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Author Dharani Hapangama

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Human Endometrial Carcinogenesis Is Associated with Significant Reduction in Long Non-Coding RNA, TERRA.

Meera Adishesh, Rafah Alnafakh, Duncan M Baird, Rhiannon E Jones, Shannon Simon, Lucy Button, Areege M Kamal, John Kirwan, S Bridget DeCruze, Josephine Drury, Gabriele Saretzki, Dharani K Hapangama,

Telomeres are transcribed as long non-coding RNAs called TERRAs (Telomeric repeat containing RNA) that participate in a variety of cellular regulatory functions. High telomerase activity (TA) is associated with endometrial cancer (EC). This study aimed to examine the levels of three TERRAs, transcribed at chromosomes 1q-2q-4q-10q-13q-22q, 16p and 20q in ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(22):]

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Laparoscopic Outcomes after Normal Clinical and Ultrasound Findings in Young Women with Chronic Pelvic Pain: A Cross-Sectional Study.

Nicola Tempest, Ekaterina Efstathiou, Zena Petros, Dharani K Hapangama,

Chronic pelvic pain (CPP) is one of the most common chronic pain problems experienced by women, with prevalence rates comparable to asthma and back pain. However, it is poorly understood and causative pathology is only seldom found. We aimed to establish prevalence of abnormal findings at diagnostic laparoscopy in young ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(8):]

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Developing a Preoperative Algorithm for the Diagnosis of Uterine Leiomyosarcoma.

Hannah Lawlor, Alexandra Ward, Alison Maclean, Steven Lane, Meera Adishesh, Sian Taylor, Shandya Bridget DeCruze, Dharani Kosala Hapangama,

Early diagnosis of the rare and life-threatening uterine leiomyosarcoma (LMS) is essential for prompt treatment, to improve survival. Preoperative distinction of LMS from benign leiomyoma remains a challenge, and thus LMS is often diagnosed post-operatively. This retrospective observational study evaluated the predictive diagnostic utility of 32 preoperative variables in 190 ... Read more >>

Diagnostics (Basel) (Diagnostics (Basel, Switzerland))
[2020, 10(10):]

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Endometriosis and the Fallopian Tubes: Theories of Origin and Clinical Implications.

Christopher J Hill, Marwa Fakhreldin, Alison Maclean, Lucy Dobson, Lewis Nancarrow, Alice Bradfield, Fiona Choi, Diandra Daley, Nicola Tempest, Dharani K Hapangama,

Endometriosis is a common, oestrogen driven chronic condition, where endometrium-like epithelial and stromal cells exist in ectopic sites. At present, no curative treatments are available and the existing evidence for disease progression is conflicting. The pathogenesis is still unknown and evidently complex, as mechanisms of initiation may depend on the ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(6):]

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Investigating the Role of Telomere and Telomerase Associated Genes and Proteins in Endometrial Cancer.

Alice Bradfield, Lucy Button, Josephine Drury, Daniel C Green, Christopher J Hill, Dharani K Hapangama,

Endometrial cancer (EC) is the commonest gynaecological malignancy. Current prognostic markers are inadequate to accurately predict patient survival, necessitating novel prognostic markers, to improve treatment strategies. Telomerase has a unique role within the endometrium, whilst aberrant telomerase activity is a hallmark of many cancers. The aim of the current in ... Read more >>

Methods Protoc (Methods and protocols)
[2020, 3(3):]

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Gabapentin for chronic pelvic pain in women (GaPP2): a multicentre, randomised, double-blind, placebo-controlled trial.

Andrew W Horne, Katy Vincent, Catherine A Hewitt, Lee J Middleton, Magda Koscielniak, Wojciech Szubert, Ann M Doust, Jane P Daniels, ,

BACKGROUND:Chronic pelvic pain affects 2-24% of women worldwide and evidence for medical treatments is scarce. Gabapentin is effective in treating some chronic pain conditions. We aimed to measure the efficacy and safety of gabapentin in women with chronic pelvic pain and no obvious pelvic pathology. METHODS:We performed a multicentre, randomised, ... Read more >>

Lancet (Lancet (London, England))
[2020, 396(10255):909-917]

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Human Uterine Biopsy: Research Value and Common Pitfalls.

Alison Maclean, Areege Kamal, Meera Adishesh, Rafah Alnafakh, Nicola Tempest, Dharani K Hapangama,

The human uterus consists of the inner endometrium, the myometrium, and the outer serosa. Knowledge of the function of the uterus in health and disease is relevant to reproduction, fertility, embryology, gynaecology, endocrinology, and oncology. Research performed on uterine biopsies is essential to further the current understanding of human uterine ... Read more >>

Int J Reprod Med (International journal of reproductive medicine)
[2020, 2020:9275360]

Cited: 1 time

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Histological 3D reconstruction and in vivo lineage tracing of the human endometrium.

Nicola Tempest, Marnix Jansen, Ann-Marie Baker, Christopher J Hill, Mike Hale, Derek Magee, Darren Treanor, Nicholas A Wright, Dharani K Hapangama,

Regular menstrual shedding and repair of the endometrial functionalis is unique to humans and higher-order primates. The current consensus postulates endometrial glands to have a single-tubular architecture, where multi-potential stem cells reside in the blind-ending glandular-bases. Utilising fixed samples from patients, we have studied the three-dimensional (3D) micro-architecture of the ... Read more >>

J Pathol (The Journal of pathology)
[2020, 251(4):440-451]

Cited: 1 time

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Babies in occiput posterior position are significantly more likely to require an emergency cesarean birth compared with babies in occiput transverse position in the second stage of labor: A prospective observational study.

Nicola Tempest, Steven Lane, Dharani Hapangama, ,

INTRODUCTION:Malposition complicates 2-13% of births at delivery, leading to increased obstetric interventions (cesarean section and instrumental delivery) and higher rates of adverse fetal and maternal outcomes. Limited data are available regarding the likely rates of obstetric intervention and subsequent neonatal and maternal outcomes of births with babies in persistent occiput ... Read more >>

Acta Obstet Gynecol Scand (Acta obstetricia et gynecologica Scandinavica)
[2020, 99(4):537-545]

Cited: 1 time

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Enriching Personalized Endometrial Cancer Research with the Harmonization of Biobanking Standards.

Meera Adishesh, Dharani K Hapangama,

Endometrial cancer is the commonest gynecological cancer, with an incidence predicted to escalate by a further 50-100% before 2025, due to the rapid rise in risk factors such as obesity and increased life expectancy. Endometrial cancer associated mortality is also rising, depicting the need for translatable research to improve our ... Read more >>

Cancers (Basel) (Cancers)
[2019, 11(11):]

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Large-scale genome-wide association meta-analysis of endometriosis reveals 13 novel loci and genetically-associated comorbidity with other pain conditions

Rahmioglu Nilufer, Banasik Karina, Christofidou Paraskevi, Danning Rebecca, Galarneau Genevieve, Giri Ayush, MacGregor Stuart, Mortlock Sally, Sapkota Yadav, Schork Andrew, Sobalska-Kwapis Marta, Stefansdottir Lilja, Turman Constance, Uimari Outi, Adachi Sosuke, Andrews Shan, Arnadottir Ragnheidur, Burgdorf Kristoffer, Campbell Archie, Cheuk SK Cecilia, Clementi Caterina, Cook James, De Vivo Immaculata, DiVasta Amy, Dorien, Edwards Todd, Fontanillas Pierre, Fung Jenny, Geirsson Reynir, Girling Jane, Harris Holly, Holdsworth-Carson Sarah, Houshdaran Sahar, Hu-Seliger Tina, Jaqrvelin Marjo-Riitta, Kepka Ewa, Kulig Bartosz, Laufer Marc, Law Matthew, Low Siew-Kee, Mangino Massimo, Marciniak Blazej, Matalliotaki Charoula, Matalliotakis Michail, Murray Alison, Nezhat Camran, Nõukas Margit, Olsen Catherine, Padmanabhan Sandosh, Paranjpe Manish, Parfitt David-Emlyn, Peters Maire, Polak Grzegorz, Porteous David, Romanowicz Hanna, Saare Merli, Shafrir Amy, Siewierska-Górska Anna, Skarp Sini, Slomka Marcin, Smith Blair, Smolarz Beata, Szaflik Tomasz, Szyllo Krzysztof, Terry Kathyrn, Thorleifsson Gudmar, Tomassetti Carla, Vanhie Arne, Vincent Katy, Vitonis Allison, Werge Thomas, Andersen, Banasik, Brunak, KS Burgdorf, Erikstrup, TF Hansen, Hjalgrim, Jemec, Jennum, KR Nielsen, Nyegaard, HM Paarup, OB Pedersen, Petersen, Sorensen, Ullum, Werge, Gudbjartsson, Stefansson, Stefansson, Þorsteinsdottir, PB Mortensen, DM Hougaard, AD Borglum, Chasman Daniel, D’Hooghe Thomas, Giudice Linda, Goulielmos George, Hapangama Dharani, Hayward Caroline, Horne Andrew, Kamatani Yoichiro, Kubo Michiaki, Martikainen Hannu, Rogers AW Peter, Saunders Philippa, Sirota Marina, Spector Tim, Strapagiel Dominik, Tung Joyce, Whiteman David, Becker Christian, Salumets Andres, Magi Reedik, Kraft Peter, Nyegaard Mette, Nyholt Dale, Steinthorsdottir Valgerdur, Stefansson Kari, Velez-Edwards Digna, Yurttas Beim Piraye, Missmer Stacey, Montgomery Grant, Morris Andrew, Zondervan Krina, , , , ,

Abstract Endometriosis is a common complex inflammatory condition characterised by the presence of endometrium-like tissue outside the uterus, mainly in the pelvic area. It is associated with chronic pelvic pain and infertility, and its pathogenesis remains poorly understood. The disease is typically classified according to the revised American Fertility Society ... Read more >>

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High AGR2 protein is a feature of low grade endometrial cancer cells.

Areege Kamal, Anthony Valentijn, Roger Barraclough, Philip Rudland, Nihad Rahmatalla, Pierre Martin-Hirsch, Helen Stringfellow, Shandya B Decruze, Dharani K Hapangama,

Background:Biomarkers for identification of endometrial cancers (ECs) with high risk of recurrence are required to reduce the rising EC-related mortality. AGR2 is a prognostic marker in several hormonally-regulated cancers. Aim:To assess the utility of AGR2 as a prognostic marker in EC. Methods:AGR2 immunoexpression was evaluated in 163 human endometrial samples. ... Read more >>

Oncotarget (Oncotarget)
[2018, 9(59):31459-31472]

Cited: 3 times

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The dynamic changes in the number of uterine natural killer cells are specific to the eutopic but not to the ectopic endometrium in women and in a baboon model of endometriosis.

Josephine A Drury, Kirstin L Parkin, Lucy Coyne, Emma Giuliani, Asgerally T Fazleabas, Dharani K Hapangama,

BACKGROUND:Endometriosis is a common condition associated with growth of endometrial-like tissue beyond the uterine cavity. Previous reports have suggested a role for uNK cells in the pathogenesis of endometriosis postulating that survival and accumulation of menstrual endometrial tissue in the peritoneal cavity may relate to a reduction in the cytotoxic ... Read more >>

Reprod Biol Endocrinol (Reproductive biology and endocrinology : RB&E)
[2018, 16(1):67]

Cited: 7 times

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Endometrial vascular development in heavy menstrual bleeding: altered spatio-temporal expression of endothelial cell markers and extracellular matrix components.

Sourima Biswas Shivhare, Judith N Bulmer, Barbara A Innes, Dharani K Hapangama, Gendie E Lash,

STUDY QUESTION:Are there any phenotypic and structural/architectural changes in the vessels of endometrium and superficial myometrium during the normal menstrual cycle in healthy women and those with heavy menstrual bleeding (HMB)? SUMMARY ANSWER:Spatial and temporal differences in protein levels of endothelial cell (EC) markers and components of the extracellular matrix ... Read more >>

Hum. Reprod. (Human reproduction (Oxford, England))
[2018, 33(3):399-410]

Cited: 1 time

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Synchrotron- and focal plane array-based Fourier-transform infrared spectroscopy differentiates the basalis and functionalis epithelial endometrial regions and identifies putative stem cell regions of human endometrial glands.

Georgios Theophilou, Camilo L M Morais, Diane E Halliwell, Kássio M G Lima, Josephine Drury, Pierre L Martin-Hirsch, Helen F Stringfellow, Dharani K Hapangama, Francis L Martin,

The cyclical process of regeneration of the endometrium suggests that it may contain a cell population that can provide daughter cells with high proliferative potential. These cell lineages are clinically significant as they may represent clonogenic cells that may also be involved in tumourigenesis as well as endometriotic lesion development. ... Read more >>

Anal Bioanal Chem (Analytical and bioanalytical chemistry)
[2018, 410(18):4541-4554]

Cited: 1 time

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Assessing Estrogen-Induced Proliferative Response in an Endometrial Cancer Cell Line Using a Universally Applicable Methodological Guide.

Christina Parkes, Areege Kamal, Anthony J Valentijn, Rafah Alnafakh, Stephane R Gross, Roger Barraclough, Diana Moss, John Kirwan, Dharani K Hapangama,

OBJECTIVE:Translational endometrial cancer (EC) research benefits from an in vitro experimental approach using EC cell lines. We demonstrated the steps that are required to examine estrogen-induced proliferative response, a simple yet important research question pertinent to EC, and devised a pragmatic methodological workflow for using EC cell lines in experimental ... Read more >>

Int. J. Gynecol. Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2018, 28(1):122-133]

Cited: 5 times

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Neonatal and maternal outcomes of successful manual rotation to correct malposition of the fetal head; A retrospective and prospective observational study.

Nicola Tempest, Naomi McGuinness, Steven Lane, Dharani K Hapangama,

To evaluate the neonatal and maternal outcomes associated with successful operative vaginal births assisted by manual rotation.Prospective and retrospective observational study.Delivery suite in a tertiary referral teaching hospital in England.A cohort of 2,426 consecutive operative births, in the second stage of labour, complicated with malposition of the fetal head during ... Read more >>

PLoS One (PloS one)
[2017, 12(5):e0176861]

Cited: 2 times

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Hormones and endometrial carcinogenesis.

Areege Kamal, Nicola Tempest, Christina Parkes, Rafah Alnafakh, Sofia Makrydima, Meera Adishesh, Dharani K Hapangama,

Endometrial cancer (EC) is the commonest gynaecological cancer in the Western World with an alarmingly increasing incidence related to longevity and obesity. Ovarian hormones regulate normal human endometrial cell proliferation, regeneration and function therefore are implicated in endometrial carcinogenesis directly or via influencing other hormones and metabolic pathways. Although the ... Read more >>

Horm Mol Biol Clin Investig (Hormone molecular biology and clinical investigation)
[2016, 25(2):129-148]

Cited: 10 times

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Pathophysiology of heavy menstrual bleeding.

Dharani K Hapangama, Judith N Bulmer,

Heavy menstrual bleeding (HMB) is a common gynecological complaint with multiple etiologies and diverse pathophysiological origins. This review discusses HMB with reference to the recently proposed PALM-COEIN classification system for abnormal uterine bleeding, initially describing the endometrial events in normal menstruation followed by discussion of the perturbations of normal endometrial ... Read more >>

Womens Health (Lond) (Women's health (London, England))
[2016, 12(1):3-13]

Cited: 6 times

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Menstrual cycle distribution of uterine natural killer cells is altered in heavy menstrual bleeding.

Sourima Biswas Shivhare, Judith N Bulmer, Barbara A Innes, Dharani K Hapangama, Gendie E Lash,

Heavy menstrual bleeding (HMB) affects 30% of women of reproductive age and significantly interferes with quality of life. Altered endometrial vascular maturation has been reported in HMB and recurrent miscarriage, the latter associated with increased uterine natural killer (uNK) cell numbers. This study compared endometrial leukocyte populations in controls and ... Read more >>

J. Reprod. Immunol. (Journal of reproductive immunology)
[2015, 112:88-94]

Cited: 9 times

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Does advanced operative obstetrics still have a place in contemporary practice?

Nicola Tempest, Kate Navaratnam, Dharani Kosala Hapangama,

This article reviews recent significant contributions to the literature concerning advanced operative obstetric procedures used for rotational vaginal deliveries and their alternative, primary caesarean section.Rising caesarean section rates are a global concern. Caesarean section in the second stage of labour is associated with high rates of maternal and fetal morbidity. ... Read more >>

Curr Opin Obstet Gynecol (Current opinion in obstetrics & gynecology)
[2015, 27(2):115-120]

Cited: 1 time

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Altered vascular smooth muscle cell differentiation in the endometrial vasculature in menorrhagia.

Sourima Biswas Shivhare, Judith N Bulmer, Barbara A Innes, Dharani K Hapangama, Gendie E Lash,

STUDY QUESTION: How does the smooth muscle content and differentiation stage of vascular smooth muscle cells (VSMCs) in endometrial blood vessels change according to the different phases of the menstrual cycle and is this altered in women with menorrhagia? SUMMARY ANSWER: The smooth muscle content (as a proportion of the ... Read more >>

Hum. Reprod. (Human reproduction (Oxford, England))
[2014, 29(9):1884-1894]

Cited: 4 times

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Molecular profiling of circulating tumor cells links plasticity to the metastatic process in endometrial cancer.

Lorena Alonso-Alconada, Laura Muinelo-Romay, Kadri Madissoo, Antonio Diaz-Lopez, Camilla Krakstad, Jone Trovik, Elisabeth Wik, Dharani Hapangama, Lieve Coenegrachts, Amparo Cano, Antonio Gil-Moreno, Luis Chiva, Juan Cueva, Maria Vieito, Eugenia Ortega, Javier Mariscal, Eva Colas, Josep Castellvi, Maite Cusido, Xavier Dolcet, Hans W Nijman, Tjalling Bosse, John A Green, Andrea Romano, Jaume Reventos, Rafael Lopez-Lopez, Helga B Salvesen, Frederic Amant, Xavier Matias-Guiu, Gema Moreno-Bueno, Miguel Abal, ,

BACKGROUND: About 20% of patients diagnosed with endometrial cancer (EC) are considered high-risk with unfavorable prognosis. In the framework of the European Network for Individualized Treatment in EC (ENITEC), we investigated the presence and phenotypic features of Circulating Tumor Cells (CTC) in high-risk EC patients. METHODS: CTC isolation was carried ... Read more >>

Mol. Cancer (Molecular cancer)
[2014, 13:223]

Cited: 42 times

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Theories on the pathogenesis of endometriosis.

Samer Sourial, Nicola Tempest, Dharani K Hapangama,

Endometriosis is a common, chronic inflammatory disease defined by the presence of extrauterine endometrial tissue. The aetiology of endometriosis is complex and multifactorial, where several not fully confirmed theories describe its pathogenesis. This review examines existing theories on the initiation and propagation of different types of endometriotic lesions, as well ... Read more >>

Int J Reprod Med (International journal of reproductive medicine)
[2014, 2014:179515]

Cited: 53 times

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Effects of the selective progesterone receptor modulator asoprisnil on uterine artery blood flow, ovarian activity, and clinical symptoms in patients with uterine leiomyomata scheduled for hysterectomy.

Julia Wilkens, Kristof Chwalisz, Cong Han, Jane Walker, Iain T Cameron, Susan Ingamells, Alexandra C Lawrence, Mary Ann Lumsden, Dharani Hapangama, Alistair R W Williams, Hilary O D Critchley,

INTRODUCTION: Asoprisnil, a novel orally active selective progesterone receptor modulator, is being studied for the management of symptomatic uterine leiomyomata. The exact mechanism of action is not yet discerned. The primary objectives of this double-blind, randomized, placebo-controlled study included evaluation of the effect of asoprisnil on uterine artery blood flow. ... Read more >>

J Clin Endocrinol Metab (The Journal of clinical endocrinology and metabolism)
[2008, 93(12):4664-4671]

Cited: 46 times

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