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Author Diederik W J Dippel

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Effect of Video Discharge Instructions for Patients With Mild Traumatic Brain Injury in the Emergency Department: A Randomized Controlled Trial.

Amber E Hoek, Marieke Joosten, Diederik W J Dippel, Ed F van Beeck, Leandra van den Hengel, Björn Dijkstra, Dafni Papathanasiou, Daphne van Rijssel, Maaike van den Hamer, Stephanie C E Schuit, Alex Burdorf, Juanita A Haagsma, Pleunie P M Rood,

<h4>Study objective</h4>We measure the effect of video discharge instructions on postconcussion symptoms in patients with mild traumatic brain injury in the emergency department.<h4>Methods</h4>A multicenter randomized controlled trial was conducted in which patients with mild traumatic brain injury were randomly assigned to either intervention (verbal, written, and video discharge information) or ... Read more >>

Ann Emerg Med (Annals of emergency medicine)
[2021, 77(3):327-337]

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MR CLEAN-LATE, a multicenter randomized clinical trial of endovascular treatment of acute ischemic stroke in The Netherlands for late arrivals: study protocol for a randomized controlled trial.

F A V Anne Pirson, Wouter H Hinsenveld, Robert-Jan B Goldhoorn, Julie Staals, Inger R de Ridder, Wim H van Zwam, Marianne A A van Walderveen, Geert J Lycklama À Nijeholt, Maarten Uyttenboogaart, Wouter J Schonewille, Aad van der Lugt, Diederik W J Dippel, Yvo B W E M Roos, Charles B L M Majoie, Robert J van Oostenbrugge, ,

<h4>Background</h4>Endovascular therapy (EVT) for acute ischemic stroke due to proximal occlusion of the anterior intracranial circulation, started within 6 h from symptom onset, has been proven safe and effective. Recently, EVT has been proven effective beyond the 6-h time window in a highly selected population using CT perfusion or MR diffusion. ... Read more >>

Trials (Trials)
[2021, 22(1):160]

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Advanced consent for acute stroke trials - Authors' reply.

Jeroen T J M van Dijck, Erwin J O Kompanje, Paul J Nederkoorn, Wilco C Peul, Diederik W J Dippel,

Lancet Neurol (The Lancet. Neurology)
[2021, 20(3):170-171]

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Endovascular Treatment for Acute Ischemic Stroke in Children: Experience From the MR CLEAN Registry.

Adriaan C G M van Es, Maayke A W Hunfeld, Ido van den Wijngaard, Ulrike Kraemer, Marc Engelen, Boudewijn A A M van Hasselt, Puck S S Fransen, Diederik W J Dippel, Charles B L M Majoie, Aad van der Lugt, Bart J Emmer, ,

<h4>Background and purpose</h4>Multiple trials have shown the efficacy and safety of endovascular therapy (EVT) of acute ischemic stroke in adults. Trials in children are lacking and only case reports and case series exist. However, the long-term outcome of children with acute ischemic stroke can be devastating with significant mortality and ... Read more >>

Stroke (Stroke)
[2021, 52(3):781-788]

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MR CLEAN-NO IV: intravenous treatment followed by endovascular treatment versus direct endovascular treatment for acute ischemic stroke caused by a proximal intracranial occlusion-study protocol for a randomized clinical trial.

Kilian M Treurniet, Natalie E LeCouffe, Manon Kappelhof, Bart J Emmer, Adriaan C G M van Es, Jelis Boiten, Geert J Lycklama, Koos Keizer, Lonneke S F Yo, Hester F Lingsma, Wim H van Zwam, Inger de Ridder, Robert J van Oostenbrugge, Aad van der Lugt, Diederik W J Dippel, Jonathan M Coutinho, Yvo B W E M Roos, Charles B L M Majoie, ,

<h4>Background</h4>Endovascular treatment (EVT) has greatly improved the prognosis of acute ischemic stroke (AIS) patients with a proximal intracranial large vessel occlusion (LVO) of the anterior circulation. Currently, there is clinical equipoise concerning the added benefit of intravenous alteplase administration (IVT) prior to EVT. The aim of this study is to ... Read more >>

Trials (Trials)
[2021, 22(1):141]

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Safety and efficacy of intra-arterial fibrinolytics as adjunct to mechanical thrombectomy: a systematic review and meta-analysis of observational data.

Johannes Kaesmacher, Thomas Raphael Meinel, Christoph Kurmann, Osama O Zaidat, Alicia C Castonguay, Syed F Zaidi, Nils Mueller-Kronast, Manon Kappelhof, Diederik W J Dippel, Marc Soudant, Serge Bracard, Michael D Hill, Mayank Goyal, Daniel Strbian, Daniel M Heiferman, William Ashley, Mohammad Anadani, Alejandro M Spiotta, Tomas Dobrocky, Eike I Piechowiak, Marcel Arnold, Martina Goeldlin, David Seiffge, Pascal J Mosimann, Pasquale Mordasini, Jan Gralla, Urs Fischer,

<h4>Background</h4>Achieving the best possible reperfusion is a key determinant of clinical outcome after mechanical thrombectomy (MT). However, data on the safety and efficacy of intra-arterial (IA) fibrinolytics as an adjunct to MT with the intention to improve reperfusion are sparse.<h4>Methods</h4>We performed a PROSPERO-registered (CRD42020149124) systematic review and meta-analysis accessing MEDLINE, ... Read more >>

J Neurointerv Surg (Journal of neurointerventional surgery)
[2021, :]

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Quantified health and cost effects of faster endovascular treatment for large vessel ischemic stroke patients in the Netherlands.

Henk van Voorst, Wolfgang G Kunz, Lucie A van den Berg, Manon Kappelhof, Floor M E Pinckaers, Mayank Goyal, Myriam G M Hunink, Bart Emmer, Maxim Johan Heymen Laurence Mulder, Diederik W J Dippel, J M Coutinho, Henk A Marquering, Hieronymus D Boogaarts, Aad van der Lugt, Wim H van Zwam, Yvo B W E M Roos, Erik Buskens, Marcel G W Dijkgraaf, Charles B L M Majoie, ,

<h4>Background</h4>The effectiveness of endovascular treatment (EVT) for large vessel occlusion (LVO) stroke severely depends on time to treatment. However, it remains unclear what the value of faster treatment is in the years after index stroke. The aim of this study was to quantify the value of faster EVT in terms ... Read more >>

J Neurointerv Surg (Journal of neurointerventional surgery)
[2021, :]

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Comparison of eight prehospital stroke scales to detect intracranial large-vessel occlusion in suspected stroke (PRESTO): a prospective observational study.

Martijne H C Duvekot, Esmee Venema, Anouk D Rozeman, Walid Moudrous, Frédérique H Vermeij, Marileen Biekart, Hester F Lingsma, Lisette Maasland, Annemarie D Wijnhoud, Laus J M M Mulder, Kees C L Alblas, Roeland P J van Eijkelenburg, Bianca I Buijck, Jeannette Bakker, Aarnout S Plaisier, Jan-Hein Hensen, Geert J Lycklama À Nijeholt, Pieter Jan van Doormaal, Adriaan C G M van Es, Aad van der Lugt, Henk Kerkhoff, Diederik W J Dippel, Bob Roozenbeek, ,

<h4>Background</h4>Due to the time-sensitive effect of endovascular treatment, rapid prehospital identification of large-vessel occlusion in individuals with suspected stroke is essential to optimise outcome. Interhospital transfers are an important cause of delay of endovascular treatment. Prehospital stroke scales have been proposed to select patients with large-vessel occlusion for direct transport ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2021, 20(3):213-221]

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Monocytes carrying GFAP detect glioma, brain metastasis and ischaemic stroke, and predict glioblastoma survival.

Wouter B L van den Bossche, Arnaud J P E Vincent, Cristina Teodosio, Jeroen Koets, Aladdin Taha, Anne Kleijn, Sandra de Bruin, Willem A Dik, Daniela Damasceno, Julia Almeida, Diederik W J Dippel, Clemens M F Dirven, Alberto Orfao, Martine L M Lamfers, Jacques J M van Dongen, ,

Diagnosis and monitoring of primary brain tumours, brain metastasis and acute ischaemic stroke all require invasive, burdensome and costly diagnostics, frequently lacking adequate sensitivity, particularly during disease monitoring. Monocytes are known to migrate to damaged tissues, where they act as tissue macrophages, continuously scavenging, phagocytizing and digesting apoptotic cells and ... Read more >>

Brain Commun (Brain communications)
[2021, 3(1):fcaa215]

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Importance of Occlusion Site for Thrombectomy Technique in Stroke: Comparison Between Aspiration and Stent Retriever.

Marie Louise E Bernsen, Robert-Jan B Goldhoorn, Hester F Lingsma, Robert J van Oostenbrugge, Wim H van Zwam, Maarten Uyttenboogaart, Yvo B W E M Roos, Jasper M Martens, Jeannette Hofmeijer, ,

<h4>Background and purpose</h4>Thrombectomy with stent retriever and direct aspiration are equally effective in the endovascular treatment of anterior circulation acute ischemic stroke. We report efficacy and safety of initial treatment technique per occlusion segment.<h4>Methods</h4>For this study, we analyzed data from the MR CLEAN Registry, a prospective, observational study in all ... Read more >>

Stroke (Stroke)
[2021, 52(1):80-90]

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Ordinal outcome analysis improves the detection of between-hospital differences in outcome.

I E Ceyisakar, N van Leeuwen, Diederik W J Dippel, Ewout W Steyerberg, H F Lingsma,

<h4>Background</h4>There is a growing interest in assessment of the quality of hospital care, based on outcome measures. Many quality of care comparisons rely on binary outcomes, for example mortality rates. Due to low numbers, the observed differences in outcome are partly subject to chance. We aimed to quantify the gain ... Read more >>

BMC Med Res Methodol (BMC medical research methodology)
[2021, 21(1):4]

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Outcome Prediction after Moderate and Severe Traumatic Brain Injury: External Validation of Two Established Prognostic Models in 1742 European Patients.

Simone A Dijkland, Isabel R A Retel Helmrich, Daan Nieboer, Mathieu van der Jagt, Diederik W J Dippel, David K Menon, Nino Stocchetti, Andrew I R Maas, Hester F Lingsma, Ewout W Steyerberg, ,

The International Mission on Prognosis and Analysis of Clinical Trials in Traumatic Brain Injury (IMPACT) and Corticoid Randomisation After Significant Head injury (CRASH) prognostic models predict functional outcome after moderate and severe traumatic brain injury (TBI). We aimed to assess their performance in a contemporary cohort of patients across Europe. ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2020, :]

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Computed Tomography Perfusion-Based Machine Learning Model Better Predicts Follow-Up Infarction in Patients With Acute Ischemic Stroke.

Hulin Kuang, Wu Qiu, Anna M Boers, Scott Brown, Keith Muir, Charles B L M Majoie, Diederik W J Dippel, Phil White, Jonathan Epstein, Peter J Mitchell, Antoni Dávalos, Serge Bracard, Bruce Campbell, Jeffrey L Saver, Tudor G Jovin, Marta Rubiera, Alexander V Khaw, Jai J Shankar, Enrico Fainardi, Michael D Hill, Andrew M Demchuk, Mayank Goyal, Bijoy K Menon,

<h4>Background and purpose</h4>Prediction of infarct extent among patients with acute ischemic stroke using computed tomography perfusion is defined by predefined discrete computed tomography perfusion thresholds. Our objective is to develop a threshold-free computed tomography perfusion-based machine learning (ML) model to predict follow-up infarct in patients with acute ischemic stroke.<h4>Methods</h4>Sixty-eight patients ... Read more >>

Stroke (Stroke)
[2021, 52(1):223-231]

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Added Prognostic Value of Hemorrhagic Transformation Quantification in Patients With Acute Ischemic Stroke.

Katinka R van Kranendonk, Kilian M Treurniet, Anna M M Boers, Olvert A Berkhemer, Jonathan M Coutinho, Hester F Lingsma, Wim H van Zwam, Aad van der Lugt, Robert J van Oostenbrugge, Diederik W J Dippel, Yvo B W E M Roos, Henk A Marquering, Charles B L M Majoie, ,

<b>Introduction and Aim:</b> Hemorrhagic transformation (HT) frequently occurs after acute ischemic stroke and negatively influences the functional outcome. Usually, HT is classified by its radiological appearance. Discriminating between the subtypes can be complicated, and interobserver variation is considerable. Therefore, we aim to quantify rather than classify hemorrhage volumes and determine ... Read more >>

Front Neurol (Frontiers in neurology)
[2020, 11:582767]

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Improving the Delivery of High-Quality Reperfusion Therapy in the United States.

Diederik W J Dippel,

Stroke (Stroke)
[2020, 51(12):3492-3494]

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Improving quality of stroke care through benchmarking center performance: why focusing on outcomes is not enough.

Marzyeh Amini, Nikki van Leeuwen, Frank Eijkenaar, Maxim J H L Mulder, Wouter Schonewille, Geert Lycklama À Nijeholt, Wouter H Hinsenveld, Robert-Jan B Goldhoorn, Pieter Jan van Doormaal, Sjoerd Jenniskens, Jan Hazelzet, Diederik W J Dippel, Bob Roozenbeek, Hester F Lingsma, ,

<h4>Background</h4>Between-center variation in outcome may offer opportunities to identify variation in quality of care. By intervening on these quality differences, patient outcomes may be improved. However, whether observed differences in outcome reflect the true quality improvement potential is not known for many diseases. Therefore, we aimed to analyze the effect ... Read more >>

BMC Health Serv Res (BMC health services research)
[2020, 20(1):998]

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Combined Effect of Age and Baseline Alberta Stroke Program Early Computed Tomography Score on Post-Thrombectomy Clinical Outcomes in the MR CLEAN Registry.

Johanna Ospel, Manon Kappelhof, Adrien E Groot, Natalie E LeCouffe, Jonathan M Coutinho, Albert J Yoo, Lonneke S F Yo, Ludo F M Beenen, Wim H van Zwam, Aad van der Lugt, Alida A Postma, Yvo B W E M Roos, Mayank Goyal, Charles B L M Majoie, ,

<h4>Background and purpose</h4>Ischemic brain tissue damage in patients with acute ischemic stroke, as measured by the Alberta Stroke Program Early CT Score (ASPECTS) may be more impactful in older than in younger patients, although this has not been studied. We aimed to investigate a possible interaction effect between age and ... Read more >>

Stroke (Stroke)
[2020, 51(12):3742-3745]

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Association of White Matter Lesions and Outcome After Endovascular Stroke Treatment.

Sven P R Luijten, Daniel Bos, Kars C J Compagne, Lennard Wolff, Charles B L M Majoie, Yvo B W E M Roos, Wim H van Zwam, Robert J van Oostenbrugge, Diederik W J Dippel, Aad van der Lugt, Adriaan C G M van Es, ,

<h4>Objective</h4>To investigate the association between white matter lesions (WML) and functional outcome in patients with acute ischemic stroke (AIS) and the modification of the effect of endovascular treatment (EVT) by WML.<h4>Methods</h4>We used data from the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands (MR ... Read more >>

Neurology (Neurology)
[2021, 96(3):e333-e342]

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Admission Blood Pressure in Relation to Clinical Outcomes and Successful Reperfusion After Endovascular Stroke Treatment.

Sophie A van den Berg, Simone M Uniken Venema, Maxim J H L Mulder, Kilian M Treurniet, Noor Samuels, Hester F Lingsma, Robert-Jan B Goldhoorn, Ivo G H Jansen, Jonathan M Coutinho, Bob Roozenbeek, Diederik W J Dippel, Yvo B W E M Roos, H Bart van der Worp, Paul J Nederkoorn, ,

<h4>Background and purpose</h4>Optimal blood pressure (BP) targets before endovascular treatment (EVT) for acute ischemic stroke are unknown. We aimed to assess the relation between admission BP and clinical outcomes and successful reperfusion after EVT.<h4>Methods</h4>We used data from the MR CLEAN (Multicenter Randomized Controlled Trial of Endovascular Treatment for Acute Ischemic ... Read more >>

Stroke (Stroke)
[2020, 51(11):3205-3214]

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Informed consent procedures for emergency interventional research in patients with traumatic brain injury and ischaemic stroke.

Erwin J O Kompanje, Jeroen T J M van Dijck, Vicky Chalos, Sophie A van den Berg, Paula M Janssen, Paul J Nederkoorn, Mathieu van der Jagt, Giuseppe Citerio, Nino Stocchetti, Diederik W J Dippel, Wilco C Peul,

Health-care professionals and researchers have a legal and ethical responsibility to inform patients before carrying out diagnostic tests or treatment interventions as part of a clinical study. Interventional research in emergency situations can involve patients with some degree of acute cognitive impairment, as is regularly the case in traumatic brain ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2020, 19(12):1033-1042]

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Blood Pressure During Endovascular Treatment Under Conscious Sedation or Local Anesthesia.

Noor Samuels, Rob A van de Graaf, Carlijn A L van den Berg, Daan Nieboer, Ismail Eralp, Kilian M Treurniet, Bart J Emmer, Rogier V Immink, Charles B L M Majoie, Wim H van Zwam, Reinoud P H Bokkers, Maarten Uyttenboogaart, Boudewijn A A M van Hasselt, Jörg Mühling, James F Burke, Bob Roozenbeek, Aad van der Lugt, Diederik W J Dippel, Hester F Lingsma, Adriaan C G M van Es, ,

<h4>Objective</h4>To evaluate the role of blood pressure (BP) as mediator of the effect of conscious sedation (CS) compared to local anesthesia (LA) on functional outcome after endovascular treatment (EVT).<h4>Methods</h4>Patients treated in the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands (MR CLEAN) Registry centers ... Read more >>

Neurology (Neurology)
[2021, 96(2):e171-e181]

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Thrombectomy for acute ischemic stroke patients with isolated distal internal carotid artery occlusion: a retrospective observational study.

Jan W Hoving, Manon Kappelhof, Mark Schembri, Bart J Emmer, Olvert A Berkhemer, Adrien E D Groot, Diederik W J Dippel, Wim H van Zwam, Jonathan M Coutinho, Henk A Marquering, Charles B L M Majoie, René van den Berg, ,

<h4>Purpose</h4>Acute stroke patients presenting with a distal internal carotid artery occlusion and patent carotid terminus, allowing for collateral flow via the circle of Willis, may have a more favorable natural history. Therefore, benefit of endovascular treatment (EVT) is less evident. We performed an exploratory analysis of EVT results compared to ... Read more >>

Neuroradiology (Neuroradiology)
[2020, :]

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Prehospital Triage Strategies for the Transportation of Suspected Stroke Patients in the United States.

Esmee Venema, James F Burke, Bob Roozenbeek, Jason Nelson, Hester F Lingsma, Diederik W J Dippel, David M Kent,

<h4>Background and purpose</h4>Ischemic stroke patients with large vessel occlusion (LVO) could benefit from direct transportation to an intervention center for endovascular treatment, but non-LVO patients need rapid IV thrombolysis in the nearest center. Our aim was to evaluate prehospital triage strategies for suspected stroke patients in the United States.<h4>Methods</h4>We used ... Read more >>

Stroke (Stroke)
[2020, 51(11):3310-3319]

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Public health and cost consequences of time delays to thrombectomy for acute ischemic stroke.

Wolfgang G Kunz, Myriam G Hunink, Mohammed A Almekhlafi, Bijoy K Menon, Jeffrey L Saver, Diederik W J Dippel, Charles B L M Majoie, Tudor G Jovin, Antoni Davalos, Serge Bracard, Francis Guillemin, Bruce C V Campbell, Peter J Mitchell, Philip White, Keith W Muir, Scott Brown, Andrew M Demchuk, Michael D Hill, Mayank Goyal, ,

<h4>Objective</h4>To determine public health and cost consequences of time delays to endovascular thrombectomy (EVT) for patients, health care systems, and society, we estimated quality-adjusted life-years (QALYs) of EVT-treated patients and associated costs based on times to treatment.<h4>Methods</h4>The Markov model analysis was performed from US health care and societal perspectives over ... Read more >>

Neurology (Neurology)
[2020, 95(18):e2465-e2475]

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Effect of age and baseline ASPECTS on outcomes in large-vessel occlusion stroke: results from the HERMES collaboration.

Johanna Maria Ospel, Manon Kappelhof, Nima Kashani, Bijoy K Menon, Bruce C V Campbell, Luis San Roman, Andrew M Demchuk, Diederik W J Dippel, Jeffrey L Saver, Tudor G Jovin, Peter Mitchell, Serge Bracard, Keith Muir, Phil White, Francis Guillemin, Charles B L M Majoie, Michael D Hill, Scott Brown, Mayank Goyal, ,

<h4>Background</h4>Patient age and baseline Alberta Stroke Program Early CT score (ASPECTS) are both independent predictors of outcome in acute ischemic stroke patients treated with endovascular therapy (EVT). We assessed the combined effect of age and ASEPCTS on clinical outcome in acute ischemic stroke patients with LVO with and without EVT, ... Read more >>

J Neurointerv Surg (Journal of neurointerventional surgery)
[2020, :]

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