Full Text Journal Articles by
Author Dina Cortes

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The impact of early and successful orchidopexy on hormonal follow-up for 208 boys with bilateral non-syndromic cryptorchidism.

Simone Hildorf, Dina Cortes, Erik Clasen-Linde, Magdalena Fossum, Jorgen Thorup,

<h4>Purpose</h4>Inhibin-B is produced by Sertoli cells and decreased values might be associated with impaired fertility potential. The aim of the study was to evaluate the impact of bilateral orchidopexy on serum inhibin-B and follicle-stimulating hormone (FSH).<h4>Methods</h4>A cohort study including 208 bilateral cryptorchid boys (median age: 1.7 year) was evaluated with serum ... Read more >>

Pediatr Surg Int (Pediatric surgery international)
[2021, :]

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PREVALENCE OF SARS-COV-2-ANTIBODIES IN DANISH CHILDREN AND ADULTS.

Maren J H Rytter, Ulrikka Nygaard, Ida Nikoline Mandic, Jonathan Peter Glenthøj, Lisbeth Samsø Schmidt, Dina Cortes, Birgitte Smith, Tatjana Zaharov, Mia Johanna Søndergaard, Marie Cecilie Lawaetz, Susanne Saekmose, Lise Heilmann Jensen, Kjeld Schmiegelow, Kim Kristensen,

In Denmark, severe acute respiratory syndrome coronavirus 2 antibodies were assessed in a cross-sectional study among 1033 children visiting pediatric departments and 750 blood donors in June 2020, using a point-of-care test. Antibodies were detected in 17 children (1.6%) and 15 blood donors (2.0%) (P = 0.58). In conclusion, children ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, Publish Ahead of Print:]

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Germ cells positive for PLAP and c-Kit in 11-16 year old normal boys with ongoing spermatogenesis.

Kolja Kvist, Simone Hildorf, Erik Clasen-Linde, Dina Cortes, Jorgen Thorup,

<h4>Introduction</h4>Positive staining of testicular germ cells for PLAP and c-Kit beyond infancy may be associated with the presence of GCNIS (Germ Cell Neoplasia In Situ). We recently reported our findings of positive staining of normal, infantile germ cells for PLAP, and c-Kit up to 2 years of age, contrary to previous ... Read more >>

Pediatr Surg Int (Pediatric surgery international)
[2020, 36(10):1249-1254]

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Fertility Potential is Impaired in Boys with Bilateral Ascending Testes.

Simone Hildorf, Erik Clasen-Linde, Magdalena Fossum, Dina Cortes, Jorgen Thorup,

<h4>Purpose</h4>Ascending testes have been documented to be descended in the scrotum within the first year of life and then reascended. The aim of this study was to investigate to what extent the fertility potential was impaired in boys with such testes compared to the fertility potential of boys with late ... Read more >>

J Urol (The Journal of urology)
[2021, 205(2):586-594]

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Multistrain Probiotic Increases the Gut Microbiota Diversity in Obese Pregnant Women: Results from a Randomized, Double-Blind Placebo-Controlled Study.

Sofie Ingdam Halkjær, Victoria Elizabeth de Knegt, Bobby Lo, Lisbeth Nilas, Dina Cortes, Anders Elm Pedersen, Hengameh Chloé Mirsepasi-Lauridsen, Lee O'Brien Andersen, Henrik Vedel Nielsen, Christen Rune Stensvold, Thor Bech Johannesen, Thomas Kallemose, Karen Angeliki Krogfelt, Andreas Munk Petersen,

Background:Maternal obesity is associated with adverse pregnancy outcomes. Probiotic supplementation during pregnancy may have positive effects on blood glucose, gestational weight gain (GWG), and the risk of gestational diabetes mellitus [GDM and glycated hemoglobin (HbA1c)]. Objectives:This feasibility study involved a daily probiotic intervention in obese pregnant women from the early ... Read more >>

Curr Dev Nutr (Current developments in nutrition)
[2020, 4(7):nzaa095]

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Newborn body composition after maternal bariatric surgery.

Emma Malchau Carlsen, Kristina Martha Renault, Bertha Kanijo Møller, Kirsten Nørgaard, Jens-Erik Beck Jensen, Jeannet Lauenborg, Dina Cortes, Ole Pryds,

INTRODUCTION:In pregnancy after Roux-en-Y gastric bypass (RYGB), there is increased risk of low birthweight in the offspring. The present study examined how offspring body composition was affected by RYGB. MATERIAL AND METHODS:Mother-newborn dyads, where the mothers had undergone RYGB were included. Main outcome measure was neonatal body composition. Neonatal body ... Read more >>

PLoS One (PloS one)
[2020, 15(5):e0231579]

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Postnatal germ cell development in cryptorchid boys.

Li-Hua Dong, Simone Hildorf, Erik Clasen-Linde, Kolja Kvist, Dina Cortes, Jørgen Thorup, Claus Yding Andersen,

Cryptorchidism is associated with infertility in adulthood. Early orchiopexy is suggested to reduce the risk. Information is lacking on the potential link between infant germ cell maturation and the risk of future infertility. The objective of the study was to evaluate age-related germ cell development in cryptorchidism. Immunostaining for markers ... Read more >>

Asian J Androl (Asian journal of andrology)
[2020, 22(3):258-264]

Cited: 2 times

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Review of injection techniques for spermatogonial stem cell transplantation.

Murat Gul, Simone Hildorf, Lihua Dong, Jorgen Thorup, Eva R Hoffmann, Christian Fuglesang S Jensen, Jens Sønksen, Dina Cortes, Jens Fedder, Claus Yding Andersen, Ellen Goossens,

BACKGROUND:Although the prognosis of childhood cancer survivors has increased dramatically during recent years, chemotherapy and radiation treatments for cancer and other conditions may lead to permanent infertility in prepubertal boys. Recent developments have shown that spermatogonial stem cell (SSC) transplantation may be a hope for restoring fertility in adult survivors ... Read more >>

Hum Reprod Update (Human reproduction update)
[2020, 26(3):368-391]

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National data with high validity and completeness showed that only 0.04% of Danish children had been registered with diagnosed hypertension.

Adam F Langhoff, Malene Landbo Børresen, Malgorzata P Wason, Mikael Andersson, Dorthe L Jeppesen, Ida M Schmidt, Dina Cortes,

AIM:Hypertension has been reported in up to 4.0% of American children, but no national data exist in Europe. We studied the frequency of registered hypertension in Danish children and evaluated the data. METHODS:This 2014-2015 study focused on patients under the age of 16 registered with hypertension in the Danish National ... Read more >>

Acta Paediatr (Acta paediatrica (Oslo, Norway : 1992))
[2020, 109(7):1458-1464]

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Reply by Authors.

Simone Hildorf, Erik Clasen-Linde, Dina Cortes, Magdalena Fossum, Jorgen Thorup,

J Urol (The Journal of urology)
[2020, 203(4):840]

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Multi-strain Probiotic Increases the Gut Microbiota Diversity in Obese Pregnant Women: Results from a Randomized, Double-blind Placebo-controlled Study

Sofie Ingdam Halkjær, Victoria Elisabeth de Knegt, Bobby Lo, Lisbeth Nilas, Dina Cortes, Anders Elm Pedersen, Hengameh Chloé Mirsepasi-Lauridsen, Lee O'Brien Andersen, Henrik Vedel Nielsen, Christen Rune Stensvold, Thor Bech Johannesen, Thomas Kallemose, Karen Angeliki Krogfelt, Andreas Munk Petersen,

<h4>Background: </h4> Maternal obesity is associated with adverse pregnancy outcomes. Probiotic supplementation during pregnancy may have positive effects on blood glucose, gestational weight gain (GWG), and the risk of gestational diabetes mellitus (GDM). The primary aim was to determine the feasibility of probiotic intervention in obese pregnant women from the ... Read more >>

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Selected Abstracts from the 28th National Urology Congress.

Turk J Urol (Turkish journal of urology)
[2019, 45(Supp. 2):S194-S242]

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Propagation of Spermatogonial Stem Cell-Like Cells From Infant Boys.

Lihua Dong, Stine Gry Kristensen, Simone Hildorf, Murat Gul, Erik Clasen-Linde, Jens Fedder, Eva R Hoffmann, Dina Cortes, Jorgen Thorup, Claus Yding Andersen,

<h4>Background</h4>Gonadotoxic treatment of malignant diseases as well as some non-malignant conditions such as cryptorchidism in young boys may result in infertility and failure to father children later in life. As a fertility preserving strategy, several centers collect testicular biopsies to cryopreserve spermatogonial stem cells (SSCs) world-wide. One of the most ... Read more >>

Front Physiol (Frontiers in physiology)
[2019, 10:1155]

Cited: 2 times

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Fertility Potential is Compromised in 20% to 25% of Boys with Nonsyndromic Cryptorchidism despite Orchiopexy within the First Year of Life.

Simone Hildorf, Erik Clasen-Linde, Dina Cortes, Magdalena Fossum, Jorgen Thorup,

PURPOSE:One of the concerns surrounding cryptorchidism is the risk of impaired fertility. Current guidelines recommend orchiopexy at age 6 to 12 months to optimize fertility outcome. We evaluated the fertility potential of boys with nonsyndromic cryptorchidism who underwent orchiopexy within the recommended age range to clarify the need for eventual ... Read more >>

J Urol (The Journal of urology)
[2020, 203(4):832-840]

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Xeno-Free Propagation of Spermatogonial Stem Cells from Infant Boys.

Lihua Dong, Murat Gul, Simone Hildorf, Susanne Elisabeth Pors, Stine Gry Kristensen, Eva R Hoffmann, Dina Cortes, Jorgen Thorup, Claus Yding Andersen,

Spermatogonial stem cell (SSC) transplantation therapy is a promising strategy to renew spermatogenesis for prepubertal boys whose fertility is compromised. However, propagation of SSCs is required due to a limited number of SSCs in cryopreserved testicular tissue. This propagation must be done under xeno-free conditions for clinical application. SSCs were ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 20(21):]

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Danish doctors' reactions to 'internationalization' in clinical training in a public university hospital.

Joyce Kling, Martin G Tolsgaard, Ellen Løkkegaard, Grete Teilmann, Gylli Mola, Jørgen Hedemark Poulsen, Lisbeth Nilas, Dina Cortes,

<h4>Objective</h4>From 2012 to 2015, two Departments of Obstetrics and Gynecology and two Departments of Pediatrics at the University of Copenhagen implemented an English medium international project. The project allowed international students to work in pairs with local Danish speaking students in a clinical setting. The student cohort was supported by ... Read more >>

BMC Res Notes (BMC research notes)
[2019, 12(1):411]

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Gonocyte transformation in congenital undescended testes: what is the role of inhibin-B in cell death?

Vanessa Wilson, Jorgen Thorup, Erick Clasen-Linde, Dina Cortes, John M Hutson, Ruili Li,

<h4>Purpose</h4>Undescended testes (UDT) are subjected to heat stress, which can disturb gonocyte transformation as well as apoptosis. This study aims to describe the apoptosis pathway occurring during minipuberty of children with unilateral (UDT), and to investigate the role of inhibin-B.<h4>Methods</h4>Testicular biopsies at unilateral orchidopexy of 10 boys (6-9 months old) with ... Read more >>

Pediatr Surg Int (Pediatric surgery international)
[2019, 35(11):1309-1316]

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Cryptorchidism, gonocyte development, and the risks of germ cell malignancy and infertility: A systematic review.

Moshe Loebenstein, Jorgen Thorup, Dina Cortes, Erik Clasen-Linde, John M Hutson, Ruili Li,

<h4>Background/aim</h4>Cryptorchidism, or undescended testis (UDT) occurs in 1%-4% of newborn males and leads to a risk of infertility and testicular malignancy. Recent research suggests that infertility and malignancy in UDT may be caused by abnormal development of the neonatal germ cells, or gonocytes, which normally transform into spermatogonial stem cells ... Read more >>

J Pediatr Surg (Journal of pediatric surgery)
[2020, 55(7):1201-1210]

Cited: 1 time

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Successful paediatric renography does not require sedation.

Claudia Mau Kai, Bente Ingvardsen, Pernille Lemvig, Line Thousig Sehested, Lasse Rahbek Søndergaard, Søren Møller, Dina Cortes,

<h4>Introduction</h4>Sedation is often used to optimise ren-ography in children < 3 years, but it requires continuous monitoring.<h4>Methods</h4>We discontinued routine use of chloral hydrate sedation of patients undergoing renography, and introduced that children < 2 years were placed in a child immobiliser for nuclear examinations at the Department of Paediatrics before ... Read more >>

Dan Med J (Danish medical journal)
[2019, 66(5):]

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Sertoli Cell Number Correlates with Serum Inhibin B in Infant Cryptorchid Boys.

Simone Hildorf, Lihua Dong, Jorgen Thorup, Erik Clasen-Linde, Claus Yding Andersen, Dina Cortes,

Postnatal maturation of Sertoli cells is crucial for male fertility. The aim of this study was to assess the association between the Sertoli cell number per tubule cross-section (SC/T), the serum level of the Sertoli cell-produced inhibin B, and the A-dark spermatogonia number per tubule (Ad/T) in cryptorchid boys. Forty ... Read more >>

Sex Dev (Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation)
[2019, 13(2):74-82]

Cited: 1 time

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Surgical Management of Undescended Testis - Timetable and Outcome: A Debate.

Jorgen Thorup, Dina Cortes,

Around 1.4-3.8% of boys in the Western world are operated because of cryptorchidism. This means that orchidopexy remains one of the most common surgical procedures performed in boys. As a consequence, several consensus reports, guidelines, and reviews dealing with the management of cryptorchidism have been published recently. Based on our ... Read more >>

Sex Dev (Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation)
[2019, 13(1):11-19]

Cited: 1 time

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Parental Acceptance Rate of Testicular Tissue Cryopreservation in Danish Boys with Cryptorchidism.

Simone Hildorf, Dina Cortes, Murat Gül, Lihua Dong, Stine G Kristensen, Christian F S Jensen, Erik Clasen-Linde, Jens Fedder, Claus Y Andersen, Eva R Hoffmann, Jens Sønksen, Magdalena Fossum, Jørgen Thorup,

Despite orchidopexy within the first year of life, 20-25% of boys with nonsyndromic cryptorchidism may risk infertility according to histological and hormonal data obtained during surgery. The aim of this study was to evaluate the acceptance rate of testicular tissue cryopreservation among parents of prepubertal boys with cryptorchidism. Fourteen boys ... Read more >>

Sex Dev (Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation)
[2019, 13(5-6):246-257]

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Postnatal germ cell development during first 18 months of life in testes from boys with non-syndromic cryptorchidism and complete or partial androgen insensitivity syndrome.

Ruili Li, Damian Azzollini, Ruidong Shen, Jorgen Thorup, Erick Clasen-Linde, Dina Cortes, John M Hutson,

INTRODUCTION:Neonatal testicular germ cells/gonocytes, transform into stem cells for spermatogenesis during 'minipuberty', driving change in timing of surgery. This study examined gonocyte transformation in cryptorchid testes in children ≤18 months of age with unilateral, bilateral undescended testes (UDT), complete or partial androgen insensitivity syndrome (CAIS, PAIS) [3,4]. MATERIAL AND METHODS:Testicular biopsies ... Read more >>

J Pediatr Surg (Journal of pediatric surgery)
[2019, 54(8):1654-1659]

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LED virtual windows are valuable in windowless consultation rooms.

Sumit Sen, Tove Nielsen, Erik Nielsen, Ole Pryds, Dina Cortes,

<h4>Introduction</h4>Due to the design of Hvidovre Hospital, the outpatient clinic of the Department of Paediatrics has windowless consultation rooms. Work environment surveys revealed that nurses and doctors working in these windowless rooms considered the lack of natural light a considerable health problem. This study evaluated the effects of installing light-emitting ... Read more >>

Dan Med J (Danish medical journal)
[2018, 65(9):]

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The Expression of Markers for Intratubular Germ Cell Neoplasia in Normal Infantile Testes.

Kolja Kvist, Erik Clasen-Linde, Oline Langballe, Steen Holger Hansen, Dina Cortes, Jorgen Thorup,

<h4>Background</h4>Positive immunohistochemical expression of testicular cancer markers is often reported beyond 12 months of age in cryptorchid testes, which is assumed to indicate delayed maturation of the fetal germ cells, or neoplastic changes. These findings allowed for questions as to the extent of positive reaction in normal testes. The aim of ... Read more >>

Front Endocrinol (Lausanne) (Frontiers in endocrinology)
[2018, 9:286]

Cited: 4 times

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