Full Text Journal Articles by
Author Diana A Gorog

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Suveer Singh, Diana A Gorog, Ciara F Mahon, Bhavin Rawal, Thomas R Semple, Edward D Nicol, Deepa R J Arachchillage, Susanna Price, Sujal Desai, Carole A Ridge, Simon P G Padley, Saeed Mirsadraee,

Crit Care Med (Critical care medicine)
[2021, 49(11):e1190-e1191]

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Low-dose ticagrelor with or without acetylsalicylic acid in patients with acute coronary syndrome: Rationale and design of the ELECTRA-SIRIO 2 trial.

Jacek Kubica, Piotr Adamski, Diana A Gorog, Aldona Kubica, Bernd Jilma, Andrzej Budaj, Jolanta M Siller-Matula, Paul A Gurbel, Dimitrios Alexopoulos, Jolita Badarienė, Paweł Dąbrowski, Dariusz Dudek, Evangelos Giannitsis, Grzegorz Horszczaruk, Miłosz Jaguszewski, Stefan James, Young-Hoon Jeong, Michał Kryjak, Piotr Niezgoda, Małgorzata Ostrowska, Giuseppe Patti, Janusz Romanek, Salvatore Di Somma, Giuseppe Specchia, Udaya Tantry, Mariusz Gąsior, Agnieszka Tycińska, Wojciech Wojakowski, Katarzyna Buszko, Robert Gil, Marcin Gruchała, Jarosław Kasprzak, Andrzej Kleinrok, Jacek Legutko, Maciej Lesiak, Eliano P Navarese,

Cardiol J (Cardiology journal)
[2021, :]

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When a meta-analysis equals a single large-scale trial with meaningful follow-up.

Eliano P Navarese, Dean J Kereiakes, Diana A Gorog, Alexandra J Lansky, Felicita Andreotti,

Eur Heart J (European heart journal)
[2021, 42(37):3884-3885]

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Cardiovascular disease and COVID-19: a consensus paper from the ESC Working Group on Coronary Pathophysiology & Microcirculation, ESC Working Group on Thrombosis and the Association for Acute CardioVascular Care (ACVC), in collaboration with the European Heart Rhythm Association (EHRA).

Edina Cenko, Lina Badimon, Raffaele Bugiardini, Marc J Claeys, Giuseppe De Luca, Cor de Wit, Geneviève Derumeaux, Maria Dorobantu, Dirk J Duncker, Etto C Eringa, Diana A Gorog, Christian Hassager, Frank R Heinzel, Kurt Huber, Olivia Manfrini, Davor Milicic, Evangelos Oikonomou, Teresa Padro, Danijela Trifunovic-Zamaklar, Zorana Vasiljevic-Pokrajcic, Marija Vavlukis, Gemma Vilahur, Dimitris Tousoulis,

The cardiovascular system is significantly affected in coronavirus disease-19 (COVID-19). Microvascular injury, endothelial dysfunction and thrombosis resulting from viral infection or indirectly related to the intense systemic inflammatory and immune responses are characteristic features of severe COVID-19. Pre-existing cardiovascular disease and viral load are linked to myocardial injury and worse ... Read more >>

Cardiovasc Res (Cardiovascular research)
[2021, :]

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Interleukin 6 and Cardiovascular Outcomes in Patients With Chronic Kidney Disease and Chronic Coronary Syndrome.

Gorav Batra, Tatevik Ghukasyan Lakic, Johan Lindbäck, Claes Held, Harvey D White, Ralph A H Stewart, Wolfgang Koenig, Christopher P Cannon, Andrzej Budaj, Emil Hagström, Agneta Siegbahn, Lars Wallentin, ,

<h4>Importance</h4>Inflammation promotes cardiovascular disease and anti-inflammatory treatment reduces cardiovascular events in patients with chronic coronary syndrome. Chronic kidney disease (CKD) is a risk factor for cardiovascular disease. It is unclear how inflammation mediated by interleukin 6 (IL-6) in patients with CKD is linked to cardiovascular disease.<h4>Objective</h4>To investigate associations between IL-6 ... Read more >>

JAMA Cardiol (JAMA cardiology)
[2021, :]

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Elevated serum transaminases in patients with acute coronary syndromes: Do we need a revision of exclusion criteria for clinical trials?

Małgorzata Jasiewicz, Michał Siedlaczek, Michał Kasprzak, Diana A Gorog, Bernd Jilma, Jolanta Siller-Matula, Karolina Obońska, Ryszard Dobosiewicz, Krzysztof Pstrągowski, Jacek Kubica,

<h4>Background</h4>Elevations of hepatic transaminase (serum alanine transaminase [ALT] and serum aspartate aminotransferase [AST]) levels in patients with acute coronary syndrome (ACS), although transient, may result in exclusions from clinical efficacy trials due to suspected liver disease. The aim of this study was to evaluate the concentrations of serum transaminases in ... Read more >>

Cardiol J (Cardiology journal)
[2021, :]

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Should we consider low LDL-cholesterol a marker of in-hospital bleeding in patients with acute coronary syndrome undergoing percutaneous coronary intervention?

Diana A Gorog, Eliano P Navarese, Felicita Andreotti,

Eur Heart J (European heart journal)
[2021, 42(33):3187-3189]

Cited: 1 time

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Spontaneous Reperfusion in Patients with Transient ST-Elevation Myocardial Infarction-Prevalence, Importance and Approaches to Management.

Mohamed Farag, Marta Peverelli, Nikolaos Spinthakis, Ying X Gue, Mohaned Egred, Diana A Gorog,

Patients with transient ST-elevation myocardial infarction (STEMI) or spontaneous resolution (SpR) of the ST-segment elevation on electrocardiogram could potentially represent a unique group of patients posing a therapeutic management dilemma. In this review, we discuss the potential mechanisms underlying SpR, its relation to clinical outcomes and the proposed management options ... Read more >>

Cardiovasc Drugs Ther (Cardiovascular drugs and therapy)
[2021, :]

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Preoperative Atrial Fibrillation is associated with long-term morTality in patients undergoing suRgical AortiC valvE Replacement.

Mohamed Farag, Yusuf Kiberu, S Ashwin Reddy, Ahmad Shoaib, Mohaned Egred, Unni Krishnan, Mina Fares, Marta Peverelli, Diana A Gorog, Walid Elmahdy, Marius Berman, Mohamed Osman, ,

<h4>Introduction</h4>Atrial fibrillation (AF) is frequent after any cardiac surgery, but evidence suggests it may have no significant impact on survival if sinus rhythm (SR) is effectively restored early after the onset of the arrhythmia. In contrast, management of preoperative AF is often overlooked during or after cardiac surgery despite several ... Read more >>

J Card Surg (Journal of cardiac surgery)
[2021, 36(10):3561-3566]

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RIC in COVID-19-a Clinical Trial to Investigate Whether Remote Ischemic Conditioning (RIC) Can Prevent Deterioration to Critical Care in Patients with COVID-19.

Sean M Davidson, Kishal Lukhna, Diana A Gorog, Alan D Salama, Alejandro Rosell Castillo, Sara Giesz, Pelin Golforoush, Siavash Beikoghli Kalkhoran, Sandrine Lecour, Aqeela Imamdin, Helison R P do Carmo, Ticiane Gonçalez Bovi, Mauricio W Perroud, Mpiko Ntsekhe, Andrei C Sposito, Derek M Yellon,

<h4>Purpose</h4>Coronavirus disease 19 (COVID-19) has, to date, been diagnosed in over 130 million persons worldwide and is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Several variants of concern have emerged including those in the United Kingdom, South Africa, and Brazil. SARS-CoV-2 can cause a dysregulated inflammatory response known ... Read more >>

Cardiovasc Drugs Ther (Cardiovascular drugs and therapy)
[2021, :]

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Correction to: RIC in COVID-19-a Clinical Trial to Investigate Whether Remote Ischemic Conditioning (RIC) Can Prevent Deterioration to Critical Care in Patients with COVID-19.

Sean M Davidson, Kishal Lukhna, Diana A Gorog, Alan D Salama, Alejandro Rosell Castillo, Sara Giesz, Pelin Golforoush, Siavash Beikoghli Kalkhoran, Sandrine Lecour, Aqeela Imamdin, Helison R P do Carmo, Ticiane Gonçalez Bovi, Mauricio W Perroud, Mpiko Ntsekhe, Andrei C Sposito, Derek M Yellon,

Cardiovasc Drugs Ther (Cardiovascular drugs and therapy)
[2021, :]

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Screening for venous thromboembolism in patients with COVID-19.

Christophe Vandenbriele, Diana A Gorog,

Pulmonary thromboembolism and deep venous thrombosis occur frequently in hospitalised patients with COVID-19, the prevalence increases on the intensive care unit (ICU) and is very high in patients on extracorporeal membrane oxygenation (ECMO). We undertook a literature review to assess the usefulness of screening for peripheral venous thrombosis or pulmonary ... Read more >>

J Thromb Thrombolysis (Journal of thrombosis and thrombolysis)
[2021, :]

Cited: 1 time

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Antithrombotic therapy in diabetes: which, when, and for how long?

Ramzi A Ajjan, Noppadol Kietsiriroje, Lina Badimon, Gemma Vilahur, Diana A Gorog, Dominick J Angiolillo, David A Russell, Bianca Rocca, Robert F Storey,

Cardiovascular disease remains the main cause of mortality in individuals with diabetes mellitus (DM) and also results in significant morbidity. Premature and more aggressive atherosclerotic disease, coupled with an enhanced thrombotic environment, contributes to the high vascular risk in individuals with DM. This prothrombotic milieu is due to increased platelet ... Read more >>

Eur Heart J (European heart journal)
[2021, 42(23):2235-2259]

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A new approach to ticagrelor-based de-escalation of antiplatelet therapy after acute coronary syndrome. A rationale for a randomized, double-blind, placebo-controlled, investigator-initiated, multicenter clinical study.

Jacek Kubica, Piotr Adamski, Piotr Niezgoda, Aldona Kubica, Przemysław Podhajski, Malwina Barańska, Julia M Umińska, Łukasz Pietrzykowski, Małgorzata Ostrowska, Jolanta M Siller-Matula, Jolita Badarienė, Stanisław Bartuś, Andrzej Budaj, Sławomir Dobrzycki, Łukasz Fidor, Mariusz Gąsior, Jacek Gessek, Marek Gierlotka, Robert Gil, Jarosław Gorący, Paweł Grzelakowski, Tomasz Hajdukiewicz, Miłosz Jaguszewski, Marianna Janion, Jarosław Kasprzak, Adam Kern, Artur Klecha, Andrzej Kleinrok, Wacław Kochman, Bartosz Krakowiak, Jacek Legutko, Maciej Lesiak, Marcin Nosal, Grzegorz Piotrowski, Andrzej Przybylski, Tomasz Roleder, Grzegorz Skonieczny, Grzegorz Sobieszek, Agnieszka Tycińska, Dariusz Wojciechowski, Wojciech Wojakowski, Jarosław Wójcik, Marzenna Zielińska, Aleksander Żurakowski, Giuseppe Specchia, Diana A Gorog, Eliano P Navarese,

The risk of ischemic events gradually decreases after acute coronary syndrome (ACS), reaching a stable level after 1 month, while the risk of bleeding remains steady during the whole period of dual antiplatelet treatment (DAPT). Several de-escalation strategies of antiplatelet treatment aiming to enhance safety of DAPT without depriving it ... Read more >>

Cardiol J (Cardiology journal)
[2021, 28(4):607-614]

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Results of an international crowdsourcing survey on the treatment of non-ST segment elevation ACS patients at high-bleeding risk undergoing percutaneous intervention.

Deepak L Bhatt, Juan Carlos Kaski, Sean Delaney, Mirvat Alasnag, Felicita Andreotti, Dominick J Angiolillo, Albert Ferro, Diana A Gorog, Alberto J Lorenzatti, Mamas Mamas, John McNeil, José C Nicolau, Philippe Gabriel Steg, Juan Tamargo, Doreen Tan, Marco Valgimigli,

<h4>Aims</h4>Choosing an antiplatelet strategy in patients with non-ST segment elevation acute coronary syndrome (NSTE-ACS) at high bleeding risk (HBR), undergoing post-percutaneous coronary intervention (PCI), is complex. We used a unique open-source approach (crowdsourcing) to document if practices varied across a small, global cross-section of antiplatelet prescribers in the post-PCI setting.<h4>Methods ... Read more >>

Int J Cardiol (International journal of cardiology)
[2021, 337:1-8]

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Incidence of thrombotic complications in COVID-19 : On behalf of ICODE: The International COVID-19 Thrombosis Biomarkers Colloquium.

William J Jenner, Diana A Gorog,

A high incidence of thrombosis in hospitalised patients with COVID-19 was identified early during the pandemic. Accurately quantifying thrombotic risk may assist prognosis and guide appropriate thromboprophylaxis. Observational studies have estimated the rate of thrombosis in both hospitalised and non-hospitalised patients with COVID-19, and how this corresponds to the severity ... Read more >>

J Thromb Thrombolysis (Journal of thrombosis and thrombolysis)
[2021, :]

Cited: 1 time

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Management of antithrombotic therapy in patients undergoing transcatheter aortic valve implantation: a consensus document of the ESC Working Group on Thrombosis and the European Association of Percutaneous Cardiovascular Interventions (EAPCI), in collaboration with the ESC Council on Valvular Heart Disease.

Jurrien Ten Berg, Dirk Sibbing, Bianca Rocca, Eric Van Belle, Bernard Chevalier, Jean-Philippe Collet, Dariusz Dudek, Martine Gilard, Diana A Gorog, Julia Grapsa, Erik Lerkevang Grove, Patrizio Lancellotti, Anna Sonia Petronio, Andrea Rubboli, Lucia Torracca, Gemma Vilahur, Adam Witkowski, Julinda Mehilli,

Transcatheter aortic valve implantation (TAVI) is effective in older patients with symptomatic severe aortic stenosis, while the indication has recently broadened to younger patients at lower risk. Although thromboembolic and bleeding complications after TAVI have decreased over time, such adverse events are still common. The recommendations of the latest 2017 ... Read more >>

Eur Heart J (European heart journal)
[2021, 42(23):2265-2269]

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Prevalence of Thrombotic Complications in ICU-Treated Patients With Coronavirus Disease 2019 Detected With Systematic CT Scanning.

Saeed Mirsadraee, Diana A Gorog, Ciara F Mahon, Bhavin Rawal, Thomas R Semple, Edward D Nicol, Deepa R J Arachchillage, Anand Devaraj, Susanna Price, Sujal R Desai, Carole A Ridge, Suveer Singh, Simon P G Padley,

<h4>Objectives</h4>Severe coronavirus disease 2019 is associated with an extensive pneumonitis and frequent coagulopathy. We sought the true prevalence of thrombotic complications in critically ill patients with severe coronavirus disease 2019 on the ICU, with or without extracorporeal membrane oxygenation.<h4>Design</h4>We undertook a single-center, retrospective analysis of 72 critically ill patients with ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(5):804-815]

Cited: 4 times

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Biomarkers of coagulation and fibrinolysis in acute myocardial infarction: a joint position paper of the Association for Acute CardioVascular Care and the European Society of Cardiology Working Group on Thrombosis.

Konstantin A Krychtiuk, Walter S Speidl, Evangelos Giannitsis, Bruna Gigante, Diana A Gorog, Allan S Jaffe, Johannes Mair, Martin Möckel, Christian Mueller, Robert F Storey, Gemma Vilahur, Johann Wojta, Kurt Huber, Sigrun Halvorsen, Tobias Geisler, Joao Morais, Bertil Lindahl, Kristian Thygesen,

The formation of a thrombus in an epicardial artery may result in an acute myocardial infarction (AMI). Despite major advances in acute treatment using network approaches to allocate patients to timely reperfusion and optimal antithrombotic treatment, patients remain at high risk for thrombotic complications. Ongoing activation of the coagulation system ... Read more >>

Eur Heart J Acute Cardiovasc Care (European heart journal. Acute cardiovascular care)
[2021, 10(3):343-355]

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Cardiac mortality in patients randomised to elective coronary revascularisation plus medical therapy or medical therapy alone: a systematic review and meta-analysis.

Eliano P Navarese, Alexandra J Lansky, Dean J Kereiakes, Jacek Kubica, Paul A Gurbel, Diana A Gorog, Marco Valgimigli, Nick Curzen, David E Kandzari, Marc P Bonaca, Marc Brouwer, Julia Umińska, Milosz J Jaguszewski, Paolo Raggi, Ron Waksman, Martin B Leon, William Wijns, Felicita Andreotti,

<h4>Aims</h4>The value of elective coronary revascularisation plus medical therapy over medical therapy alone in managing stable patients with coronary artery disease is debated. We reviewed all trials comparing the two strategies in this population.<h4>Methods and results</h4>From inception through November 2020, MEDLINE, EMBASE, Google Scholar, and other databases were searched for ... Read more >>

Eur Heart J (European heart journal)
[2021, :]

Cited: 1 time

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Fibrinolysis in Platelet Thrombi.

Rahim Kanji, Ying X Gue, Vassilios Memtsas, Diana A Gorog,

The extent and duration of occlusive thrombus formation following an arterial atherothrombotic plaque disruption may be determined by the effectiveness of endogenous fibrinolysis. The determinants of endogenous fibrinolysis are the subject of much research, and it is now broadly accepted that clot composition as well as the environment in which ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(10):]

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Author Correction: Development of a novel risk score to predict mortality in patients admitted to hospital with COVID-19.

Ying X Gue, Maria Tennyson, Jovia Gao, Shuhui Ren, Rahim Kanji, Diana A Gorog,

Sci Rep (Scientific reports)
[2021, 11(1):8011]

Cited: 1 time

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Antithrombotic therapy in patients with acute coronary syndrome complicated by cardiogenic shock or out-of-hospital cardiac arrest: a joint position paper from the European Society of Cardiology (ESC) Working Group on Thrombosis, in association with the Acute Cardiovascular Care Association (ACCA) and European Association of Percutaneous Cardiovascular Interventions (EAPCI).

Diana A Gorog, Susanna Price, Dirk Sibbing, Andreas Baumbach, Davide Capodanno, Bruna Gigante, Sigrun Halvorsen, Kurt Huber, Maddalena Lettino, Sergio Leonardi, Joao Morais, Andrea Rubboli, Jolanta M Siller-Matula, Robert F Storey, Pascal Vranckx, Bianca Rocca,

Timely and effective antithrombotic therapy is critical to improving outcome, including survival, in patients with acute coronary syndrome (ACS). Achieving effective platelet inhibition and anticoagulation, with minimal risk, is particularly important in high-risk ACS patients, especially those with cardiogenic shock (CS) or those successfully resuscitated following out-of-hospital cardiac arrest (OHCA), ... Read more >>

Eur Heart J Cardiovasc Pharmacother (European heart journal. Cardiovascular pharmacotherapy)
[2021, 7(2):125-140]

Cited: 4 times

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Thrombotic complications in 2928 patients with COVID-19 treated in intensive care: a systematic review.

William J Jenner, Rahim Kanji, Saeed Mirsadraee, Ying X Gue, Susanna Price, Sanjay Prasad, Diana A Gorog,

A prothrombotic state is reported with severe COVID-19 infection, which can manifest in venous and arterial thrombotic events. Coagulopathy is reflective of more severe disease and anticoagulant thromboprophylaxis is recommended in hospitalized patients. However, the prevalence of thrombosis on the intensive care unit (ICU) remains unclear, including whether this is ... Read more >>

J Thromb Thrombolysis (Journal of thrombosis and thrombolysis)
[2021, 51(3):595-607]

Cited: 14 times

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Ethnic Difference of Thrombogenicity in Patients with Cardiovascular Disease: a Pandora Box to Explain Prognostic Differences.

Hyun Kuk Kim, Udaya S Tantry, Hyun Woong Park, Eun Seok Shin, Tobias Geisler, Diana A Gorog, Paul A Gurbel, Young Hoon Jeong,

Arterial and venous atherothrombotic events are finely regulated processes involving a complex interplay between vulnerable blood, vulnerable vessel, and blood stasis. Vulnerable blood ('thrombogenicity') comprises complex interactions between cellular components and plasma factors (inflammatory, procoagulant, anticoagulant, and fibrinolytic factors). The extent of thrombogenicity may determine the progression of atheroma and ... Read more >>

Korean Circ J (Korean circulation journal)
[2021, 51(3):202-221]

Cited: 0 times

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