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Author Dierk Scheinert

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Photoablative atherectomy followed by a paclitaxel-coated balloon to inhibit restenosis in instent femoro-popliteal obstructions (PHOTOPAC).

Tanja Böhme, Elias Noory, Ulrich Beschorner, Frederik Lerke, Andrej Schmidt, Dierk Scheinert, Wulf Ito, Thomas Zeller, Aljoscha Rastan,

<i>Background:</i> To evaluate the safety and effectiveness of preparing instent femoropopliteal lesion with photoablative laser atherectomy or plain balloon angioplasty (POBA) prior to drug-coated balloon (DCB) angioplasty. <i>Patients and methods:</i> The prospective, multicenter, randomized study enrolled patients with Rutherford-Becker-class (RBC) 1 to 5 and instent lesions located in superficial femoral ... Read more >>

Vasa (VASA. Zeitschrift fur Gefasskrankheiten)
[2021, :1-7]

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Intravascular Lithotripsy for Peripheral Artery Calcification: 30-Day Outcomes From the Randomized Disrupt PAD III Trial.

Gunnar Tepe, Marianne Brodmann, Martin Werner, William Bachinsky, Andrew Holden, Thomas Zeller, Sarang Mangalmurti, Claus Nolte-Ernsting, Barry Bertolet, Dierk Scheinert, William A Gray, ,

<h4>Objectives</h4>The study sought to compare short-term outcomes in patients with femoropopliteal artery calcification receiving vessel preparation with intravascular lithotripsy (IVL) or percutaneous transluminal angioplasty (PTA) prior to drug-coated balloon (DCB) for symptomatic peripheral artery disease.<h4>Background</h4>Endovascular treatment of calcified peripheral artery lesions is associated with suboptimal vessel expansion and increased complication ... Read more >>

JACC Cardiovasc Interv (JACC. Cardiovascular interventions)
[2021, 14(12):1352-1361]

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Assessment of 5-Year Mortality Outcomes for Femoropoliteal Interventions Using Drug-Eluting Devices in the REAL-PTX Study.

Tim Wittig, Thomas Zeller, Marc Bosiers, Patrick Peeters, Steffen Brucks, Yvonne Bausback, Andrej Schmidt, Dierk Scheinert, Sabine Steiner,

JACC Cardiovasc Interv (JACC. Cardiovascular interventions)
[2021, 14(10):1165-1168]

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Stroke rate after thoracic endovascular aortic repair using de-airing of stentgrafts with high-volume of saline solution.

Daniela Branzan, Antonia Geisler, Sabine Steiner, Tina Lautenschlaeger, Markus Doss, Manuela Matschuck, Dierk Scheinert, Andrej Schmidt,

<i>Background</i>: Our aim was to determine the rate of ischemic stroke following thoracic endovascular aortic repair (TEVAR) after reducing gas volume released during stentgraft deployment by de-airing of thoracic stentgrafts with high-volume of 0.9% heparinized saline solution. <i>Patients and methods</i>: A single center retrospective analysis of all consecutive patients undergoing ... Read more >>

Vasa (VASA. Zeitschrift fur Gefasskrankheiten)
[2021, 50(3):186-192]

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The Influence of 3D Printed Aortic Models on the Evolution of Physician Modified Stent Grafts for the Urgent Treatment of Thoraco-abdominal and Pararenal Aortic Pathologies.

Daniela Branzan, Antonia Geisler, Ronny Grunert, Sabine Steiner, Yvonne Bausback, Ines Gockel, Dierk Scheinert, Andrej Schmidt,

<h4>Objective</h4>The aim was to describe the outcomes of high risk patients with symptomatic or contained rupture of pararenal (PRAs) and thoraco-abdominal aortic aneurysms (TAAAs) with anatomy unsuitable for commercially available stent grafts who underwent fenestrated endovascular aneurysm repair (FEVAR) using physician modified stent grafts (PMSGs) planned with 3D image analysis ... Read more >>

Eur J Vasc Endovasc Surg (European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery)
[2021, 61(3):407-412]

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Type II endoleak and aortic aneurysm sac shrinkage after preemptive embolization of aneurysm sac side branches.

Daniela Branzan, Antonia Geisler, Sabine Steiner, Markus Doss, Manuela Matschuck, Dierk Scheinert, Andrej Schmidt,

<h4>Objective</h4>Type II endoleak (T2EL) is the most common endoleak after endovascular aneurysm repair (EVAR). Its optimal management has been controversially discussed. Thus, preliminary selective embolization of aneurysm sac side branches (ASSBs) has been adopted to prevent T2EL. Our goal was to determine the rate of T2EL and the diameter decrease ... Read more >>

J Vasc Surg (Journal of vascular surgery)
[2021, 73(6):1973-1979.e1]

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Stent-grafts are the best way to treat complex in-stent restenosis lesions in the superficial femoral artery: 24-month results from a multicenter randomized trial.

Marc Bosiers, Koen Deloose, Joren Callaert, Jürgen Verbist, Jeroen Hendriks, Patrick Lauwers, Herman Schroë, Wouter Lansink, Dierk Scheinert, Andrej Schmidt, Thomas Zeller, Ulrich Beschorner, Elias Noory, Giovanni Torsello, Martin Austermann, Jeroen Wauters,

<h4>Background</h4>This clinical trial aims to evaluate the outcome (up to 24-months) of the treatment of in-stent restenotic or reoccluded lesions in the femoropopliteal arteries, by comparing the treatment of the GORE<sup>®</sup> VIABAHN<sup>®</sup> Endoprosthesis with PROPATEN Bioactive Surface (W. L. Gore & Associates, Flagstaff, AZ, USA) with a standard PTA treatment. ... Read more >>

J Cardiovasc Surg (Torino) (The Journal of cardiovascular surgery)
[2020, 61(5):617-625]

Cited: 1 time

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Heparin-Bonded Stent-Graft for the Treatment of TASC II C and D Femoropopliteal Lesions: 36-Month Results of the Viabahn 25 cm Trial.

Tanja Böhme, Elias Noory, Klaus Brechtel, Dierk Scheinert, Marc Bosiers, Ulrich Beschorner, Thomas Zeller,

<h4>Purpose</h4>To evaluate the 36-month technical and clinical outcome after implantation of the 25-cm Viabahn endoprosthesis with Propaten bioactive surface in TransAtlantic Inter-Society Consensus II C and D lesions of the superficial femoral and proximal popliteal arteries.<h4>Materials and methods</h4>This prospective, multicenter, single-arm trial (<i>ClinicalTrials.gov</i>; identifier NCT01263665) enrolled 71 patients (mean age ... Read more >>

J Endovasc Ther (Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists)
[2021, 28(2):222-228]

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Three-Year Sustained Clinical Efficacy of Drug-Coated Balloon Angioplasty in a Real-World Femoropopliteal Cohort.

Giovanni Torsello, Konstantinos Stavroulakis, Marianne Brodmann, Antonio Micari, Gunnar Tepe, Pierfrancesco Veroux, Andrew Benko, Donghoon Choi, Frank E G Vermassen, Michael R Jaff, Jia Guo, Reka Dobranszki, Thomas Zeller, ,

<b>Purpose:</b> To report the 36-month outcomes from the prospective, multicenter, single-arm IN.PACT Global Study (<i>ClinicalTrials.gov</i> identifier NCT01609296) evaluating the performance of the IN.PACT Admiral drug-coated balloon (DCB) in real-world patients with femoropopliteal occlusive disease. <b>Materials and Methods:</b> The IN.PACT Global Study was conducted at 64 international sites and enrolled 1535 ... Read more >>

J Endovasc Ther (Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists)
[2020, 27(5):693-705]

Cited: 4 times

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Vessel Calcification Patterns Should Determine Optimal Balloon Size Strategy in Below the Knee Angioplasty Procedures.

Rutger H A Welling, Gert J de Borst, Daniel A F van den Heuvel, Daniela Branzan, Andrej Schmidt, Dierk Scheinert, Olaf J Bakker,

Eur J Vasc Endovasc Surg (European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery)
[2020, 60(4):636-637]

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Two-year Review on Mortality and Morbidity after Femoropopliteal Drug-coated Balloon Angioplasty in the Randomized EffPac Trial.

Ulf Teichgräber, Thomas Lehmann, René Aschenbach, Markus Thieme, Thomas Zeller, Ulrich Beschorner, Dierk Scheinert,

Radiology (Radiology)
[2020, 296(3):638-640]

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COMPARE: prospective, randomized, non-inferiority trial of high- vs. low-dose paclitaxel drug-coated balloons for femoropopliteal interventions.

Sabine Steiner, Andrej Schmidt, Thomas Zeller, Gunnar Tepe, Marcus Thieme, Lars Maiwald, Henrik Schröder, Wulf Euringer, Matthias Ulrich, Klaus Brechtel, Steffen Brucks, Erwin Blessing, Johannes Schuster, Ralf Langhoff, Sebastian Schellong, Norbert Weiss, Dierk Scheinert,

<h4>Aims</h4>Drug-coated balloons (DCBs) for femoropopliteal interventions have not been tested against each other. We aimed to directly compare efficacy and safety of a high-dose (In.Pact™) vs. low-dose (Ranger™) DCB with nominal paclitaxel densities of 3.5 vs. 2.0 μg/mm2.<h4>Methods and results</h4>Within a prospective, multicentre, non-inferiority, clinical trial 414 patients with symptomatic femoropopliteal ... Read more >>

Eur Heart J (European heart journal)
[2020, 41(27):2541-2552]

Cited: 1 time

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One-year outcome of the paclitaxel-eluting Legflow balloon catheter in the treatment of long and complex femoropopliteal lesions.

Marc Bosiers, Koen Deloose, Giovanni Torsello, Dierk Scheinert, Jürgen Verbist, Wouter van den Eynde, Lieven Maene, Roel Beelen, Koen Keirse, Jeroen Hendriks, Joren Callaert, Michel Bosiers, Jeroen Wauters,

<h4>Background</h4>The aim of this study is to investigate the efficacy of the paclitaxel-eluting Legflow balloon catheter in the treatment of "real-world" long and complex femoropopliteal lesions.<h4>Methods</h4>The REFLOW study was a prospective, multi-national, non-randomized, single arm study evaluating the safety and efficacy of the Legflow paclitaxel-eluting balloon dilatation catheter in the ... Read more >>

J Cardiovasc Surg (Torino) (The Journal of cardiovascular surgery)
[2020, 61(4):471-477]

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One-year results from the DETOUR I trial of the PQ Bypass DETOUR System for percutaneous femoropopliteal bypass.

Dainis K Krievins, Grzegorz Halena, Dierk Scheinert, Janis Savlovskis, Piotr Szopiński, Albrecht Krämer, Kenneth Ouriel, Kasthuri Nair, Andrew Holden, Andrej Schmidt,

<h4>Objective</h4>The objective of this study was to evaluate the 1-year safety and effectiveness outcomes associated with the PQ Bypass DETOUR System (PQ Bypass, Milpitas, Calif) for the percutaneous bypass of long-segment femoropopliteal occlusive disease.<h4>Methods</h4>This prospective, single-arm, multicenter trial enrolled patients with long-segment femoropopliteal arterial disease. The DETOUR System percutaneously deploys ... Read more >>

J Vasc Surg (Journal of vascular surgery)
[2020, 72(5):1648-1658.e2]

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Efficacy and safety of a novel paclitaxel-nano-coated balloon for femoropopliteal angioplasty: one-year results of the EffPac trial.

Ulf Teichgräber, Thomas Lehmann, René Aschenbach, Dierk Scheinert, Thomas Zeller, Klaus Brechtel, Erwin Blessing, Michael Lichtenberg, Sebastian Sixt, Steffen Brucks, Ulrich Beschorner, Christof Tobias Klumb, Markus Thieme, ,

AIMS:Although paclitaxel drug-coated balloon (DCB) angioplasty is an established endovascular treatment for peripheral artery disease, restenosis remains a major concern. Thus, we compared a novel paclitaxel-coated DCB with nano-coating technology with uncoated plain old balloon angioplasty (POBA). METHODS AND RESULTS:This multicentre trial randomly assigned 171 patients with stenotic and occlusive ... Read more >>

EuroIntervention (EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology)
[2020, 15(18):e1633-e1640]

Cited: 3 times

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Drug-coated Balloon Angioplasty of Femoropopliteal Lesions Maintained Superior Efficacy over Conventional Balloon: 2-year Results of the Randomized EffPac Trial.

Ulf Teichgräber, Thomas Lehmann, René Aschenbach, Dierk Scheinert, Thomas Zeller, Klaus Brechtel, Erwin Blessing, Michael Lichtenberg, Peter von Flotow, Britta Heilmeier, Sebastian Sixt, Steffen Brucks, Christian Erbel, Ulrich Beschorner, Michael Werk, Vicenç Riambau, Andreas Wienke, Christof Tobias Klumb, Markus Thieme,

Background Paclitaxel drug-coated balloon (DCB) catheter angioplasty is the preferred treatment for revascularization of femoropopliteal lesions in peripheral artery disease, but mortality is a safety concern. Purpose To assess 2-year efficacy and safety of DCB angioplasty compared with conventional balloon angioplasty (also known as plain old balloon angioplasty or POBA). ... Read more >>

Radiology (Radiology)
[2020, 295(2):478-487]

Cited: 3 times

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The IN.PACT DEEP Clinical Drug-Coated Balloon Trial: 5-Year Outcomes.

Thomas Zeller, Antonio Micari, Dierk Scheinert, Iris Baumgartner, Marc Bosiers, Frank E G Vermassen, Martin Banyai, Mehdi H Shishehbor, Hong Wang, Marianne Brodmann, ,

<h4>Objectives</h4>The goal of this study was to evaluate the 5-year follow-up data of the IN.PACT DEEP (Randomized IN.PACT Amphirion Drug-Coated Balloon [DCB] vs. Standard Percutaneous Transluminal Angioplasty [PTA] for the Treatment of Below-the-Knee Critical Limb Ischemia [CLI]) trial.<h4>Background</h4>Initial studies from randomized controlled trials have shown comparable short-term outcomes of DCB ... Read more >>

JACC Cardiovasc Interv (JACC. Cardiovascular interventions)
[2020, 13(4):431-443]

Cited: 2 times

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ZILVERPASS Study: ZILVER PTX Stent vs Bypass Surgery in Femoropopliteal Lesions.

Marc Bosiers, Carlo Setacci, Gianmarco De Donato, Giovanni Torsello, Pierre Galvagni Silveira, Koen Deloose, Dierk Scheinert, Pierfrancesco Veroux, Jeroen Hendriks, Lieven Maene, Koen Keirse, Tulio Navarro, Joren Callaert, Hans-Henning Eckstein, Jörg Teβarek, Alessia Giaquinta, Jeroen Wauters,

Purpose: To report the 12-month results of a multicenter, prospective, randomized controlled trial to determine if the ZILVER PTX paclitaxel-eluting stent was noninferior in terms of safety and efficacy compared with surgical bypass. Materials and Methods: This is a study in symptomatic TransAtlantic Inter-Society Consensus (TASC) C and D femoropopliteal ... Read more >>

J Endovasc Ther (Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists)
[2020, 27(2):287-295]

Cited: 0 times

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Endothelialization of Titanium Surfaces by Bioinspired Cell Adhesion Peptide Coatings.

Franziska Clauder, Anne Sophie Czerniak, Sabrina Friebe, Stefan G Mayr, Dierk Scheinert, Annette G Beck-Sickinger,

Common interventional therapies for cardiovascular occlusive diseases, such as the implantation of stents, are at risk of complications like thrombosis or restenosis. Drug-eluting stents have improved patency but simultaneously worsen the endothelialization of the implant. Here, we present a novel peptide coating derived from three proteins of the extracellular matrix ... Read more >>

Bioconjug Chem (Bioconjugate chemistry)
[2019, 30(10):2664-2674]

Cited: 1 time

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Safety of Paclitaxel-Coated Balloon Angioplasty for Femoropopliteal Peripheral Artery Disease.

Kenneth Ouriel, Mark A Adelman, Kenneth Rosenfield, Dierk Scheinert, Marianne Brodmann, Constantino Peña, Patrick Geraghty, Arthur Lee, Roseann White, Daniel G Clair,

<h4>Objectives</h4>The aim of this study was to assess safety outcomes of femoropopliteal drug-coated balloon (DCB) angioplasty using patient-level data from the Lutonix clinical program.<h4>Background</h4>A recent systematic review and meta-analysis of heterogenous trials and summary-level data identified increased long-term mortality in patients treated with paclitaxel-coated balloons and stents.<h4>Methods</h4>We evaluated DCB angioplasty ... Read more >>

JACC Cardiovasc Interv (JACC. Cardiovascular interventions)
[2019, 12(24):2515-2524]

Cited: 9 times

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First-in-Human Experience With Sirolimus-Eluting Self-Expanding Stent for Femoropopliteal Lesions.

Sabine Steiner, Antoine Sauguet, Ralf Langhoff, Andrea Kahlberg, Marcus Thieme, Thomas Zeller, Philippe Garot, Philippe Commeau, Alberto Cremonesi, Enrico Maria Marone, Dierk Scheinert,

J Am Coll Cardiol (Journal of the American College of Cardiology)
[2019, 74(17):2216-2218]

Cited: 0 times

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Retrograde Tibioperoneal Access for Complex Infrainguinal Occlusions: Short- and Long-Term Outcomes of 554 Endovascular Interventions.

Andrej Schmidt, Yvonne Bausback, Michael Piorkowski, Tim Wittig, Ursula Banning-Eichenseer, Holger Thiele, Samer Aldmour, Daniela Branzan, Dierk Scheinert, Sabine Steiner,

<h4>Objectives</h4>This study sought to report short- and long-term efficacy and safety outcomes of retrograde tibioperoneal access for endovascular treatment of chronic total occlusions (CTOs).<h4>Background</h4>Antegrade recanalization of peripheral CTO is associated with a high failure rate and retrograde puncture of tibioperoneal arteries has been adopted to overcome this limitation.<h4>Methods</h4>Within a retrospective ... Read more >>

JACC Cardiovasc Interv (JACC. Cardiovascular interventions)
[2019, 12(17):1714-1726]

Cited: 1 time

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Endovascular Repair of the Thoracic or Thoracoabdominal Aorta Following the Frozen Elephant Trunk Procedure.

Martin Haensig, Andrej Schmidt, Holger Staab, Sabine Steiner, Dierk Scheinert, Daniela Branzan,

<h4>Background</h4>This study evaluated the outcomes of endovascular repair of the thoracoabdominal aorta following the frozen elephant trunk (fET) procedure.<h4>Methods</h4>Between October 2014 and July 2018, 249 patients underwent thoracic or thoracoabdominal endovascular aortic repair in our institution. Of these, 10 patients (50% male) underwent second-stage endovascular repair after previous fET implantation. ... Read more >>

Ann Thorac Surg (The Annals of thoracic surgery)
[2020, 109(3):695-701]

Cited: 1 time

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Percutaneous Axillary Artery Access for Endovascular Treatment of Complex Thoraco-abdominal Aortic Aneurysms.

Daniela Branzan, Sabine Steiner, Martin Haensig, Dierk Scheinert, Andrej Schmidt,

<h4>Objective</h4>The aim of this study was to determine the feasibility and safety of percutaneous axillary artery (AxA) access using vascular closure devices (VCD) for endovascular repair (ER) of thoraco-abdominal aortic aneurysms (TAAA) using fenestrated, branched, and chimney stent grafts.<h4>Methods</h4>Between September 2013 and December 2017, 40 high risk patients (27 men; ... Read more >>

Eur J Vasc Endovasc Surg (European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery)
[2019, 58(3):344-349]

Cited: 0 times

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Long-Term Clinical Effectiveness of a Drug-Coated Balloon for the Treatment of Femoropopliteal Lesions.

John A Laird, Peter A Schneider, Michael R Jaff, Marianne Brodmann, Thomas Zeller, D Chris Metzger, Prakash Krishnan, Dierk Scheinert, Antonio Micari, Hong Wang, Michele Masters, Gunnar Tepe,

Background While randomized trials have demonstrated the superiority of drug-coated balloon (DCB) angioplasty versus standard percutaneous transluminal angioplasty (PTA) in patients with femoropopliteal peripheral artery disease, the long-term durability of DCB angioplasty remains uncertain. Methods and Results IN.PACT SFA is a prospective, multicenter, randomized single-blinded trial (Randomized Trial of IN.PACT ... Read more >>

Circ Cardiovasc Interv (Circulation. Cardiovascular interventions)
[2019, 12(6):e007702]

Cited: 16 times

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