Full Text Journal Articles by
Author Doaa A Ghareeb


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Electronic nose versus quadrupole mass spectrometry for identifying viral hepatitis C patients.

Ehab I Mohamed, Sameh M El-Ghnam, Amani M Bayoumi, Samir M Abdel-Mageed, Doaa A Ghareeb, Brian Ross,

Hepatitis C is a leading cause of liver disease and transplantation and is a significant burden on public health worldwide. This study aimed to apply the Electronic Nose (E-Nose) and quadrupole Mass Spectrometry (MS/MS) technologies for screening blood samples from hepatitis C patients and healthy controls. We analysed volatile organic ... Read more >>

J Viral Hepat (Journal of viral hepatitis)
[2021, :]

Cited: 0 times

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Eco-friendly polyurethane acrylate (PUA)/natural filler-based composite as an antifouling product for marine coating.

Huda S El-Sheshtawy, Mahmoud R Sofy, Doaa A Ghareeb, Galila A Yacout, Maha A Eldemellawy, Basma M Ibrahim,

In the current study, the polyurethane acrylate (PUA) polymer was synthesized by the addition reaction between an isophorone diisocyanate (IPDI) and 2-hydroxyethyl acrylate and cured by polyol. Different properties of the synthesized PUA were determined through diverse analysis methods. The polyurethane acrylate (PUA)/natural filler-based composite (rhizome water extract of Costus ... Read more >>

Appl Microbiol Biotechnol (Applied microbiology and biotechnology)
[2021, 105(18):7023-7034]

Cited: 0 times

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Pharmacological implications of ipriflavone against environmental metal-induced neurodegeneration and dementia in rats.

Hend M Hussien, Doaa A Ghareeb, Hany E A Ahmed, Hani S Hafez, Samar R Saleh,

Long-term exposure to environmental neurotoxic metals is implicated in the induction of dementia and cognitive decline. The present study aims to illustrate the therapeutic role of ipriflavone as a synthetic isoflavone against environmental metal-induced cognitive impairment in rats. Dementia was induced by a mixture of aluminum, cadmium, and fluoride for 90 ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2021, :]

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Trichoderma reesei fungal degradation boosted the potentiality of date pit extract in fighting scopolamine-induced neurotoxicity in male rats.

Samar R Saleh, Asmaa M Masry, Doaa A Ghareeb, Al-Sayeda A Newairy, Eman Sheta, Adham M Maher,

Date pits are nutritious by-products, containing high levels of indigestible carbohydrates and polyphenols. To maximize the biological effects of the active ingredients, the hard shell of the polysaccharide must be degraded. Therefore, the current study aimed to assess the protective potentials of date pits extract (DP) and fungal degraded date ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):14872]

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Potential therapeutic effects of Ulva lactuca water fraction on monosodium glutamate-induced testicular and prostatic tissue damage in rats.

Aya M Helal, Mohamed S Abdel-Latif, Mosleh Mohammed Abomughaid, Doaa A Ghareeb, Mohamed M El-Sayed,

Male infertility is considered one of the most critical health problems that are expected to expand worldwide. Ulva lactuca is a species of green seaweeds which is known to be a rich source of many important nutrients. Accordingly, this study is designated to investigate the therapeutic role of Ulva lactuca ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2021, 28(23):29629-29642]

Cited: 0 times

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In vitro biological activities and in vivo hepatoprotective role of brown algae-isolated fucoidans.

Marwa E Atya, Amr El-Hawiet, Mohamed A Alyeldeen, Doaa A Ghareeb, Mohamed M Abdel-Daim, Mohamed M El-Sadek,

Brown seaweeds are rich in polysaccharides, such as fucoidan (FUC) which has shown beneficial effects in several medical conditions. The aim of the present study was to assess the antioxidant, anti-inflammatory, and hepatoprotective properties of Colpomenia sinuosa- and Sargassum prismaticum-isolated FUC in vitro and in vivo. The hot acid extraction ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2021, 28(16):19664-19676]

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Berberine Nanoencapsulation Attenuates Hallmarks of Scoplomine Induced Alzheimer's-Like Disease in Rats.

Samar R Saleh, Mariam M Abady, Mohammed Nofal, Nashwa W Yassa, Mohamed S Abdel-Latif, Mohamed Ismail Nounou, Doaa A Ghareeb, Nihad Abdel-Monaem,

<h4>Background</h4>Berberine (BBR), an isoquinoline alkaloid, acts as a multipotent active pharmaceutical ingredient to counteract several types of dementia based on its numerous pharmacological actions including antioxidant, anti-inflammatory, cholesterol-lowering effect, and inhibition of Aβ production and AChE. However, BBR suffers from poor absorption, bioavailability and brain drug uptake. The present study ... Read more >>

Curr Rev Clin Exp Pharmacol (Current reviews in clinical and experimental pharmacology)
[2021, 16(2):139-154]

Cited: 1 time

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Efficacy-directed discrimination of the essential oils of three Juniperus species based on their in-vitro antimicrobial and anti-inflammatory activities.

Reham S Darwish, Hala M Hammoda, Doaa A Ghareeb, Ali S A Abdelhamid, El Moataz Bellah El Naggar, Fathallah M Harraz, Eman Shawky,

<h4>Ethnopharmacological relevance</h4>Juniperus plants are considered important sources of cedar-wood oil which is used widely in folk medicine as antiseptic and in treatment of inflammatory disorders such as, rheumatoid arthritis but there is not enough scientific evidence to support the claimed uses and there is no specification of a certain Juniperus ... Read more >>

J Ethnopharmacol (Journal of ethnopharmacology)
[2020, 259:112971]

Cited: 3 times

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Phytochemical Analysis and Toxicity Assessment of Artichoke By-product Extract.

Olfat M Eldin Awad, Sobhy A El-Sohaimy, Doaa A Ghareeb, A M Aboulenein, Samar R Saleh, Nourhan M Abd El-Aziz,

BACKGROUND AND OBJECTIVE:Egypt produced 236,314 t of artichoke in 2016, which produce a huge amount of useless by-product, which can be used as cheaper source for many active compounds can be applied for some medical application. The objective of this study was to assess the toxicity of the artichoke by-product ... Read more >>

Pak J Biol Sci (Pakistan journal of biological sciences : PJBS)
[2020, 23(1):81-91]

Cited: 2 times

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Ulva lactuca methanolic extract improves oxidative stress-related male infertility induced in experimental animals.

Doaa A Ghareeb, Alshimaa Abd-Elgwad, Nihal El-Guindy, Galila Yacout, Hala H Zaatout,

<h4>Aim</h4>This study designated to investigate and compare the therapeutic effect of <i>Ulva lactuca</i> methanolic extract against oxidative stress (OS)-infertility induced by naturally occurring prooxidants (gossypol) and selenium- vitamins A, C, and E (selenium-ACE) drug.<h4>Methods</h4>Male infertility was induced in rat by intraperitoneal injection of 5 mg/kg gossypol eight times then the treatment ... Read more >>

Arch Physiol Biochem (Archives of physiology and biochemistry)
[2021, 127(5):397-405]

Cited: 0 times

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Protective effect of surface-modified berberine nanoparticles against LPS-induced neurodegenerative changes: a preclinical study.

Salma A Soudi, Mohamed I Nounou, Salah A Sheweita, Doaa A Ghareeb, Layla K Younis, Labiba K El-Khordagui,

Berberine (BBR) exerts documented protection against neurodegenerative disorders. However, data on the effect of nano-encapsulation on the neuroprotective effect of BBR are lacking. We investigated the effect of BBR loading into chitosan (CS) nanoparticles (NPs) and their surface modification with Tween 80 (T80), polyethylene glycol 4000 (PEG), and miltefosine (MFS) ... Read more >>

Drug Deliv Transl Res (Drug delivery and translational research)
[2019, 9(5):906-919]

Cited: 3 times

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Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.

Ehab D AlFadly, Perihan A Elzahhar, Anna Tramarin, Salwa Elkazaz, Hossam Shaltout, Marwa M Abu-Serie, Jana Janockova, Ondrej Soukup, Doaa A Ghareeb, Ahmed F El-Yazbi, Rim W Rafeh, Nour-Mounira Z Bakkar, Firas Kobeissy, Isabel Iriepa, Ignacio Moraleda, Manal N S Saudi, Manuela Bartolini, Ahmed S F Belal,

Neuroinflammation and cholinergic deficit are key detrimental processes involved in Alzheimer's disease. Hence, in the search for novel and effective treatment strategies, the multi-target-directed ligand paradigm was applied to the rational design of two series of new hybrids endowed with anti-inflammatory and anticholinesterase activity via triple targeting properties, namely able ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2019, 167:161-186]

Cited: 7 times

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The Ameliorating Effect of Berberine-Rich Fraction against Gossypol-Induced Testicular Inflammation and Oxidative Stress.

Samar R Saleh, Rana Attia, Doaa A Ghareeb,

This study was aimed at evaluating the efficacy of berberine-rich fraction (BF) as a protective and/or a therapeutic agent against inflammation and oxidative stress during male infertility. Sexually mature Sprague-Dawley male rats were divided into five groups treated with either corn oil, BF (100 mg/kg BW, orally, daily for 30 days), ... Read more >>

Oxid Med Cell Longev (Oxidative medicine and cellular longevity)
[2018, 2018:1056173]

Cited: 4 times

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Potential Prophylactic Effect of Berberine against Rat Colon Carcinoma Induce by 1,2-Dimethyl Hydrazine

Ahmed E Ghareeb, Fatma S M Moawed, Doaa A Ghareeb, Eman I Kandil,

Introduction: Colon Cancer remains one of the major worldwide causes of cancer related morbidity and mortality in both genders. Berberine (BBR), a major component of alkaloids that possess a variety of pharmacological properties. Objective: This study shows the ameliorating roles of berberine on 1,2 Di methyl hydrazine (DMH) induced colon cancer in male ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2018, 19(6):1685-1690]

Cited: 5 times

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Neuroprotective effect of berberine against environmental heavy metals-induced neurotoxicity and Alzheimer's-like disease in rats.

Hend M Hussien, Aml Abd-Elmegied, Doaa A Ghareeb, Hani S Hafez, Hany E A Ahmed, Nehad Abd El-Moneam,

Heavy metals are reported as neurodegenerative disorders progenitor. They play a role in the precipitation of abnormal β-amyloid protein and hyper-phosphorylated tau, the main hallmarks of Alzheimer's disease (AD). The present study aimed to validate the heavy metals-induced Alzheimer's-like disease in rats as an experimental model of AD and explore ... Read more >>

Food Chem Toxicol (Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association)
[2018, 111:432-444]

Cited: 18 times

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Neuroprotective effect of ipriflavone against scopolamine-induced memory impairment in rats.

Hani S Hafez, Doaa A Ghareeb, Samar R Saleh, Mariam M Abady, Maha A El Demellawy, Hend Hussien, Nihad Abdel-Monem,

<h4>Background</h4>Alzheimer's disease is an age-related neurodegenerative disorder characterized clinically by a progressive loss of memory and cognitive functions resulting in severe dementia. Ipriflavone (IPRI) is a non-hormonal, semi-synthetic isoflavone, clinically used in some countries for the treatment and prevention of postmenopausal osteoporosis. Moreover, ipriflavone is a non-peptidomimetic small molecule AChE ... Read more >>

Psychopharmacology (Berl) (Psychopharmacology)
[2017, 234(20):3037-3053]

Cited: 11 times

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Differential metformin dose-dependent effects on cognition in rats: role of Akt.

Dalia K Mostafa, Cherine A Ismail, Doaa A Ghareeb,

<h4>Rational</h4>Epidemiological evidence suggests that individuals with diabetes mellitus are at greater risk of developing Alzheimer's disease, and controversy overwhelms the usefulness of the widely prescribed insulin-sensitizing drug, metformin, on cognition.<h4>Objectives</h4>Through the scopolamine-induced memory deficit model, we investigated metformin influence on cognitive dysfunction and explored underlying mechanisms.<h4>Methods</h4>Sixty adult male Wistar rats ... Read more >>

Psychopharmacology (Berl) (Psychopharmacology)
[2016, 233(13):2513-2524]

Cited: 17 times

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Berberine Reduces Neurotoxicity Related to Nonalcoholic Steatohepatitis in Rats.

Doaa A Ghareeb, Sofia Khalil, Hani S Hafez, Jürgen Bajorath, Hany E A Ahmed, Eman Sarhan, Eiman Elwakeel, Maha A El-Demellawy,

Berberine is a plant alkaloid that has several pharmacological effects such as antioxidant, antilipidemic, and anti-inflammatory effects. Nonalcoholic steatohepatitis (NASH) triggers different aspects of disorders such as impaired endogenous lipid metabolism, hypercholesterolemia, oxidative stress, and neurotoxicity. In this study, we examined the mechanism by which NASH induces neurotoxicity and the ... Read more >>

Evid Based Complement Alternat Med (Evidence-based complementary and alternative medicine : eCAM)
[2015, 2015:361847]

Cited: 8 times

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In vitro screening for anti-acetylcholiesterase, anti-oxidant, anti-glucosidase, anti-inflammatory and anti-bacterial effect of three traditional medicinal plants.

Doaa A Ghareeb, Amani M D ElAhwany, Sherif M El-Mallawany, Ashraf A Saif,

In this study we investigated the phytoconstituents <i>Calluna vulgaris</i>, <i>Ferula hermonis</i> and <i>Tribulus terrestris</i>, and then assessed their possible biological activities by using standard methods. A preliminary phytochemical investigation of the three extracts revealed the presence of alkaloids, flavonoids, proteins, lipids, phenolic compounds, saponins, sterols and amino acids. Three extracts ... Read more >>

Biotechnol Biotechnol Equip (Biotechnology, biotechnological equipment)
[2014, 28(6):1155-1164]

Cited: 5 times

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Imbalanced Diet Deficient in Calcium and Vitamin D- Induced Juvenile Osteopenia in Rats; the Potential Therapeutic Effect of Egyptian Moghat Roots Water Extract (Glossostemon bruguieri).

Doaa A Ghareeb, Fatma H El-Rashidy, Sherif El-Mallawany,

This study aimed to explore and validate a new juvenile osteopenic (JO) rat model then examine the efficacy of moghat (Glossostemon bruguieri) as an alternative reversal therapy for JO. Phytochemical screening analysis showed that moghat contains 5.8% alkaloids, 1.5% flavonoids and 13.2% total phenols. Juvenile osteopenia was induced in 15 ... Read more >>

Iran J Pharm Res (Iranian journal of pharmaceutical research : IJPR)
[2014, 13(2):623-635]

Cited: 0 times

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Non-alcoholic fatty liver induces insulin resistance and metabolic disorders with development of brain damage and dysfunction.

Doaa A Ghareeb, Hani S Hafez, Hend M Hussien, Nihal F Kabapy,

In the present study we investigated the effect of the non-alcoholic fatty liver disease (NAFLD) on the alterations in the activity of neurotransmitters catabolizing enzymes and energy catabolising enzymes, prooxidants, endogenous antioxidants and proinflammatory cytokines in brain tissue of NAFLD rats. Rats were intraperitonealy injected with CCl4 solution at a ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2011, 26(4):253-267]

Cited: 25 times

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Vanadium improves brain acetylcholinesterase activity on early stage alloxan-diabetic rats.

Doaa A Ghareeb, Hend M Hussen,

The present study is designed to screen the possible effects of sodium orthovanadate therapy on the kinetic parameters of brain membrane-bound and soluble acetylcholinesterase (AChE) forms in alloxan-induced diabetic rats. The diabetic rats were treated with 300 mg/kg sodium orthovanadate orally for 45 days. While diabetes significantly decreased the brain ... Read more >>

Neurosci Lett (Neuroscience letters)
[2008, 436(1):44-47]

Cited: 13 times

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