Full Text Journal Articles by
Author Dolly Mehta

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Diversity and prevalence of ANTAR RNAs across actinobacteria

Dolly Mehta, Arati Ramesh,

ABSTRACT Computational approaches are often used to predict regulatory RNAs in bacteria, but their success is limited to RNAs that are highly conserved across phyla, in sequence and structure. The ANTAR regulatory system consists of a family of RNAs (the ANTAR-target RNAs) that selectively recruit ANTAR proteins. This protein-RNA complex ... Read more >>

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Discovery of iron-sensing bacterial riboswitches.

Siladitya Bandyopadhyay, Susmitnarayan Chaudhury, Dolly Mehta, Arati Ramesh,

Despite the central role of iron in biology, our understanding of how cells sense iron is limited to protein-dependent mechanisms. Here, we report the discovery of iron-sensing riboswitches (named Sensei). Present across bacterial phyla, these RNAs reside in the 5' untranslated regions or within coding regions of messenger RNAs (mRNAs) ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, :]

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IL-1β suppression of VE-cadherin transcription underlies sepsis-induced inflammatory lung injury.

Shiqin Xiong, Zhigang Hong, Long Shuang Huang, Yoshikazu Tsukasaki, Saroj Nepal, Anke Di, Ming Zhong, Wei Wu, Zhiming Ye, Xiaopei Gao, Gadiparthi N Rao, Dolly Mehta, Jalees Rehman, Asrar B Malik,

Unchecked inflammation is a hallmark of inflammatory tissue injury in diseases such as acute respiratory distress syndrome (ARDS). Yet the mechanisms of inflammatory lung injury remain largely unknown. Here we showed that bacterial endotoxin lipopolysaccharide (LPS) and cecal ligation and puncture-induced (CLP-induced) polymicrobial sepsis decreased the expression of transcription factor ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2020, 130(7):3684-3698]

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Post-translational modifications of S1PR1 and endothelial barrier regulation.

Mumtaz Anwar, Dolly Mehta,

Sphingosine-1-phosphate receptor-1 (S1PR1), a G-protein coupled receptor that is expressed in endothelium and activated upon ligation by the bioactive lipid sphingosine-1-phosphate (S1P), is an important vascular-barrier protective mechanism at the level of adherens junctions (AJ). Loss of endothelial barrier function is a central factor in the pathogenesis of various inflammatory ... Read more >>

Biochim Biophys Acta Mol Cell Biol Lipids (Biochimica et biophysica acta. Molecular and cell biology of lipids)
[2020, 1865(9):158760]

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Discovery of ANTAR-RNAs and their Mechanism of Action in Mycobacteria.

Dolly Mehta, Anjali Koottathazhath, Arati Ramesh,

Non-coding RNAs play pivotal roles in bacterial signaling. However, RNAs from certain phyla (specially high-GC actinobacteria) still remain elusive. Here, by re-engineering the existing genome-wide search approach, we discover a family of structurally conserved RNAs that are present ubiquitously across actinobacteria, including mycobacteria. In vitro analysis shows that RNAs belonging ... Read more >>

J. Mol. Biol. (Journal of molecular biology)
[2020, 432(14):4032-4048]

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S1PR1 and VEGFR2 - a synergy that promotes tumor angiogenesis?

Vijay Avin Balaji Ragunathrao, Vigneshwaran Vellingiri, Mumtaz Anwar, Md Zahid Akhter, Dolly Mehta,

We have recently uncovered that endothelial cell (EC) S1PR1 controls the effectiveness of VEGFR2 driven tumor angiogenesis. By using tumor ECs, EC-S1PR1-/- mice and S1PR1 antagonist, we showed that VEGF-VEGFR2 pathway requires EC-S1PR1-induced signaling to efficiently drive tumor vascularization and growth, indicating combining S1PR1 antagonist with anti-VEGF/VEGFR2 therapy may eradicate ... Read more >>

Mol Cell Oncol (Molecular & cellular oncology)
[2020, 7(4):1746131]

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SPHK2-Generated S1P in CD11b+ Macrophages Blocks STING to Suppress the Inflammatory Function of Alveolar Macrophages.

Jagdish C Joshi, Bhagwati Joshi, Ian Rochford, Sheikh Rayees, Md Zahid Akhter, Sukriti Baweja, Koteshwara Rao Chava, Mohammad Tauseef, Hazem Abdelkarim, Viswanathan Natarajan, Vadim Gaponenko, Dolly Mehta,

Acute lung injury (ALI) is a lethal inflammatory lung disorder whose incidence is on the rise. Alveolar macrophages normally act to resolve inflammation, but when dysregulated they can provoke ALI. We demonstrate that monocyte-derived macrophages (CD11b+ macrophages) recruited into the airspace upregulate the anti-inflammatory function of alveolar macrophages by suppressing ... Read more >>

Cell Rep (Cell reports)
[2020, 30(12):4096-4109.e5]

Cited: 1 time

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Sphingosine-1-Phosphate Receptor 1 Activity Promotes Tumor Growth by Amplifying VEGF-VEGFR2 Angiogenic Signaling.

Vijay Avin Balaji Ragunathrao, Mumtaz Anwar, Md Zahid Akhter, Alejandra Chavez, De Yu Mao, Viswanathan Natarajan, Sribalaji Lakshmikanthan, Magdalena Chrzanowska-Wodnicka, Arkadiusz Z Dudek, Lena Claesson-Welsh, Jan K Kitajewski, Kishore K Wary, Asrar B Malik, Dolly Mehta,

The vascular endothelial growth factor-A (VEGF-A)-VEGFR2 pathway drives tumor vascularization by activating proangiogenic signaling in endothelial cells (ECs). Here, we show that EC-sphingosine-1-phosphate receptor 1 (S1PR1) amplifies VEGFR2-mediated angiogenic signaling to enhance tumor growth. We show that cancer cells induce S1PR1 activity in ECs, and thereby, conditional deletion of S1PR1 ... Read more >>

Cell Rep (Cell reports)
[2019, 29(11):3472-3487.e4]

Cited: 0 times

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Non-coding RNAs control metabolic state in mycobacteria

Dolly Mehta, Anjali, Achuthan, Ritu Gupta, Arati Ramesh,

ABSTRACT Non-coding RNAs play pivotal roles in bacterial signaling. However, RNAs from certain phyla (specially high-GC actinobacteria) remain elusive. Here, by revamping existing approaches we discover a family of structurally conserved RNAs in actinobacteria. These RNAs function by the recruiting ANTAR proteins to select transcripts; regulating them via translational repression. ... Read more >>

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PAR2-Mediated cAMP Generation Suppresses TRPV4-Dependent Ca2+ Signaling in Alveolar Macrophages to Resolve TLR4-Induced Inflammation.

Sheikh Rayees, Jagdish Chandra Joshi, Mohammad Tauseef, Mumtaz Anwar, Sukriti Baweja, Ian Rochford, Bhagwati Joshi, Morley D Hollenberg, Sekhar P Reddy, Dolly Mehta,

Alveolar macrophages (AMs), upon sensing pathogens, trigger host defense by activating toll-like receptor 4 (TLR4), but the counterbalancing mechanisms that deactivate AM inflammatory signaling and prevent lethal edema, the hallmark of acute lung injury (ALI), remain unknown. Here, we demonstrate the essential role of AM protease-activating receptor 2 (PAR2) in ... Read more >>

Cell Rep (Cell reports)
[2019, 27(3):793-805.e4]

Cited: 5 times

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Piezo1 mediates angiogenesis through activation of MT1-MMP signaling.

Hojin Kang, Zhigang Hong, Ming Zhong, Jennifer Klomp, Kayla J Bayless, Dolly Mehta, Andrei V Karginov, Guochang Hu, Asrar B Malik,

Angiogenesis is initiated in response to a variety of external cues, including mechanical and biochemical stimuli; however, the underlying signaling mechanisms remain unclear. Here, we investigated the proangiogenic role of the endothelial mechanosensor Piezo1. Genetic deletion and pharmacological inhibition of Piezo1 reduced endothelial sprouting and lumen formation induced by wall ... Read more >>

Am. J. Physiol., Cell Physiol. (American journal of physiology. Cell physiology)
[2019, 316(1):C92-C103]

Cited: 7 times

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A genome-wide structure-based survey of nucleotide binding proteins in M. tuberculosis.

Raghu Bhagavat, Heung-Bok Kim, Chang-Yub Kim, Thomas C Terwilliger, Dolly Mehta, Narayanaswamy Srinivasan, Nagasuma Chandra,

Nucleoside tri-phosphates (NTP) form an important class of small molecule ligands that participate in, and are essential to a large number of biological processes. Here, we seek to identify the NTP binding proteome (NTPome) in M. tuberculosis (M.tb), a deadly pathogen. Identifying the NTPome is useful not only for gaining ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):12489]

Cited: 2 times

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Embryonic Stem Cell Differentiation to Functional Arterial Endothelial Cells through Sequential Activation of ETV2 and NOTCH1 Signaling by HIF1α.

Kit Man Tsang, James S Hyun, Kwong Tai Cheng, Micaela Vargas, Dolly Mehta, Masuko Ushio-Fukai, Li Zou, Kostandin V Pajcini, Jalees Rehman, Asrar B Malik,

The generation of functional arterial endothelial cells (aECs) from embryonic stem cells (ESCs) holds great promise for vascular tissue engineering. However, the mechanisms underlying their generation and the potential of aECs in revascularizing ischemic tissue are not fully understood. Here, we observed that hypoxia exposure of mouse ESCs induced an ... Read more >>

Stem Cell Reports (Stem cell reports)
[2017, 9(3):796-806]

Cited: 8 times

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Lung Interstitial Macrophages Redefined: It Is Not That Simple Anymore.

Sekhar P Reddy, Dolly Mehta,

Am. J. Respir. Cell Mol. Biol. (American journal of respiratory cell and molecular biology)
[2017, 57(2):135-136]

Cited: 3 times

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Protein Interactions at Endothelial Junctions and Signaling Mechanisms Regulating Endothelial Permeability.

Yulia A Komarova, Kevin Kruse, Dolly Mehta, Asrar B Malik,

The monolayer of endothelial cells lining the vessel wall forms a semipermeable barrier (in all tissue except the relatively impermeable blood-brain and inner retinal barriers) that regulates tissue-fluid homeostasis, transport of nutrients, and migration of blood cells across the barrier. Permeability of the endothelial barrier is primarily regulated by a ... Read more >>

Circ Res (Circulation research)
[2017, 120(1):179-206]

Cited: 71 times

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Response by Komarova et al to Letter Regarding Article, "Protein Interactions at Endothelial Junctions and Signaling Mechanisms Regulating Endothelial Permeability".

Yulia Komarova, Kevin J Kruse, Dolly Mehta, Asrar B Malik,

Circ Res (Circulation research)
[2017, 120(5):e28]

Cited: 0 times

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MicroRNA-150 Suppression of Angiopoetin-2 Generation and Signaling Is Crucial for Resolving Vascular Injury.

Charu Rajput, Mohammad Tauseef, Mohammad Farazuddin, Pascal Yazbeck, Md-Ruhul Amin, Vijay Avin Br, Tiffany Sharma, Dolly Mehta,

Increased vascular permeability is a hallmark of sepsis and acute respiratory distress syndrome. Angiopoietin (Ang2) induces vascular leak, and excess Ang2 generation is associated with patient mortality from these diseases. However, mechanisms dampening Ang2 generation during injury remain unclear. Interestingly, microRNA (miR)-150 levels were decreased in septic patients. miR regulate ... Read more >>

Arterioscler Thromb Vasc Biol (Arteriosclerosis, thrombosis, and vascular biology)
[2016, 36(2):380-388]

Cited: 21 times

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ROS-activated calcium signaling mechanisms regulating endothelial barrier function.

Anke Di, Dolly Mehta, Asrar B Malik,

Increased vascular permeability is a common pathogenic feature in many inflammatory diseases. For example in acute lung injury (ALI) and its most severe form, the acute respiratory distress syndrome (ARDS), lung microvessel endothelia lose their junctional integrity resulting in leakiness of the endothelial barrier and accumulation of protein rich edema. ... Read more >>

Cell Calcium (Cell calcium)
[2016, 60(3):163-171]

Cited: 22 times

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Visualization of Fra-1/AP-1 activation during LPS-induced inflammatory lung injury using fluorescence optical imaging.

Subbiah Rajasekaran, Chandramohan R Tamatam, Haranatha R Potteti, Venu Raman, Jae-Woo Lee, Michael A Matthay, Dolly Mehta, Narsa M Reddy, Sekhar P Reddy,

Inappropriate lung inflammatory response following oxidant and toxicant exposure can lead to abnormal repair and disease pathogenesis, including fibrosis. Thus early detection of molecular and cellular processes and mediators promoting lung inflammation is necessary to develop better strategies for therapeutic intervention and disease management. Previously, we have shown that transcription ... Read more >>

Am. J. Physiol. Lung Cell Mol. Physiol. (American journal of physiology. Lung cellular and molecular physiology)
[2015, 309(4):L414-24]

Cited: 2 times

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Transient receptor potential channel 1 maintains adherens junction plasticity by suppressing sphingosine kinase 1 expression to induce endothelial hyperpermeability.

Mohammad Tauseef, Mohammad Farazuddin, Sukriti Sukriti, Charu Rajput, James Otto Meyer, Suresh Kumar Ramasamy, Dolly Mehta,

Stability of endothelial cell (EC) adherens junctions (AJs) is central for prevention of tissue edema, the hallmark of chronic inflammatory diseases including acute respiratory distress syndrome. Here, we demonstrate a previously unsuspected role of sphingosine kinase 1 (SPHK1) in the mechanism by which transient receptor potential channel 1 (Trpc1)-mediated Ca(2+) ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2016, 30(1):102-110]

Cited: 6 times

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Notch Activation of Ca(2+) Signaling in the Development of Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension.

Kimberly A Smith, Guillaume Voiriot, Haiyang Tang, Dustin R Fraidenburg, Shanshan Song, Hisao Yamamura, Aya Yamamura, Qiang Guo, Jun Wan, Nicole M Pohl, Mohammad Tauseef, Rolf Bodmer, Karen Ocorr, Patricia A Thistlethwaite, Gabriel G Haddad, Frank L Powell, Ayako Makino, Dolly Mehta, Jason X-J Yuan,

Hypoxic pulmonary vasoconstriction (HPV) is an important physiological response that optimizes the ventilation/perfusion ratio. Chronic hypoxia causes vascular remodeling, which is central to the pathogenesis of hypoxia-induced pulmonary hypertension (HPH). We have previously shown that Notch3 is up-regulated in HPH and that activation of Notch signaling enhances store-operated Ca(2+) entry ... Read more >>

Am. J. Respir. Cell Mol. Biol. (American journal of respiratory cell and molecular biology)
[2015, 53(3):355-367]

Cited: 26 times

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All-Trans Retinoic Acid Induces TGF-β2 in Intestinal Epithelial Cells via RhoA- and p38α MAPK-Mediated Activation of the Transcription Factor ATF2.

Kopperuncholan Namachivayam, Krishnan MohanKumar, Dima Arbach, Ramasamy Jagadeeswaran, Sunil K Jain, Viswanathan Natarajan, Dolly Mehta, Robert P Jankov, Akhil Maheshwari,

We have shown previously that preterm infants are at risk of necrotizing enterocolitis (NEC), an inflammatory bowel necrosis typically seen in infants born prior to 32 weeks' gestation, because of the developmental deficiency of transforming growth factor (TGF)-β2 in the intestine. The present study was designed to investigate all-trans retinoic ... Read more >>

PLoS One (PloS one)
[2015, 10(7):e0134003]

Cited: 9 times

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ROCK2 primes the endothelium for vascular hyperpermeability responses by raising baseline junctional tension.

Cora M L Beckers, Nebojsa Knezevic, Erik T Valent, Mohammad Tauseef, Ramaswamy Krishnan, Kavitha Rajendran, C Corey Hardin, Jurjan Aman, Jan van Bezu, Paul Sweetnam, Victor W M van Hinsbergh, Dolly Mehta, Geerten P van Nieuw Amerongen,

Rho kinase mediates the effects of inflammatory permeability factors by increasing actomyosin-generated traction forces on endothelial adherens junctions, resulting in disassembly of intercellular junctions and increased vascular leakage. In vitro, this is accompanied by the Rho kinase-driven formation of prominent radial F-actin fibers, but the in vivo relevance of those ... Read more >>

Vascul Pharmacol (Vascular pharmacology)
[2015, 70:45-54]

Cited: 15 times

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Mechanisms regulating endothelial permeability.

Sukriti Sukriti, Mohammad Tauseef, Pascal Yazbeck, Dolly Mehta,

The endothelial monolayer partitioning underlying tissue from blood components in the vessel wall maintains tissue fluid balance and host defense through dynamically opening intercellular junctions. Edemagenic agonists disrupt endothelial barrier function by signaling the opening of the intercellular junctions leading to the formation of protein-rich edema in the interstitial tissue, ... Read more >>

(Pulmonary circulation)
[2014, 4(4):535-551]

Cited: 86 times

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S1PR1 Tyr143 phosphorylation downregulates endothelial cell surface S1PR1 expression and responsiveness.

Alejandra Chavez, Tracy Thennes Schmidt, Pascal Yazbeck, Charu Rajput, Bhushan Desai, Sukriti Sukriti, Kristina Giantsos-Adams, Nebojsa Knezevic, Asrar B Malik, Dolly Mehta,

Activation of sphingosine-1-phosphate receptor 1 (S1PR1) plays a key role in repairing endothelial barrier function. We addressed the role of phosphorylation of the three intracellular tyrosine residues of S1PR1 in endothelial cells in regulating the receptor responsiveness and endothelial barrier function regulated by sphingosine 1-phosphate (S1P)-mediated activation of S1PR1. We ... Read more >>

J. Cell. Sci. (Journal of cell science)
[2015, 128(5):878-887]

Cited: 8 times

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