Full Text Journal Articles by
Author Diclehan Orhan

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Adrenocortical tumours in children: a review of surgical management at a tertiary care centre.

Burak Ardicli, Idil R User, Arbay O Ciftci, Canan Akyuz, Mustafa T Kutluk, Bilgehan Yalcin, Nazli Gonc, Zeynep A Ozon, Ayfer Alikasifoglu, Berna Oguz, Mithat Haliloglu, Diclehan Orhan, Feridun C Tanyel, Ibrahim Karnak, Saniye Ekinci,

Adrenocortical tumours (ACT) are rare tumours of childhood usually presenting with endocrine dysfunction. This retrospective study is designed to review our institutional experience in surgical management. Records of children treated for ACT between 1999 and 2019 were reviewed retrospectively. The median age of 24 children was 78 months. Fourteen patients had ... Read more >>

ANZ J Surg (ANZ journal of surgery)
[2021, :]

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A Patient With AIRE Mutation Who Presented With Severe Diarrhea and Lung Abscess.

Elif Soyak Aytekin, Oguzhan Serin, Deniz Cagdas, Cagman Tan, Tekin Aksu, Yagmur Unsal, Selma Yeni, Diclehan Orhan, Zeynep Alev Ozon, Ilhan Tezcan,

Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) (polyglandular endocrinopathy type 1) is a rare autosomal recessive disorder caused by mutations in the autoimmune regulator gene (AIRE). The major clinical features of APECED are hypoparathyroidism, adrenal insufficiency (Addison disease), and chronic mucocutaneous candidiasis. This disease is also associated with multiple other and uncommon autoimmune ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(1):66-69]

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Inflammatory milieu of muscle biopsies in juvenile dermatomyositis.

Erdal Sag, Gulsev Kale, Goknur Haliloglu, Yelda Bilginer, Zuhal Akcoren, Diclehan Orhan, Safak Gucer, Haluk Topaloglu, Seza Ozen, Beril Talim,

Juvenile dermatomyositis (JDM) is an inflammatory myopathy which causes severe morbidity and high mortality if untreated. In this study, we aimed to define the T-helper cell profile in the muscle biopsies of JDM patients. Muscle biopsies of twenty-six patients (50% female) were included in the study. Immunohistochemical expression of CD3, ... Read more >>

Rheumatol Int (Rheumatology international)
[2020, :]

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Histopathological features and satellite cell population characteristics in human inferior oblique muscle biopsies: clinicopathological correlation.

Ata Baytaroğlu, Hande Taylan Şekeroğlu, Kadriye Erkan Turan, Diclehan Orhan,

<h4>Purpose</h4>To investigate the correlation between clinical characteristics and histopathological and immunohistochemical features of inferior oblique muscles in patients with primary and secondary inferior oblique overaction.<h4>Methods</h4>Inferior oblique muscle specimens of patients who underwent inferior oblique-weakening procedures for primary or secondary inferior oblique overaction were recruited. Subjects were mainly divided into two ... Read more >>

J AAPOS (Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus)
[2020, 24(5):285.e1-285.e6]

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Intrapericardial inflammatory myofibroblastic tumour in a 3-month-old infant associated with Coronavirus OC43 presenting with pericardial tamponade.

Yasemin Nuran Donmez, Hayrettin Hakan Aykan, Diclehan Orhan, Recep Oktay Peker, Mustafa Yilmaz, Tevfik Karagoz,

Inflammatory myofibroblastic tumour usually has a benign course and is very rarely associated with the heart. It can have life-threatening consequences, depending on its position or the presence of aggressive and metastatic complications. A 3-month-old boy presented with pericardial tamponade and was diagnosed with intrapericardial inflammatory myofibroblastic tumour associated with ... Read more >>

Paediatr Int Child Health (Paediatrics and international child health)
[2020, 40(4):261-267]

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Fulminant COVID-19-related myocarditis in an infant.

Selman Kesici, Hayrettin Hakan Aykan, Diclehan Orhan, Benan Bayrakci,

Eur Heart J (European heart journal)
[2020, 41(31):3021]

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Erratum.

Shubha S Bellur, Ian S D Roberts, Stéphan Troyanov, Virginie Royal, Rosanna Coppo, H Terence Cook, Daniel Cattran, Yolanda Arce Terroba, Anna Maria Asunis, Ingeborg Bajema, Elisabetta Bertoni, Jan A Bruijn, Pablo Cannata-Ortiz, Donatella Casartelli, Anna Maria Di Palma, Franco Ferrario, Mirella Fortunato, Luciana Furci, Hariklia Gakiopoulou, Danica Galesic Ljubanovic, Konstantinos Giannakakis, Montserrat Gomà, Hermann-Josef Gröne, Eduardo Gutiérrez, S Asma Haider, Eva Honsova, Elli Ioachim, Henryk Karkoszka, David Kipgen, Jagoda Maldyk, Gianna Mazzucco, Diclehan Orhan, Yasemin Ozluk, Afroditi Pantzaki, Agnieszka Perkowska-Ptasinska, Zivili Riispere, Magnus P Soderberg, Eric Steenbergen, Antonella Stoppacciaro, Birgitta Sundelin Von Feilitzen, Regina Tardanico,

Nephrol Dial Transplant (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association)
[2020, 35(8):1453]

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Primary gastric lymphoma: A report of 16 pediatric cases treated at a single institute and review of the literature.

Nilgün Kurucu, Canan Akyüz, Bilgehan Yalçın, İnci Y Bajin, Ali Varan, Diclehan Orhan, İbrahim Karnak, Burça Aydın, Tezer Kutluk,

Gastrointestinal tract is the most common extranodal site for childhood non-Hodgkin lymphomas (NHLs). However, primary gastric lymphoma (PGL) is very rare. We report our experience with PGL. Between 1972 and 2019, patients with PGL among 1696 NHL cases were evaluated retrospectively. Patient characteristics, treatments, and survival rates were recorded. We ... Read more >>

Pediatr Hematol Oncol (Pediatric hematology and oncology)
[2020, :1-9]

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Variation in the bombesin staining of pulmonary neuroendocrine cells in pediatric pulmonary disorders-A useful marker for airway maturity.

Nagehan Emiralioğlu, Diclehan Orhan, Güzin Cinel, Gökçen Dilşa Tuğcu, Ebru Yalçın, Deniz Doğru, Uğur Özçelik, Matthias Griese, Nural Kiper,

<h4>Objectives</h4>Pulmonary neuroendocrine cells (NEC) increase with age due to pulmonary maturity. The aim of this study was to determine whether open lung biopsies from patients with interstitial lung diseases have increased pulmonary NEC compared with neuroendocrine cell hyperplasia of infancy (NEHI). Our second aim was to assess pulmonary NECs in ... Read more >>

Pediatr Pulmonol (Pediatric pulmonology)
[2020, 55(9):2383-2388]

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Deep fungal infection at the sites of previous insect bites.

Ecem Bostan, Duygu Gulseren, Ozay Gokoz, Diclehan Orhan, Selin Aytac, Sibel Ersoy-Evans,

J Cosmet Dermatol (Journal of cosmetic dermatology)
[2021, 20(1):366-367]

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C3 glomerulopathy: experience of a pediatric nephrology center.

Fatma Yazılıtaş, Evrim Kargın Çakıcı, Eda Didem Kurt Şükür, Gökçe Can, Tülin Güngör, Diclehan Orhan, Mehmet Bülbül,

Background: C3 glomerulopathy (C3G) is an uncommon disease characterized by the deposition of complement factors in the glomeruli due to overactivation and dysregulation of the alternative pathway of complement.Objectives: This study aimed to describe the clinicopathological features, laboratory testing, clinical course, treatment, and outcomes of pediatric patients with C3G.Patients and ... Read more >>

Acta Clin Belg (Acta clinica Belgica)
[2020, :1-5]

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CD80 expression and infiltrating regulatory T cells in idiopathic nephrotic syndrome of childhood.

Fehime Kara Eroglu, Diclehan Orhan, Mihriban İnözü, Ali Duzova, Bora Gulhan, Fatih Ozaltin, Rezan Topaloglu,

<h4>Background</h4>CD80 (also known as B7-1) is a co-stimulatory molecule that is expressed in biopsies and also excreted in urine in patients with minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS). CD80 is inhibited by the cytotoxic T-lymphocyte-associated-antigen 4 (CTLA4), which is mainly expressed on regulatory T cells (Tregs). Ineffective ... Read more >>

Pediatr Int (Pediatrics international : official journal of the Japan Pediatric Society)
[2019, 61(12):1250-1256]

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Childhood diffuse parenchymal lung diseases: We need a new classification.

Güzin Cinel, Nural Kiper, Diclehan Orhan, Nagehan Emiralioğlu, Ebru Yalçın, Deniz Doğru, Uğur Özçelik, Berna Oğuz, Mithat Haliloğlu,

INTRODUCTION:Childhood diffuse parenchymal lung diseases (DPLD) are a heterogeneous group of respiratory disorders of both known and unknown causes that share common histological features. To date, there is not an exact consensus about the terminology, classification, therapy and follow up of this disease because of its rarity and wide clinical ... Read more >>

Clin Respir J (The clinical respiratory journal)
[2020, 14(2):102-108]

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Reproducibility of the Oxford classification of immunoglobulin A nephropathy, impact of biopsy scoring on treatment allocation and clinical relevance of disagreements: evidence from the VALidation of IGA study cohort.

Shubha S Bellur, Ian S D Roberts, Stéphan Troyanov, Virginie Royal, Rosanna Coppo, H Terence Cook, Daniel Cattran, Yolanda Arce Terroba, Anna Maria Asunis, Ingeborg Bajema, Elisabetta Bertoni, Jan A Bruijn, Pablo Cannata-Ortiz, Donatella Casartelli, Anna Maria Di Palma, Franco Ferrario, Mirella Fortunato, Luciana Furci, Hariklia Gakiopoulou, Danica Galesic Ljubanovic, Konstantinos Giannakakis, Montserrat Gomà, Hermann-Josef Gröne, Eduardo Gutiérrez, S Asma Haider, Eva Honsova, Elli Ioachim, Henryk Karkoszka, David Kipgen, Jagoda Maldyk, Gianna Mazzucco, Diclehan Orhan, Yasemin Ozluk, Afroditi Pantzaki, Agnieszka Perkowska-Ptasinska, Zivili Riispere, Magnus P Soderberg, Eric Steenbergen, Antonella Stoppacciaro, Birgitta Sundelin Von Feilitzen, Regina Tardanico,

BACKGROUND:The VALidation of IGA (VALIGA) study investigated the utility of the Oxford Classification of immunoglobulin A nephropathy (IgAN) in 1147 patients from 13 European countries. Methods. Biopsies were scored by local pathologists followed by central review in Oxford. We had two distinct objectives: to assess how closely pathology findings were ... Read more >>

Nephrol Dial Transplant (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association)
[2019, 34(10):1681-1690]

Cited: 1 time

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Anteroposterior Duplicated Exstrophy: A Case Report.

Burak Ardicli, Hasan Serkan Dogan, Tariq Asi, Diclehan Orhan, Serdar Tekgul,

Duplicated bladder exstrophy is an extremely rare variant of the exstrophy/epispadias complex. Duplicated exstrophy defines an exstrophic mucosal plate in hypogastric area with a normal closed bladder. We present a unique case of an anteroposterior duplicated exstrophy in a female newborn. ... Read more >>

Urology (Urology)
[2019, 131:220-222]

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A rare cause of cutaneous ulceration: Prolidase deficiency.

Artoghrul Lsazade, Gonca Elçin, Sibel Doğan, Duygu Gülseren, Özay Gököz, Berrak Gürbüz, Diclehan Orhan, Serap Sivri, Ayşen Karaduman,

Int Wound J (International wound journal)
[2019, 16(4):1057-1058]

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Solid pseudopapillary neoplasm of the pancreas in children: Hacettepe experience.

Bilgehan Yalçın, Begül Yağcı-Küpeli, Saniye Ekinci, Diclehan Orhan, Berna Oğuz, Ali Varan, Tezer Kutluk, Canan Akyüz,

<h4>Background</h4>Solid pseudopapillary neoplasm of the pancreas (SPNP) is mostly seen in young women in the second and third decades of life; it is quite uncommon in children. We aimed to review our institutional experience with SPNP in children.<h4>Methods</h4>Hospital charts of children <18 years of age diagnosed to have SPNP were reviewed ... Read more >>

ANZ J Surg (ANZ journal of surgery)
[2019, 89(6):E236-E240]

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A retrospective analysis of children with Henoch-Schonlein purpura and re-evaluation of renal pathologies using Oxford classification.

Evrim Kargın Çakıcı, Gökçe Gür, Fatma Yazılıtaş, Fehime Kara Eroğlu, Tülin Güngör, Nilüfer Arda, Diclehan Orhan, Funda Seher Özalp Ateş, Mehmet Bülbül,

BACKGROUND:Henoch-Schönlein purpura (HSP) is the most common vasculitis in childhood. The long-term prognosis is variable and depends on renal involvement. The aims of this study were to investigate the clinical and laboratory characteristics of our HSP patients, to identify the risk factors for the development of Henoch-Schönlein purpura nephritis (HSPN) ... Read more >>

Clin Exp Nephrol (Clinical and experimental nephrology)
[2019, 23(7):939-947]

Cited: 3 times

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Erratum to 'Response to early coenzyme Q10 supplementation is not sustained in CoQ10 deficiency caused by CoQ2 mutation' [Pediatric Neurology 88 (2018) 71-74].

Fehime K Eroglu, Fatih Ozaltin, Nazli Gönç, Hülya Nalçacıoğlu, Z Birsin Özçakar, Dilek Yalnızoğlu, Şafak Güçer, Diclehan Orhan, Fatma Tuba Eminoğlu, Rahşan Göçmen, Ayfer Alikaşifoğlu, Rezan Topaloğlu, Ali Düzova,

Pediatr Neurol (Pediatric neurology)
[2019, 94:84]

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Bilateral Pulmonary Langerhans's Cell Histiocytosis is Surgical Challenge in Children: A Case Report.

Tutku Soyer, Gül Özyüksel, Özlem Boybeyi Türer, Kübra Çakmakkaya, Sinan Yavuz, Bilgehan Yalçın, Diclehan Orhan, Ebru Yalçın, Deniz Doğru, Benan Bayrakçı, Nural Kiper, Canan Akyüz,

<b>Background</b>  Pulmonary Langerhans's cell histiocytosis (PLCH) is a rare cause of interstitial lung disease in children and more than half of the cases are bilateral. Persistent respiratory distress due to spontaneous pneumothorax (SP) in bilateral PLCH may refractory to conservative treatment and posed a great challenge to surgical modalities. A ... Read more >>

European J Pediatr Surg Rep (European journal of pediatric surgery reports)
[2019, 7(1):e8-e11]

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Clinical and histopathological prognostic factors affecting the renal outcomes in childhood ANCA-associated vasculitis.

Gül Özçelik, Hafize Emine Sönmez, Sezgin Şahin, Ayşim Özağarı, Meral Torun Bayram, Rümeysa Yasemin Çiçek, Evrim Kargın Çakıcı, Elif Çomak, Kenan Barut, Nihal Şahin, Sevcan Bakkaloğlu, İbrahim Gökçe, Ali Düzova, Yelda Bilginer, Ceyhun Açarı, Engin Melek, Beltinge Demircioğlu Kılıç, Semanur Özdel, Amra Adroviç, Özgür Kasapçopur, Erbil Ünsal, Harika Alpay, Diclehan Orhan, Rezan Topaloğlu, Ruhan Düşünsel, Seza Özen,

<h4>Objective</h4>Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are very rare in childhood with an increased risk of morbidity and mortality. We aimed to evaluate renal prognostic factors in childhood AAV from the perspective of ANCA serotype, histopathological classification, and five-factor score (FFS).<h4>Methods</h4>Pediatric AAV patients from 11 referral centers in Turkey had ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2019, 34(5):847-854]

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Ewing sarcoma in an infant and review of the literature.

Çağlayan Selenge Bedük-Esen, Melis Gültekin, G Burça Aydın, Canan Akyüz, Kader Karlı Oğuz, Diclehan Orhan, Mustafa Cengiz, Murat Gürkaynak, Ferah Yıldız,

Bedük Esen ÇS, Gültekin M, Aydın GB, Akyüz C, Karlı Oğuz K, Orhan D, Cengiz M, Gürkaynak M, Yıldız F. Ewing sarcoma in an infant and review of the literature. Turk J Pediatr 2019; 61: 760-764. Ewing sarcoma (ES) is a rare tumor in infants and prognosis is controversial. There ... Read more >>

Turk J Pediatr (The Turkish journal of pediatrics)
[2019, 61(5):760-764]

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Two siblings with PRKDC defect who presented with cutaneous granulomas and review of the literature.

Saliha Esenboga, Can Akal, Betül Karaatmaca, Baran Erman, Sibel Dogan, Diclehan Orhan, Kaan Boztug, Deniz Ayvaz, İlhan Tezcan,

V(D)J recombination, during which recognition and repair of broken DNA chains are accomplished by non-homologous end joining pathway, is a critical process in B and T cell development.Null mutations of each enzyme or protein of this pathway result in T- B- NK+ severe combined immunodeficiency whereas hypomorphic mutations result in ... Read more >>

Clin Immunol (Clinical immunology (Orlando, Fla.))
[2018, 197:1-5]

Cited: 1 time

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Response to Early Coenzyme Q10 Supplementation Is not Sustained in CoQ10 Deficiency Caused by CoQ2 Mutation.

Fehime K Eroglu, Fatih Ozaltin, Nazlı Gönç, Hülya Nalçacıoğlu, Z Birsin Özçakar, Dilek Yalnızoğlu, Şafak Güçer, Diclehan Orhan, Fatma Tuba Eminoğlu, Rahşan Göçmen, Ayfer Alikaşifoğlu, Rezan Topaloğlu, Ali Düzova,

<h4>Background</h4>COQ2 mutations cause a rare infantile multisystemic disease with heterogeneous clinical features. Promising results have been reported in response to Coenzyme Q10 treatment, especially for kidney involvement, but little is known about the long-term outcomes.<h4>Methods</h4>We report four new patients from two families with the c.437G→A (p.Ser146Asn) mutation in COQ2 and ... Read more >>

Pediatr Neurol (Pediatric neurology)
[2018, 88:71-74]

Cited: 1 time

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Neuroencorine Tumor Arising within a Tailgut Cyst in an Adolescent Boy.

Tutku Soyer, Burça Aydin, Diclehan Orhan, Feridun C Tanyel,

<h4>Introduction</h4>Neuroendocrine tumors (NET) within tailgut cysts (TC) are usually seen in middle-aged females. A 14 year-old boy who underwent surgical excision of NET within TC is presented to discuss the clinical features, diagnosis and treatment options.<h4>Case report</h4>A 14-year-old boy with rectal bleeding and constipation had a 5 × 4 cm mass ... Read more >>

Fetal Pediatr Pathol (Fetal and pediatric pathology)
[2018, 37(4):270-275]

Cited: 1 time

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