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Evidence of integrated primary-secondary health care in low-and middle-income countries: protocol for a scoping review.

Md Zabir Hasan, Shalini Singh, Dinesh Arora, Nishant Jain, Shivam Gupta,

<h4>Background</h4>Integrated care is a people-centered health delivery approach that ensures the comprehensiveness, quality, and continuity of service across the settings and levels of health systems. The World Health Organization (WHO) recommends integration across levels and building-blocks of health systems as a prerequisite of Universal Health Coverage (UHC). While health systems ... Read more >>

Syst Rev (Systematic reviews)
[2020, 9(1):260]

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Evidence of integrated primary-secondary health care in low-and middle-income countries: protocol for a scoping review

Md Zabir Hasan, Shalini Singh, Dinesh Arora, Nishant Jain, Shivam Gupta,

<h4>Background: </h4> Integrated care is a people-centered health delivery approach that ensures the comprehensiveness, quality, and continuity of service across the settings and levels of health systems. The World Health Organization (WHO) recommends integration across levels and building-blocks of health systems as a prerequisite of Universal Health Coverage (UHC). While ... Read more >>

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An algorithmic approach to serological work-up of ABO sub-groups which present as ABO discrepancies in resource constraint settings.

Aseem K Tiwari, Divya Setya, Dinesh Arora, Swati Pabbi Mehta, Geet Aggarwal, Subhasis Mitra,

<h4>Background</h4>ABO subgroups or weaker variants of A or B are group A or B subjects whose erythrocytes give a weak or negative reaction serologically with anti-A or Anti - B antisera respectively. Occurrence of these subgroups may lead to an ABO discrepancy which often puts transfusion services in a quandary. ... Read more >>

J Immunol Methods (Journal of immunological methods)
[2020, 487:112895]

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Evidence of integrated health service delivery during COVID-19 in low- and middle-income countries: protocol for a scoping review

Rachel Neill, Md Zabir Hasan, Priyanka Das, Vasuki Venugopal, Nishant Jain, Dinesh Arora, Shivam Gupta,

<h4>Introduction</h4> The importance of integrated, people-centered health systems has been recognized as a central component of achieving Universal Health Coverage. Integration has also been highlighted as a critical element for building resilient health systems that can stand the shock of health emergencies. However, there is dearth of research and systematic ... Read more >>

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The frequent and the unusual red cell phenotypes in Indian blood donors: A quest for rare donors.

Divya Setya, Aseem Kumar Tiwari, Dinesh Arora, Subhasis Mitra, Swati Pabbi Mehta, Geet Aggarwal,

A clinically significant red cell alloantibody is capable of accelerated destruction of red cells bearing the corresponding antigen. Knowledge of prevalence of these antigens is necessary for performing day to day work and for research in immunohematology. The primary aim of this study was to find the prevalence of 18 ... Read more >>

Transfus Apher Sci (Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis)
[2020, 59(4):102765]

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Utility of grey zone testing strategy in transfusion transmissible infection testing in blood bank is of limited value!

Gunjan Bhardwaj, Aseem K Tiwari, Dinesh Arora, Geet Aggarwal, Swati Pabbi, Divya Setya,

Several blood banks use grey zone (GZ) phenomenon (defined as samples with optical density within 10% below the cut off in enzyme immuno-assay [EIA]/chemiluminescence immunoassay [CLIA]) to further augment blood safety. There is paucity of data regarding usefulness of GZ sample and its application in Transfusion Transmissible Infection (TTI) screening ... Read more >>

Indian J Pathol Microbiol (Indian journal of pathology & microbiology)
[2020, 63(2):255-257]

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Applying Donath-Landsteiner test for the diagnosis of paroxysmal cold hemoglobinuria.

Aseem Kumar Tiwari, Geet Aggarwal, Subhasis Mitra, Dinesh Arora, Gunjan Bhardwaj, Ankita Ratan, Divya Setya,

61-year old male patient was admitted to the hospital with clinical picture of hemolytic anemia with hemoglobinuria. Patient was suspected to have Infectious Mononucleosis (IM) with Auto Immune Hemolytic Anemia (AIHA). DAT was positive with anti-C3d specificity. Donath Landsteiner (DL) test was positive; confirming Paroxysmal Cold Hemoglobinuria (PCH). The final ... Read more >>

Asian J Transfus Sci (Asian journal of transfusion science)
[2020, 14(1):57-59]

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Immunoadsorption in ABO-incompatible kidney transplantation in adult and pediatric patients with follow-up on graft and patient survival: First series from India.

Aseem Kumar Tiwari, Geet Aggarwal, Dinesh Arora, Gunjan Bhardwaj, Manish Jain, Shyam Bihari Bansal, Sidharth K Sethi,

<h4>Background</h4>There are no published reports on desensitization protocol for ABO-incompatible kidney transplants using Immuno-Adsorption (IA) plasmapheresis from India. IA offers certain advantages including processing of larger plasma volumes, quicker reduction of isoagglutinin titers and no requirement of replacement fluids.<h4>Aims and objectives</h4>Authors' center evaluated success of desensitization protocol, and graft/patient outcomes ... Read more >>

Asian J Transfus Sci (Asian journal of transfusion science)
[2020, 14(1):13-18]

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Red blood cell exchange in sickle cell disease patient with multiple alloantibodies.

Geet Aggarwal, Aseem Kumar Tiwari, Pratibha Dhiman, Dinesh Arora, Swati Mehta Pabbi, Divya Setya,

There are several reports in medical literature about Red Cell Exchange (RCE) being routinely performed pre-operatively in sickle cell disease patients to provide immediate decrease in HbS concentration and prevent post-operative complications. We would like to present one such case of SCD who also had multiple allo-antibodies and had to ... Read more >>

Asian J Transfus Sci (Asian journal of transfusion science)
[2020, 14(1):70-73]

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Discordance between Flow-Cytometry Crossmatch and Single Antigen Bead (SAB) Assay: An Uncommon Finding and its Resolution.

Simmi Mehra, Aseem Kumar Tiwari, Geet Aggarwal, Dinesh Arora, Abhishek Saini, Chhavi Rajvanshi, Poonam Kumari, Pranav Dorwal,

Indian J Nephrol (Indian journal of nephrology)
[2020, 30(1):55-57]

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Application of sequential serological testing strategy for detection of Hepatitis B surface antigen (HBsAg) for diagnosing HBV infection.

Aseem Kumar Tiwari, Swati Pabbi, Geet Aggarwal, Dinesh Arora, Gunjan Bhardwaj, Divya Setya, Jyoti Sharma,

The diagnostic accuracy of any serological test for detection of HBsAg is not 100%. We hypothesized that the sequential testing strategy proven for anti-HIV laboratory diagnosis should also apply to other infectious disease markers like HBsAg. Therefore, we evaluated the diagnostic accuracy of these strategies, I (single test), II (two ... Read more >>

J Virol Methods (Journal of virological methods)
[2019, 274:113726]

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Comparison of a column agglutination technology-based automated immunohematology analyzer and a semiautomated system in pretransfusion testing.

Ravi C Dara, Aseem Kumar Tiwari, Subhasis Mitra, Deviprasad Acharya, Geet Aggarwal, Dinesh Arora, Gunjan Bhardwaj,

INTRODUCTION:Semi-automated equipment using Column agglutination technology (CAT) is widely used where centrifugation and incubation are automated but substantial amount of the work is still executed manually. Larger laboratories are moving towards automation to eliminate errors, reducing exposure to bio-hazardous samples, assuring traceability, reliability, turnaround time (TAT) and throughput. Moving towards ... Read more >>

Asian J Transfus Sci (Asian journal of transfusion science)
[2019, 13(2):115-119]

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Successful treatment of Sezary syndrome with extracorporeal photopheresis - The first attempt in India.

Aseem K Tiwari, Dinesh Arora, Pratibha Dhiman, Sheilly Kapoor, Geet Aggarwal, Ravi C Dara, Ashok Vaid,

Sezary syndrome (SS) is more aggressive leukemic variant of cutaneous T-cell lymphoma in which a significant number of circulating malignant (Sezary) cells are observed in peripheral blood. Although single-agent or combination chemotherapy regimens have produced moderately high response rates in patients with advanced-stage SS, these responses are invariably not durable. ... Read more >>

Asian J Transfus Sci (Asian journal of transfusion science)
[2019, 13(1):66-69]

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Applying newer parameter Ret-He (reticulocyte haemoglobin equivalent) to assess latent iron deficiency (LID) in blood donors-study at a tertiary care hospital in India.

Aseem K Tiwari, Gunjan Bhardwaj, Dinesh Arora, Geet Aggarwal, Swati Pabbi, Ravi C Dara, Ritesh Sachdev, Arun Raizada, Monisha Sethi,

<h4>Background</h4>It is important to detect Latent Iron Deficiency (LID) to prevent development of an overt iron deficiency anemia. Early detection is difficult by using conventional hematological and biochemical parameters. Soluble transferrin receptor (sTfR) is presently the gold standard for diagnosing LID. We evaluated the utility of Reticulocyte Hemoglobin Equivalent (Ret-He), ... Read more >>

Vox Sang (Vox sanguinis)
[2018, 113(7):639-646]

Cited: 2 times

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Severe hypertriglyceridemia-induced pancreatitis successfully managed with therapeutic plasma exchange: Report from India.

Swati Pabbi Mehta, Aseem Kumar Tiwari, Rajesh Puri, Dinesh Arora, Geet Aggarwal, Ankita Ratan,

Hypertriglyceridemia (HTG) is the third most significant risk factor for acute pancreatitis after gallstones and alcohol. Therapeutic plasma exchange (TPE) has been considered a possible treatment for HTG-induced pancreatitis, especially in severe and refractory cases. Here, we report one such clinical experience with a patient of severe HTG-induced pancreatitis. He ... Read more >>

Asian J Transfus Sci (Asian journal of transfusion science)
[2018, 12(2):154-156]

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Notification and counselling of hepatitis positive blood donors, their immediate emotional response, contact-testing and their follow-up: Study from a tertiary care hospital!

Aseem K Tiwari, Gunjan Bhardwaj, Ravi C Dara, Dinesh Arora, Geet Aggarwal, Richa Bhargava, Kaushal Madan,

INTRODUCTION:Post-donation counselling informs donors of unusual test results. Timely notification and counselling regarding their Transfusion Transmitted Infection (TTI) status is necessary for early clinical intervention in the donor and reducing risk of transmission. We share our experience with respect to Hepatitis B (HBV) and Hepatitis C (HCV) positive donors who ... Read more >>

Transfus Apher Sci (Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis)
[2018, 57(3):391-397]

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Pediatric ABO-incompatible kidney transplantation: Evolving with the advancing apheresis technology: A single-center experience.

Sidharth Kumar Sethi, Shyam Bihari Bansal, Nikita Wadhwani, Aseem Tiwari, Dinesh Arora, Reetesh Sharma, Ashish Nandwani, Dinesh Kumar Yadav, Amit Kumar Mahapatra, Manish Jain, Pranaw Jha, Prasun Ghosh, Anil Bhan, Maninder Dhaliwal, Veena Raghunathan, Vijay Kher,

Recent literature has endorsed favorable outcomes following ABOi kidney transplantation in pediatric population. Nevertheless, reluctance to pursue an ABOi still remains pervasive. This could be ascribed to various legitimate reasons, namely less extensive pediatric ABOi data, technical difficulties encountered during PP, cost restraints, and concerns regarding higher rates of antibody-mediated ... Read more >>

Pediatr Transplant (Pediatric transplantation)
[2018, 22(3):e13138]

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Advantages of type and screen policy: Perspective from a developing country!

Geet Aggarwal, Aseem K Tiwari, Dinesh Arora, Ravi C Dara, Devi P Acharya, Gunjan Bhardwaj, Jyoti Sharma,

INTRODUCTION:The authors' center recently changed their pretransfusion testing protocol from "conventional" type and screen (TS) with anti-human globulin (AHG) crossmatch (Policy A) to TS with immediate-spin (IS) crossmatch (Policy B). Red blood cell (RBC) units were issued after compatible IS crossmatch as and when required instead of AHG crossmatch. This ... Read more >>

Asian J Transfus Sci (Asian journal of transfusion science)
[2018, 12(1):42-45]

Cited: 1 time

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Evaluation of new indigenous "point-of-care" ABO and Rh grouping device.

Aseem Kumar Tiwari, Divya Setya, Geet Aggarwal, Dinesh Arora, Ravi C Dara, Ankita Ratan, Gunjan Bhardwaj, Devi Prasad Acharya,

BACKGROUND:Erycard 2.0 is a "point-of-care" device that is primarily being used for patient blood grouping before transfusion. MATERIALS AND METHODS:Erycard 2.0 was compared with conventional slide technology for accuracy and time taken for ABO and Rh forward grouping result with column agglutination technology (CAT) being the gold standard. Erycard 2.0 ... Read more >>

J Lab Physicians (Journal of laboratory physicians)
[2018, 10(1):80-84]

Cited: 1 time

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Changing Trends in Therapeutic Plasmapheresis: An Indian Perspective.

Aseem K Tiwari, Gunjan Bhardwaj, Geet Aggarwal, Dinesh Arora, Ravi C Dara, Devi P Acharya, Sangeetha Gayam, Jui Choudhuri,

Indications for therapeutic apheresis (TA) are dynamic; they keep changing and expanding because of introduction of newer treatment modalities and accumulating evidence in the form of case-reports, case-series and original articles. We evaluated our therapeutic plasmapheresis (TP) data and compared this data with an earlier published Indian report for indications, ... Read more >>

Ther Apher Dial (Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy)
[2017, 21(5):500-506]

Cited: 2 times

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Co-infection of blood borne viruses in blood donors: A cross-sectional study from North India.

Ravi C Dara, Aseem K Tiwari, Dinesh Arora, Geet Aggarwal, Ganesh Singh Rawat, Jyoti Sharma, Devi Prasad Acharya, Gunjan Bhardwaj,

<h4>Background</h4>There are several studies on prevalence of individual infectious disease markers (mono-infection) in donors but none on prevalence of coinfection. Co-infection is significant as it leads to accelerated disease progression. We, therefore, evaluated the prevalence of co-infection among blood donors.<h4>Materials and methods</h4>The cross-sectional analysis was conducted in blood donors. All ... Read more >>

Transfus Apher Sci (Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis)
[2017, 56(3):367-370]

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Successful tandem transplant in a young aplastic anemia patient from a small-weight 11-month-old sibling donor.

Dinesh Arora, Aseem Kumar Tiwari, Ravi C Dara, Ruchira Misra, Geet Aggarwal, Devi Prasad Acharya, Vimarsh Raina,

Five years five month old male child diagnosed with aplastic anemia required blood and platelet support regularly. He was advised bone marrow transplant (BMT) and had 6/6 match with a younger sibling (11 months old). He was admitted for planned BMT and was put on preparatory regimen five days prior ... Read more >>

Transfus Apher Sci (Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis)
[2016, 54(1):144-146]

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First Indian study to establish safety of immediate-spin crossmatch for red blood cell transfusion in antibody screen-negative recipients.

Aseem Kumar Tiwari, Geet Aggarwal, Ravi C Dara, Dinesh Arora, Gautam Kumar Gupta, Vimarsh Raina,

<h4>Background and objectives</h4>The US Food and Drug Administration and American Association of Blood Banks approved the type and screen approach in 1980s, long after antibody screen (AS) was introduced in 1950s. The present study omits conventional anti-human globulin (AHG) crossmatch and replaces it with immediate-spin (IS) crossmatch as part of ... Read more >>

Asian J Transfus Sci (Asian journal of transfusion science)
[2017, 11(1):40-44]

Cited: 1 time

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Applications of selected cells in immunohematology in a developing country: case studies.

Ravi C Dara, Aseem K Tiwari, Dinesh Arora, Subhasis Mitra, Geet Aggarwal, Devi P Acharya, Gunjan Bhardwaj,

<h4>Conclusions</h4>When an antibody is detected, its specificity should be determined and its likely clinical significance should be assessed. When one antibody has been identified, it becomes necessary to confirm the presence of additional significant antibodies to ensure that compatible blood is provided to the patient. To perform this confirmation, specific ... Read more >>

Immunohematology (Immunohematology)
[2017, 33(1):27-35]

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Alloimmunization in autoimmune hemolytic anemia patient: The differential adsorption approach.

Ravi C Dara, Aseem Kumar Tiwari, Dinesh Arora, Subhasis Mitra, Devi Prasad Acharya, Geet Aggarwal, Jyoti Sharma,

Patients of β-thalassemia major are dependent on regular blood transfusions for their entire lifetime. Development of antibodies against red blood cell (RBC) antigen which may be alloantibody or autoantibody, several times as a result of frequent red cell component transfusions, further complicates the subsequent transfusion therapy. Among the autoantibodies, warm-reactive ... Read more >>

Asian J Transfus Sci (Asian journal of transfusion science)
[2017, 11(1):53-57]

Cited: 1 time

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