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Author Dirk Wilhelm

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Morphology Matters: A Critical Reappraisal of the Clinical Relevance of Morphologic Criteria From the 2019 WHO Classification in a Large Colorectal Cancer Cohort Comprising 1004 Cases.

Moritz Jesinghaus, Maxime Schmitt, Corinna Lang, Marianne Reiser, Alexander Scheiter, Björn Konukiewitz, Katja Steiger, Miguel Silva, Markus Tschurtschenthaler, Sebastian Lange, Sebastian Foersch, Karl F Becker, Dieter Saur, Helmut Friess, Kathrin Halfter, Jutta Engel, Melanie Boxberg, Nicole Pfarr, Dirk Wilhelm, Wilko Weichert,

The 2019 World Health Organization (WHO) classification of colorectal carcinoma (CRC) profoundly reclassified CRC subtypes and introduces tumor budding as a second major grading criterion, while condensing conventional grade into a 2-tiered system. So far it remains largely unexplored how these parameters interact with each other and whether they truly ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2021, 45(7):969-978]

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Effective operating room (OR) utilization by performing low-complex surgical procedures during the 2020 corona pandemic.

Thomas Vogel, Dina Schippers, Balqees Aldarweesh, Ilaria Pergolini, Martina Stollreiter, Klaus Wagner, Dirk Wilhelm, Helmut Friess, Michael Kranzfelder,

<h4>Purpose</h4>The SARS-CoV-2 pandemic has almost stopped all elective surgical treatment throughout the world. As operating room (OR) capacities are reduced everywhere to ensure availability of intensive care capacities, especially low-complex surgical procedures are often postponed. These include totally implantable central-venous access ports which are important for the oncologic treatment of ... Read more >>

Int J Comput Assist Radiol Surg (International journal of computer assisted radiology and surgery)
[2021, :]

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Design of a force-measuring setup for colorectal compression anastomosis and first ex-vivo results.

Jana Steger, Isabella Patzke, Maximilian Berlet, Stefanie Ficht, Markus Eblenkamp, Petra Mela, Dirk Wilhelm,

<h4>Purpose</h4>The introduction of novel endoscopic instruments is essential to reduce trauma in visceral surgery. However, endoscopic device development is hampered by challenges in respecting the dimensional restrictions, due to the narrow access route, and by achieving adequate force transmission. As the overall goal of our research is the development of ... Read more >>

Int J Comput Assist Radiol Surg (International journal of computer assisted radiology and surgery)
[2021, :]

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Crohn's disease: a population-based study of surgery in the age of biological therapy.

Christian Stöss, Maximilian Berlet, Stefan Reischl, Ulrich Nitsche, Marie-Christin Weber, Helmut Friess, Dirk Wilhelm, Philipp-Alexander Neumann,

<h4>Purpose</h4>Despite primary conservative therapy for Crohn's disease, a considerable proportion of patients ultimately needs to undergo surgery. Presumably, due to the increased use of biologics, the number of surgeries might have decreased. This study aimed to delineate current case numbers and trends in surgery in the era of biological therapy ... Read more >>

Int J Colorectal Dis (International journal of colorectal disease)
[2021, :]

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Acute Appendicitis: Trends in Surgical Treatment.

Christian Stöß, Ulrich Nitsche, Philipp-Alexander Neumann, Victoria Kehl, Dirk Wilhelm, Reinhard Busse, Helmut Friess, Ulrike Nimptsch,

<h4>Background</h4>Appendectomy is the gold standard for treatment of acute appendicitis. However, recent studies favor primary antibiotic therapy. The aim of this observational study was to explore changes in the numbers of operations for acute appendicitis in the period 2010-2017, paying special attention to disease severity.<h4>Methods</h4>Data from diagnosis-related group statistics were ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(14):244-249]

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Acute Appendicitis: Trends in Surgical Treatment—A Population-Based Study of Over 800 000 Patients.

Christian Stöß, Ulrich Nitsche, Philipp-Alexander Neumann, Victoria Kehl, Dirk Wilhelm, Reinhard Busse, Helmut Friess, Ulrike Nimptsch,

<h4>Background</h4>Appendectomy is the gold standard for treatment of acute appendicitis. However, recent studies favor primary antibiotic therapy. The aim of this observational study was to explore changes in the numbers of operations for acute appendicitis in the period 2010-2017, paying special attention to disease severity.<h4>Methods</h4>Data from diagnosis-related group statistics were ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Retrospective study of prognosis of patients with multiple colorectal carcinomas: synchronous versus metachronous makes the difference.

Christoph Barz, Christian Stöss, Philipp-Alexander Neumann, Dirk Wilhelm, Klaus-Peter Janssen, Helmut Friess, Ulrich Nitsche,

<h4>Purpose</h4>Little is known about difference between synchronous colorectal cancer (SCRC) and metachronous colorectal cancer (MCRC) despite the relevance for this selected patient group. The aim of this retrospective review was to analyze patients with SCRC and MCRC.<h4>Methods</h4>All patients who underwent surgery for SCRC and MCRC between 1982 and 2019 were ... Read more >>

Int J Colorectal Dis (International journal of colorectal disease)
[2021, 36(7):1487-1498]

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CARS guidelines for Scholarly Video communication.

Heinz U Lemke, Dirk Wilhelm,

Int J Comput Assist Radiol Surg (International journal of computer assisted radiology and surgery)
[2021, 16(4):525-528]

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Rethinking the causes of pilonidal sinus disease: a matched cohort study.

Dietrich Doll, Imke Brengelmann, Patrick Schober, Andreas Ommer, Friederike Bosche, Apostolos E Papalois, Sven Petersen, Dirk Wilhelm, Johannes Jongen, Markus M Luedi,

Our understanding of pilonidal sinus disease (PSD) is based on a paper published 29 years ago by Karydakis. Since then, surgeons have been taught that hair more easily penetrates wet skin, leading to the assumption that sweating promotes PSD. This postulate, however, has never been proven. Thus we used pilocarpine iontophoresis ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):6210]

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Risk of colectomy after conservative treatment of diverticulitis of the left hemicolon complicated by abdominal or pelvic abscess: protocol of a systematic review and meta-analysis.

Maximilian Sohn, Ayman Agha, Igors Iesalnieks, Anna Tiefes, Alfred Hochrein, Helmut Friess, Dirk Wilhelm, Stephan Schorn,

<h4>Introduction</h4>Acute diverticulitis of the sigmoid colon is increasingly treated by a non-operative approach. The need for colectomy after recovery from a flare of acute diverticulitis of the left colon, complicated diverticular abscess is still controversial. The primary aim of this study is to assess the risk of interval emergency surgery ... Read more >>

BMJ Open (BMJ open)
[2020, 10(12):e042350]

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Positionspapier „Digitalisierung in der Chirurgie“ – Konsequenzen?

Dirk Wilhelm, Beat Müller-Stich, Daniel Ostler, Thomas Schmitz-Rixen, Hubertus Feussner,

Zentralbl Chir (Zentralblatt fur Chirurgie)
[2020, 145(6):495-498]

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Artificial Intelligence in Visceral Medicine.

Dirk Wilhelm, Loubna Bouarfa, Nassir Navab, Alexander Meining, Beat Müller-Stich, Anthony Jarc, Nicolas Padoy,

Visc Med (Visceral medicine)
[2020, 36(6):471-475]

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Artificial Intelligence in Medicine: Passing Hype or the Holy Grail of Solutions?

Dirk Wilhelm, Nicolas Padoy,

Visc Med (Visceral medicine)
[2020, 36(6):425-427]

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Machine Learning in the OR: A Collaborative Environment for Surgical Interventions in Visceral Medicine.

Daniel Ostler, Dirk Wilhelm, Lukas Bernhard, Jonas Fuchtmann, Michael Kranzfelder, Thomas Vogel, Hubertus Feussner,

Modern surgical methods are becoming increasingly sophisticated and the number of technical devices that are used during these interventions is increasing. However, the surgical operating room (OR) remains a mere conglomerate of unconnected medical devices. The increase in the complexity of device functionality, in addition to the demands of surgery, ... Read more >>

Surg Technol Int (Surgical technology international)
[2020, 37:16-21]

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Innovative approaches for induction of gastrointestinal anastomotic healing: an update on experimental and clinical aspects.

Stefan Reischl, Dirk Wilhelm, Helmut Friess, Philipp-Alexander Neumann,

PURPOSE:In most cases, traditional techniques to perform an anastomosis following gastrointestinal resections lead to successful healing. However, despite focused research in the field, in certain high-risk situations leakage rates remain almost unchanged. Here, additional techniques may help the surgeon to protect the anastomosis and prevent leakage. We give an overview of ... Read more >>

Langenbecks Arch Surg (Langenbeck's archives of surgery)
[2020, :]

Cited: 1 time

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Evaluation of long-term stability of monolithic 3D-printed robotic manipulator structures for minimally invasive surgery.

Yannick S Krieger, Daniel Ostler, Korbinian Rzepka, Alexander Meining, Hubertus Feussner, Dirk Wilhelm, Tim C Lueth,

<h4>Purpose</h4>In the era of patient-centered medicine, clinical procedures, tools and instruments should be individually adapted to the patient. In this context, the presented 3D-printed Single-Port Overtube Manipulator System follows the aims to provide patient- and task-specific disposable manipulators for minimally invasive surgery. In a first experiment, the robustness of the ... Read more >>

Int J Comput Assist Radiol Surg (International journal of computer assisted radiology and surgery)
[2020, 15(10):1693-1697]

Cited: 0 times

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Acoustic signal analysis of instrument-tissue interaction for minimally invasive interventions.

Daniel Ostler, Matthias Seibold, Jonas Fuchtmann, Nicole Samm, Hubertus Feussner, Dirk Wilhelm, Nassir Navab,

<h4>Purpose</h4>Minimally invasive surgery (MIS) has become the standard for many surgical procedures as it minimizes trauma, reduces infection rates and shortens hospitalization. However, the manipulation of objects in the surgical workspace can be difficult due to the unintuitive handling of instruments and limited range of motion. Apart from the advantages ... Read more >>

Int J Comput Assist Radiol Surg (International journal of computer assisted radiology and surgery)
[2020, 15(5):771-779]

Cited: 1 time

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Integrating autonomously navigating assistance systems into the clinic: guiding principles and the ANTS-OR approach.

Lukas Bernhard, Daniel Ostler, Hubertus Feußner, Dirk Wilhelm,

PURPOSE:Autonomously self-navigating clinical assistance systems (ASCAS) seem highly promising for improving clinical workflows. There is great potential for easing staff workload and improving overall efficiency by reducing monotonous and physically demanding tasks. However, a seamless integration of such systems into complex human-supervised clinical workflows is challenging. As of yet, guiding ... Read more >>

Int J Comput Assist Radiol Surg (International journal of computer assisted radiology and surgery)
[2020, 15(6):1063-1067]

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Annexin A1 Expression Capacity as a Determinant for Disease Severity in Crohn's Disease.

Stefan Reischl, Jasmin Troger, Moritz Jesinghaus, Atsuko Kasajima, Dirk Felix Wilhelm, Helmut Friess, Philipp-Alexander Neumann,

INTRODUCTION:Crohn's disease (CD) is characterized by relapsing intestinal inflammation. The anti-inflammatory protein annexin A1 (ANXA1) has been linked to inflammatory processes in the gut. OBJECTIVE:To examine ANXA1 expression patterns in the inflamed intestine of patients with CD and associate ANXA1 expression capacity with disease characteristics. METHODS:Surgical specimens of patients with ... Read more >>

Dig Dis (Digestive diseases (Basel, Switzerland))
[2020, 38(5):398-407]

Cited: 2 times

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Post-neoadjuvant cellular dissociation grading based on tumour budding and cell nest size is associated with therapy response and survival in oesophageal squamous cell carcinoma.

Moritz Jesinghaus, Melanie Boxberg, Dirk Wilhelm, Stefan Münch, Hendrik Dapper, Michael Quante, Christoph Schlag, Sebastian Lange, Jan Budczies, Björn Konukiewitz, Martin Mollenhauer, Anna Melissa Schlitter, Karl Friedrich Becker, Marcus Feith, Helmut Friess, Katja Steiger, Stephanie E Combs, Wilko Weichert,

<h4>Background</h4>Cellular Dissociation Grade (CDG) composed of tumour budding and cell nest size has been shown to independently predict prognosis in pre-therapeutic biopsies and primary resections of oesophageal squamous cell carcinoma (ESCC). Here, we aimed to evaluate the prognostic impact of CDG in ESCC after neoadjuvant therapy.<h4>Methods</h4>We evaluated cell nest size ... Read more >>

Br J Cancer (British journal of cancer)
[2019, 121(12):1050-1057]

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5th-Generation Mobile Communication: Data Highway for Surgery 4.0.

Alissa Jell, Thomas Vogel, Daniel Ostler, Nils Marahrens, Dirk Wilhelm, Nicole Samm, Josef Eichinger, Walter Weigel, Hubertus Feussner, Helmut Friess, Michael Kranzfelder,

INTRODUCTION:5th generation cellular mobile communications (5G) is one of the main requirements for the digital future. The new standard will offer high bandwidths (10GB/s), low latency (<1ms), and a high quality of service. It is not yet known whether 5G performance is sufficient for demanding eHealth applications (e.g., telemedicine). MATERIAL ... Read more >>

Surg Technol Int (Surgical technology international)
[2019, 35:36-42]

Cited: 4 times

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Multiple intestinal intussusceptions caused by highly impaired gastrointestinal motility in a patient with chronic cannabis consumption.

Olga Prokopchuk, Philipp-Alexander Neumann, Norbert Hüser, Helmut Friess, Dirk Wilhelm,

Since the therapeutic use of cannabis and its derivatives is currently rising, the adverse effects of cannabis and cannabinoids are of special interest. However little is known about the possible effects of long-term use of cannabis on the gastrointestinal motility. Herewith we describe the case of a patient with a ... Read more >>

J Surg Case Rep (Journal of surgical case reports)
[2019, 2019(5):rjz160]

Cited: 1 time

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Mechatronic Support System for NOTES and Monoport Surgery - A New Approach.

Hubertus Feussner, Yannick Krieger, Dirk Wilhelm, Stephan Brunner, Daniel Ostler, Alexander Meining, Tim Lueth,

To circumvent the drawbacks of currently available platforms for natural orifice transluminal endoscopic surgery (NOTES) and monoport surgery (MPS), we developed a patient-specific, disposable, surgical soft robotic system. The system (Single-Port Overtube; SPOT) is designed as an overtube for standard surgical equipment. The platform body and the manipulators can be ... Read more >>

Surg Technol Int (Surgical technology international)
[2019, 34:23-29]

Cited: 1 time

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Cellular Dissociation Grading Based on the Parameters Tumor Budding and Cell Nest Size in Pretherapeutic Biopsy Specimens Allows for Prognostic Patient Stratification in Esophageal Squamous Cell Carcinoma Independent From Clinical Staging.

Moritz Jesinghaus, Frido Brühl, Katja Steiger, Peter Klare, Marianne Reiser, Alexander Scheiter, Björn Konukiewitz, Peer Kuhn, Stefan Münch, Michael Quante, Roland M Schmid, Dirk Wilhelm, Markus Feith, Helmut Friess, Stephanie E Combs, Dieter Saur, Melanie Boxberg, Wilko Weichert,

Initial treatment planning in esophageal squamous cell carcinoma mainly relies on clinical staging. Recently, a highly prognostic grading system based on the cellular dissociation parameters Tumor Budding and Cell Nest Size has been proposed for resected esophageal squamous cell carcinoma. To probe for the transferability and relevance of this established ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2019, 43(5):618-627]

Cited: 6 times

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Mortality and postoperative complications after different types of surgical reconstruction following pancreaticoduodenectomy-a systematic review with meta-analysis.

Stephan Schorn, Ihsan Ekin Demir, Thomas Vogel, Rebekka Schirren, Daniel Reim, Dirk Wilhelm, Helmut Friess, Güralp Onur Ceyhan,

BACKGROUND:Pancreaticoduodenectomy/PD is a technically demanding pancreatic resection. Options of surgical reconstruction include (1) the child reconstruction defined as pancreatojejunostomy/PJ followed by hepaticojejunostomy/HJ and the gastrojejunostomy/GJ "the standard/s-Child," (2) the s-child reconstruction with an additional Braun enteroenterostomy "BE-Child," or (3) Isolated-Roux-En-Y-pancreaticojejunostomy "Iso-Roux-En-Y," in which the pancreas anastomosis is reconstructed in a ... Read more >>

Langenbecks Arch Surg (Langenbeck's archives of surgery)
[2019, 404(2):141-157]

Cited: 3 times

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