Full Text Journal Articles by
Author Dina P Matheos

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Microglial dyshomeostasis drives perineuronal net and synaptic loss in a CSF1R+/- mouse model of ALSP, which can be rescued via CSF1R inhibitors.

Miguel A Arreola, Neelakshi Soni, Joshua D Crapser, Lindsay A Hohsfield, Monica R P Elmore, Dina P Matheos, Marcelo A Wood, Vivek Swarup, Ali Mortazavi, Kim N Green,

Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia is an autosomal dominant neurodegenerative disease caused by mutations in colony-stimulating factor 1 receptor (CSF1R). We sought to identify the role of microglial CSF1R haploinsufficiency in mediating pathogenesis. Using an inducible <i>Cx3cr1</i> <sup>CreERT2/+</sup>-<i>Csf1r</i> <sup>+/fl</sup> system, we found that postdevelopmental, microglia-specific <i>Csf1r</i> haploinsufficiency ... Read more >>

Sci Adv (Science advances)
[2021, 7(35):]

Cited: 0 times

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Cocaine induces paradigm-specific changes to the transcriptome within the ventral tegmental area.

Rianne R Campbell, Siwei Chen, Joy H Beardwood, Alberto J López, Lilyana V Pham, Ashley M Keiser, Jessica E Childs, Dina P Matheos, Vivek Swarup, Pierre Baldi, Marcelo A Wood,

During the initial stages of drug use, cocaine-induced neuroadaptations within the ventral tegmental area (VTA) are critical for drug-associated cue learning and drug reinforcement processes. These neuroadaptations occur, in part, from alterations to the transcriptome. Although cocaine-induced transcriptional mechanisms within the VTA have been examined, various regimens and paradigms have ... Read more >>

Neuropsychopharmacology (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology)
[2021, 46(10):1768-1779]

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Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer's disease-like pathology.

David Baglietto-Vargas, Stefania Forner, Lena Cai, Alessandra C Martini, Laura Trujillo-Estrada, Vivek Swarup, Marie Minh Thu Nguyen, Kelly Do Huynh, Dominic I Javonillo, Kristine Minh Tran, Jimmy Phan, Shan Jiang, Enikö A Kramár, Cristina Nuñez-Diaz, Gabriela Balderrama-Gutierrez, Franklin Garcia, Jessica Childs, Carlos J Rodriguez-Ortiz, Juan Antonio Garcia-Leon, Masashi Kitazawa, Mohammad Shahnawaz, Dina P Matheos, Xinyi Ma, Celia Da Cunha, Ken C Walls, Rahasson R Ager, Claudio Soto, Antonia Gutierrez, Ines Moreno-Gonzalez, Ali Mortazavi, Andrea J Tenner, Grant R MacGregor, Marcelo Wood, Kim N Green, Frank M LaFerla,

The majority of Alzheimer's disease (AD) cases are late-onset and occur sporadically, however most mouse models of the disease harbor pathogenic mutations, rendering them better representations of familial autosomal-dominant forms of the disease. Here, we generated knock-in mice that express wildtype human Aβ under control of the mouse App locus. ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):2421]

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Aging mice show impaired memory updating in the novel OUL updating paradigm.

Janine L Kwapis, Yasaman Alaghband, Ashley A Keiser, Tri N Dong, Christina M Michael, Diane Rhee, Guanhua Shu, Richard T Dang, Dina P Matheos, Marcelo A Wood,

Memories do not persist in a permanent, static state but instead must be dynamically modified in response to new information. Although new memory formation is typically studied in a laboratory setting, most real-world associations are modifications to existing memories, particularly in the aging, experienced brain. To date, the field has ... Read more >>

Neuropsychopharmacology (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology)
[2020, 45(2):337-346]

Cited: 4 times

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PP4-dependent HDAC3 dephosphorylation discriminates between axonal regeneration and regenerative failure.

Arnau Hervera, Luming Zhou, Ilaria Palmisano, Eilidh McLachlan, Guiping Kong, Thomas H Hutson, Matt C Danzi, Vance P Lemmon, John L Bixby, Andreu Matamoros-Angles, Kirsi Forsberg, Francesco De Virgiliis, Dina P Matheos, Janine Kwapis, Marcelo A Wood, Radhika Puttagunta, José Antonio Del Río, Simone Di Giovanni,

The molecular mechanisms discriminating between regenerative failure and success remain elusive. While a regeneration-competent peripheral nerve injury mounts a regenerative gene expression response in bipolar dorsal root ganglia (DRG) sensory neurons, a regeneration-incompetent central spinal cord injury does not. This dichotomic response offers a unique opportunity to investigate the fundamental ... Read more >>

EMBO J (The EMBO journal)
[2019, 38(13):e101032]

Cited: 13 times

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HDAC3-Mediated Repression of the Nr4a Family Contributes to Age-Related Impairments in Long-Term Memory.

Janine L Kwapis, Yasaman Alaghband, Alberto J López, Jeffrey M Long, Xiang Li, Guanhua Shu, Kasuni K Bodinayake, Dina P Matheos, Peter R Rapp, Marcelo A Wood,

Aging is accompanied by cognitive deficits, including impairments in long-term memory formation. Understanding the molecular mechanisms that support preserved cognitive function in aged animals is a critical step toward identifying novel therapeutic targets that could improve memory in aging individuals. One potential mechanism is the <i>Nr4a</i> family of genes, a ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2019, 39(25):4999-5009]

Cited: 15 times

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Epigenetic regulation of immediate-early gene Nr4a2/Nurr1 in the medial habenula during reinstatement of cocaine-associated behavior.

Alberto J López, Thekla J Hemstedt, Yousheng Jia, Philip H Hwang, Rianne R Campbell, Janine L Kwapis, Andre O White, Om Chitnis, Vanessa M Scarfone, Dina P Matheos, Gary Lynch, Marcelo A Wood,

Propensity to relapse following long periods of abstinence is a key feature of substance use disorder. Drugs of abuse, such as cocaine, cause long-term changes in the neural circuitry regulating reward, motivation, and memory processes through dysregulation of various molecular mechanisms, including epigenetic regulation of activity-dependent gene expression. Underlying drug-induced ... Read more >>

Neuropharmacology (Neuropharmacology)
[2019, 153:13-19]

Cited: 4 times

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Extinction Versus Epigenetic Intergenerational Inheritance: Who Wins?

Dina P Matheos, Marcelo A Wood,

Biol Psychiatry (Biological psychiatry)
[2019, 85(3):184-186]

Cited: 0 times

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Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory.

Janine L Kwapis, Yasaman Alaghband, Enikö A Kramár, Alberto J López, Annie Vogel Ciernia, André O White, Guanhua Shu, Diane Rhee, Christina M Michael, Emilie Montellier, Yu Liu, Christophe N Magnan, Siwei Chen, Paolo Sassone-Corsi, Pierre Baldi, Dina P Matheos, Marcelo A Wood,

Aging is accompanied by impairments in both circadian rhythmicity and long-term memory. Although it is clear that memory performance is affected by circadian cycling, it is unknown whether age-related disruption of the circadian clock causes impaired hippocampal memory. Here, we show that the repressive histone deacetylase HDAC3 restricts long-term memory, ... Read more >>

Nat Commun (Nature communications)
[2018, 9(1):3323]

Cited: 27 times

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Medial habenula cholinergic signaling regulates cocaine-associated relapse-like behavior.

Alberto J López, Yousheng Jia, André O White, Janine L Kwapis, Monica Espinoza, Philip Hwang, Rianne Campbell, Yasaman Alaghband, Om Chitnis, Dina P Matheos, Gary Lynch, Marcelo A Wood,

Propensity to relapse, even following long periods of abstinence, is a key feature in substance use disorders. Relapse and relapse-like behaviors are known to be induced, in part, by re-exposure to drug-associated cues. Yet, while many critical nodes in the neural circuitry contributing to relapse have been identified and studied, ... Read more >>

Addict Biol (Addiction biology)
[2019, 24(3):403-413]

Cited: 14 times

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Habits Are Negatively Regulated by Histone Deacetylase 3 in the Dorsal Striatum.

Melissa Malvaez, Venuz Y Greenfield, Dina P Matheos, Nicolas A Angelillis, Michael D Murphy, Pamela J Kennedy, Marcelo A Wood, Kate M Wassum,

BACKGROUND:Optimal behavior and decision making result from a balance of control between two strategies, one cognitive/goal-directed and one habitual. These systems are known to rely on the anatomically distinct dorsomedial and dorsolateral striatum, respectively. However, the transcriptional regulatory mechanisms required to learn and transition between these strategies are unknown. Here ... Read more >>

Biol Psychiatry (Biological psychiatry)
[2018, 84(5):383-392]

Cited: 15 times

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Distinct roles for the deacetylase domain of HDAC3 in the hippocampus and medial prefrontal cortex in the formation and extinction of memory.

Yasaman Alaghband, Janine L Kwapis, Alberto J López, André O White, Osasumwen V Aimiuwu, Amni Al-Kachak, Kasuni K Bodinayake, Nicole C Oparaugo, Richard Dang, Mariam Astarabadi, Dina P Matheos, Marcelo A Wood,

Histone deacetylases (HDACs) are chromatin modifying enzymes that have been implicated as powerful negative regulators of memory processes. HDAC3has been shown to play a pivotal role in long-term memory for object location as well as the extinction of cocaine-associated memory, but it is unclear whether this function depends on the ... Read more >>

Neurobiol Learn Mem (Neurobiology of learning and memory)
[2017, 145:94-104]

Cited: 15 times

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Mutation of neuron-specific chromatin remodeling subunit BAF53b: rescue of plasticity and memory by manipulating actin remodeling.

Annie Vogel Ciernia, Enikö A Kramár, Dina P Matheos, Robbert Havekes, Thekla J Hemstedt, Christophe N Magnan, Keith Sakata, Ashley Tran, Soraya Azzawi, Alberto Lopez, Richard Dang, Weisheng Wang, Brian Trieu, Joyce Tong, Ruth M Barrett, Rebecca J Post, Pierre Baldi, Ted Abel, Gary Lynch, Marcelo A Wood,

Recent human exome-sequencing studies have implicated polymorphic Brg1-associated factor (BAF) complexes (mammalian SWI/SNF chromatin remodeling complexes) in several intellectual disabilities and cognitive disorders, including autism. However, it remains unclear how mutations in BAF complexes result in impaired cognitive function. Post-mitotic neurons express a neuron-specific assembly, nBAF, characterized by the neuron-specific ... Read more >>

Learn Mem (Learning & memory (Cold Spring Harbor, N.Y.))
[2017, 24(5):199-209]

Cited: 11 times

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Context and Auditory Fear are Differentially Regulated by HDAC3 Activity in the Lateral and Basal Subnuclei of the Amygdala.

Janine L Kwapis, Yasaman Alaghband, Alberto J López, André O White, Rianne R Campbell, Richard T Dang, Diane Rhee, Ashley V Tran, Allison E Carl, Dina P Matheos, Marcelo A Wood,

Histone acetylation is a fundamental epigenetic mechanism that is dynamically regulated during memory formation. Histone acetyltransferases (HATs) and histone deacetylases (HDACs) compete to modulate histone acetylation, allowing for rapid changes in acetylation in response to a learning event. HDACs are known to be powerful negative regulators of memory formation, but ... Read more >>

Neuropsychopharmacology (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology)
[2017, 42(6):1284-1294]

Cited: 20 times

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BDNF rescues BAF53b-dependent synaptic plasticity and cocaine-associated memory in the nucleus accumbens.

André O White, Enikö A Kramár, Alberto J López, Janine L Kwapis, John Doan, David Saldana, M Felicia Davatolhagh, Yasaman Alaghband, Mathew Blurton-Jones, Dina P Matheos, Marcelo A Wood,

Recent evidence implicates epigenetic mechanisms in drug-associated memory processes. However, a possible role for one major epigenetic mechanism, nucleosome remodelling, in drug-associated memories remains largely unexplored. Here we examine mice with genetic manipulations targeting a neuron-specific nucleosome remodelling complex subunit, BAF53b. These mice display deficits in cocaine-associated memory that are ... Read more >>

Nat Commun (Nature communications)
[2016, 7:11725]

Cited: 27 times

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Promoter-Specific Effects of DREADD Modulation on Hippocampal Synaptic Plasticity and Memory Formation.

Alberto J López, Enikö Kramár, Dina P Matheos, André O White, Janine Kwapis, Annie Vogel-Ciernia, Keith Sakata, Monica Espinoza, Marcelo A Wood,

<h4>Unlabelled</h4>Designer receptors exclusively activated by designer drug (DREADDs) are a novel tool with the potential to bidirectionally drive cellular, circuit, and ultimately, behavioral changes. We used DREADDs to evaluate memory formation in a hippocampus-dependent task in mice and effects on synaptic physiology in the dorsal hippocampus. We expressed neuron-specific (hSyn ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2016, 36(12):3588-3599]

Cited: 41 times

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Unlocking the constraints on memory formation.

Dina P Matheos, Marcelo A Wood,

Nat Neurosci (Nature neuroscience)
[2014, 17(7):895-896]

Cited: 0 times

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The neuron-specific chromatin regulatory subunit BAF53b is necessary for synaptic plasticity and memory.

Annie Vogel-Ciernia, Dina P Matheos, Ruth M Barrett, Enikö A Kramár, Soraya Azzawi, Yuncai Chen, Christophe N Magnan, Michael Zeller, Angelina Sylvain, Jakob Haettig, Yousheng Jia, Anthony Tran, Richard Dang, Rebecca J Post, Meredith Chabrier, Alex H Babayan, Jiang I Wu, Gerald R Crabtree, Pierre Baldi, Tallie Z Baram, Gary Lynch, Marcelo A Wood,

Recent exome sequencing studies have implicated polymorphic Brg1-associated factor (BAF) complexes (mammalian SWI/SNF chromatin remodeling complexes) in several human intellectual disabilities and cognitive disorders. However, it is currently unknown how mutations in BAF complexes result in impaired cognitive function. Postmitotic neurons express a neuron-specific assembly, nBAF, characterized by the neuron-specific ... Read more >>

Nat Neurosci (Nature neuroscience)
[2013, 16(5):552-561]

Cited: 126 times

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Differential roles for Nr4a1 and Nr4a2 in object location vs. object recognition long-term memory.

Susan E McNulty, Ruth M Barrett, Annie Vogel-Ciernia, Melissa Malvaez, Nicole Hernandez, M Felicia Davatolhagh, Dina P Matheos, Aaron Schiffman, Marcelo A Wood,

Nr4a1 and Nr4a2 are transcription factors and immediate early genes belonging to the nuclear receptor Nr4a family. In this study, we examine their role in long-term memory formation for object location and object recognition. Using siRNA to block expression of either Nr4a1 or Nr4a2, we found that Nr4a2 is necessary ... Read more >>

Learn Mem (Learning & memory (Cold Spring Harbor, N.Y.))
[2012, 19(12):588-592]

Cited: 52 times

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CBP in the nucleus accumbens regulates cocaine-induced histone acetylation and is critical for cocaine-associated behaviors.

Melissa Malvaez, Emanuela Mhillaj, Dina P Matheos, Maura Palmery, Marcelo A Wood,

Cocaine exposure triggers molecular events that lead to long-lasting changes in brain structure and function. These changes can lead to the development of persistent and robust behavioral adaptations that characterize addiction. Recent evidence suggests the regulation of transcription via chromatin modification, such as histone acetylation, has an important role in ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2011, 31(47):16941-16948]

Cited: 63 times

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Hippocampal focal knockout of CBP affects specific histone modifications, long-term potentiation, and long-term memory.

Ruth M Barrett, Melissa Malvaez, Eniko Kramar, Dina P Matheos, Abraham Arrizon, Sara M Cabrera, Gary Lynch, Robert W Greene, Marcelo A Wood,

To identify the role of the histone acetyltransferase (HAT) CREB-binding protein (CBP) in neurons of the CA1 region of the hippocampus during memory formation, we examine the effects of a focal homozygous knockout of CBP on histone modifications, gene expression, synaptic plasticity, and long-term memory. We show that CBP is ... Read more >>

Neuropsychopharmacology (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology)
[2011, 36(8):1545-1556]

Cited: 125 times

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HDAC3 is a critical negative regulator of long-term memory formation.

Susan C McQuown, Ruth M Barrett, Dina P Matheos, Rebecca J Post, George A Rogge, Theresa Alenghat, Shannon E Mullican, Steven Jones, James R Rusche, Mitchell A Lazar, Marcelo A Wood,

Gene expression is dynamically regulated by chromatin modifications on histone tails, such as acetylation. In general, histone acetylation promotes transcription, whereas histone deacetylation negatively regulates transcription. The interplay between histone acetyltranserases and histone deacetylases (HDACs) is pivotal for the regulation of gene expression required for long-term memory processes. Currently, very ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2011, 31(2):764-774]

Cited: 264 times

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