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Sleep Problems Are Related to a Worse Quality of Life and a Greater Non-Motor Symptoms Burden in Parkinson's Disease.

Diego Santos-García, E Suárez Castro, T de Deus Fonticoba, M J Feal Panceiras, J G Muñoz Enriquez, J M Paz González, C Cores Bartolomé, L L Planellas, J García Caldentey, N Caballol, I Legarda, I Cabo López, L López Manzanares, M A Ávila Rivera, M J Catalán, V Nogueira, C Borrué, M Álvarez Sauco, L Vela, E Cubo, J C Martínez Castrillo, P Sánchez Alonso, M G Alonso Losada, N López Ariztegui, M I Gastón, J Kulisevsky, J Pagonabarraga, M Seijo, J Ruíz Martínez, C Valero, M Kurtis, J González Ardura, C Prieto, P Mir, P Martinez-Martin,

INTRODUCTION:The aim of the present study was to examine the frequency of self-reported sleep problems and their associated factors in a large cohort of PD patients. METHODS:PD patients and controls, recruited from 35 centers of Spain from the COPPADIS cohort were included in this cross-sectional study. Sleep problems were assessed ... Read more >>

J Geriatr Psychiatry Neurol (Journal of geriatric psychiatry and neurology)
[2020, :891988720964250]

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Glucosylation prevents plant defense activation in phloem-feeding insects.

Osnat Malka, Michael L A E Easson, Christian Paetz, Monika Götz, Michael Reichelt, Beate Stein, Katrin Luck, Aleksa Stanišić, Ksenia Juravel, Diego Santos-Garcia, Lilach L Mondaca, Simon Springate, John Colvin, Stephan Winter, Jonathan Gershenzon, Shai Morin, Daniel G Vassão,

The metabolic adaptations by which phloem-feeding insects counteract plant defense compounds are poorly known. Two-component plant defenses, such as glucosinolates, consist of a glucosylated protoxin that is activated by a glycoside hydrolase upon plant damage. Phloem-feeding herbivores are not generally believed to be negatively impacted by two-component defenses due to ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, :]

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Impact of Coronavirus Disease 2019 Pandemic on Parkinson's Disease: A Cross-Sectional Survey of 568 Spanish Patients.

Diego Santos-García, Mila Oreiro, Patricia Pérez, Gemma Fanjul, Jose Manuel Paz González, María José Feal Painceiras, Carlos Cores Bartolomé, Lorena Valdés Aymerich, Carlos García Sancho, Maria Del Mar Castellanos Rodrigo,

BACKGROUND:The aim of this study was to know the impact of the coronavirus disease 2019 (COVID-19) pandemic on Spanish patients with Parkinson's disease (PD). METHODS:This is a descriptive, observational, cross-sectional study. An anonymous online survey with 95 questions was distributed among patients. Responses were collected from 11 May 2020 to ... Read more >>

Mov Disord (Movement disorders : official journal of the Movement Disorder Society)
[2020, 35(10):1712-1716]

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Effects of Motor Symptom Laterality on Clinical Manifestations and Quality of Life in Parkinson's Disease.

Esther Cubo, Pablo Martínez-Martín, Jerónimo González-Bernal, Elena Casas, Sandra Arnaiz, Javier Miranda, Pedro Gámez, Diego Santos-García, ,

BACKGROUND:The asymmetry of motor manifestations present in Parkinson's disease (PD) suggests the existence of differences between both hemispheres. As a consequence, this asymmetry might contribute to different PD clinical phenotypes. OBJECTIVE:To study the relationship between motor symptom laterality with motor, non-motor symptoms (NMS), freezing of gait (FOG), and quality of ... Read more >>

J Parkinsons Dis (Journal of Parkinson's disease)
[2020, :]

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The impact of freezing of gait on functional dependency in Parkinson's disease with regard to motor phenotype.

Diego Santos-García, Teres de Deus-Fonticoba, Ester Suárez Castro, Ángel M Aneiros Díaz, María J Feal-Painceiras, Jose M Paz-González, Carlos García-Sancho, Silvia Jesús, Pablo Mir, Lluís Planellas, Juan García-Caldentey, Nuria Caballol, Inés Legarda, Jorge Hernández-Vara, Isabel González-Aramburu, María A Ávila-Rivera, María J Catalán, Víctor Nogueira, María Álvarez-Sauco, Lydia Vela, Sonia Escalante, Esther Cubo, Pilar Sánchez-Alonso, María G Alonso-Losada, Nuria López-Ariztegui, Pablo Martinez-Martin, ,

BACKGROUND AND OBJECTIVE:Freezing of gait (FOG) is a disabling symptom more frequent in Parkinson's disease (PD) patients with postural instability gait difficulty (PIGD) phenotype. The aim of this study was to determine the prevalence of self-reported FOG in a large group of PD patients as well as assess its relationship ... Read more >>

Neurol. Sci. (Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology)
[2020, 41(10):2883-2892]

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Molecular Evolution of the Glutathione S-Transferase Family in the Bemisia tabaci Species Complex.

Ofer Aidlin Harari, Diego Santos-Garcia, Mirit Musseri, Pnina Moshitzky, Mitulkumar Patel, Paul Visendi, Susan Seal, Rotem Sertchook, Osnat Malka, Shai Morin,

The glutathione S-transferase (GST) family plays an important role in the adaptation of herbivorous insects to new host plants and other environmental constrains. The family codes for enzymes that neutralize reactive oxygen species and phytotoxins through the conjugation of reduced glutathione. Here, we studied the molecular evolution of the GST ... Read more >>

Genome Biol Evol (Genome biology and evolution)
[2020, 12(2):3857-3872]

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Inside out: microbiota dynamics during host-plant adaptation of whiteflies.

Diego Santos-Garcia, Natividad Mestre-Rincon, Einat Zchori-Fein, Shai Morin,

While most insect herbivores are selective feeders, a small proportion of them feed on a wide range of plants. This polyphagous habit requires overcoming a remarkable array of defenses, which often necessitates an adaptation period. Efforts for understanding the mechanisms involved mostly focus on the insect's phenotypic plasticity. Here, we ... Read more >>

ISME J (The ISME journal)
[2020, 14(3):847-856]

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High ultrasensitive serum C-reactive protein may be related to freezing of gait in Parkinson's disease patients.

Diego Santos-García, T de Deus Fonticoba, E Suárez Castro, A Aneiros Díaz, J M Paz González, M J Feal Panceiras, C García Sancho, S Jesús, P Mir, M Aguilar, P Pastor, J Hernández Vara, O de Fábregues-Boixar, V Puente, A Crespo Cuevas, I González-Aramburu, J Infante, F Carrillo Padilla, M Pueyo, S Escalante, N Bernardo, B Solano, A Cots Foraster, P Martinez-Martin, ,

C-reactive protein (CRP) is a biomarker of systemic inflammation that has been linked to accelerated decline in walking speed in older adults. The aim of the present study was to compare the CRP levels of PD patients with vs patients without freezing of gait (FOG). Patients and controls participating in ... Read more >>

J Neural Transm (Vienna) (Journal of neural transmission (Vienna, Austria : 1996))
[2019, 126(12):1599-1608]

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Complete Assembly of the Genome of an Acidovorax citrulli Strain Reveals a Naturally Occurring Plasmid in This Species.

Rongzhi Yang, Diego Santos Garcia, Francisco Pérez Montaño, Gustavo Mateus da Silva, Mei Zhao, Irene Jiménez Guerrero, Tally Rosenberg, Gong Chen, Inbar Plaschkes, Shai Morin, Ron Walcott, Saul Burdman,

Acidovorax citrulli is the causal agent of bacterial fruit blotch (BFB), a serious threat to cucurbit crop production worldwide. Based on genetic and phenotypic properties, A. citrulli strains are divided into two major groups: group I strains have been generally isolated from melon and other non-watermelon cucurbits, while group II ... Read more >>

(Frontiers in microbiology)
[2019, 10:1400]

Cited: 2 times

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Frateuria defendens sp. nov., bacterium isolated from the yellows grapevine's disease vector Hyalesthes obsoletus.

Ofir Lidor, Diego Santos-Garcia, Netta Mozes-Daube, Vered Naor, Eyal Cohen, Lilach Iasur-Kruh, Ofir Bahar, Einat Zchori-Fein,

A Dyella-like bacterium was previously isolated from the planthopper Hyalesthes obsoletus (Hemiptera). Based on its 16S rRNA gene sequence, strain DHoT was assigned to the family Rhodanobacteraceae with Dyella and Frateuria as its closest relatives. The closest 16S rRNA gene sequences were Frateuria aurantia DSM 6220T (98.2 %), Dyella thiooxydans ATSB10T ... Read more >>

Int. J. Syst. Evol. Microbiol. (International journal of systematic and evolutionary microbiology)
[2019, 69(5):1281-1287]

Cited: 1 time

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Impact of Disease Duration in Effectiveness of Treatment with Levodopa-Carbidopa Intestinal Gel and Factors Leading to Discontinuation.

Ignacio Regidor, Diego Santos-García, Mar Ia José Catalán, Vıctor Puente, Francesc Valldeoriola, Francisco Grandas, Pablo Mir, Juan Carlos Parra, José Matías Arbelo,

BACKGROUND:Levodopa-carbidopa intestinal gel (LCIG) is effective in the treatment of advanced Parkinson's disease (PD). However, the patients' profile that might benefit from treatment with LCIG has not been characterized. OBJECTIVE:This retrospective study explored the influence of disease duration (DD) on the effectiveness of LCIG and identified factors associated with treatment ... Read more >>

J Parkinsons Dis (Journal of Parkinson's disease)
[2019, 9(1):173-182]

Cited: 1 time

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Genome Analysis of Haplotype D of Candidatus Liberibacter Solanacearum.

Leron Katsir, Ruan Zhepu, Diego Santos Garcia, Alon Piasezky, Jiandong Jiang, Noa Sela, Shiri Freilich, Ofir Bahar,

Candidatus Liberibacter solanacearum (Lso) haplotype D (LsoD) is a suspected bacterial pathogen, spread by the phloem-feeding psyllid Bactericera trigonica Hodkinson and found to infect carrot plants throughout the Mediterranean. Haplotype D is one of six haplotypes of Lso that each have specific and overlapping host preferences, disease symptoms, and psyllid ... Read more >>

(Frontiers in microbiology)
[2018, 9:2933]

Cited: 1 time

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Species-complex diversification and host-plant associations in Bemisia tabaci: A plant-defence, detoxification perspective revealed by RNA-Seq analyses.

Osnat Malka, Diego Santos-Garcia, Ester Feldmesser, Elad Sharon, Renate Krause-Sakate, Hélène Delatte, Sharon van Brunschot, Mitulkumar Patel, Paul Visendi, Habibu Mugerwa, Susan Seal, John Colvin, Shai Morin,

Insect-plant associations and their role in diversification are mostly studied in specialists. Here, we aimed to identify macroevolution patterns in the relationships between generalists and their host plants that have the potential to promote diversification. We focused on the Bemisia tabaci species complex containing more than 35 cryptic species. Mechanisms ... Read more >>

Mol Ecol (Molecular ecology)
[2018, 27(21):4241-4256]

Cited: 3 times

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To B or Not to B: Comparative Genomics Suggests Arsenophonus as a Source of B Vitamins in Whiteflies.

Diego Santos-Garcia, Ksenia Juravel, Shiri Freilich, Einat Zchori-Fein, Amparo Latorre, Andrés Moya, Shai Morin, Francisco J Silva,

Insect lineages feeding on nutritionally restricted diets such as phloem sap, xylem sap, or blood, were able to diversify by acquiring bacterial species that complement lacking nutrients. These bacteria, considered obligate/primary endosymbionts, share a long evolutionary history with their hosts. In some cases, however, these endosymbionts are not able to ... Read more >>

(Frontiers in microbiology)
[2018, 9:2254]

Cited: 6 times

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Modeling trophic dependencies and exchanges among insects' bacterial symbionts in a host-simulated environment.

Itai Opatovsky, Diego Santos-Garcia, Zhepu Ruan, Tamar Lahav, Shany Ofaim, Laurence Mouton, Valérie Barbe, Jiandong Jiang, Einat Zchori-Fein, Shiri Freilich,

BACKGROUND:Individual organisms are linked to their communities and ecosystems via metabolic activities. Metabolic exchanges and co-dependencies have long been suggested to have a pivotal role in determining community structure. In phloem-feeding insects such metabolic interactions with bacteria enable complementation of their deprived nutrition. The phloem-feeding whitefly Bemisia tabaci (Hemiptera: Aleyrodidae) ... Read more >>

BMC Genomics (BMC genomics)
[2018, 19(1):402]

Cited: 10 times

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To B or not to B: Arsenophonus as a source of B-vitamins in whiteflies

Diego Santos-Garcia, Ksenia Juravel, Shiri Freilich, Einat Zchori-Fein, Amparo Latorre, Andrés Moya, Shai Morin, Francisco Silva,

1 Abstract Insect lineages feeding on nutritionally restricted diets such as phloem, xylem, or blood, were able to diversify by acquiring bacterial species that complemented the missing nutrients. These bacteria, considered obligate/primary endosymbionts, share a long evolutionary history with their hosts. In some cases, however, these endosymbionts are not able ... Read more >>

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The All-Rounder Sodalis: A New Bacteriome-Associated Endosymbiont of the Lygaeoid Bug Henestaris halophilus (Heteroptera: Henestarinae) and a Critical Examination of Its Evolution.

Diego Santos-Garcia, Francisco J Silva, Shai Morin, Konrad Dettner, Stefan Martin Kuechler,

Hemipteran insects are well-known in their ability to establish symbiotic relationships with bacteria. Among them, heteropteran insects present an array of symbiotic systems, ranging from the most common gut crypt symbiosis to the more restricted bacteriome-associated endosymbiosis, which have only been detected in members of the superfamily Lygaeoidea and the ... Read more >>

Genome Biol Evol (Genome biology and evolution)
[2017, 9(10):2893-2910]

Cited: 6 times

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Tremblaya phenacola PPER: an evolutionary beta-gammaproteobacterium collage.

Rosario Gil, Carlos Vargas-Chavez, Sergio López-Madrigal, Diego Santos-García, Amparo Latorre, Andrés Moya,

Many insects rely on bacterial endosymbionts to obtain nutrients that are scarce in their highly specialized diets. The most surprising example corresponds to the endosymbiotic system found in mealybugs from subfamily Pseudococcinae in which two bacteria, the betaproteobacterium 'Candidatus Tremblaya princeps' and a gammaproteobacterium, maintain a nested endosymbiotic consortium. In ... Read more >>

ISME J (The ISME journal)
[2018, 12(1):124-135]

Cited: 4 times

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The genomic sequence of Exiguobacterium chiriqhucha str. N139 reveals a species that thrives in cold waters and extreme environmental conditions.

Ana Gutiérrez-Preciado, Carlos Vargas-Chávez, Mariana Reyes-Prieto, Omar F Ordoñez, Diego Santos-García, Tania Rosas-Pérez, Jorge Valdivia-Anistro, Eria A Rebollar, Andrés Saralegui, Andrés Moya, Enrique Merino, María Eugenia Farías, Amparo Latorre, Valeria Souza,

We report the genome sequence of Exiguobacterium chiriqhucha str. N139, isolated from a high-altitude Andean lake. Comparative genomic analyses of the Exiguobacterium genomes available suggest that our strain belongs to the same species as the previously reported E. pavilionensis str. RW-2 and Exiguobacterium str. GIC 31. We describe this species ... Read more >>

(PeerJ)
[2017, 5:e3162]

Cited: 2 times

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Modeling trophic dependencies and exchanges among insects’ bacterial symbionts in a host-simulated environment

Itai Opatovsky, Diego Santos-Garcia, Tamar Lahav, Shani Ofaim, Laurence Mouton, Valérie Barbe, Einat Zchori-Fein, Shiri Freilich,

Abstract Individual organisms are linked to their communities and ecosystems via metabolic activities. Metabolic exchanges and co-dependencies have long been suggested to have a pivotal role in determining community structure. Metabolic interactions with bacteria have been key drivers in the evolution of sap-feeding insects, enabling complementation of their deprived nutrition. ... Read more >>

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Exiguobacterium pavilionensis str. N139, a halotolerant, UV-B and metal resistant bacteria from a high-altitude Andean lake

Ana Gutiérrez-Preciado, Carlos Vargas-Chávez, Mariana Reyes-Prieto, Omar Ordoñez, Diego Santos-García, Tania Rosas-Pérez, Jorge Valdivia-Anistro, Eria Rebollar, Andrés Saralegui, Andrés Moya, Enrique Merino, María Eugenia Farías, Amparo Latorre, Valeria Souza,

We report the genome sequence of Exiguobacterium pavilionensis str. N139, isolated from a high-altitude Andean lake. The 2,952,588-bp genome contains one chromosome and three megaplasmids. The genome analysis suggests the presence of enzymes that confer E. pavilionensis str. N139 the ability to grow under multiple environmental extreme conditions, including high ... Read more >>

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Nature lessons: The whitefly bacterial endosymbiont is a minimal amino acid factory with unusual energetics.

Jorge Calle-Espinosa, Miguel Ponce-de-Leon, Diego Santos-Garcia, Francisco J Silva, Francisco Montero, Juli Peretó,

Reductive genome evolution is a universal phenomenon observed in endosymbiotic bacteria in insects. As the genome reduces its size and irreversibly losses coding genes, the functionalities of the cell system, including the energetics processes, are more restricted. Several energetic pathways can also be lost. How do these reduced metabolic networks ... Read more >>

J. Theor. Biol. (Journal of theoretical biology)
[2016, 407:303-317]

Cited: 3 times

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Long-term effectiveness of levodopa-carbidopa intestinal gel in 177 Spanish patients with advanced Parkinson's disease.

Francesc Valldeoriola, Francisco Grandas, Diego Santos-García, Ignacio Regidor, María José Catalán, José Matías Arbelo, Víctor Puente, Pablo Mir, Juan Carlos Parra,

To assess long-term effectiveness and tolerability of levodopa-carbidopa intestinal gel (LCIG) in Spanish patients with advanced Parkinson's disease.This was an observational, multicenter, cross-sectional, retrospective study.Data of 177 patients were analyzed. LCIG treatment led to a reduction in the percentage of daily 'off' time (16.2 vs 47.6% before LCIG), an increase ... Read more >>

Neurodegener Dis Manag (Neurodegenerative disease management)
[2016, 6(4):289-298]

Cited: 9 times

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Causes and factors related to dopamine agonist withdrawal in Parkinson's disease.

Ester Suárez Castro, Diego Santos-García, Teresa de Deus Fonticoba, Irene Expósito Ruíz, Cintia Tuñas Gesto, Mercedes Macías Arribí,

BACKGROUND:Although dopamine agonists (DAs) are useful in Parkinson's disease (PD), they are not frequently used in elderly patients due to adverse effects. However, there is a lack of evidence because few elderly PD patients are enrolled in clinical trials. AIMS OF THE STUDY:The aims of this study were to analyze ... Read more >>

Brain Behav (Brain and behavior)
[2016, 6(7):e00453]

Cited: 2 times

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Clinical management of patients with advanced Parkinson's disease treated with continuous intestinal infusion of levodopa/carbidopa.

Diego Santos García, Juan Carlos Martínez Castrillo, Víctor Puente Périz, Agustín Seoane Urgorri, Servando Fernández Díez, Vicente Benita León, Beatriz Udaeta Baldivieso, Antonia Campolongo Perillo, Natividad Mariscal Pérez,

Patients with Parkinson's disease often have a good initial response to dopaminergic therapy but later usually develop motor fluctuations and dyskinesia. In these patients, continuous infusion of levodopa-carbidopa intestinal gel (LCIG) allows for maintaining adequate dopamine levels and for improving motor and nonmotor symptoms, as well as quality of life ... Read more >>

Neurodegener Dis Manag (Neurodegenerative disease management)
[2016, 6(3):187-202]

Cited: 1 time

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