Full Text Journal Articles by
Author Diana M Stafforini

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Deletion of diacylglycerol kinase ε confers susceptibility to obesity via reduced lipolytic activity in murine adipocytes.

Tomoyuki Nakano, Keiko Seino, Ichiro Wakabayashi, Diana M Stafforini, Matthew K Topham, Kaoru Goto,

Lipid metabolism is closely involved with signal transduction and energy homeostasis. Excess calorie intake causes abnormal lipid metabolism, promoting obesity and insulin resistance. Diacylglycerol (DG) represents not only a lipidic second messenger but also an intermediate metabolite for triglyceride metabolism in the endoplasmic reticulum (ER). However, it remains undetermined how ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2018, 32(8):4121-4131]

Cited: 3 times

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Plasma PAF-AH (PLA2G7): Biochemical Properties, Association with LDLs and HDLs, and Regulation of Expression.

Diana M Stafforini,

This chapter is focused on the plasma form of PAF-acetylhydrolase (PAF-AH), a lipoprotein-bound, calcium-independent phospholipase A2 activity also referred to as lipoprotein-associated phospholipase A2 and PLA2G7. PAF-AH catalyzes the removal of the acyl group at the sn-2 position of PAF and truncated phospholipids generated in settings of inflammation and oxidant ... Read more >>

Enzymes (The Enzymes)
[2015, 38:71-93]

Cited: 6 times

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Diverse Functions of Plasma PAF-AH in Tumorigenesis.

Diana M Stafforini,

This chapter is focused on the role of the plasma form of platelet-activating factor-acetylhydrolase (PAF-AH), heretofore referred to as PAF-AH, in tumorigenic responses. Biochemical and other properties of this enzyme were discussed in detail in chapter "Plasma PAF-AH (PLA2G7): Biochemical Properties, Association with LDLs and HDLs, and Regulation of Expression" ... Read more >>

Enzymes (The Enzymes)
[2015, 38:157-179]

Cited: 4 times

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Arachidonic acid downregulates acyl-CoA synthetase 4 expression by promoting its ubiquitination and proteasomal degradation.

Chin Fung Kelvin Kan, Amar Bahadur Singh, Diana M Stafforini, Salman Azhar, Jingwen Liu,

ACSL4 is a member of the long-chain acyl-CoA synthetase (ACSL) family with a marked preference for arachidonic acid (AA) as its substrate. Although an association between elevated levels of ACSL4 and hepatosteatosis has been reported, the function of ACSL4 in hepatic FA metabolism and the regulation of its functional expression ... Read more >>

J. Lipid Res. (Journal of lipid research)
[2014, 55(8):1657-1667]

Cited: 15 times

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Deficiency of phospholipase A2 group 7 decreases intestinal polyposis and colon tumorigenesis in Apc(Min/+) mice.

Changxin Xu, Ethan C Reichert, Tomoyuki Nakano, Mariah Lohse, Alison A Gardner, Mónica P Revelo, Matthew K Topham, Diana M Stafforini,

Platelet-activating factor (PAF) is a naturally occurring phospholipid that mediates diverse effects such as physiological and pathological inflammation, immunosuppression, and cancer. Several lines of evidence support both positive and negative roles for PAF in carcinogenesis. PAF stimulates cell growth, oncogenic transformation, and metastasis, but can also limit proliferation and induce ... Read more >>

Cancer Res (Cancer research)
[2013, 73(9):2806-2816]

Cited: 13 times

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Platelet-activating factor stimulates sodium-hydrogen exchange in ventricular myocytes.

Yoichi Ajiro, Noriko Saegusa, Wayne R Giles, Diana M Stafforini, Kenneth W Spitzer,

Sodium-hydrogen exchanger (NHE), the principal sarcolemmal acid extruder in ventricular myocytes, is stimulated by a variety of autocrine/paracrine factors and contributes to myocardial injury and arrhythmias during ischemia-reperfusion. Platelet-activating factor (PAF; 1-o-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is a potent proinflammatory phospholipid that is released in the heart in response to oxidative stress and promotes ... Read more >>

Am J Physiol Heart Circ Physiol (American journal of physiology. Heart and circulatory physiology)
[2011, 301(6):H2395-401]

Cited: 3 times

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Mouse plasminogen has oxidized phosphatidylcholine adducts that are not metabolized by lipoprotein-associated phospholipase A₂under basal conditions.

Celina Edelstein, Ditta Pfaffinger, Ethan C Reichert, Diana M Stafforini, Angelo M Scanu,

We previously showed that plasminogen (Plg) isolated from the plasma of normal human subjects contains 1-2 moles of oxidized phosphatidylcholine (oxPtdPC) adducts/mole of protein. Moreover, we suggested that these species are generated at the hepatic site and speculated that they may play a role in the reported cardiovascular pathogenicity of ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2010, 11(12):5339-5347]

Cited: 1 time

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Novel mechanism for regulation of plasma platelet-activating factor acetylhydrolase expression in mammalian cells.

Alison A Gardner, Ethan C Reichert, Timothy S Alexander, Matthew K Topham, Diana M Stafforini,

The plasma form of PAF-AH [PAF (platelet-activating factor) acetylhydrolase; also known as LpPLA(2) (lipopoprotein-associated phospholipase A(2)), PLA(2)G7] catalyses the release of sn-2 fatty acyl residues from PAF, oxidatively fragmented phospholipids, and esterified isoprostanes. The plasma levels of this enzyme vary widely among mammalian species, including mice and humans, but the ... Read more >>

Biochem J (The Biochemical journal)
[2010, 428(2):269-279]

Cited: 2 times

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Increased blood flow induces oxidative stress through an endothelium- and nitric oxide-independent mechanism.

Pete Fong, Diana M Stafforini, Nancy J Brown, Mias Pretorius,

Bradykinin, a potent vasodilator, stimulates the formation of reactive oxygen species and F(2)-isoprostanes in vitro. The effect of bradykinin on oxidative stress in humans is not known. This study tested the hypothesis that bradykinin induces oxidative stress through a nitric oxide (NO)-dependent mechanism in the human vasculature. We measured forearm ... Read more >>

Free Radic Biol Med (Free radical biology & medicine)
[2010, 49(2):301-305]

Cited: 3 times

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Diacylglycerol kinase delta and protein kinase C(alpha) modulate epidermal growth factor receptor abundance and degradation through ubiquitin-specific protease 8.

Jinjin Cai, Tracy M Crotty, Ethan Reichert, Kermit L Carraway, Diana M Stafforini, Matthew K Topham,

Many human epithelial cancers are characterized by abnormal activation of the epidermal growth factor receptor (EGFR), which is often caused by its excessive expression in tumor cells. The abundance of EGFR is modulated, in part, by its ubiquitination, which targets it for degradation. The components responsible for adding ubiquitin to ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2010, 285(10):6952-6959]

Cited: 13 times

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New perspectives on APC control of cell fate and proliferation in colorectal cancer.

Reid A Phelps, Talmage J Broadbent, Diana M Stafforini, David A Jones,

Aberrant Wnt/beta-catenin signaling following loss of the tumor suppressor adenomatous polyposis coli (APC) is thought to initiate colon adenoma formation. Considerable evidence for this model has come from mouse models of Apc truncation where nuclear beta-catenin is detectable soon after loss of Apc. However, examination of tumors from familial adenomatous ... Read more >>

Cell Cycle (Cell cycle (Georgetown, Tex.))
[2009, 8(16):2549-2556]

Cited: 49 times

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Expression of Long-chain Fatty Acyl-CoA Synthetase 4 in Breast and Prostate Cancers Is Associated with Sex Steroid Hormone Receptor Negativity.

Marie E Monaco, Chad J Creighton, Peng Lee, Xuanyi Zou, Matthew K Topham, Diana M Stafforini,

Previous studies have shown that key enzymes involved in lipid metabolic pathways are differentially expressed in normal compared with tumor tissues. However, the precise role played by dysregulated expression of lipid metabolic enzymes and altered lipid homeostasis in carcinogenesis remains to be established. Fatty acid synthase is overexpressed in a ... Read more >>

(Translational oncology)
[2010, 3(2):91-98]

Cited: 37 times

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The levels of retinoic acid-inducible gene I are regulated by heat shock protein 90-alpha.

Tomoh Matsumiya, Tadaatsu Imaizumi, Hidemi Yoshida, Kei Satoh, Matthew K Topham, Diana M Stafforini,

Retinoic acid-inducible gene I (RIG-I) is an intracellular pattern recognition receptor that plays important roles during innate immune responses to viral dsRNAs. The mechanisms and signaling molecules that participate in the downstream events that follow activation of RIG-I are incompletely characterized. In addition, the factors that define intracellular availability of ... Read more >>

J Immunol (Journal of immunology (Baltimore, Md. : 1950))
[2009, 182(5):2717-2725]

Cited: 17 times

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PAF-acetylhydrolase expressed during megakaryocyte differentiation inactivates PAF-like lipids.

Jason M Foulks, Gopal K Marathe, Noemi Michetti, Diana M Stafforini, Guy A Zimmerman, Thomas M McIntyre, Andrew S Weyrich,

Platelet activating factor (PAF) and PAF-like lipids induce inflammatory responses in target cells. These lipid mediators are inactivated by PAF-acetylhydrolase (PAF-AH). The PAF signaling system affects the growth of hematopoietic CD34(+) cells, but roles for PAF-AH in this process are unknown. Here, we investigated PAF-AH function during megakaryopoiesis and found ... Read more >>

Blood (Blood)
[2009, 113(26):6699-6706]

Cited: 11 times

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Biology of platelet-activating factor acetylhydrolase (PAF-AH, lipoprotein associated phospholipase A2).

Diana M Stafforini,

This article is focused on platelet-activating factor acetylhydrolase (PAF-AH), a lipoprotein bound, calcium-independent phospholipase A(2) activity also referred to as lipoprotein-associated phospholipase A(2) or PLA(2)G7. PAF-AH catalyzes the removal of the acyl group at the sn-2 position of PAF and truncated phospholipids generated in settings of inflammation and oxidant stress.Here, ... Read more >>

Cardiovasc Drugs Ther (Cardiovascular drugs and therapy)
[2009, 23(1):73-83]

Cited: 105 times

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Transgenic expression of cyclooxygenase-2 in mouse intestine epithelium is insufficient to initiate tumorigenesis but promotes tumor progression.

Mazin A Al-Salihi, A Terrece Pearman, Thao Doan, Ethan C Reichert, Daniel W Rosenberg, Stephen M Prescott, Diana M Stafforini, Matthew K Topham,

We generated mice expressing a COX-2 transgene in colon epithelium and found that they did not develop spontaneous colon tumors. But when treated with azoxymethane, a colon carcinogen, COX-2 mice had a higher tumor load compared to wild-type mice. There was no change in the number of pre-neoplastic lesions, indicating ... Read more >>

Cancer Lett (Cancer letters)
[2009, 273(2):225-232]

Cited: 22 times

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IFN-epsilon mediates TNF-alpha-induced STAT1 phosphorylation and induction of retinoic acid-inducible gene-I in human cervical cancer cells.

Tomoh Matsumiya, Stephen M Prescott, Diana M Stafforini,

Retinoic acid inducible gene-I (RIG-I) plays important roles during innate immune responses to viral infections and as a transducer of cytokine signaling. The mechanisms of RIG-I up-regulation after cytokine stimulation are incompletely characterized. It was previously reported that IFN-gamma induces the expression of RIG-I in endothelial cells. In this study, ... Read more >>

J. Immunol. (Journal of immunology (Baltimore, Md. : 1950))
[2007, 179(7):4542-4549]

Cited: 26 times

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Retinoic acid inhibits beta-catenin through suppression of Cox-2: a role for truncated adenomatous polyposis coli.

Annie L Eisinger, Lincoln D Nadauld, Dawne N Shelton, Stephen M Prescott, Diana M Stafforini, David A Jones,

Mutations in adenomatous polyposis coli (APC) underlie the earliest stages of colorectal carcinogenesis. Consequences of APC mutation include stabilization of beta-catenin, dysregulation of cyclooxygenase-2 (COX-2) expression, and loss of retinoic acid production, events with poorly defined interactions. Here we showed that treatment of zebrafish expressing a truncated form of Apc ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2007, 282(40):29394-29400]

Cited: 14 times

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Lung production of platelet-activating factor acetylhydrolase in oleic acid-induced acute lung injury.

Jorge I Salluh, Alexandre V Pino, Adriana R Silva, Rachel N Gomes, Heitor S Souza, Jose Roberto Lapa e Silva, Frederico C Jandre, Antonio Giannella-Neto, Guy A Zimmerman, Diana M Stafforini, Stephen M Prescott, Hugo C Castro-Faria-Neto, Patrícia T Bozza, Fernando A Bozza,

Platelet-activating factor (PAF) is a proinflammatory mediator that plays a central role in acute lung injury (ALI). PAF- acetylhydrolases (PAF-AHs) terminate PAF's signals and regulate inflammation. In this study, we describe the kinetics of plasma and bronchoalveolar lavage (BAL) PAF-AH in the early phase of ALI. Six pigs with oleic ... Read more >>

Prostaglandins Leukot Essent Fatty Acids (Prostaglandins, leukotrienes, and essential fatty acids)
[2007, 77(1):1-8]

Cited: 6 times

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Integrin alphaDbeta2 is dynamically expressed by inflamed macrophages and alters the natural history of lethal systemic infections.

Yasunari Miyazaki, Michaeline Bunting, Diana M Stafforini, Estelle S Harris, Thomas M McIntyre, Stephen M Prescott, Valber S Frutuoso, Fabio C Amendoeira, Danielle de Oliveira Nascimento, Adriana Vieira-de-Abreu, Andrew S Weyrich, Hugo C Castro-Faria-Neto, Guy A Zimmerman,

The leukocyte integrins have critical roles in host defense and inflammatory tissue injury. We found that integrin alphaDbeta2, a novel but largely uncharacterized member of this family, is restricted to subsets of macrophages and a small population of circulating leukocytes in wild-type mice in the absence of inflammatory challenge and ... Read more >>

J Immunol (Journal of immunology (Baltimore, Md. : 1950))
[2008, 180(1):590-600]

Cited: 12 times

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Cyclooxygenase-2 transactivates the epidermal growth factor receptor through specific E-prostanoid receptors and tumor necrosis factor-alpha converting enzyme.

Mazin A Al-Salihi, Scott C Ulmer, Thao Doan, Cory D Nelson, Tracy Crotty, Stephen M Prescott, Diana M Stafforini, Matthew K Topham,

Cyclooxygenase-2 is often highly expressed in epithelial malignancies and likely has an active role in tumor development. But how it promotes tumorigenesis is not clearly defined. Recent evidence suggests that this may involve transactivation of the epidermal growth factor receptor through E-prostanoid receptors, but reports differ about the mechanism by ... Read more >>

Cell Signal (Cellular signalling)
[2007, 19(9):1956-1963]

Cited: 19 times

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The role of cyclooxygenase-2 and prostaglandins in colon cancer.

Annie L Eisinger, Stephen M Prescott, David A Jones, Diana M Stafforini,

The temporal association between loss of function of the tumor suppressor adenomatous polyposis coli (APC) and overexpression of cyclooxygenase 2 (COX-2) has been demonstrated in vivo and has led to the hypothesis that APC regulates COX-2 expression. This could potentially occur through a variety of mechanisms including the well-characterized ability ... Read more >>

Prostaglandins Other Lipid Mediat. (Prostaglandins & other lipid mediators)
[2007, 82(1-4):147-154]

Cited: 48 times

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Exogenous platelet-activating factor acetylhydrolase reduces mortality in mice with systemic inflammatory response syndrome and sepsis.

Rachel N Gomes, Fernando A Bozza, Rodrigo T Amâncio, André M Japiassú, Rosa C S Vianna, Andréa P Larangeira, Juliana M Gouvêa, Marcela S Bastos, Guy A Zimmerman, Diana M Stafforini, Stephen M Prescott, Patrícia T Bozza, Hugo C Castro-Faria-Neto,

Current evidence indicates that dysregulation of the host inflammatory response to infectious agents is central to the mortality of patients with sepsis and in those with systemic inflammatory response syndrome. Strategies to block inflammatory mediators, often with complicated outcomes, are currently being investigated as new adjuvant therapies for sepsis. Here, ... Read more >>

Shock (Shock (Augusta, Ga.))
[2006, 26(1):41-49]

Cited: 39 times

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The adenomatous polyposis coli tumor suppressor gene regulates expression of cyclooxygenase-2 by a mechanism that involves retinoic acid.

Annie L Eisinger, Lincoln D Nadauld, Dawne N Shelton, Peter W Peterson, Reid A Phelps, Stephanie Chidester, Diana M Stafforini, Stephen M Prescott, David A Jones,

Mutations in the adenomatous polyposis coli (APC) gene result in uncontrolled proliferation of intestinal epithelial cells and are associated with the earliest stages of colorectal carcinogenesis. Cyclooxygenase-2 (COX-2) is elevated in human colorectal cancers and plays an important role in colorectal tumorigenesis; however, the mechanisms by which APC mutations result ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2006, 281(29):20474-20482]

Cited: 31 times

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Release of free F2-isoprostanes from esterified phospholipids is catalyzed by intracellular and plasma platelet-activating factor acetylhydrolases.

Diana M Stafforini, James R Sheller, Timothy S Blackwell, Adam Sapirstein, Fiona E Yull, Thomas M McIntyre, Joseph V Bonventre, Stephen M Prescott, L Jackson Roberts,

F2-isoprostanes are produced in vivo by nonenzymatic peroxidation of arachidonic acid esterified in phospholipids. Increased urinary and plasma F2-isoprostane levels are associated with a number of human diseases. These metabolites are regarded as excellent markers of oxidant stress in vivo. Isoprostanes are initially generated in situ, i.e. when the arachidonate ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2006, 281(8):4616-4623]

Cited: 119 times

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