S Yukiko Asaki, Andrea Mazzanti, J Martijn Bos, Izabela Tuleta, Alison R Muir, Lia Crotti, Andrew D Krahn, Valentina Kutyifa, M Benjamin Shoemaker, Christopher L Johnsrude, Takeshi Aiba, Luciana Marcondes, Anwar Baban, Sharmila Udupa, Brynn Dechert, Peter Fischbach, Linda M Knight, Eric Vittinghoff, Deni Kukavica, Birgit Stallmeyer, John R Giudicessi, Carla Spazzolini, Keiko Shimamoto, Rafik Tadros, Julia Cadrin-Tourigny, Henry J Duff, Christopher S Simpson, Thomas M Roston, Yanushi D Wijeyeratne, Imane El Hajjaji, Maisoon D Yousif, Lorne J Gula, Peter Leong-Sit, Nikhil Chavali, Andrew P Landstrom, Gregory M Marcus, Sven Dittmann, Arthur A M Wilde, Elijah R Behr, Jacob Tfelt-Hansen, Melvin M Scheinman, Marco V Perez, Juan Pablo Kaski, Robert M Gow, Fabrizio Drago, Peter F Aziz, Dominic J Abrams, Michael H Gollob, Jonathan R Skinner, Wataru Shimizu, Elizabeth S Kaufman, Dan M Roden, Wojciech Zareba, Peter J Schwartz, Eric Schulze-Bahr, Susan P Etheridge, Silvia G Priori, Michael J Ackerman,

BACKGROUND:Insight into type 5 long QT syndrome (LQT5) has been limited to case reports and small family series. Improved understanding of the clinical phenotype and genetic features associated with rare KCNE1 variants implicated in LQT5 was sought through an international multicenter collaboration. METHODS:Patients with either presumed autosomal dominant LQT5 (N ... Read more >>

Circulation (Circulation)
[2020, 141(6):429-439]

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Outcomes of catheter ablation of anteroseptal and midseptal accessory pathways in pediatric patients.

Joshua R Kovach, Douglas Y Mah, Dominic J Abrams, Mark E Alexander, Frank Cecchin, John K Triedman, Edward P Walsh,

BACKGROUND:Outcomes for catheter ablation of accessory pathways in pediatric patients have steadily improved, with the exception of pathways located in the anteroseptal (AS) and midseptal (MS) regions, where success is limited by the close proximity of normal atrioventricular conduction. OBJECTIVE:The purpose of this study was to evaluate the efficacy of ... Read more >>

Heart Rhythm (Heart rhythm)
[2020, 17(5 Pt A):759-767]

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Arrhythmia Mechanisms and Outcomes of Ablation in Pediatric Patients With Congenital Heart Disease.

Charlotte A Houck, Stephanie F Chandler, Ad J J C Bogers, John K Triedman, Edward P Walsh, Natasja M S de Groot, Dominic J Abrams,

BACKGROUND:In contrast to the adult population with congenital heart disease (CHD), arrhythmia mechanisms and outcomes of ablation in pediatric patients with CHD in recent era have not been studied in detail. Aims of this study were to determine arrhythmia mechanisms and to evaluate procedural and long-term outcomes in pediatric patients ... Read more >>

Circ Arrhythm Electrophysiol (Circulation. Arrhythmia and electrophysiology)
[2019, 12(11):e007663]

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2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy: Executive summary.

Jeffrey A Towbin, William J McKenna, Dominic J Abrams, Michael J Ackerman, Hugh Calkins, Francisco C C Darrieux, James P Daubert, Christian de Chillou, Eugene C DePasquale, Milind Y Desai, N A Mark Estes, Wei Hua, Julia H Indik, Jodie Ingles, Cynthia A James, Roy M John, Daniel P Judge, Roberto Keegan, Andrew D Krahn, Mark S Link, Frank I Marcus, Christopher J McLeod, Luisa Mestroni, Silvia G Priori, Jeffrey E Saffitz, Shubhayan Sanatani, Wataru Shimizu, J Peter van Tintelen, Arthur A M Wilde, Wojciech Zareba,

Arrhythmogenic cardiomyopathy (ACM) is an arrhythmogenic disorder of the myocardium not secondary to ischemic, hypertensive, or valvular heart disease. ACM incorporates a broad spectrum of genetic, systemic, infectious, and inflammatory disorders. This designation includes, but is not limited to, arrhythmogenic right/left ventricular cardiomyopathy, cardiac amyloidosis, sarcoidosis, Chagas disease, and left ... Read more >>

Heart Rhythm (Heart rhythm)
[2019, 16(11):e373-e407]

Cited: 0 times

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Molecular mechanisms of arrhythmogenic cardiomyopathy.

Karyn M Austin, Michael A Trembley, Stephanie F Chandler, Stephen P Sanders, Jeffrey E Saffitz, Dominic J Abrams, William T Pu,

Arrhythmogenic cardiomyopathy is a genetic disorder characterized by the risk of life-threatening arrhythmias, myocardial dysfunction and fibrofatty replacement of myocardial tissue. Mutations in genes that encode components of desmosomes, the adhesive junctions that connect cardiomyocytes, are the predominant cause of arrhythmogenic cardiomyopathy and can be identified in about half of ... Read more >>

Nat Rev Cardiol (Nature reviews. Cardiology)
[2019, 16(9):519-537]

Cited: 6 times

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Insights Into the Pathogenesis of Catecholaminergic Polymorphic Ventricular Tachycardia From Engineered Human Heart Tissue.

Sung-Jin Park, Donghui Zhang, Yan Qi, Yifei Li, Keel Yong Lee, Vassilios J Bezzerides, Pengcheng Yang, Shutao Xia, Sean L Kim, Xujie Liu, Fujian Lu, Francesco S Pasqualini, Patrick H Campbell, Judith Geva, Amy E Roberts, Andre G Kleber, Dominic J Abrams, William T Pu, Kevin Kit Parker,

BACKGROUND:Modeling of human arrhythmias with induced pluripotent stem cell-derived cardiomyocytes has focused on single-cell phenotypes. However, arrhythmias are the emergent properties of cells assembled into tissues, and the impact of inherited arrhythmia mutations on tissue-level properties of human heart tissue has not been reported. METHODS:Here, we report an optogenetically based, ... Read more >>

Circulation (Circulation)
[2019, 140(5):390-404]

Cited: 3 times

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Phenotypic Manifestations of Arrhythmogenic Cardiomyopathy in Children and Adolescents.

Elizabeth S DeWitt, Stephanie F Chandler, Robyn J Hylind, Virginie Beausejour Ladouceur, Elizabeth D Blume, Christina VanderPluym, Andrew J Powell, Francis Fynn-Thompson, Amy E Roberts, Stephen P Sanders, Vassilios Bezzerides, Neal K Lakdawala, Calum A MacRae, Dominic J Abrams,

BACKGROUND:Arrhythmogenic cardiomyopathy (ACM) is a variably penetrant disease increasingly identified in young patients. OBJECTIVES:This study sought to describe the diverse phenotype, genotype, and outcomes in pediatric and adolescent patients. METHODS:Records from 1999 to 2016 were reviewed for individuals age <21 years with a consistent personal or family history. Patients were categorized by ... Read more >>

J. Am. Coll. Cardiol. (Journal of the American College of Cardiology)
[2019, 74(3):346-358]

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Gene Therapy for Catecholaminergic Polymorphic Ventricular Tachycardia by Inhibition of Ca2+/Calmodulin-Dependent Kinase II.

Vassilios J Bezzerides, Ana Caballero, Suya Wang, Yulan Ai, Robyn J Hylind, Fujian Lu, Danielle A Heims-Waldron, Kristina D Chambers, Donghui Zhang, Dominic J Abrams, William T Pu,

BACKGROUND:Catecholaminergic polymorphic ventricular tachycardia (CPVT), an inherited cardiac arrhythmia characterized by adrenergically triggered arrhythmias, is inadequately treated by current standard of care. Ca2+/calmodulin-dependent protein kinase II (CaMKII), an adrenergically activated kinase that contributes to arrhythmogenesis in heart disease models, is a candidate therapeutic target in CPVT. However, translation of CaMKII ... Read more >>

Circulation (Circulation)
[2019, 140(5):405-419]

Cited: 2 times

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2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy.

Jeffrey A Towbin, William J McKenna, Dominic J Abrams, Michael J Ackerman, Hugh Calkins, Francisco C C Darrieux, James P Daubert, Christian de Chillou, Eugene C DePasquale, Milind Y Desai, N A Mark Estes, Wei Hua, Julia H Indik, Jodie Ingles, Cynthia A James, Roy M John, Daniel P Judge, Roberto Keegan, Andrew D Krahn, Mark S Link, Frank I Marcus, Christopher J McLeod, Luisa Mestroni, Silvia G Priori, Jeffrey E Saffitz, Shubhayan Sanatani, Wataru Shimizu, J Peter van Tintelen, Arthur A M Wilde, Wojciech Zareba,

Arrhythmogenic cardiomyopathy (ACM) is an arrhythmogenic disorder of the myocardium not secondary to ischemic, hypertensive, or valvular heart disease. ACM incorporates a broad spectrum of genetic, systemic, infectious, and inflammatory disorders. This designation includes, but is not limited to, arrhythmogenic right/left ventricular cardiomyopathy, cardiac amyloidosis, sarcoidosis, Chagas disease, and left ventricular ... Read more >>

Heart Rhythm (Heart rhythm)
[2019, 16(11):e301-e372]

Cited: 4 times

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Phenotypic Characterization of Individuals With Variants in Cardiovascular Genes in the Absence of a Primary Cardiovascular Indication for Testing.

Robyn J Hylind, Stephanie F Chandler, Virginie Beausejour Ladouceur, Amy E Roberts, Vassilios Bezzerides, Kurt D Christensen, Matthew Coggins, Neal K Lakdawala, Calum A MacRae, Dominic J Abrams,

Circ Genom Precis Med (Circulation. Genomic and precision medicine)
[2019, 12(3):e002463]

Cited: 0 times

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International Triadin Knockout Syndrome Registry.

Daniel J Clemens, David J Tester, John R Giudicessi, J Martijn Bos, Ram K Rohatgi, Dominic J Abrams, Seshadri Balaji, Lia Crotti, Julien Faure, Carlo Napolitano, Silvia G Priori, Vincent Probst, Caroline Rooryck-Thambo, Nathalie Roux-Buisson, Frederic Sacher, Peter J Schwartz, Michael J Silka, Mark A Walsh, Michael J Ackerman,

BACKGROUND:Triadin knockout syndrome (TKOS) is a rare, inherited arrhythmia syndrome caused by recessive null mutations in TRDN-encoded cardiac triadin. Based previously on 5 triadin null patients, TKOS has been characterized by extensive T-wave inversions, transient QT prolongation, and severe disease expression of exercise-induced cardiac arrest in early childhood refractory to ... Read more >>

Circ Genom Precis Med (Circulation. Genomic and precision medicine)
[2019, 12(2):e002419]

Cited: 0 times

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The Real-World Utility of the LINQ Implantable Loop Recorder in Pediatric and Adult Congenital Heart Patients.

Vassilios J Bezzerides, Amy Walsh, Maria Martuscello, Carolina A Escudero, Kimberlee Gauvreau, Geralyn Lam, Dominic J Abrams, John K Triedman, Mark E Alexander, Laura Bevilacqua, Douglas Y Mah,

OBJECTIVES:This study sought to determine the practical use of the recently introduced LINQ implantable loop recorder (LINQ-ILR) in a cohort of pediatric and adult congenital arrhythmia patients. BACKGROUND:Correlating symptoms to a causative arrhythmia is a key aspect of diagnosis and management in clinical electrophysiology. METHODS:Retrospective review of clinical data, implantation ... Read more >>

JACC Clin Electrophysiol (JACC. Clinical electrophysiology)
[2019, 5(2):245-251]

Cited: 0 times

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Genetic Testing for Inherited Cardiac Arrhythmias: Current State-of-the-Art and Future Avenues.

Robyn J Hylind, Stephanie F Chandler, Jonathan R Skinner, Dominic J Abrams,

The seminal discovery that sequence variation in genes encoding cardiac ion channels was behind the inherited cardiac arrhythmic syndromes has led to major advances in understanding the functional biological mechanisms of cardiomyocyte depolarization and repolarization. The cost and speed with which these genes can now be sequenced have allowed for ... Read more >>

J Innov Card Rhythm Manag (The Journal of innovations in cardiac rhythm management)
[2018, 9(11):3406-3416]

Cited: 0 times

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SCN5A mutations in 442 neonates and children: genotype-phenotype correlation and identification of higher-risk subgroups.

Alban-Elouen Baruteau, Florence Kyndt, Elijah R Behr, Arja S Vink, Matthias Lachaud, Anna Joong, Jean-Jacques Schott, Minoru Horie, Isabelle Denjoy, Lia Crotti, Wataru Shimizu, Johan M Bos, Elizabeth A Stephenson, Leonie Wong, Dominic J Abrams, Andrew M Davis, Annika Winbo, Anne M Dubin, Shubhayan Sanatani, Leonardo Liberman, Juan Pablo Kaski, Boris Rudic, Sit Yee Kwok, Claudine Rieubland, Jacob Tfelt-Hansen, George F Van Hare, Béatrice Guyomarc'h-Delasalle, Nico A Blom, Yanushi D Wijeyeratne, Jean-Baptiste Gourraud, Hervé Le Marec, Junichi Ozawa, Véronique Fressart, Jean-Marc Lupoglazoff, Federica Dagradi, Carla Spazzolini, Takeshi Aiba, David J Tester, Laura A Zahavich, Virginie Beauséjour-Ladouceur, Mangesh Jadhav, Jonathan R Skinner, Sonia Franciosi, Andrew D Krahn, Mena Abdelsayed, Peter C Ruben, Tak-Cheung Yung, Michael J Ackerman, Arthur A Wilde, Peter J Schwartz, Vincent Probst,

Aims:To clarify the clinical characteristics and outcomes of children with SCN5A-mediated disease and to improve their risk stratification. Methods and results:A multicentre, international, retrospective cohort study was conducted in 25 tertiary hospitals in 13 countries between 1990 and 2015. All patients ≤16 years of age diagnosed with a genetically confirmed SCN5A ... Read more >>

Eur. Heart J. (European heart journal)
[2018, 39(31):2879-2887]

Cited: 1 time

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Utility of incomplete right bundle branch block as an isolated ECG finding in children undergoing initial cardiac evaluation.

Omar Meziab, Dominic J Abrams, Mark E Alexander, Laura Bevilacqua, Vassilios Bezzerides, Doug Y Mah, Edward P Walsh, John K Triedman,

This study evaluates the ability of experienced pediatric electrophysiologists (EPs) to reliably classify incomplete right bundle branch block (IRBBB) and assesses its clinical utility as an isolated ECG finding in a group of healthy outpatient children without prior cardiac evaluation.We performed a retrospective analysis of all electrocardiographic and echocardiographic records ... Read more >>

Congenit Heart Dis (Congenital heart disease)
[2018, 13(3):419-427]

Cited: 0 times

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Postmortem Genetic Testing for Cardiac Ion Channelopathies in Stillbirths.

Patricia B Munroe, Shea Addison, Dominic J Abrams, Neil J Sebire, James Cartwright, Ian Donaldson, Marta M Cohen, Charles Mein, Andrew Tinker, Stephen C Harmer, Qadeer Aziz, Anna Terry, Monika Struebig, Helen R Warren, Bhumita Vadgama, Darren J Fowler, Donald Peebles, Andrew M Taylor, Peter J Lally, Sudhin Thayyil,

BACKGROUND:Although stillbirth is a significant health problem worldwide, the definitive cause of death remains elusive in many cases, despite detailed autopsy. In this study of partly explained and unexplained stillbirths, we used next-generation sequencing to examine an extended panel of 35 candidate genes known to be associated with ion channel ... Read more >>

Circ Genom Precis Med (Circulation. Genomic and precision medicine)
[2018, 11(1):e001817]

Cited: 0 times

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Cardiac Conduction System in Congenitally Corrected Transposition of the Great Arteries and Its Clinical Relevance.

Alban-Elouen Baruteau, Dominic J Abrams, Siew Yen Ho, Jean-Benoit Thambo, Christopher J McLeod, Maully J Shah,

J Am Heart Assoc (Journal of the American Heart Association)
[2017, 6(12):]

Cited: 2 times

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Genotype-phenotype-guided medical and surgical intervention in long QT syndrome.

Robyn J Hylind, Virginie Beausejour Ladouceur, Francis Fynn-Thompson, Shannon E Hourigan, Vassilios J Bezzerides, Dominic J Abrams,

HeartRhythm Case Rep (HeartRhythm case reports)
[2018, 4(1):14-17]

Cited: 0 times

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Role of Genetic Testing in Inherited Cardiovascular Disease: A Review.

Allison L Cirino, Stephanie Harris, Neal K Lakdawala, Michelle Michels, Iacopo Olivotto, Sharlene M Day, Dominic J Abrams, Philippe Charron, Colleen Caleshu, Christopher Semsarian, Jodie Ingles, Harry Rakowski, Daniel P Judge, Carolyn Y Ho,

Importance:Genetic testing is a valuable tool for managing inherited cardiovascular disease in patients and families, including hypertrophic, dilated, and arrhythmogenic cardiomyopathies and inherited arrhythmias. By identifying the molecular etiology of disease, genetic testing can improve diagnostic accuracy and refine family management. However, unique features associated with genetic testing affect the ... Read more >>

JAMA Cardiol (JAMA cardiology)
[2017, 2(10):1153-1160]

Cited: 14 times

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Cardiac Events During Competitive, Recreational, and Daily Activities in Children and Adolescents With Long QT Syndrome.

Kristina D Chambers, Virginie Beausejour Ladouceur, Mark E Alexander, Robyn J Hylind, Laura Bevilacqua, Douglas Y Mah, Vassilios Bezzerides, John K Triedman, Edward P Walsh, Dominic J Abrams,

The 2005 Bethesda Conference Guidelines advise patients with long QT syndrome against competitive sports. We assessed cardiac event rates during competitive and recreational sports, and daily activities among treated long QT syndrome patients.Long QT syndrome patients aged ≥4 years treated with anti-adrenergic therapy were included. Demographics included mechanism of presentation, corrected ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2017, 6(9):]

Cited: 1 time

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Ebstein Anomaly.

Elizabeth D Sherwin, Dominic J Abrams,

Ebstein anomaly is a rare form of congenital heart disease with a uniquely high prevalence of arrhythmias. The most prevalent arrhythmia mechanisms are intrinsic to the underlying embryologic defects and may manifest at any stage. Current electrophysiological and surgical strategies are well equipped to address these arrhythmia mechanisms, yet despite ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2017, 9(2):245-254]

Cited: 3 times

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