Full Text Journal Articles by
Author Dingkang Xu

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Intracranial Metastases Originating From Pediatric Primary Spinal Cord Glioblastoma Multiforme: A Case Report and Literature Review.

Dengpan Song, Dingkang Xu, Qiang Gao, Peizhu Hu, Fuyou Guo,

Primary spinal cord glioblastoma multiforme (scGBM) is an uncommon entity in pediatrics, and intracranial metastasis originating in spinal cord gliomas is very rare. A 7-year-old female presented with weakness in the limbs, paralysis of the lower limbs and incontinence. The initial MRI of the spinal cord revealed expansion and abnormal ... Read more >>

Front Oncol (Frontiers in Oncology)
[2020, 10:99]

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A novel neuroimaging assessment of predictive risk factors associated with intraoperative massive hemorrhage in intracranial solid hemangioblastoma.

Qiang Gao, Lan Zhang, Guoqing Wang, Dingkang Xu, Mengzhao Feng, Fang Wang, Qingjie Wei, Xianzhi Liu, Fuyou Guo,

Background:A solid hemangioblastoma (SH) is a benign and highly vascularized tumor. Microsurgical treatment of SH is still challenging due to excessive intraoperative bleeding. Methods:Sixty-six consecutive patients with SH were retrospectively analyzed. The volume of intraoperative blood loss (IBL) and the features detected by magnetic resonance imaging (MRI) were evaluated by ... Read more >>

Quant Imaging Med Surg (Quantitative imaging in medicine and surgery)
[2019, 9(11):1781-1791]

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Clinicopathological Features and Microsurgical Management of Lesions Located in the Cavernous Sinus: Analysis of 66 Cases.

Mengzhao Feng, Dingkang Xu, Guoqing Wang, Fang Wang, Fuyou Guo,

AIM:To investigate the clinicopathological features and related factors affecting microsurgical resection of lesions in the cavernous sinus. MATERIAL AND METHODS:Clinical data of 66 patients undergoing microsurgery for lesions located in the cavernous sinus from January 2011 to December 2017 were retrospectively reviewed. RESULTS:Histopathological examination revealed benign lesions in 60 (90.9%) ... Read more >>

Turk Neurosurg (Turkish neurosurgery)
[2020, 30(2):171-177]

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Chemokine CCL2 contributes to BBB disruption via the p38 MAPK signaling pathway following acute intracerebral hemorrhage.

Fuyou Guo, Dingkang Xu, Yazhou Lin, Guoqing Wang, Fang Wang, Qiang Gao, Qingjie Wei, Shixiong Lei,

Intracerebral hemorrhage (ICH) remains a devastating type of stroke that lacks an effective treatment. Recent evidence has demonstrated that CCL2 is involved in the blood-brain barrier (BBB) disruption and propagermanium (PG) as a CCL2 receptor inhibitor is neuroprotective in ischemic stroke. However, whether PG therapy exert effective role in acute ... Read more >>

FASEB J. (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2020, 34(1):1872-1884]

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Risk factors associated with postoperative recurrence in atypical intracranial meningioma: analysis of 263 cases at a single neurosurgical centre.

Fang Wang, Dingkang Xu, Yumeilan Liu, Yazhou Lin, Qingjie Wei, Qiang Gao, Shixiong Lei, Fuyou Guo,

OBJECTIVE:Atypical meningioma (AM) has a high rate of local recurrence after surgery, and the role of adjuvant radiotherapy in AM remains controversial. We analysed progression-free survival (PFS) and identified the factors associated with postoperative recurrence in AM patients. METHODS:Data were obtained from 263 AM patients who underwent surgery at our ... Read more >>

Acta Neurochir (Wien) (Acta neurochirurgica)
[2019, 161(12):2563-2570]

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Minocycline Preserves the Integrity and Permeability of BBB by Altering the Activity of DKK1-Wnt Signaling in ICH Model.

Guoqing Wang, Zhihua Li, Shujian Li, Junling Ren, Vigneyshwar Suresh, Dingkang Xu, Weidong Zang, Xianzhi Liu, Wei Li, Huizhi Wang, Fuyou Guo,

Disruption of the blood-brain barrier (BBB) and subsequent neurological deficits are the most severe consequence of intracerebral hemorrhage (ICH). Minocycline has been wildly used clinically as a neurological protective agent in clinical practice. However, the underlying mechanisms by which minocycline functions remain unclear. Therefore, we assessed the influence of minocycline ... Read more >>

Neuroscience (Neuroscience)
[2019, 415:135-146]

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Clinical analysis of syringomyelia resulting from spinal hemangioblastoma in a single series of 38 consecutive patients.

Dingkang Xu, Mengzhao Feng, Vigneyshwar Suresh, Guoqing Wang, Fang Wang, Laijun Song, Fuyou Guo,

OBJECTIVE:Syringomyelia was predominantly caused by Chiari malformation or intramedullary ependymoma. The goal of this study was to identify factors related to clinical outcomes and spinal hemangioblastoma (SH)-induced syringomyelia formation in a single series of patients. PATIENT AND METHODS:Thirty-eight patients with SH were treated with microsurgery from January 2013 to December ... Read more >>

Clin Neurol Neurosurg (Clinical neurology and neurosurgery)
[2019, 181:58-63]

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Multiple Distinctive Demyelinating Lesions Caused by Eosinophilic Granulomatosis With Polyangiitis: Case Report and Literature Review.

Dingkang Xu, Hongen Xu, Fang Wang, Guoqing Wang, Qingjie Wei, Shixiong Lei, Qiang Gao, Qi Zhang, Fuyou Guo,

Eosinophilic granulomatosis with polyangiitis (EGPA) is an extremely rare rheumatic immune disease characterized by vasculitis of small- and medium-sized blood vessels. Central nervous system (CNS) involvement frequently consists of cerebrovascular disease; a manifestation with multiple demyelinating lesions has never been reported in detail. This report describes a 38-year-old man, who ... Read more >>

Front Neurol (Frontiers in neurology)
[2019, 10:213]

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Identification of Novel Genes Involved in the Pathogenesis of an ACTH-Secreting Pituitary Carcinoma: A Case Report and Literature Review.

Fuyou Guo, Guoqing Wang, Fang Wang, DingKang Xu, Xianzhi Liu,

Pituitary carcinomas (PCs) is considerable uncommon entities with a poor prognosis that represents only 0. 1-0.2% of all pituitary tumors. There are fewer than 150 reported cases up to now. In addition, the molecular pathogenesis leading to malignant pituitary transformation remain unclear due to the rarity of PCs. Here we ... Read more >>

Front Oncol (Frontiers in oncology)
[2018, 8:510]

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Unusual presentation of epilepsy of germinoma located in the frontal-lobe: case report and literature review.

Fang Wang, Guoqing Wang, Mengzhao Feng, Dingkang Xu, Fuyou Guo,

Germinoma is rare in peripheral lobar locations in the brain, with only 10 cases of primary frontal lobe germinoma having been reported in the previous literature. Epilepsy is a rare manifestation of germinomas. We describe an unusual case of a primary frontal germinoma in a 21-year-old man who presented with ... Read more >>

Br J Neurosurg (British journal of neurosurgery)
[2018, :1-3]

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Clinical study on microsurgical treatment for craniopharyngioma in a single consecutive institutional series of 335 patients.

Fuyou Guo, Guoqing Wang, Vigneyshwar Suresh, Dingkang Xu, Xiaoyang Zhang, Mengzhao Feng, Fang Wang, Xianzhi Liu, Laijun Song,

OBJECTIVES:The optimal management of craniopharyngioma is still controversial. The aim of this study is to explore microsurgical outcomes of craniopharyngioma in 335 cases. PATIENTS AND METHODS:Clinical data of 335 consecutive patients with craniopharyngioma between March 2011 and March 2017 were retrospectively analyzed. RESULTS:Gross total resection (GTR) was achieved in 265 ... Read more >>

Clin Neurol Neurosurg (Clinical neurology and neurosurgery)
[2018, 167:162-172]

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