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Author Dick Tibboel

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Impact of haemolysis on vancomycin disposition in a full-term neonate treated with extracorporeal membrane oxygenation.

Pavla Pokorná, Martin Šíma, Dick Tibboel, Ondřej Slanař,

INTRODUCTION:Extracorporeal membrane oxygenation (ECMO) is a lifesaving support technology for potentially reversible neonatal cardiac and/or respiratory failure. Pharmacological consequences of ECMO-induced haemolysis in neonates are not well understood. CASE REPORT:We report a case report of a full-term neonate treated for congenital diaphragmatic hernia and sepsis with ECMO and with vancomycin. ... Read more >>

Perfusion (Perfusion)
[2020, :267659120973595]

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Histological, immunohistochemical and transcriptomic characterization of human tracheoesophageal fistulas.

Erwin Brosens, Janine F Felix, Anne Boerema-de Munck, Elisabeth M de Jong, Elisabeth M Lodder, Sigrid Swagemakers, Marjon Buscop-van Kempen, Ronald R de Krijger, Rene M H Wijnen, Wilfred F J van IJcken, Peter van der Spek, Annelies de Klein, Dick Tibboel, Robbert J Rottier,

Esophageal atresia (EA) and tracheoesophageal fistula (TEF) are relatively frequently occurring foregut malformations. EA/TEF is thought to have a strong genetic component. Not much is known regarding the biological processes disturbed or which cell type is affected in patients. This hampers the detection of the responsible culprits (genetic or environmental) ... Read more >>

PLoS One (PloS one)
[2020, 15(11):e0242167]

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Prediction of Global Functional Outcome and Post-Concussive Symptoms after Mild Traumatic Brain Injury: External Validation of Prognostic Models in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Study.

Ana Mikolić, Suzanne Polinder, Ewout W Steyerberg, Isabel R A Retel Helmrich, Joseph T Giacino, Andrew I R Maas, Joukje van der Naalt, Daphne C Voormolen, Nicole von Steinbüchel, Lindsay Wilson, Hester F Lingsma, David van Klaveren, ,

The majority of traumatic brain injuries (TBIs) are categorized as mild, according to a baseline Glasgow Coma Scale (GCS) score of 13-15. Prognostic models that were developed to predict functional outcome and persistent post-concussive symptoms (PPCS) after mild TBI have rarely been externally validated. We aimed to externally validate models ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2020, :]

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Severity parameters for asphyxia or hypoxic-ischemic encephalopathy do not explain interindividual variability in the pharmacokinetics of phenobarbital in newborns treated with therapeutic hypothermia.

Pavla Pokorná, Danica Michaličková, Swantje Völler, Karolina Hronová, Dick Tibboel, Ondřej Slanař, Elke H Krekels,

BACKGROUND:The current study uses a population modeling approach to evaluate and quantify the impact of severity of asphyxia and hypoxic-ischemic encephalopathy (HIE) on the pharmacokinetics of phenobarbital in asphyxiated newborns treated with therapeutic hypothermia. METHODS:Included newborns received phenobarbital (the TOBY trial protocol). 120 plasma sample were available from 50 newborns, ... Read more >>

Minerva Pediatr (Minerva pediatrica)
[2020, :]

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Size matters: large copy number losses reveal novel Hirschsprung disease genes

Laura Kuil, Katherine MacKenzie, Clara Tang, Jonathan Windster, Thuy Linh Le, Anwarul Karim, Bianca de Graaf, Robert van der Helm, Yolande van Bever, Cornelius E.J. Sloots, Conny Meeussen, Dick Tibboel, Annelies de Klein, René Wijnen, Jeanne Amiel, Stanislas Lyonnet, Maria-Mercè Garcia-Barcelo, Paul K.H. Tam, Maria Alves, Alice Brooks, Robert M.W. Hofstra, Erwin Brosens,

Abstract Background Hirschsprung disease (HSCR) is characterized by absence of ganglia in the intestine. Approximately 18% of patients have additional anatomical malformations or neurological symptoms (HSCR-AAM). HSCR is a complex genetic disease in which the loss of enteric ganglia stems from a combination of genetic alterations: rare coding variants, predisposing ... Read more >>

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Diagnosis and Treatment of Chronic Neuropathic and Mixed Pain in Children and Adolescents: Results of a Survey Study amongst Practitioners.

Thomas G de Leeuw, Tjitske van der Zanden, Simona Ravera, Mariagrazia Felisi, Donato Bonifazi, Dick Tibboel, Adriana Ceci, Florentia Kaguelidou, Saskia N de Wildt, On Behalf Of The Gapp Consortium,

Validated diagnostic tools to diagnose chronic neuropathic and mixed pain in children are missing. Therapeutic options are often derived from therapeutics for adults. To investigate the international practice amongst practitioners for the diagnosis and treatment of chronic, neuropathic pain in children and adolescents, we performed a survey study among members ... Read more >>

Children (Basel) (Children (Basel, Switzerland))
[2020, 7(11):]

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Sedation With Midazolam After Cardiac Surgery in Children With and Without Down Syndrome: A Pharmacokinetic-Pharmacodynamic Study.

Abraham J Valkenburg, Sebastiaan C Goulooze, Cormac V Breatnach, Ron A A Mathôt, Dick Tibboel, Monique van Dijk, Catherijne A J Knibbe, Mariska Y M Peeters,

OBJECTIVES:To compare the pharmacokinetics and pharmacodynamics of IV midazolam after cardiac surgery between children with and without Down syndrome. DESIGN:Prospective, single-center observational trial. SETTING:PICU in a university-affiliated pediatric teaching hospital. PATIENTS:Twenty-one children with Down syndrome and 17 without, 3-36 months, scheduled for cardiac surgery with cardiopulmonary bypass. INTERVENTIONS:Postoperatively, nurses regularly ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2020, :]

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Proenkephalin as a new biomarker for pediatric acute kidney injury - reference values and performance in children under one year of age.

Stan J F Hartman, Alexandra J M Zwiers, Nadies E C van de Water, Joost van Rosmalen, Joachim Struck, Janin Schulte, Oliver Hartmann, Peter Pickkers, Remi Beunders, Dick Tibboel, Michiel F Schreuder, Saskia N de Wildt,

Objectives Acute kidney injury (AKI) is common in critically ill children, but current biomarkers are suboptimal. Proenkephalin A 119-159 (PENK) is a promising new biomarker for AKI in adults, but pediatric data is lacking. We determined PENK reference intervals for healthy children, crucial for clinical implementation, and explored concentrations in ... Read more >>

Clin Chem Lab Med (Clinical chemistry and laboratory medicine)
[2020, 58(11):1911-1919]

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Predicting Unacceptable Pain in Cardiac Surgery Patients Receiving Morphine Maintenance and Rescue Doses: A Model-Based Pharmacokinetic-Pharmacodynamic Analysis.

Sebastiaan C Goulooze, Elke H Krekels, Mohammed A Saleh, Sabine J Ahlers, Pyry A Välitalo, Eric P van Dongen, Ron H van Schaik, Thomas Hankemeier, Dick Tibboel, Catherijne A J Knibbe,

BACKGROUND:Optimal analgesic treatment following cardiac surgery is crucial for both patient comfort and successful postoperative recovery. While knowledge of both the pharmacokinetics and pharmacodynamics of analgesics is required to predict optimal drug dosing, models quantifying the pharmacodynamics are scarce. Here, we quantify the pharmacodynamics of morphine by modeling the need ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2020, :]

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Differences between Men and Women in Treatment and Outcome after Traumatic Brain Injury.

Ana Mikolić, David van Klaveren, Joost Oude Groeniger, Eveline J A Wiegers, Hester F Lingsma, Marina Zeldovich, Nicole von Steinbüchel, Andrew I R Maas, Jeanine E Roeters van Lennep, Suzanne Polinder, ,

Traumatic brain injury (TBI) is a significant cause of disability, but little is known about sex and gender differences after TBI. We aimed to analyze the association between sex/gender, and the broad range of care pathways, treatment characteristics, and outcomes following mild and moderate/severe TBI. We performed mixed-effects regression analyses ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2020, :]

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Delivering transformative action in paediatric pain: a Lancet Child & Adolescent Health Commission.

Christopher Eccleston, Emma Fisher, Richard F Howard, Rebeccah Slater, Paula Forgeron, Tonya M Palermo, Kathryn A Birnie, Brian J Anderson, Christine T Chambers, Geert Crombez, Gustaf Ljungman, Isabel Jordan, Zachary Jordan, Caitriona Roberts, Neil Schechter, Christine B Sieberg, Dick Tibboel, Suellen M Walker, Dominic Wilkinson, Chantal Wood,

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, :]

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Rectal Omeprazole in Infants With Gastroesophageal Reflux Disease: A Randomized Pilot Trial.

Petra Bestebreurtje, Barbara A E de Koning, Nel Roeleveld, Catherijne A J Knibbe, Dick Tibboel, Bianca van Groen, Cees P van de Ven, Frans B Plötz, Saskia N de Wildt,

BACKGROUND AND OBJECTIVE:Omeprazole is a proton pump inhibitor that is used in acid suppression therapy in infants. Infants cannot swallow the oral tablets or capsules. Since, infants require a non-standard dose of omeprazole, the granules or tablets are often crushed or suspended in water or sodium bicarbonate, which may destroy ... Read more >>

Eur J Drug Metab Pharmacokinet (European journal of drug metabolism and pharmacokinetics)
[2020, 45(5):635-643]

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Correction to: Frequency of fatigue and its changes in the first 6 months after traumatic brain injury: results from the CENTER-TBI study.

Nada Andelic, Cecilie Røe, Cathrine Brunborg, Marina Zeldovich, Marianne Løvstad, Daniel Løke, Ida M Borgen, Daphne C Voormolen, Emilie I Howe, Marit V Forslund, Hilde M Dahl, Nicole von Steinbuechel, ,

The original version of this article unfortunately contained a mistake. ... Read more >>

J Neurol (Journal of neurology)
[2020, :]

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Timing and Cause of Death in Children Following Return of Circulation After Out-of-Hospital Cardiac Arrest: A Single-Center Retrospective Cohort Study.

Maayke Hunfeld, Vinay M Nadkarni, Alexis Topjian, Jasmijn Harpman, Dick Tibboel, Joost van Rosmalen, Matthijs de Hoog, Coriene E Catsman-Berrevoets, Corinne M P Buysse,

OBJECTIVES:To determine timing and cause of death in children admitted to the PICU following return of circulation after out-of-hospital cardiac arrest. DESIGN:Retrospective observational study. SETTING:Single-center observational cohort study at the PICU of a tertiary-care hospital (Erasmus MC-Sophia, Rotterdam, the Netherlands) between 2012 and 2017. PATIENTS:Children younger than 18 years old ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2020, :]

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Impact of enantiomer-specific changes in pharmacokinetics between infants and adults on the target concentration of racemic ketorolac: A pooled analysis.

Michael E Cloesmeijer, Michiel J van Esdonk, Anne M Lynn, Anne Smits, Dick Tibboel, Youssef Daali, Klaus T Olkkola, Karel Allegaert, Paola Mian,

AIMS:Ketorolac is a nonsteroidal anti-inflammatory racemic drug with analgesic effects only attributed to its S-enantiomer. The aim of this study is to quantify enantiomer-specific maturational pharmacokinetics (PK) of ketorolac and investigate if the contribution of both enantiomers to the total ketorolac concentration remains equal between infants and adults or if ... Read more >>

Br J Clin Pharmacol (British journal of clinical pharmacology)
[2020, :]

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A Systematic Review of Neuromonitoring Modalities in Children Beyond Neonatal Period After Cardiac Arrest.

Maayke Hunfeld, Naomi Ketharanathan, Coriene Catsman, Dirk C G Straver, Marjolein H G Dremmen, Wichor Bramer, Enno Wildschut, Dick Tibboel, Corinne Buysse,

OBJECTIVES:Postresuscitation care in children focuses on preventing secondary neurologic injury and attempts to provide (precise) prognostication for both caregivers and the medical team. This systematic review provides an overview of neuromonitoring modalities and their potential role in neuroprognostication in postcardiac arrest children. DATA RESOURCES:Databases EMBASE, Web of Science, Cochrane, MEDLINE ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2020, 21(10):e927-e933]

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Mitochondrial Oxygen Monitoring During Surgical Repair of Congenital Diaphragmatic Hernia or Esophageal Atresia: A Feasibility Study.

Sophie A Costerus, Mark Wefers Bettink, Dick Tibboel, Jurgen C de Graaff, Egbert G Mik,

Current monitoring techniques in neonates lack sensitivity for hypoxia at cellular level. The recent introduction of the non-invasive Cellular Oxygen METabolism (COMET) monitor enables measuring in vivo mitochondrial oxygen tension (mitoPO2), based on oxygen-dependent quenching of delayed fluorescence of 5-aminolevulinic acid (ALA)-enhanced protoporphyrin IX. The aim is to determine the ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2020, 8:532]

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Routine Intubation in Newborns With Congenital Diaphragmatic Hernia.

Suzan C M Cochius-den Otter, Emily J J Horn-Oudshoorn, Karel Allegaert, Philip L J DeKoninck, Nina C J Peters, Titia E Cohen-Overbeek, Irwin K M Reiss, Dick Tibboel,

Pediatrics (Pediatrics)
[2020, 146(4):]

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Safeguarding children's right to health in hospital during COVID-19.

Jennifer McIntosh, Montserrat Esquerda Aresté, Joe Brierley, Cristina Giugni, Kathleen S McGreevy, Francisco José Cambra, Dick Tibboel, Ruben Diaz, Alberto Zanobini, ,

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, 4(11):800-802]

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Innovative approaches and recent advances in the study of ontogeny of drug metabolism and transport.

Bianca D van Groen, Karel Allegaert, Dick Tibboel, Saskia N de Wildt,

The disposition of a drug is driven by various processes, such as drug metabolism, drug transport, glomerular filtration and body composition. These processes are subject to developmental changes reflecting growth and maturation along the paediatric continuum. However, knowledge gaps exist on these changes and their clinical impact. Filling these gaps ... Read more >>

Br J Clin Pharmacol (British journal of clinical pharmacology)
[2020, :]

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Numbers, Numbers: Great, Great…But?!

Pavla Pokorna, Dick Tibboel,

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2020, 21(9):844-845]

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Rapid Increase in Clearance of Phenobarbital in Neonates on Extracorporeal Membrane Oxygenation: A Pilot Retrospective Population Pharmacokinetic Analysis.

Danica Michaličková, Pavla Pokorná, Dick Tibboel, Ondřej Slanař, Catherijne A J Knibbe, Elke H J Krekels,

OBJECTIVES:This study characterizes the changes in the pharmacokinetics of phenobarbital associated with extracorporeal membrane oxygenation treatment in neonates, to illustrate our findings and provide guidance on dosing. DESIGN:Retrospective pilot population pharmacokinetic analysis. SETTING:Neonatal ICU. PATIENTS:Thirteen critically ill neonates (birth body weight, 3.21 kg [2.65-3.72 kg]; postnatal age at start of treatment: ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2020, 21(9):e707-e715]

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Sequestration of Voriconazole and Vancomycin Into Contemporary Extracorporeal Membrane Oxygenation Circuits: An in vitro Study.

Genny Raffaeli, Giacomo Cavallaro, Karel Allegaert, Birgit C P Koch, Fabio Mosca, Dick Tibboel, Enno D Wildschut,

Background: Bacterial and fungal infections are common and often contribute to death in patients undergoing extracorporeal membrane oxygenation (ECMO). Drug disposition is altered during ECMO, and adsorption in the circuit is an established causative factor. Vancomycin and voriconazole are widely used, despite the lack of evidence-based prescription guidelines. Objective: The ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2020, 8:468]

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Towards integrative neuromonitoring of the surgical newborn: A systematic review.

Sophie A Costerus, Camille E van Hoorn, Dries Hendrikx, Jorinde Kortenbout, Maayke Hunfeld, John Vlot, Gunnar Naulaers, Dick Tibboel, Jurgen C de Graaff,

BACKGROUND:The altered neurodevelopment of children operated on during the neonatal period might be due to peri-operative changes in the homeostasis of brain perfusion. Monitoring of vital signs is a standard of care, but it does not usually include monitoring of the brain. OBJECTIVES:To evaluate methods of monitoring the brain that ... Read more >>

Eur J Anaesthesiol (European journal of anaesthesiology)
[2020, 37(8):701-712]

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Tracheal intubation in traumatic brain injury: a multicentre prospective observational study.

Benjamin Yael Gravesteijn, Charlie Aletta Sewalt, Daan Nieboer, David Krishna Menon, Andrew Maas, Fiona Lecky, Markus Klimek, Hester Floor Lingsma, ,

BACKGROUND:We aimed to study the associations between pre- and in-hospital tracheal intubation and outcomes in traumatic brain injury (TBI), and whether the association varied according to injury severity. METHODS:Data from the international prospective pan-European cohort study, Collaborative European NeuroTrauma Effectiveness Research for TBI (CENTER-TBI), were used (n=4509). For prehospital intubation, ... Read more >>

Br J Anaesth (British journal of anaesthesia)
[2020, 125(4):505-517]

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