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Author Dinesh Kumar Yadav

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Prevalence and Outcome of Sepsis-induced Myocardial Dysfunction in Children with 'Sepsis' 'With' and 'Without Shock'-A Prospective Observational Study.

Aditi Jain, Jhuma Sankar, Anubhuti Anubhuti, Dinesh Kumar Yadav, M Jeeva Sankar,

Objective:To estimate the prevalence and effects of sepsis-induced myocardial dysfunction (SIMD) in children with septic shock. Methodology:Enrolled children with septic shock (n = 31) and sepsis (n = 30) underwent echocardiography and cardiac troponin-I (cTnI) estimation within first 3 h. SIMD was defined as presence of systolic/diastolic dysfunction by echocardiography. Results:The prevalence of SIMD was ... Read more >>

J. Trop. Pediatr. (Journal of tropical pediatrics)
[2018, 64(6):501-509]

Cited: 2 times

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Total anomalous pulmonary venous connection masking an aortopulmonary window: A rare combination of defects.

Shyamajit Samaddar, Dheeraj Bhatt, Munish Guleria, Dinesh Kumar Yadav, Anubhav Gupta,

The association of aortopulmonary (AP) window with total anomalous pulmonary venous connection (TAPVC) has so far not been reported. We report a unique case of an 8-month-old child who presented with congestive cardiac failure and severe pulmonary arterial hypertension. Initial echocardiography revealed supracardiac TAPVC. Cardiac computed tomography showed the presence ... Read more >>

Ann Pediatr Cardiol (Annals of pediatric cardiology)
[2018, 11(3):322-324]

Cited: 0 times

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Heparin free dialysis in critically sick children using sustained low efficiency dialysis (SLEDD-f): A new hybrid therapy for dialysis in developing world.

Sidharth Kumar Sethi, Shyam B Bansal, Anshika Khare, Maninder Dhaliwal, Veena Raghunathan, Nikita Wadhwani, Ashish Nandwani, Dinesh Kumar Yadav, Amit Kumar Mahapatra, Rupesh Raina,

In critically sick adults, sustained low efficiency dialysis [SLED] appears to be better tolerated hemodynamically and outcomes seem to be comparable to CRRT. However, there is paucity of data in critically sick children. In children, two recent studies from Taiwan (n = 11) and India (n = 68) showed benefits ... Read more >>

PLoS ONE (PloS one)
[2018, 13(4):e0195536]

Cited: 0 times

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Tectona grandis (teak) - A review on its phytochemical and therapeutic potential.

Pooja Vyas, Dinesh Kumar Yadav, Poonam Khandelwal,

Tectona grandis Linn (Teak), is locally known as Sagwan, belongs to Lamiaceae family. It is one of the most valuable timber in the world, due to its beautiful surface and its resistance to termite and fungal damage. The main active ingredient compounds that are responsible for these action are tectoquinone, ... Read more >>

Nat. Prod. Res. (Natural product research)
[2019, 33(16):2338-2354]

Cited: 2 times

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Pediatric ABO-incompatible kidney transplantation: Evolving with the advancing apheresis technology: A single-center experience.

Sidharth Kumar Sethi, Shyam Bihari Bansal, Nikita Wadhwani, Aseem Tiwari, Dinesh Arora, Reetesh Sharma, Ashish Nandwani, Dinesh Kumar Yadav, Amit Kumar Mahapatra, Manish Jain, Pranaw Jha, Prasun Ghosh, Anil Bhan, Maninder Dhaliwal, Veena Raghunathan, Vijay Kher,

Recent literature has endorsed favorable outcomes following ABOi kidney transplantation in pediatric population. Nevertheless, reluctance to pursue an ABOi still remains pervasive. This could be ascribed to various legitimate reasons, namely less extensive pediatric ABOi data, technical difficulties encountered during PP, cost restraints, and concerns regarding higher rates of antibody-mediated ... Read more >>

Pediatr Transplant (Pediatric transplantation)
[2018, 22(3):e13138]

Cited: 0 times

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Staphylococcal endocarditis after chicken pox in a child with structurally normal heart.

Dheeraj Deo Bhatt, Nihit Kharkwal, Dinesh Kumar Yadav,

Ann Pediatr Cardiol (Annals of pediatric cardiology)
[2017, 10(3):312-313]

Cited: 0 times

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Classification and conservation priority of five Deccani sheep ecotypes of Maharashtra, India.

Dinesh Kumar Yadav, Reena Arora, Anand Jain,

Characterization of Indian livestock breeds has mostly been limited to single breed/population focused on either physical description of traditionally recognized breeds/populations or to their genetic description. Usually, morphological and genetic characterization has taken place in isolation. A parallel morphological characterization of genetically identified breeds or genetic characterization of morphologically described ... Read more >>

PLoS ONE (PloS one)
[2017, 12(9):e0184691]

Cited: 0 times

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Severe Hypertriglyceridemia Causing Pancreatitis in a Child with New-onset Type-I Diabetes Mellitus Presenting with Diabetic Ketoacidosis.

Pradeep Kumar Sharma, Maneesh Kumar, Dinesh Kumar Yadav,

The triad of pancreatitis, hypertriglyceridemia, and diabetic ketoacidosis and its treatment has not been extensively discussed in the pediatric literature. We report a 4-year-old child with severe hypertriglyceridemia, pancreatitis, and diabetic ketoacidosis. Hypertriglyceridemia and pancreatitis with diabetic ketoacidosis can be successfully managed with insulin and hydration therapy in children. Early ... Read more >>

Indian J Crit Care Med (Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine)
[2017, 21(3):176-178]

Cited: 4 times

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Inferior vena cava thrombosis in a case of amoebic liver abscess: is hypercomplementemia responsible for this rare entity?

Sudha Chandelia, Sarika Jain, Dinesh Kumar Yadav, Nand Kishore Dubey,

Among the liver abscesses, thrombosis of the inferior vena cava (IVC) has been reported mainly in amoebic liver abscess (ALA) caused by Entamoeba histolytica (E.H). It is an unusual complication especially in paediatric age group. Association of hypercomplementemia and IVC thrombosis has not been discussed previously. Published data suggest that ... Read more >>

Indian J Pathol Microbiol (Indian journal of pathology & microbiology)
[2014, 57(2):329-331]

Cited: 0 times

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Pericardial effusion in children: experience from tertiary care center in northern India.

Narendra Kumar Bagri, Dinesh Kumar Yadav, Sheetal Agarwal, Tenukala Aier, Vijay Gupta,

OBJECTIVE:To describe profile and outcome in children with significant pericardial effusion. METHODS:Hospital records of 25 children admitted with significant pericardial effusion during January 2010 to March 2013 were analyzed. RESULTS:Thirteen (52%) children had tubercular, 6 (24%) had bacterial, 3 viral, 2 recurrent idiopathic and one had malignant pericardial effusion. Only ... Read more >>

Indian Pediatr (Indian pediatrics)
[2014, 51(3):211-213]

Cited: 5 times

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Comparison of oral ibuprofen with oral indomethacin for PDA closure in Indian preterm neonates: a randomized controlled trial.

Sanju Yadav, Sheetal Agarwal, Arti Maria, Ajay Dudeja, N K Dubey, Puneet Anand, Dinesh Kumar Yadav,

Oral ibuprofen is being used as an alternative to indomethacin in medical management of patent ductus arteriosus (PDA), but limited data exist on oral efficacy of these drugs for PDA closure in India. To assess and compare the efficacy of oral ibuprofen and oral indomethacin for PDA closure in preterm ... Read more >>

Pediatr Cardiol (Pediatric cardiology)
[2014, 35(5):824-830]

Cited: 11 times

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Failure of secondary prophylaxis with erythromycin in rheumatic heart disease.

Dinesh Kumar Yadav, Puneet Anand, Eden Bhutia,

BACKGROUND:Erythromycin is recommended for secondary prophylaxis in children with rheumatic heart disease, who are allergic to penicillin. CASE CHARACTERISTICS:A 9-year-old girl, with rheumatic heart disease, on secondary prophylaxis with erythromycin 250 mg BD, presented with acute rheumatic fever. OUTCOME:Responded to steroids and started on a higher dose (250 mg TDS) ... Read more >>

Indian Pediatr (Indian pediatrics)
[2013, 50(11):1058-1059]

Cited: 0 times

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The Tei index and asymptomatic myocarditis in children with severe dengue.

Dinesh Kumar Yadav, Sandeep Choudhary, Pankaj Kumar Gupta, Mukesh Kumar Beniwal, Sheetal Agarwal, Umesh Shukla, N K Dubey, Jhuma Sankar, Pradeep Kumar,

This study aimed to assess myocardial involvement in infants and children with severe dengue (as per the new World Health Organization [WHO] classification 2009) using the Tei index. This prospective observational study was conducted in the Department of Pediatrics, PGIMER and the associated Dr. RML Hospital, New Delhi from August ... Read more >>

Pediatr Cardiol (Pediatric cardiology)
[2013, 34(6):1307-1313]

Cited: 6 times

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Classification of four ovine breeds of southern peninsular zone of India: Morphometric study using classical discriminant function analysis.

Dinesh Kumar Yadav, Anand Jain, Viswanath Sheshagirirao Kulkarni, Mandera Giriyappa Govindaiah, Thimmappa Aswathnarayan, Devinder Kumar Sadana,

Six morphometric traits (height at withers, body length, chest girth, ear length, tail length and body weight) were analyzed to characterize from a breed point of view 1981 sheep from four ovine breeds (Bellary, Kenguri, Hassan and Mandya) of southern peninsular zone of India. Discriminant Function Analysis was used to ... Read more >>

Springerplus (SpringerPlus)
[2013, 2(1):29]

Cited: 3 times

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Bardet-Biedl syndrome a rare cause of cardiomyopathy.

Dinesh Kumar Yadav, Mukesh Kumar Beniwal, Aditi Jain,

Bardet Biedl syndrome (BBS) is a rare autosomal recessive condition characterized by retinitis pigmentosa, polydactyly, obesity, learning disabilities, hypogonadism and renal anomalies. Cardiomyopathy in association with BBS has previously being reported only twice in literature. We report a case of a patient presenting with features of cardiomyopathy, who was subsequently ... Read more >>

Indian Pediatr (Indian pediatrics)
[2013, 50(6):599-601]

Cited: 2 times

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Two Indian families with Greig cephalopolysyndactyly with non-syndromic phenotype.

Sidharth Kumar Sethi, Deepak Goyal, Sumaira Khalil, Dinesh Kumar Yadav,

The Greig cephalopolysyndactyly syndrome (GCPS) is a rare, autosomal dominant, pleiotropic, multiple congenital anomaly syndrome. The typical findings include hypertelorism, macrocephaly with frontal bossing, and polysyndactyly. We present two families, with GCPS with a non-syndromic phenotype, without the characteristic craniofacial anomalies and with the presence of complex digital anomalies including ... Read more >>

Eur. J. Pediatr. (European Journal of Pediatrics)
[2013, 172(8):1131-1135]

Cited: 3 times

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Formononetin reverses established osteopenia in adult ovariectomized rats.

Abdul Malik Tyagi, Kamini Srivastava, Anuj Kumar Singh, Avinash Kumar, Bendangla Changkija, Rashmi Pandey, Shibani Lahiri, Geet K Nagar, Dinesh Kumar Yadav, Rakesh Maurya, Ritu Trivedi, Divya Singh,

OBJECTIVE: Formononetin (Formo) prevents ovariectomy (Ovx)-induced bone loss in rats. However, there are no reports on the curative effects of Formo. The objective of this study was to investigate the ability of Formo in restoring trabecular microarchitecture and promoting new bone formation in osteopenic rats. METHODS: Adult Sprague-Dawley rats were ... Read more >>

Menopause (Menopause (New York, N.Y.))
[2012, 19(8):856-863]

Cited: 11 times

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Ruptured sinus of Valsalva masquerading as rheumatic heart disease.

Mukesh Kumar Beniwal, Dinesh Kumar Yadav, Pankaj Kumar Gupta,

Ruptured sinus of Valsalva is a rare lesion in pediatric age group. We are reporting a twelve year old child with hyperdynamic circulation being diagnosed and treated as Rheumatic heart disease. ... Read more >>

Indian Pediatr (Indian pediatrics)
[2012, 49(10):829-830]

Cited: 0 times

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Rice heterotrimeric G-protein gamma subunits (RGG1 and RGG2) are differentially regulated under abiotic stress.

Dinesh Kumar Yadav, S M Shahinul Islam, Narendra Tuteja,

Heterotrimeric G-proteins (α, β and γ subunits) are primarily involved in diverse signaling processes by transducing signals from an activated transmembrane G-protein coupled receptor (GPCR) to appropriate downstream effectors within cells. The role of α and β G-protein subunits in salinity and heat stress has been reported but the regulation ... Read more >>

Plant Signal Behav (Plant signaling & behavior)
[2012, 7(7):733-740]

Cited: 17 times

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N-Methyl-6, 7-dimethoxyisoquinolone in Annona squamosa twigs is the major immune modifier to elicit polarized Th1 immune response in BALB/c mice.

Vishal Kumar Soni, Dinesh Kumar Yadav, Nasreen Bano, Preety Dixit, Manisha Pathak, Rakesh Maurya, Mahendra Sahai, Swatantra Kumar Jain, Shailja Misra-Bhattacharya,

Annona squamosa (AS) has traditionally been used as ethnomedicine. We have earlier extracted and fractionated the twigs of AS based upon its bioactivity and observed its immune potentiating activity that was localized in its three fractions. Present communication deals with the phytochemical analysis and pharmacological investigation of the most active ... Read more >>

Fitoterapia (Fitoterapia)
[2012, 83(1):110-116]

Cited: 2 times

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Rice G-protein coupled receptor (GPCR): in silico analysis and transcription regulation under abiotic stress.

Dinesh Kumar Yadav, Narendra Tuteja,

Majority of transmembrane signal transduction in response to diverse external stimuli is mediated by G-protein coupled receptors (GPCRs) and are the principal signal transducers. GPCRs are characterized by seven membrane-spanning domains with an extracellular N-terminus and a cytoplasmic C-terminus which functions along with GTP-binding protein in a highly coordinated fashion. ... Read more >>

Plant Signal Behav (Plant signaling & behavior)
[2011, 6(8):1079-1086]

Cited: 7 times

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Predictors of acute kidney injury post-cardiopulmonary bypass in children.

Sidharth Kumar Sethi, Deepak Goyal, Dinesh Kumar Yadav, Umesh Shukla, Pyare Lal Kajala, V K Gupta, Vijay Grover, Pragati Kapoor, Atul Juneja,

To investigate the incidence, implicating factors and outcome of acute kidney injury (AKI) after cardiopulmonary bypass (CPB) in patients admitted to a pediatric cardiothoracic intensive care unit (ICU).A retrospective review study.A 10-bed cardiothoracic ICU.One hundred and twenty-four children (<18 years of age) admitted to the cardiothoracic ICU following CPB between ... Read more >>

Clin. Exp. Nephrol. (Clinical and experimental nephrology)
[2011, 15(4):529-534]

Cited: 30 times

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Reverse phase-HPLC method for determination of marker compounds in NP-1, an anti-osteoporotic plant product from Butea monosperma.

Varsha Gupta, Anil Kumar Dwivedi, Dinesh Kumar Yadav, Manmeet Kumar, Rakesh Maurya,

An isocratic, reversed phase, high-performance liquid chromatographic (HPLC) method was developed for the determination of the marker compounds K052 (iso-formononetin), K054 (methoxy derivative) and K080 (formononetin) in NP-1, an anti-osteoporotic plant product from Butea monosperma. The separation was achieved on a C18 column with a mobile phase consisted of a ... Read more >>

Nat Prod Commun (Natural product communications)
[2010, 5(1):47-50]

Cited: 1 time

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Methoxylated isoflavones, cajanin and isoformononetin, have non-estrogenic bone forming effect via differential mitogen activated protein kinase (MAPK) signaling.

Biju Bhargavan, Abnish Kumar Gautam, Divya Singh, Amit Kumar, Sumit Chaurasia, Abdul Malik Tyagi, Dinesh Kumar Yadav, Jay Sharan Mishra, Amar Bahadur Singh, Sabyasachi Sanyal, Atul Goel, Rakesh Maurya, Naibedya Chattopadhyay,

Following a lead obtained from stem-bark extract of Butea monosperma, two structurally related methoxyisoflavones; cajanin and isoformononetin were studied for their effects in osteoblasts. Cajanin had strong mitogenic as well as differentiation-promoting effects on osteoblasts that involved subsequent activation of MEK-Erk and Akt pathways. On the other hand, isoformononetin exhibited ... Read more >>

J. Cell. Biochem. (Journal of cellular biochemistry)
[2009, 108(2):388-399]

Cited: 39 times

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Constituents of Ocimum sanctum with antistress activity.

Prasoon Gupta, Dinesh Kumar Yadav, Kiran Babu Siripurapu, Guatam Palit, Rakesh Maurya,

Three new compounds, ocimumosides A (1) and B (2) and ocimarin (3), were isolated from an extract of the leaves of holy basil (Ocimum sanctum), together with eight known substances, apigenin, apigenin-7-O-beta-D-glucopyranoside, apigenin-7-O-beta-D-glucuronic acid ( 4), apigenin-7- O-beta- d-glucuronic acid 6''-methyl ester, luteolin-7-O-beta-D-glucuronic acid 6''-methyl ester, luteolin-7-O-beta-D-glucopyranoside, luteolin-5-O-beta-D-glucopyranoside, and 4-allyl-1-O-beta-D-glucopyronosyl-2-hydroxybenzene ... Read more >>

J. Nat. Prod. (Journal of natural products)
[2007, 70(9):1410-1416]

Cited: 16 times

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