Full Text Journal Articles by
Author Dirk Bauerschlag

Advertisement

Find full text journal articles






High Antitumor Activity of the Dual Topoisomerase Inhibitor P8-D6 in Breast Cancer.

Inken Flörkemeier, Tamara N Steinhauer, Nina Hedemann, Jörg Paul Weimer, Christoph Rogmans, Marion T van Mackelenbergh, Nicolai Maass, Bernd Clement, Dirk O Bauerschlag,

Breast cancer constitutes the leading cause of cancer deaths among females. However, numerous shortcomings, including low bioavailability, resistance and significant side effects, are responsible for insufficient treatment. The ultimate goal, therefore, is to improve the success rates and, thus, the range available treatment options for breast cancer. Consequently, the identification, ... Read more >>

Cancers (Basel) (Cancers)
[2021, 14(1):]

Cited: 0 times

View full text PDF listing >>



The Novel Dual Topoisomerase Inhibitor P8-D6 Shows Anti-myeloma Activity In Vitro and In Vivo.

Katja Klausz, Christian Kellner, Carina Lynn Gehlert, Steffen Krohn, Hauke Wilcken, Inken Floerkemeier, Andreas Günther, Dirk O Bauerschlag, Bernd Clement, Martin Gramatzki, Matthias Peipp,

P8-D6 is a novel dual inhibitor of human topoisomerase I (TOP1) and II (TOP2) with broad pro-apoptotic antitumor activity. NCI-60 screening revealed markedly improved cytotoxicity of P8-D6 against solid and leukemia cell lines compared with other single and dual topoisomerase inhibitors, for example, irinotecan, doxorubicin, or pyrazoloacridine. In this study, ... Read more >>

Mol Cancer Ther (Molecular cancer therapeutics)
[2022, 21(1):70-78]

Cited: 0 times

View full text PDF listing >>



Advertisement

Tumor cell lysis and synergistically enhanced antibody-dependent cell-mediated cytotoxicity by NKG2D engagement with a bispecific immunoligand targeting the HER2 antigen.

Christian Kellner, Sebastian Lutz, Hans-Heinrich Oberg, Daniela Wesch, Anna Otte, Katarina J Diemer, Hauke Wilcken, Dirk Bauerschlag, Claus-Christian Glüer, Christian Wichmann, Dieter Kabelitz, Jeanette H W Leusen, Katja Klausz, Andreas Humpe, Martin Gramatzki, Matthias Peipp,

Natural killer group 2 member D (NKG2D) plays an important role in the regulation of natural killer (NK) cell cytotoxicity in cancer immune surveillance. With the aim of redirecting NK cell cytotoxicity against tumors, the NKG2D ligand UL-16 binding protein 2 (ULBP2) was fused to a single-chain fragment variable (scFv) ... Read more >>

Biol Chem (Biological chemistry)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Newly developed dual topoisomerase inhibitor P8-D6 is highly active in ovarian cancer.

Inken Flörkemeier, Tamara N Steinhauer, Nina Hedemann, Magnus Ölander, Per Artursson, Bernd Clement, Dirk O Bauerschlag,

<h4>Background</h4>Ovarian cancer (OvCa) constitutes a rare and highly aggressive malignancy and is one of the most lethal of all gynaecologic neoplasms. Due to chemotherapy resistance and treatment limitations because of side effects, OvCa is still not sufficiently treatable. Hence, new drugs for OvCa therapy such as P8-D6 with promising antitumour ... Read more >>

Ther Adv Med Oncol (Therapeutic advances in medical oncology)
[2021, 13:17588359211059896]

Cited: 0 times

View full text PDF listing >>



ADAM17-A Potential Blood-Based Biomarker for Detection of Early-Stage Ovarian Cancer.

Christoph Rogmans, Jan Dominik Kuhlmann, Gerrit Hugendieck, Theresa Link, Norbert Arnold, Jörg Paul Weimer, Inken Flörkemeier, Anna-Christina Rambow, Wolfgang Lieb, Nicolai Maass, Dirk O Bauerschlag, Nina Hedemann,

Ovarian cancer has the highest mortality rate among gynecological tumors. This is based on late diagnosis and the lack of early symptoms. To improve early detection, it is essential to find reliable biomarkers. The metalloprotease ADAM17 could be a potential marker, as it is highly expressed in many solid tumors, ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(21):]

Cited: 0 times

View full text PDF listing >>



Pembrolizumab for Persistent, Recurrent, or Metastatic Cervical Cancer.

Nicoletta Colombo, Coraline Dubot, Domenica Lorusso, M Valeria Caceres, Kosei Hasegawa, Ronnie Shapira-Frommer, Krishnansu S Tewari, Pamela Salman, Edwin Hoyos Usta, Eduardo Yañez, Mahmut Gümüş, Mivael Olivera Hurtado de Mendoza, Vanessa Samouëlian, Vincent Castonguay, Alexander Arkhipov, Sarper Toker, Kan Li, Stephen M Keefe, Bradley J Monk, ,

<h4>Background</h4>Pembrolizumab has efficacy in programmed death ligand 1 (PD-L1)-positive metastatic or unresectable cervical cancer that has progressed during chemotherapy. We assessed the relative benefit of adding pembrolizumab to chemotherapy with or without bevacizumab.<h4>Methods</h4>In a double-blind, phase 3 trial, we randomly assigned patients with persistent, recurrent, or metastatic cervical cancer in ... Read more >>

N Engl J Med (The New England journal of medicine)
[2021, 385(20):1856-1867]

Cited: 1 time

View full text PDF listing >>



Challenges and Controversies in the Surgical Treatment of Cervical Cancer: Open Radical Hysterectomy versus Minimally Invasive Radical Hysterectomy.

Jona Röseler, Robert Wolff, Dirk O Bauerschlag, Nicolai Maass, Peter Hillemanns, Helder Ferreira, Marie Debrouwere, Fülöp Scheibler, Friedemann Geiger, Mohamed Elessawy,

<h4>Objective</h4>The aim of the study was to perform a systematic assessment of disease-free survival (DFS), overall survival, and morbidity rates after open radical hysterectomy (ORH) and minimally invasive surgery (MIS) for early-stage cervical cancer and discuss with experts the consequences of the LACC trial (published by Ramirez et al. in ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(17):]

Cited: 0 times

View full text PDF listing >>



Massive uterine fibroid: a diagnostic dilemma: a case report and review of the literature.

Wiesener Viva, Dhanawat Juhi, Andresen Kristin, Mathiak Micaela, Both Marcus, Alkatout Ibrahim, Bauerschlag Dirk,

<h4>Background</h4>Fibroids of the uterus are the most common benign pelvic tumors in women worldwide. Their diagnosis is usually not missed because of the widespread and well-established use of ultrasound in gynecological clinics. Hence, the development of an unusually large myoma is a rare event, particularly in first-world countries such as ... Read more >>

J Med Case Rep (Journal of medical case reports)
[2021, 15(1):344]

Cited: 1 time

View full text PDF listing >>



Newly Developed Dual Topoisomerase Inhibitor P8-D6 is Highly Active in Ovarian Cancer

Inken Flörkemeier, Tamara Steinhauer, Nina Hedemann, Magnus Ölander, Per Artursson, Bernd Clement, Dirk Bauerschlag,

<h4>Background: </h4> Ovarian cancer (OvCa) constitutes a rare and highly aggressive malignancy and is one of the most lethal of all gynaecologic neoplasms. Due to chemotherapy resistance and treatment limitations because of side effects, OvCa is still not sufficiently treatable. Hence, new drugs for OvCa therapy such as P8-D6 with ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



ADAM17 Inhibition Increases the Impact of Cisplatin Treatment in Ovarian Cancer Spheroids.

Nina Hedemann, Andreas Herz, Jan Hendrik Schiepanski, Jan Dittrich, Susanne Sebens, Astrid Dempfle, Julia Feuerborn, Christoph Rogmans, Nils Tribian, Inken Flörkemeier, Jörg Weimer, Sandra Krüger, Nicolai Maass, Dirk O Bauerschlag,

Chemotherapy resistance is a major challenge in ovarian cancer (OvCa). Thus, novel treatment combinations are highly warranted. However, many promising drug candidates tested in two-dimensional (2D) cell culture have not proved successful in the clinic. For this reason, we analyzed our drug combination not only in monolayers but also in ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(9):]

Cited: 1 time

View full text PDF listing >>



Mucinous Cystic Neoplasm of Pancreas in a Pregnant Woman Presenting with Severe Anemia and Gastric Bleeding: Case Report and Review of the Literature.

Susan Farahmandi, Mohamed Elessawy, Dirk O Bauerschlag, Ulrich Pecks, Samir Abdullazade, Jan Henrik Beckmann, Thorsten Heilmann, Anna-Lena Rumpf, Nicolai Maass, Peer Jansen, Vincent Winkler,

Mucinous cystic neoplasms of the pancreas are uncommon and especially their occurrence during pregnancy is an extremely rare event which necessitates an individualized and interdisciplinary management. A 33-year old woman was referred to our department during her third trimester of pregnancy (34th week of gestation) with severe anemia and tarry ... Read more >>

Healthcare (Basel) (Healthcare (Basel, Switzerland))
[2021, 9(5):]

Cited: 0 times

View full text PDF listing >>



Metastases-directed Radiotherapy in Addition to Standard Systemic Therapy in Patients with Oligometastatic Breast Cancer: Study protocol for a randomized controlled multi-national and multi-center clinical trial (OLIGOMA).

David Krug, Reinhard Vonthein, Alicia Illen, Denise Olbrich, Jörg Barkhausen, Julia Richter, Wolfram Klapper, Claudia Schmalz, Achim Rody, Nicolai Maass, Dirk Bauerschlag, Nicole Heßler, Inke R König, Kathrin Dellas, Jürgen Dunst,

<h4>Background</h4>Several recent randomized therapeutic exploratory trials demonstrated improvement of progression-free survival and in some even overall survival using stereotactic body radiotherapy in patients with oligometastatic disease. However, only very few patients enrolled in these trials had breast cancer, and results from confirmatory trials are lacking.<h4>Methods/design</h4>The OLIGOMA-trial is a randomized controlled ... Read more >>

Clin Transl Radiat Oncol (Clinical and translational radiation oncology)
[2021, 28:90-96]

Cited: 0 times

View full text PDF listing >>



Involvement of medical students in a surgery congress: impact on learning motivation, decision-making for a career in surgery, and educational curriculum.

Ibrahim Alkatout, Veronika Günther, Sandra Brügge, Johannes Ackermann, Magret Krüger, Dirk Bauerschlag, Nicolai Maass, Sebastian Lippross, Ingolf Cascorbi, Jan-Hendrik Egberts, Thomas Becker, Daniar Osmonov, Klaus-Peter Jünemann, Thilo Wedel,

During the preclinical period of medical school, the clinical relevance of theoretical knowledge is given little attention. Medical students of the second year were invited to participate in an interdisciplinary congress for robot-assisted and digital surgery. The students had to evaluate the impact of the congress on their learning motivation, ... Read more >>

Wien Med Wochenschr (Wiener medizinische Wochenschrift (1946))
[2021, 171(7-8):182-193]

Cited: 0 times

View full text PDF listing >>



Evaluation of Laparoscopy Virtual Reality Training on the Improvement of Trainees' Surgical Skills.

Mohamed Elessawy, Mohamed Mabrouk, Thorsten Heilmann, Marion Weigel, Mohamed Zidan, Ghada Abu-Sheasha, Andre Farrokh, Dirk Bauerschlag, Nicolai Maass, Mohamed Ibrahim, Dina Kamel,

<i>Background and objectives</i>: The primary objective was to evaluate the benefit of training with virtual reality simulation. The secondary objective was to describe the short-term skill acquisition obtained by simulation training and to determine the factors affecting its magnitude. <i>Materials and Methods</i>: We prospectively performed a three-stage evaluation: face, constructive, ... Read more >>

Medicina (Kaunas) (Medicina (Kaunas, Lithuania))
[2021, 57(2):]

Cited: 0 times

View full text PDF listing >>



p53 and p16 expression profiles in vulvar cancer: a translational analysis by the Arbeitsgemeinschaft Gynäkologische Onkologie Chemo and Radiotherapy in Epithelial Vulvar Cancer study group.

Linn Woelber, Katharina Prieske, Christine Eulenburg, Leticia Oliveira-Ferrer, Nikolaus de Gregorio, Ruediger Klapdor, Matthias Kalder, Iona Braicu, Sophie Fuerst, Maximilian Klar, Hans-Georg Strauss, Matthias Beckmann, Werner Meier, Atanas Ignatov, Alexander Mustea, Julia Jueckstock, Georg Schmidt, Dirk Bauerschlag, Martin Hellriegel, Ulrich Canzler, Karl Ulrich Petry, Stefan Kommoss, Peer Hantschmann, Martin Heubner, Sven Mahner, Eike Burandt,

<h4>Background</h4>There are 2 known pathways for tumorigenesis of vulvar squamous cell carcinoma-a human papillomavirus-dependent pathway characterized by p16 overexpression and a human papillomavirus-independent pathway linked to lichen sclerosus, characterized by TP53 mutation. A correlation of human papillomavirus dependency with a favorable prognosis has been proposed.<h4>Objective</h4>The objective of the study was ... Read more >>

Am J Obstet Gynecol (American journal of obstetrics and gynecology)
[2021, 224(6):595.e1-595.e11]

Cited: 2 times

View full text PDF listing >>



Impact of Multiparametric MRI (mMRI) on the Therapeutic Management of Adnexal Masses Detected with Transvaginal Ultrasound (TVUS): An Interdisciplinary Management Approach.

Timm Dirrichs, Dirk Bauerschlag, Nicolai Maass, Christiane K Kuhl, Simone Schrading,

<h4>Rationale and objectives</h4>Adnexal masses detected incidentally at transvaginal ultrasound (TVUS) are a common and still challenging diagnostic problem. The primary goal of further imaging is an accurate tissue characterization so an optimal treatment plan can be devised including surgery only for lesions that are indeterminate or malignant. The aim of ... Read more >>

Acad Radiol (Academic radiology)
[2022, 29(2):183-197]

Cited: 3 times

View full text PDF listing >>



Correction: SNiPER: a novel hypermethylation biomarker panel for liquid biopsy based early breast cancer detection.

Jolein Mijnes, Janina Tiedemann, Julian Eschenbruch, Janina Gasthaus, Sarah Bringezu, Dirk Bauerschlag, Nicolai Maass, Norbert Arnold, Jörg Weimer, Tobias Anzeneder, Peter A Fasching, Matthias Rübner, Benjamin Bruno, Uwe Heindrichs, Jennifer Freres, Hanna Schulz, Ralf-Dieter Hilgers, Nadina Ortiz-Brüchle, Sonja von Serenyi, Ruth Knüchel, Vera Kloten, Edgar Dahl,

[This corrects the article DOI: 10.18632/oncotarget.27303.]. ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(30):2958]

Cited: 1 time

View full text PDF listing >>



A Giant Mammary Hamartoma in a Young Breast Cancer Patient.

Anna-Lena Rumpf, Micaela Mathiak, Fritz K Schäfer, Almuth Caliebe, Andre Farrokh, Mohamed Elessawy, Dirk O Bauerschlag, Nicolai Maass, Marion van Mackelenbergh, Thorsten Heilmann,

<h4>Background</h4>Hamartomas of the breast are rare benign tumors. Pre- and also postoperative differentiation from other benign or even malignant tumors is challenging.<h4>Case presentation</h4>A 36-year-old female presented with a giant tumor of the left breast. The patient had suffered from an early breast cancer of the contralateral right breast the year ... Read more >>

Breast Care (Basel) (Breast care (Basel, Switzerland))
[2021, 16(1):85-88]

Cited: 0 times

View full text PDF listing >>



Bispecific antibodies enhance tumor-infiltrating T cell cytotoxicity against autologous HER-2-expressing high-grade ovarian tumors.

Hans-Heinrich Oberg, Lisa Janitschke, Vjola Sulaj, Jörg Weimer, Daniel Gonnermann, Nina Hedemann, Norbert Arnold, Dieter Kabelitz, Matthias Peipp, Dirk Bauerschlag, Daniela Wesch,

Epithelial ovarian cancer displays the highest mortality of all gynecological tumors. A relapse of the disease even after successful surgical treatment is a significant problem. Resistance against the current platinum-based chemotherapeutic standard regime requires a detailed ex vivo immune profiling of tumor-infiltrating cells and the development of new therapeutic strategies. ... Read more >>

J Leukoc Biol (Journal of leukocyte biology)
[2020, 107(6):1081-1095]

Cited: 10 times

View full text PDF listing >>



Olaparib plus Bevacizumab as First-Line Maintenance in Ovarian Cancer.

Isabelle Ray-Coquard, Patricia Pautier, Sandro Pignata, David Pérol, Antonio González-Martín, Regina Berger, Keiichi Fujiwara, Ignace Vergote, Nicoletta Colombo, Johanna Mäenpää, Frédéric Selle, Jalid Sehouli, Domenica Lorusso, Eva M Guerra Alía, Alexander Reinthaller, Shoji Nagao, Claudia Lefeuvre-Plesse, Ulrich Canzler, Giovanni Scambia, Alain Lortholary, Frederik Marmé, Pierre Combe, Nikolaus de Gregorio, Manuel Rodrigues, Paul Buderath, Coraline Dubot, Alexander Burges, Benoît You, Eric Pujade-Lauraine, Philipp Harter, ,

<h4>Background</h4>Olaparib has shown significant clinical benefit as maintenance therapy in women with newly diagnosed advanced ovarian cancer with a <i>BRCA</i> mutation. The effect of combining maintenance olaparib and bevacizumab in patients regardless of <i>BRCA</i> mutation status is unknown.<h4>Methods</h4>We conducted a randomized, double-blind, international phase 3 trial. Eligible patients had newly ... Read more >>

N Engl J Med (The New England journal of medicine)
[2019, 381(25):2416-2428]

Cited: 185 times

View full text PDF listing >>



SNiPER: a novel hypermethylation biomarker panel for liquid biopsy based early breast cancer detection.

Jolein Mijnes, Janina Tiedemann, Julian Eschenbruch, Janina Gasthaus, Sarah Bringezu, Dirk Bauerschlag, Nicolai Maass, Norbert Arnold, Jörg Weimer, Tobias Anzeneder, Peter A Fasching, Matthias Rübner, Benjamin Bruno, Uwe Heindrichs, Jennifer Freres, Hanna Schulz, Ralf-Dieter Hilgers, Nadina Ortiz-Brüchle, Sonja von Serenyi, Ruth Knüchel, Vera Kloten, Edgar Dahl,

<h4>Introduction</h4>Mammography is the gold standard for early breast cancer detection, but shows important limitations. Blood-based approaches on basis of cell-free DNA (cfDNA) provide minimally invasive screening tools to characterize epigenetic alterations of tumor suppressor genes and could serve as a liquid biopsy, complementing mammography.<h4>Methods</h4>Potential biomarkers were identified from The Cancer ... Read more >>

Oncotarget (Oncotarget)
[2019, 10(60):6494-6508]

Cited: 2 times

View full text PDF listing >>



ACT-FASTER, a Prospective Cohort Study Exploring Treatment Patterns with Fulvestrant and Exemestane in Postmenopausal Patients with Advanced Hormone Receptor-Positive Breast Cancer under Real-Life Conditions in Germany.

Nicolai Maass, Helmut Ostermann, Kurt Possinger, Peter Klein, Hans Tesch, Lars Mühlenhoff, Dirk Bauerschlag,

Background:Endocrine therapy is recommended for the treatment of postmenopausal women with hormone receptor-positive (HR+) advanced breast cancer (ABC). Methods:ACT-FASTER was a German prospective non-interventional cohort study in postmenopausal women with HR+ ABC receiving fulvestrant 500 mg as first line (1 L), second line (2 L) or third line (3 L), ... Read more >>

Breast Care (Basel) (Breast care (Basel, Switzerland))
[2019, 14(6):401-408]

Cited: 0 times

View full text PDF listing >>



A randomized phase II study to determine the efficacy and tolerability of two doses of eribulin plus lapatinib in trastuzumab-pretreated patients with HER-2-positive metastatic breast cancer (E-VITA).

Joachim Bischoff, Jana Barinoff, Christoph Mundhenke, Dirk O Bauerschlag, Serban-Dan Costa, Daniel Herr, Kristina Lübbe, Frederik Marmé, Nicolai Maass, Gunter von Minckwitz, Eva-Maria Grischke, Volkmar Müller, Marcus Schmidt, Bernd Gerber, Sherko Kümmel, Claudia Schumacher, Petra Krabisch, Sabine Seiler, Marc Thill, Valentina Nekljudova, Sibylle Loibl,

The E-VITA study evaluated the efficacy and tolerability of two schedules of eribulin and lapatinib in patients with trastuzumab-pretreated HER-2-positive metastatic breast cancer. This multicenter, open-label phase II trial, randomly assigned patients with trastuzumab-pretreated HER-2-positive metastatic breast cancer to lapatinib 1000 mg daily with eribulin 1.23 mg/m (equivalent to 1.4 mg/m eribulin mesylate) ... Read more >>

Anticancer Drugs (Anti-cancer drugs)
[2019, 30(4):394-401]

Cited: 0 times

View full text PDF listing >>



RNA based individualized drug selection in breast cancer patients without patient-matched normal tissue.

Michael Forster, Adam Mark, Friederike Egberts, Elisa Rosati, Elke Rodriguez, Martin Stanulla, Dirk Bauerschlag, Christian Schem, Nicolai Maass, Anu Amallraja, Karla K Murphy, Bruce R Prouse, Raed A Sulaiman, Brandon M Young, Micaela Mathiak, Georg Hemmrich-Stanisak, David Ellinghaus, Stephan Weidinger, Philip Rosenstiel, Norbert Arnold, Brian Leyland-Jones, Casey B Williams, Andre Franke, Tobias Meißner,

<h4>Background</h4>While standard RNA expression tests stratify patients into risk groups, RNA-Seq can guide personalized drug selection based on expressed mutations, fusion genes, and differential expression (DE) between tumor and normal tissue. However, patient-matched normal tissue may be unavailable. Additionally, biological variability in normal tissue and technological biases may confound results. ... Read more >>

Oncotarget (Oncotarget)
[2018, 9(64):32362-32372]

Cited: 1 time

View full text PDF listing >>



Evaluation of the effects of sensorimotor exercise on physical and psychological parameters in breast cancer patients undergoing neurotoxic chemotherapy.

Paul Lennart Vollmers, Christoph Mundhenke, Nicolai Maass, Dirk Bauerschlag, Stefan Kratzenstein, Christoph Röcken, Thorsten Schmidt,

<h4>Introduction</h4>Breast cancer is the most common cancer disease of women in industrialized countries. Neurotoxic chemotherapy drugs are known to harm peripheral nerves and cause a chemotherapy-induced peripheral neuropathy (CIPN). CIPN is one of the most common adverse events associated with Paclitaxel chemotherapy and may remain present long after the termination ... Read more >>

J Cancer Res Clin Oncol (Journal of cancer research and clinical oncology)
[2018, 144(9):1785-1792]

Cited: 17 times

View full text PDF listing >>



Advertisement


Disclaimer

1.2446 s