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Author Dick Tibboel

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Sedation With Midazolam After Cardiac Surgery in Children With and Without Down Syndrome: A Pharmacokinetic-Pharmacodynamic Study.

Abraham J Valkenburg, Sebastiaan C Goulooze, Cormac V Breatnach, Ron A A Mathôt, Dick Tibboel, Monique van Dijk, Catherijne A J Knibbe, Mariska Y M Peeters,

<h4>Objectives</h4>To compare the pharmacokinetics and pharmacodynamics of IV midazolam after cardiac surgery between children with and without Down syndrome.<h4>Design</h4>Prospective, single-center observational trial.<h4>Setting</h4>PICU in a university-affiliated pediatric teaching hospital.<h4>Patients</h4>Twenty-one children with Down syndrome and 17 without, 3-36 months, scheduled for cardiac surgery with cardiopulmonary bypass.<h4>Interventions</h4>Postoperatively, nurses regularly assessed the children's pain ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2021, 22(4):e259-e269]

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Feasibility of Doppler Ultrasound for Cortical Cerebral Blood Flow Velocity Monitoring During Major Non-cardiac Surgery of Newborns.

Sophie A Costerus, Anna J Kortenbout, Hendrik J Vos, Paul Govaert, Dick Tibboel, René M H Wijnen, Nico de Jong, Johan G Bosch, Jurgen C de Graaff,

<b>Background and Aim:</b> Newborns needing major surgical intervention are at risk of brain injury and impaired neurodevelopment later in life. Disturbance of cerebral perfusion might be an underlying factor. This study investigates the feasibility of serial transfontanellar ultrasound measurements of the pial arteries during neonatal surgery, and whether perioperative changes ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2021, 9:656806]

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Use and impact of high intensity treatments in patients with traumatic brain injury across Europe: a CENTER-TBI analysis.

Jilske A Huijben, Abhishek Dixit, Nino Stocchetti, Andrew I R Maas, Hester F Lingsma, Mathieu van der Jagt, David Nelson, Giuseppe Citerio, Lindsay Wilson, David K Menon, Ari Ercole, ,

<h4>Purpose</h4>To study variation in, and clinical impact of high Therapy Intensity Level (TIL) treatments for elevated intracranial pressure (ICP) in patients with traumatic brain injury (TBI) across European Intensive Care Units (ICUs).<h4>Methods</h4>We studied high TIL treatments (metabolic suppression, hypothermia (< 35 °C), intensive hyperventilation (PaCO<sub>2</sub> < 4 kPa), and secondary decompressive craniectomy) in patients receiving ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):78]

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Postoperative breakthrough pain in paediatric cardiac surgery not reduced by increased morphine concentrations.

Sjoerd de Hoogd, Sebastiaan C Goulooze, Abraham J Valkenburg, Elke H J Krekels, Monique van Dijk, Dick Tibboel, Catherijne A J Knibbe,

<h4>Background</h4>Morphine is commonly used for postoperative analgesia in children. Here we studied the pharmacodynamics of morphine in children after cardiac surgery receiving protocolized morphine.<h4>Methods</h4>Data on morphine rescue requirements guided by validated pain scores in children (n = 35, 3-36 months) after cardiac surgery receiving morphine as loading dose (100 μg kg<sup>-1</sup>) with continuous infusion ... Read more >>

Pediatr Res (Pediatric research)
[2021, :]

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Opposing Effects of TGFβ and BMP in the Pulmonary Vasculature in Congenital Diaphragmatic Hernia.

Daphne S Mous, Marjon J Buscop-van Kempen, Rene M H Wijnen, Dick Tibboel, Rory E Morty, Robbert J Rottier,

<b>Background:</b> Pulmonary hypertension is the major cause of morbidity and mortality in congenital diaphragmatic hernia (CDH). Mutations in several genes that encode signaling molecules of the transforming growth factor β (TGFβ) and bone morphogenetic protein (BMP) pathways have previously been associated with CDH. Since studies on the activation of these ... Read more >>

Front Med (Lausanne) (Frontiers in medicine)
[2021, 8:642577]

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Persistent postconcussive symptoms in children and adolescents with mild traumatic brain injury receiving initial head computed tomography.

Lennart Riemann, Daphne C Voormolen, Katrin Rauen, Klaus Zweckberger, Andreas Unterberg, Alexander Younsi, ,

<h4>Objective</h4>The aim of this paper was to evaluate the prevalence of postconcussive symptoms and their relation to health-related quality of life (HRQOL) in pediatric and adolescent patients with mild traumatic brain injury (mTBI) who received head CT imaging during initial assessment.<h4>Methods</h4>Patients aged between 5 and 21 years with mTBI (Glasgow ... Read more >>

J Neurosurg Pediatr (Journal of neurosurgery. Pediatrics)
[2021, :1-10]

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Missing Data in Prediction Research: A Five-Step Approach for Multiple Imputation, Illustrated in the CENTER-TBI Study.

Benjamin Yaël Gravesteijn, Charlie Aletta Sewalt, Esmee Venema, Daan Nieboer, Ewout W Steyerberg, ,

In medical research, missing data is common. In acute diseases, such as traumatic brain injury (TBI), even well-conducted prospective studies may suffer from missing data in baseline characteristics and outcomes. Statistical models may simply drop patients with any missing values, potentially leaving a selected subset of the original cohort. Imputation ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2021, :]

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Predicting Unacceptable Pain in Cardiac Surgery Patients Receiving Morphine Maintenance and Rescue Doses: A Model-Based Pharmacokinetic-Pharmacodynamic Analysis.

Sebastiaan C Goulooze, Elke H Krekels, Mohammed A Saleh, Sabine J Ahlers, Pyry A Välitalo, Eric P van Dongen, Ron H van Schaik, Thomas Hankemeier, Dick Tibboel, Catherijne A J Knibbe,

<h4>Background</h4>Optimal analgesic treatment following cardiac surgery is crucial for both patient comfort and successful postoperative recovery. While knowledge of both the pharmacokinetics and pharmacodynamics of analgesics is required to predict optimal drug dosing, models quantifying the pharmacodynamics are scarce. Here, we quantify the pharmacodynamics of morphine by modeling the need ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2021, 132(3):726-734]

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Correction to: Frequency of fatigue and its changes in the first 6 months after traumatic brain injury: results from the CENTER-TBI study.

Nada Andelic, Cecilie Røe, Cathrine Brunborg, Marina Zeldovich, Marianne Løvstad, Daniel Løke, Ida M Borgen, Daphne C Voormolen, Emilie I Howe, Marit V Forslund, Hilde M Dahl, Nicole von Steinbuechel, ,

J Neurol (Journal of neurology)
[2021, 268(1):74-76]

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Methadone effectively attenuates acute and long-term consequences of neonatal repetitive procedural pain in a rat model.

Nynke J van den Hoogen, Thomas J de Geus, Jacob Patijn, Dick Tibboel, Elbert A Joosten,

<h4>Background</h4>Painful procedures in early life cause acute pain and can alter pain processing at a spinal level lasting into adulthood. Current methods of analgesia seem unable to prevent both acute and long-term hypersensitivity associated with neonatal pain. The current study aims to prevent acute and long-term hypersensitivity associated with neonatal ... Read more >>

Pediatr Res (Pediatric research)
[2021, :]

Cited: 1 time

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Acute Kidney Injury in Traumatic Brain Injury Patients: Results From the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury Study.

Chiara Robba, Erika Banzato, Paola Rebora, Carolina Iaquaniello, Chao-Yuan Huang, Eveline J A Wiegers, Geert Meyfroidt, Giuseppe Citerio, ,

<h4>Objectives</h4>Acute kidney injury is frequent in polytrauma patients, and it is associated with increased mortality and extended hospital length of stay. However, the specific prevalence of acute kidney injury after traumatic brain injury is less recognized. The present study aims to describe the occurrence rate, risk factors, timing, and association ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(1):112-126]

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Timing and Cause of Death in Children Following Return of Circulation After Out-of-Hospital Cardiac Arrest: A Single-Center Retrospective Cohort Study.

Maayke Hunfeld, Vinay M Nadkarni, Alexis Topjian, Jasmijn Harpman, Dick Tibboel, Joost van Rosmalen, Matthijs de Hoog, Coriene E Catsman-Berrevoets, Corinne M P Buysse,

<h4>Objectives</h4>To determine timing and cause of death in children admitted to the PICU following return of circulation after out-of-hospital cardiac arrest.<h4>Design</h4>Retrospective observational study.<h4>Setting</h4>Single-center observational cohort study at the PICU of a tertiary-care hospital (Erasmus MC-Sophia, Rotterdam, The Netherlands) between 2012 and 2017.<h4>Patients</h4>Children younger than 18 years old with out-of-hospital cardiac ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2021, 22(1):101-113]

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Outcome Prediction after Moderate and Severe Traumatic Brain Injury: External Validation of Two Established Prognostic Models in 1742 European Patients.

Simone A Dijkland, Isabel R A Retel Helmrich, Daan Nieboer, Mathieu van der Jagt, Diederik W J Dippel, David K Menon, Nino Stocchetti, Andrew I R Maas, Hester F Lingsma, Ewout W Steyerberg, ,

The International Mission on Prognosis and Analysis of Clinical Trials in Traumatic Brain Injury (IMPACT) and Corticoid Randomisation After Significant Head injury (CRASH) prognostic models predict functional outcome after moderate and severe traumatic brain injury (TBI). We aimed to assess their performance in a contemporary cohort of patients across Europe. ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2020, :]

Cited: 1 time

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Coagulation complications after conversion from roller to centrifugal pump in neonatal and pediatric extracorporeal membrane oxygenation.

Özge Erdem, Jan Willem Kuiper, Robert Jan Houmes, Cornelia Heleen van Ommen, Joost van Rosmalen, Dick Tibboel, Enno Diederik Wildschut,

<h4>Background/purpose</h4>Coagulation complications are frequent, unwanted occurrences in extracorporeal membrane oxygenation (ECMO) treatment, possibly influenced by the pump in the ECMO-circuit. We hypothesized that fewer complications would occur with a smaller, heparin-coated ECMO system with a centrifugal pump (CP) than with one with a roller pump (RP) and that after conversion, ... Read more >>

J Pediatr Surg (Journal of pediatric surgery)
[2020, :]

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Understanding the relationship between cognitive performance and function in daily life after traumatic brain injury.

Lindsay Wilson, Lindsay Horton, Kevin Kunzmann, Barbara J Sahakian, Virginia Fj Newcombe, Emmanuel A Stamatakis, Nicole von Steinbuechel, Katrin Cunitz, Amra Covic, Andrew Maas, Dominique Van Praag, David Menon, ,

<h4>Objective</h4>Cognitive impairment is a key cause of disability after traumatic brain injury (TBI) but relationships with overall functioning in daily life are often modest. The aim is to examine cognition at different levels of function and identify domains associated with disability.<h4>Methods</h4>1554 patients with mild-to-severe TBI were assessed at 6 months ... Read more >>

J Neurol Neurosurg Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2020, :]

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Global Characterisation of Coagulopathy in Isolated Traumatic Brain Injury (iTBI): A CENTER-TBI Analysis.

Julia K Böhm, Helge Güting, Sophie Thorn, Nadine Schäfer, Victoria Rambach, Herbert Schöchl, Oliver Grottke, Rolf Rossaint, Simon Stanworth, Nicola Curry, Rolf Lefering, Marc Maegele, ,

<h4>Background</h4>Trauma-induced coagulopathy in patients with traumatic brain injury (TBI) is associated with high rates of complications, unfavourable outcomes and mortality. The mechanism of the development of TBI-associated coagulopathy is poorly understood.<h4>Methods</h4>This analysis, embedded in the prospective, multi-centred, observational Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study, aimed ... Read more >>

Neurocrit Care (Neurocritical care)
[2020, :]

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Impact of haemolysis on vancomycin disposition in a full-term neonate treated with extracorporeal membrane oxygenation.

Pavla Pokorná, Martin Šíma, Dick Tibboel, Ondřej Slanař,

<h4>Introduction</h4>Extracorporeal membrane oxygenation (ECMO) is a lifesaving support technology for potentially reversible neonatal cardiac and/or respiratory failure. Pharmacological consequences of ECMO-induced haemolysis in neonates are not well understood.<h4>Case report</h4>We report a case report of a full-term neonate treated for congenital diaphragmatic hernia and sepsis with ECMO and with vancomycin. While ... Read more >>

Perfusion (Perfusion)
[2020, :267659120973595]

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Histological, immunohistochemical and transcriptomic characterization of human tracheoesophageal fistulas.

Erwin Brosens, Janine F Felix, Anne Boerema-de Munck, Elisabeth M de Jong, Elisabeth M Lodder, Sigrid Swagemakers, Marjon Buscop-van Kempen, Ronald R de Krijger, Rene M H Wijnen, Wilfred F J van IJcken, Peter van der Spek, Annelies de Klein, Dick Tibboel, Robbert J Rottier,

Esophageal atresia (EA) and tracheoesophageal fistula (TEF) are relatively frequently occurring foregut malformations. EA/TEF is thought to have a strong genetic component. Not much is known regarding the biological processes disturbed or which cell type is affected in patients. This hampers the detection of the responsible culprits (genetic or environmental) ... Read more >>

PLoS One (PloS one)
[2020, 15(11):e0242167]

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Severity parameters for asphyxia or hypoxic-ischemic encephalopathy do not explain interindividual variability in the pharmacokinetics of phenobarbital in newborns treated with therapeutic hypothermia.

Pavla Pokorná, Danica Michaličková, Swantje Völler, Karolina Hronová, Dick Tibboel, Ondřej Slanař, Elke H Krekels,

<h4>Background</h4>The current study uses a population modeling approach to evaluate and quantify the impact of severity of asphyxia and hypoxic-ischemic encephalopathy (HIE) on the pharmacokinetics of phenobarbital in asphyxiated newborns treated with therapeutic hypothermia.<h4>Methods</h4>Included newborns received phenobarbital (the TOBY trial protocol). 120 plasma sample were available from 50 newborns, median ... Read more >>

Minerva Pediatr (Minerva pediatrica)
[2020, :]

Cited: 1 time

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Prediction of Global Functional Outcome and Post-Concussive Symptoms after Mild Traumatic Brain Injury: External Validation of Prognostic Models in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Study.

Ana Mikolić, Suzanne Polinder, Ewout W Steyerberg, Isabel R A Retel Helmrich, Joseph T Giacino, Andrew I R Maas, Joukje van der Naalt, Daphne C Voormolen, Nicole von Steinbüchel, Lindsay Wilson, Hester F Lingsma, David van Klaveren, ,

The majority of traumatic brain injuries (TBIs) are categorized as mild, according to a baseline Glasgow Coma Scale (GCS) score of 13-15. Prognostic models that were developed to predict functional outcome and persistent post-concussive symptoms (PPCS) after mild TBI have rarely been externally validated. We aimed to externally validate models ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2021, 38(2):196-209]

Cited: 1 time

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Impact of enantiomer-specific changes in pharmacokinetics between infants and adults on the target concentration of racemic ketorolac: A pooled analysis.

Michael E Cloesmeijer, Michiel J van Esdonk, Anne M Lynn, Anne Smits, Dick Tibboel, Youssef Daali, Klaus T Olkkola, Karel Allegaert, Paola Mian,

<h4>Aims</h4>Ketorolac is a nonsteroidal anti-inflammatory racemic drug with analgesic effects only attributed to its S-enantiomer. The aim of this study is to quantify enantiomer-specific maturational pharmacokinetics (PK) of ketorolac and investigate if the contribution of both enantiomers to the total ketorolac concentration remains equal between infants and adults or if ... Read more >>

Br J Clin Pharmacol (British journal of clinical pharmacology)
[2021, 87(3):1443-1454]

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Size matters: large copy number losses reveal novel Hirschsprung disease genes

Laura Kuil, Katherine MacKenzie, Clara Tang, Jonathan Windster, Thuy Linh Le, Anwarul Karim, Bianca de Graaf, Robert van der Helm, Yolande van Bever, Cornelius E.J. Sloots, Conny Meeussen, Dick Tibboel, Annelies de Klein, René Wijnen, Jeanne Amiel, Stanislas Lyonnet, Maria-Mercè Garcia-Barcelo, Paul K.H. Tam, Maria Alves, Alice Brooks, Robert M.W. Hofstra, Erwin Brosens,

<h4>Background</h4> Hirschsprung disease (HSCR) is characterized by absence of ganglia in the intestine. Approximately 18% of patients have additional anatomical malformations or neurological symptoms (HSCR-AAM). HSCR is a complex genetic disease in which the loss of enteric ganglia stems from a combination of genetic alterations: rare coding variants, predisposing haplotypes ... Read more >>

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Proenkephalin as a new biomarker for pediatric acute kidney injury - reference values and performance in children under one year of age.

Stan J F Hartman, Alexandra J M Zwiers, Nadies E C van de Water, Joost van Rosmalen, Joachim Struck, Janin Schulte, Oliver Hartmann, Peter Pickkers, Remi Beunders, Dick Tibboel, Michiel F Schreuder, Saskia N de Wildt,

Objectives Acute kidney injury (AKI) is common in critically ill children, but current biomarkers are suboptimal. Proenkephalin A 119-159 (PENK) is a promising new biomarker for AKI in adults, but pediatric data is lacking. We determined PENK reference intervals for healthy children, crucial for clinical implementation, and explored concentrations in ... Read more >>

Clin Chem Lab Med (Clinical chemistry and laboratory medicine)
[2020, 58(11):1911-1919]

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Diagnosis and Treatment of Chronic Neuropathic and Mixed Pain in Children and Adolescents: Results of a Survey Study amongst Practitioners.

Thomas G de Leeuw, Tjitske van der Zanden, Simona Ravera, Mariagrazia Felisi, Donato Bonifazi, Dick Tibboel, Adriana Ceci, Florentia Kaguelidou, Saskia N de Wildt, On Behalf Of The Gapp Consortium,

Validated diagnostic tools to diagnose chronic neuropathic and mixed pain in children are missing. Therapeutic options are often derived from therapeutics for adults. To investigate the international practice amongst practitioners for the diagnosis and treatment of chronic, neuropathic pain in children and adolescents, we performed a survey study among members ... Read more >>

Children (Basel) (Children (Basel, Switzerland))
[2020, 7(11):]

Cited: 1 time

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Delivering transformative action in paediatric pain: a Lancet Child & Adolescent Health Commission.

Christopher Eccleston, Emma Fisher, Richard F Howard, Rebeccah Slater, Paula Forgeron, Tonya M Palermo, Kathryn A Birnie, Brian J Anderson, Christine T Chambers, Geert Crombez, Gustaf Ljungman, Isabel Jordan, Zachary Jordan, Caitriona Roberts, Neil Schechter, Christine B Sieberg, Dick Tibboel, Suellen M Walker, Dominic Wilkinson, Chantal Wood,

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2021, 5(1):47-87]

Cited: 3 times

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