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Author Diego Robledo

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Development and Validation of an Open Access Snp Array for Nile Tilapia (Oreochromis niloticus).

Carolina Peñaloza, Diego Robledo, Agustin Barría, Trọng Q Trịnh, Mahirah Mahmuddin, Pamela Wiener, John A H Benzie, Ross D Houston,

Tilapia are amongst the most important farmed fish species worldwide, and are fundamental for the food security of many developing countries. Several genetically improved Nile tilapia (Oreochromis niloticus) strains exist, such as the iconic Genetically Improved Farmed Tilapia (GIFT), and breeding programmes typically follow classical pedigree-based selection. The use of ... Read more >>

G3 (Bethesda) (G3 (Bethesda, Md.))
[2020, :]

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Genetic control of Campylobacter colonisation in broiler chickens: genomic and transcriptomic characterisation

Androniki Psifidi, Andreas Kranis, Lisa Rothwell, Abi Bremner, Kay Russell, Diego Robledo, Stephen Bush, Mark Fife, Paul Hocking, Georgios Banos, David Hume, Jim Kaufman, Richard Bailey, Santiago Avendano, Kellie Watson, Pete Kaiser, Mark. Stevens,

Abstract Campylobacter is the leading cause of bacterial foodborne gastroenteritis in many countries. Source attribution studies unequivocally identify the handling or consumption of contaminated poultry meat as the primary risk factor. One potential strategy to control Campylobacter is to select poultry with increased resistance to colonisation. We conducted genomic and ... Read more >>

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The structural variation landscape in 492 Atlantic salmon genomes

Alicia Bertolotti, Ryan Layer, Manu Kumar Gundappa, Michael Gallagher, Ege Pehlivanoglu, Torfinn Nome, Diego Robledo, Matthew Kent, Line Røsæg, Matilde Holen, Teshome Mulugeta, Thomas Ashton, Kjetil Hindar, Harald Sægrov, Bjørn Florø-Larsen, Jaakko Erkinaro, Craig Primmer, Louis Bernatchez, Samuel A.M. Martin, Ian Johnston, Simen Sandve, Sigbjørn Lien, Daniel Macqueen,

Abstract Structural variants (SVs) are a major source of genetic and phenotypic variation, but remain challenging to accurately type and are hence poorly characterized in most species. We present an approach for reliable SV discovery in non-model species using whole genome sequencing and report 15,483 high-confidence SVs in 492 Atlantic ... Read more >>

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Harnessing genomics to fast-track genetic improvement in aquaculture.

Ross D Houston, Tim P Bean, Daniel J Macqueen, Manu Kumar Gundappa, Ye Hwa Jin, Tom L Jenkins, Sarah Louise C Selly, Samuel A M Martin, Jamie R Stevens, Eduarda M Santos, Andrew Davie, Diego Robledo,

Aquaculture is the fastest-growing farmed food sector and will soon become the primary source of fish and shellfish for human diets. In contrast to crop and livestock production, aquaculture production is derived from numerous, exceptionally diverse species that are typically in the early stages of domestication. Genetic improvement of production ... Read more >>

Nat. Rev. Genet. (Nature reviews. Genetics)
[2020, 21(7):389-409]

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Inhibition of Gamma-Secretase Promotes Axon Regeneration After a Complete Spinal Cord Injury.

Daniel Sobrido-Cameán, Diego Robledo, Daniel Romaus-Sanjurjo, Vanessa Pérez-Cedrón, Laura Sánchez, María Celina Rodicio, Antón Barreiro-Iglesias,

In a recent study, we showed that GABA and baclofen (a GABAB receptor agonist) inhibit caspase activation and promote axon regeneration in descending neurons of the sea lamprey brainstem after a complete spinal cord injury (Romaus-Sanjurjo et al., 2018a). Now, we repeated these treatments and performed 2 independent Illumina RNA-Sequencing ... Read more >>

Front Cell Dev Biol (Frontiers in cell and developmental biology)
[2020, 8:173]

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Major gene expression changes and epigenetic remodelling in Nile tilapia muscle after just one generation of domestication.

Ioannis Konstantinidis, Pål Sætrom, Robin Mjelle, Artem V Nedoluzhko, Diego Robledo, Jorge M O Fernandes,

The historically recent domestication of fishes has been essential to meet the protein demands of a growing human population. Selection for traits of interest during domestication is a complex process whose epigenetic basis is poorly understood. Cytosine hydroxymethylation is increasingly recognized as an important DNA modification involved in epigenetic regulation. ... Read more >>

Epigenetics (Epigenetics)
[2020, :1-16]

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Characterising the mechanisms underlying genetic resistance to amoebic gill disease in Atlantic salmon using RNA sequencing.

Diego Robledo, Alastair Hamilton, Alejandro P Gutiérrez, James E Bron, Ross D Houston,

BACKGROUND:Gill health is one of the main concerns for Atlantic salmon aquaculture, and Amoebic Gill Disease (AGD), attributable to infection by the amoeba Neoparamoeba perurans, is a frequent cause of morbidity. In the absence of preventive measures, increasing genetic resistance of salmon to AGD via selective breeding can reduce the ... Read more >>

BMC Genomics (BMC genomics)
[2020, 21(1):271]

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Genomic Prediction Using Low Density Marker Panels in Aquaculture: Performance Across Species, Traits, and Genotyping Platforms.

Christina Kriaridou, Smaragda Tsairidou, Ross D Houston, Diego Robledo,

Genomic selection increases the rate of genetic gain in breeding programs, which results in significant cumulative improvements in commercially important traits such as disease resistance. Genomic selection currently relies on collecting genome-wide genotype data accross a large number of individuals, which requires substantial economic investment. However, global aquaculture production predominantly ... Read more >>

Front Genet (Frontiers in genetics)
[2020, 11:124]

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New insights into the Manila clam - Perkinsus olseni interaction based on gene expression analysis of clam hemocytes and parasite trophozoites through in vitro challenges.

Abul Farah Md Hasanuzzaman, Asunción Cao, Paolo Ronza, Sergio Fernández-Boo, Juan Andrés Rubiolo, Diego Robledo, Antonio Gómez-Tato, Jose Antonio Alvarez-Dios, Belén G Pardo, Antonio Villalba, Paulino Martínez,

The Manila clam (Ruditapes philippinarum) is the bivalve species with the highest global production from both fisheries and aquaculture, but its production is seriously threatened by perkinsosis, a disease caused by the protozoan parasite Perkinsus olseni. To understand the molecular mechanisms underlying R. philippinarum-P. olseni interactions, we analysed the gene ... Read more >>

Int. J. Parasitol. (International journal for parasitology)
[2020, 50(3):195-208]

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Optimizing Low-Cost Genotyping and Imputation Strategies for Genomic Selection in Atlantic Salmon.

Smaragda Tsairidou, Alastair Hamilton, Diego Robledo, James E Bron, Ross D Houston,

Genomic selection enables cumulative genetic gains in key production traits such as disease resistance, playing an important role in the economic and environmental sustainability of aquaculture production. However, it requires genome-wide genetic marker data on large populations, which can be prohibitively expensive. Genotype imputation is a cost-effective method for obtaining ... Read more >>

G3 (Bethesda) (G3 (Bethesda, Md.))
[2020, 10(2):581-590]

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Genomic prediction using low density marker panels in aquaculture: performance across species, traits, and genotyping platforms

Christina Kriaridou, Smaragda Tsairidou, Ross Houston, Diego Robledo,

ABSTRACT Genomic selection increases the rate of genetic gain in breeding programmes, which results in significant cumulative improvements in commercially important traits such as disease resistance. Genomic selection currently relies on collecting genome-wide genotype data accross a large number of individuals which requires substantial economic investment. However, global aquaculture production ... Read more >>

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Multiple evidences suggest sox2 as the main driver of a young and complex sex determining ZW/ZZ system in turbot (Scophthalmus maximus)

Paulino Martínez, Diego Robledo, Xoana Taboada, Andrés Blanco, Antonio Gómez-Tato, Blanca Álvarez-Blázquez, Santiago Cabaleiro, Francesc Piferrer, Carmen Bouza, Ana Viñas,

ABSTRACT A major challenge in evolutionary biology is to find an explanation for the variation in sex-determining (SD) systems across taxa and to understand the mechanisms driving sex chromosome differentiation. We studied the turbot, holding a ZW/ZZ SD system and no sex chromosome heteromorphism, by combining classical genetics and genomics ... Read more >>

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Characterising the mechanisms underlying genetic resistance to amoebic gill disease in Atlantic salmon using RNA sequencing

Diego Robledo, Alastair Hamilton, Alejandro Gutiérrez, James Bron, Ross Houston,

ABSTRACT Background Gill health is one of the main concerns for Atlantic salmon aquaculture, and Amoebic Gill Disease (AGD), attributable to infection by the amoeba Neoparamoeba perurans , is a frequent cause of morbidity. In the absence of preventive measures, increasing genetic resistance of salmon to AGD via selective breeding ... Read more >>

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Serotonin inhibits axonal regeneration of identifiable descending neurons after a complete spinal cord injury in lampreys.

Daniel Sobrido-Cameán, Diego Robledo, Laura Sánchez, María Celina Rodicio, Antón Barreiro-Iglesias,

Classical neurotransmitters are mainly known for their roles as neuromodulators, but they also play important roles in the control of developmental and regenerative processes. Here, we used the lamprey model of spinal cord injury to study the effect of serotonin in axon regeneration at the level of individually identifiable descending ... Read more >>

Dis Model Mech (Disease models & mechanisms)
[2019, 12(2):]

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Discovery and Functional Annotation of Quantitative Trait Loci Affecting Resistance to Sea Lice in Atlantic Salmon.

Diego Robledo, Alejandro P Gutiérrez, Agustín Barría, Jean P Lhorente, Ross D Houston, José M Yáñez,

Sea lice (Caligus rogercresseyi) are ectoparasitic copepods which have a large negative economic and welfare impact in Atlantic salmon (Salmo salar) aquaculture, particularly in Chile. A multi-faceted prevention and control strategy is required to tackle lice, and selective breeding contributes via cumulative improvement of host resistance to the parasite. While ... Read more >>

Front Genet (Frontiers in genetics)
[2019, 10:56]

Cited: 2 times

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Corrigendum: Integrating Genomic and Morphological Approaches in Fish Pathology Research: The Case of Turbot (Scophthalmus Maximus) Enteromyxosis.

Paolo Ronza, Diego Robledo, Roberto Bermúdez, Ana Paula Losada, Belén G Pardo, Paulino Martínez, María Isabel Quiroga,

[This corrects the article DOI: 10.3389/fgene.2019.00026.]. ... Read more >>

Front Genet (Frontiers in genetics)
[2019, 10:225]

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Integrating Genomic and Morphological Approaches in Fish Pathology Research: The Case of Turbot (Scophthalmus maximus) Enteromyxosis.

Paolo Ronza, Diego Robledo, Roberto Bermúdez, Ana Paula Losada, Belén G Pardo, Paulino Martínez, María Isabel Quiroga,

Enteromyxosis, caused by Enteromyxum scophthalmi, is one of the most devastating diseases stemming from myxozoan parasites in turbot (Scophthalmus maximus L.), being a limiting factor for its production. The disease develops as a cachectic syndrome, associated to catarrhal enteritis and leukocytic depletion, with morbidity and mortality rates usually reaching 100%. ... Read more >>

Front Genet (Frontiers in genetics)
[2019, 10:26]

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CTCs-derived xenograft development in a triple negative breast cancer case.

Tais Pereira-Veiga, Manuel Abreu, Diego Robledo, Xavier Matias-Guiu, María Santacana, Laura Sánchez, Juan Cueva, Patricia Palacios, Ihab Abdulkader, Rafael López-López, Laura Muinelo-Romay, Clotilde Costa,

Triple-negative breast cancer (TNBC) is characterized by high rates of metastasis and no available molecular targets. CTCs derived xenografts (CDX) have demonstrated to be a promising tool for understanding cancer biology. In our study, a CDX from a TNBC patient was developed for the first time. After CDX characterization, WNT ... Read more >>

Int. J. Cancer (International journal of cancer)
[2019, 144(9):2254-2265]

Cited: 2 times

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Mapping and Sequencing of a Significant Quantitative Trait Locus Affecting Resistance to Koi Herpesvirus in Common Carp.

Christos Palaiokostas, Diego Robledo, Tomas Vesely, Martin Prchal, Dagmar Pokorova, Veronika Piackova, Lubomir Pojezdal, Martin Kocour, Ross D Houston,

Cyprinids are the most highly produced group of fishes globally, with common carp being one of the most valuable species of the group. Koi herpesvirus (KHV) infections can result in high levels of mortality, causing major economic losses, and is listed as a notifiable disease by the World Organization for ... Read more >>

G3 (Bethesda) (G3 (Bethesda, Md.))
[2018, 8(11):3507-3513]

Cited: 2 times

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Balancing selection at a premature stop mutation in the myostatin gene underlies a recessive leg weakness syndrome in pigs

Oswald Matika, Diego Robledo, Ricardo Pong-Wong, Stephen Bishop, Valentina Riggio, Heather Finlayson, Natalie Lowe, Annabelle Hoste, Grant Walling, Alan Archibald, John Woolliams, Ross Houston,

ABSTRACT Balancing selection provides a plausible explanation for the maintenance of deleterious alleles at moderate frequency in livestock, including lethal recessives exhibiting heterozygous advantage in carriers. In the current study, a leg weakness syndrome causing mortality of piglets in a commercial line showed monogenic recessive inheritance, and a region on ... Read more >>

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SNP markers for the genetic characterization of Mexican shrimp broodstocks.

Ricardo Perez-Enriquez, Diego Robledo, Ross D Houston, Raúl Llera-Herrera,

Selective breeding of shrimp has major potential to enhance production traits, including growth and disease resistance. Genetic characterization of broodstock populations is a key element of breeding programs, as it enables decisions on inbreeding restrictions, family structure, and the potential use of genomic selection. Single Nucleotide Polymorphisms (SNPs) are suitable ... Read more >>

Genomics (Genomics)
[2018, 110(6):423-429]

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Discovery and functional annotation of quantitative trait loci affecting resistance to sea lice in Atlantic salmon

Diego Robledo, Alejandro Gutiérrez, Agustín Barría, Jean Lhorente, Ross Houston, José Yáñez,

ABSTRACT Sea lice ( Caligus rogercresseyi ) are ectoparasitic copepods which have a large negative economic and welfare impact in Atlantic salmon ( Salmo salar ) aquaculture, particularly in Chile. A multi-faceted prevention and control strategy is required to tackle lice, and selective breeding contributes via cumulative improvement of host ... Read more >>

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Gene Expression Response to Sea Lice in Atlantic Salmon Skin: RNA Sequencing Comparison Between Resistant and Susceptible Animals.

Diego Robledo, Alejandro P Gutiérrez, Agustín Barría, José M Yáñez, Ross D Houston,

Sea lice are parasitic copepods that cause large economic losses to salmon aquaculture worldwide. Frequent chemotherapeutic treatments are typically required to control this parasite, and alternative measures such as breeding for improved host resistance are desirable. Insight into the host-parasite interaction and mechanisms of host resistance can lead to improvements ... Read more >>

Front Genet (Frontiers in genetics)
[2018, 9:287]

Cited: 3 times

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Genome-Wide Association and Genomic Selection for Resistance to Amoebic Gill Disease in Atlantic Salmon.

Diego Robledo, Oswald Matika, Alastair Hamilton, Ross D Houston,

Amoebic gill disease (AGD) is one of the largest threats to salmon aquaculture, causing serious economic and animal welfare burden. Treatments can be expensive and environmentally damaging, hence the need for alternative strategies. Breeding for disease resistance can contribute to prevention and control of AGD, providing long-term cumulative benefits in ... Read more >>

G3 (Bethesda) (G3 (Bethesda, Md.))
[2018, 8(4):1195-1203]

Cited: 12 times

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Serotonin inhibits axonal regeneration of identifiable descending neurons after a complete spinal cord injury in lampreys

Daniel Sobrido-Cameán, Diego Robledo, Laura Sánchez, María Celina Rodicio, Antón Barreiro-Iglesias,

Summary Classical neurotransmitters are mainly known for their roles as neuromodulators, but they also play important roles in the control of developmental and regenerative processes. Here, we used the lamprey model of spinal cord injury to study the effect of serotonin in axon regeneration at the level of individually identifiable ... Read more >>

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