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Author Dhanunjaya Lakkireddy

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Effectiveness of SharpSense™ algorithms in reducing bradycardia and pause detection: real-world performance in Confirm Rx™ insertable cardiac monitor.

Rakesh Gopinathannair, Dhanunjaya Lakkireddy, Muhammad R Afzal, Christopher Piorkowski, Fujian Qu, Fady Dawoud, Kevin Davis, Kyungmoo Ryu, John Ip,

SharpSense™ technology is an upgradable software enhancement introduced to the Abbott Confirm Rx™ insertable cardiac monitor (ICM). This study aims to characterize the real-world performance of SharpSense algorithms by comparing device detected pause and bradycardia episodes before and after the SharpSense upgrade. Confirm Rx devices with at least 90 days monitoring ... Read more >>

J Interv Card Electrophysiol (Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing)
[2021, :]

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Role of Digital Health During COVID-19 Pandemic and Future Perspectives

Adnan Ahmed, Rishi Charate, Naga Venkata K. Pothineni, Surya Kiran Aedma, Rakesh Gopinathannair, Dhanunjaya Lakkireddy,

Abstract: The Coronavirus disease (COVID-19) revolutionized the digital health care. This pandemic was the catalyst for not only a sudden but also widespread paradigm shift in patient care, with nearly 80% of the U.S. population indicating they have used one form of digital health. Cardiac electrophysiology took the initiative to ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, :]

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Half-Dose Direct Oral Anticoagulation Versus Standard Antithrombotic Therapy After Left Atrial Appendage Occlusion.

Domenico G Della Rocca, Michele Magnocavallo, Luigi Di Biase, Sanghamitra Mohanty, Chintan Trivedi, Nicola Tarantino, Carola Gianni, Carlo Lavalle, Christoffel Johannes Van Niekerk, Jorge Romero, David F Briceño, Mohamed Bassiouny, Amin Al-Ahmad, J David Burkhardt, Veronica N Natale, G Joseph Gallinghouse, Armando Del Prete, Giovanni B Forleo, Javier Sanchez, Dhanunjaya Lakkireddy, Rodney P Horton, Douglas N Gibson, Andrea Natale,

<h4>Objectives</h4>This study evaluated the long-term efficacy of a standard antithrombotic strategy versus half-dose direct oral anticoagulation (DOAC) after Watchman implantation.<h4>Background</h4>No consensus currently exists on the selection of the most effective antithrombotic strategy to prevent device-related thrombosis (DRT) in patients undergoing endocardial left atrial appendage closure.<h4>Methods</h4>After successful left atrial appendage closure, ... Read more >>

JACC Cardiovasc Interv (JACC. Cardiovascular interventions)
[2021, 14(21):2353-2364]

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Postapproval safety profile of Watchman-Flx left atrial appendage occlusion device: Analysis from the MAUDE database.

Jalaj Garg, Kuldeep Shah, Daniel Pinkhas, Rahul Bhardwaj, Tahmeed Contractor, Ravi Mandapati, Mohit K Turagam, Dhanunjaya Lakkireddy,

Heart Rhythm (Heart rhythm)
[2021, :]

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His-bundle pacing following transcatheter aortic valve replacement.

Jalaj Garg, Siddharth Shah, Kuldeep Shah, Mohit K Turagam, Andrea Natale, Dhanunjaya Lakkireddy,

Pacing Clin Electrophysiol (Pacing and clinical electrophysiology : PACE)
[2021, 44(10):1786-1789]

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Amplatzer Amulet Left Atrial Appendage Occluder Versus Watchman Device for Stroke Prophylaxis (Amulet IDE): A Randomized, Controlled Trial.

Dhanunjaya Lakkireddy, David Thaler, Christopher R Ellis, Vijendra Swarup, Lars Sondergaard, John Carroll, Michael R Gold, James Hermiller, Hans-Christoph Diener, Boris Schmidt, Lee MacDonald, Moussa Mansour, Brijeshwar Maini, Laura O'Brien, Stephan Windecker,

<h4>Background</h4>Percutaneous closure of the left atrial appendage (LAA) is an alternative to chronic oral anticoagulation to reduce stroke risk in patients with nonvalvular atrial fibrillation. The Amulet IDE trial (Amplatzer Amulet Left Atrial Appendage Occluder IDE Trial) was designed to evaluate the safety and effectiveness of the dual-seal mechanism of ... Read more >>

Circulation (Circulation)
[2021, 144(19):1543-1552]

Cited: 2 times

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Rhythm- Versus Rate-Control in Atrial Fibrillation-ELECTRAM Investigators.

Jalaj Garg, Kuldeep Shah, Mohit K Turagam, Andrea Natale, Dhanunjaya Lakkireddy,

Am J Ther (American journal of therapeutics)
[2021, 28(5):e581-e583]

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A randomized study of yoga therapy for the prevention of recurrent reflex vasovagal syncope.

Jayaprakash Shenthar, Ritesh Singh Gangwar, Bharatraj Banavalikar, David G Benditt, Dhanunjaya Lakkireddy, Deepak Padmanabhan,

<h4>Aims</h4>Vasovagal syncope (VVS) is a common cardiovascular dysautonomic disorder that significantly impacts health and quality of life (QoL). Yoga has been shown to have a positive influence on cardiovascular autonomics. This study assessed the effectiveness of yoga therapy on the recurrence of VVS and QoL.<h4>Methods and results</h4>We randomized subjects with ... Read more >>

Europace (Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology)
[2021, 23(9):1479-1486]

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Sinus node sparing novel hybrid approach for treatment of inappropriate sinus tachycardia/postural sinus tachycardia: multicenter experience.

Carlo de Asmundis, Gian-Battista Chierchia, Dhanunjaya Lakkireddy, Ahmed Romeya, Eric Okum, Gaurang Gandhi, Juan Sieira, Margot Vloka, Stephen D Jones, Hemal Shah, Marshall Winner, Dilesh Patel, S Patrick Whalen, Elijah H Beaty, Edward Hal Kincaid, Anson Lee, Chad Brodt, Benadict J Taylor, Ilyas Colombowala, Matthew Romano, Fred Morady, Erwin Ströker, Ingrid Overeinder, Gezim Bala, Justin Van Meeteren, Yoaav Krauthammer, Scott Koerber, Christian Shults, Athanasios Thomaides, Nitish Badhwar, Rakesh Gopinathannair, Alap Shah, Rangarao Tummala, David Bello, Steve Hoff, Alexandre Almorad, Kenneth Frazier, Pedro Brugada, Mark La Meir,

<h4>Background</h4>The ideal treatment of inappropriate sinus tachycardia (IST) and postural orthostatic tachycardia syndrome (POTS) still needs to be defined. Medical treatments yield suboptimal results. Endocardial catheter ablation of the sinus node (SN) may risk phrenic nerve damage and open-heart surgery may be accompanied by unjustified invasive risks.<h4>Methods</h4>We describe our first ... Read more >>

J Interv Card Electrophysiol (Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing)
[2021, :]

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Targeting non-pulmonary vein triggers in persistent atrial fibrillation: results from a prospective, multicentre, observational registry.

Domenico G Della Rocca, Luigi Di Biase, Sanghamitra Mohanty, Chintan Trivedi, Carola Gianni, Jorge Romero, Nicola Tarantino, Michele Magnocavallo, Mohamed Bassiouny, Veronica N Natale, Angel Quintero Mayedo, Bryan Macdonald, Carlo Lavalle, Ghulam Murtaza, Krishna Akella, Giovanni B Forleo, Amin Al-Ahmad, John David Burkhardt, Gerald Joseph Gallinghouse, Javier E Sanchez, Rodney P Horton, Juan F Viles-Gonzalez, Dhanunjaya Lakkireddy, Andrea Natale,

<h4>Aims</h4>We evaluated the efficacy of an ablation strategy empirically targeting pulmonary veins (PVs) and posterior wall (PW) and the prevalence and clinical impact of extrapulmonary trigger inducibility and ablation in a large cohort of patients with persistent atrial fibrillation (PerAF).<h4>Methods and results</h4>A total of 1803 PerAF patients were prospectively enrolled. ... Read more >>

Europace (Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology)
[2021, :]

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Implantable cardioverter-defibrillator in patients with spontaneous coronary artery dissection presenting with sudden cardiac arrest.

Jalaj Garg, Kuldeep Shah, Siddharth Shah, Mohit K Turagam, Andrea Natale, Dhanunjaya Lakkireddy,

<h4>Introduction</h4>The role of secondary prevention implantable cardioverter-defibrillator (ICD) remains uncertain in spontaneous coronary artery dissection (SCAD) patients presenting with sudden cardiac arrest (SCA).<h4>Methods</h4>We aimed at assessing the outcomes following SCA and the role of ICD therapy in SCAD. The meta-analysis was performed using a meta-package for R version 4.0/RStudio version ... Read more >>

J Cardiovasc Electrophysiol (Journal of cardiovascular electrophysiology)
[2021, 32(9):2595-2600]

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Use of a cerebral protection device to facilitate pulmonary vein isolation in a patient with left atrial mass arising from the interatrial septum.

Rakesh Gopinathannair, Mehmet Ali Elbey, Jayasheel Eshcol, Frederic L Seligson, Donita Atkins, Dhanunjaya Lakkireddy,

Sentinel cerebral embolic protection devices (CPDs) may limit periprocedural cerebrovascular events by preventing micro and macro-embolization to the brain, and has been used in many cardiology and radiology procedures. We hereby report the use of a Sentinel CPD to facilitate safe and effective atrial fibrillation ablation in a patient with a ... Read more >>

J Cardiovasc Electrophysiol (Journal of cardiovascular electrophysiology)
[2021, 32(9):2601-2603]

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B-PO03-160 OUTCOMES IN PATIENTS WITH COVID-19 INFECTION AND T-WAVE INVERSIONS: A PROPENSITY SCORE-MATCHED ANALYSIS

Luigi Di Biase, Dhanunjaya R. Lakkireddy, Isabella Alviz, David F. Briceno, Abhishek Jaiswal, Dalvert Polanco, Juan C. Diaz, Daniel Rodriguez, Mohamed Gabr, Chintan G. Trivedi, Sanghamitra Mohanty, Domenico G. Della Rocca, Andrea Natale, Jorge Romero,

Heart Rhythm (Heart rhythm)
[2021, 18(8):S254-S254]

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Safety/Efficacy of DOAC Versus Aspirin for Reduction of Risk of Cerebrovascular Events Following VT Ablation.

Dhanunjaya Lakkireddy, Jayaprakash Shenthar, Jalaj Garg, Deepak Padmanabhan, Rakesh Gopinathannair, Luigi Di Biase, Jorge Romero, Sanghamitra Mohanty, David J Burkhardt, Amin Al-Ahmad, Donita Atkins, Sudha Bommana, Andrea Natale,

<h4>Objectives</h4>The STROKE-VT (Safety and Efficacy of Direct Oral Anticoagulant Versus Aspirin for Reduction of Risk of Cerebrovascular Events in Patients Undergoing Ventricular Tachycardia Ablation) study is a multicenter, randomized controlled trial that examined the differences in cerebrovascular events between direct oral anticoagulant (DOAC) and aspirin (ASA) use postprocedurally in patients ... Read more >>

JACC Clin Electrophysiol (JACC. Clinical electrophysiology)
[2021, :]

Cited: 2 times

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Left Atrial Appendage Occlusion With New Watchman-FLX Device.

Jalaj Garg, Kuldeep Shah, Siddharth Shah, Mohit K Turagam, Andrea Natale, Dhanunjaya Lakkireddy,

Am J Cardiol (The American journal of cardiology)
[2021, 154:135-137]

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Sinus Node Sparing Hybrid Thoracoscopic Ablation Outcomes in Patients with Inappropriate Sinus Tachycardia (SUSRUTA-IST) Registry.

Dhanunjaya Lakkireddy, Jalaj Garg, Carlo DeAsmundis, Mark LaMeier, Ahmed Romeya, Justin Vanmeetren, Peter Park, Rangarao Tummala, Scott Koerber, Chandra Vasamreddy, Alap Shah, Poojita Shivamurthy, Ken Frazier, Yashi Awasthi, Gian Battista Chierchia, Donita Atkins, Sudha Bommana, Luigi Di Biase, Amin Al-Ahmad, Andrea Natale, Rakesh Gopinathannair,

<h4>Background</h4>Medical treatment of inappropriate sinus tachycardia (IST) remains suboptimal. Radiofrequency sinus node (RF-SN) ablation has poor success and higher complication rates.<h4>Objective</h4>We aimed to compare clinical outcomes of the novel SN sparing hybrid ablation technique with those of RF-SN modification for IST management.<h4>Methods</h4>This is a multicenter prospective registry comparing the SN ... Read more >>

Heart Rhythm (Heart rhythm)
[2021, :]

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Radiofrequency Energy Applications Targeting Significant Residual Leaks After Watchman Implantation: A Prospective, Multicenter Experience.

Domenico G Della Rocca, Ghulam Murtaza, Luigi Di Biase, Krishna Akella, Subramaniam C Krishnan, Michele Magnocavallo, Sanghamitra Mohanty, Carola Gianni, Chintan Trivedi, Carlo Lavalle, Giovanni B Forleo, Veronica N Natale, Nicola Tarantino, Jorge Romero, Rakesh Gopinathannair, Philip J Patel, Mohamed Bassiouny, Armando Del Prete, Amin Al-Ahmad, J David Burkhardt, G Joseph Gallinghouse, Javier E Sanchez, Shephal K Doshi, Rodney P Horton, Dhanunjaya Lakkireddy, Andrea Natale,

<h4>Objectives</h4>The aim of this study was to evaluate the efficacy of radiofrequency (RF) energy applications targeting the atrial side of a significant residual leak in patients with acute and chronic evidence of incomplete percutaneous left atrial appendage (LAA) occlusion.<h4>Background</h4>RF applications have been proved to prevent recanalization of intracranial aneurysms after ... Read more >>

JACC Clin Electrophysiol (JACC. Clinical electrophysiology)
[2021, :]

Cited: 1 time

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Safety and efficacy of left atrial appendage closure using an epicardial suture snaring device: Systematic review and current status.

Syed Rafay Ali Sabzwari, Nikhil A Mehta, Lohit Garg, Lekha Racharla, Emilee Kurtz, Muhammad R Afzal, Mohit K Turagam, Dhanunjaya Lakkireddy,

<h4>Introduction</h4>The LARIAT epicardial suture snaring device has been fraught with technical challenges and procedural complications. Over time, technique modification and improved operator experience have helped overcome many of these challenges. METHODS AND RESULTS: Studies reporting left atrial appendage epicardial closure over a 12-year period from 2009 to 2020 were evaluated. The ... Read more >>

J Cardiovasc Electrophysiol (Journal of cardiovascular electrophysiology)
[2021, 32(8):2189-2198]

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Current practice and future prospects in left atrial appendage occlusion.

Bharat Narasimhan, Surya Kiran Aedma, Kirtipal Bhatia, Jalaj Garg, Sri Harsha Kanuri, Mohit K Turagam, Dhanunjaya Lakkireddy,

The thromboembolic complications of Atrial fibrillation (AF) remain a major problem in contemporary clinical practice. Despite advances and developments in anticoagulation strategies, therapy is complicated by the high risk of bleeding complications and need for meticulous medication compliance. Over the past few decades, the left atrial appendage has emerged as ... Read more >>

Pacing Clin Electrophysiol (Pacing and clinical electrophysiology : PACE)
[2021, 44(7):1236-1252]

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Incidence of Device-Related Thrombosis in Watchman Patients Undergoing a Genotype-Guided Antithrombotic Strategy.

Domenico G Della Rocca, Rodney P Horton, Luigi Di Biase, Carola Gianni, Chintan Trivedi, Sanghamitra Mohanty, Alisara Anannab, Michele Magnocavallo, Qiong Chen, Nicola Tarantino, Mohamed Bassiouny, Carlo Lavalle, Veronica N Natale, Giovanni B Forleo, Armando Del Prete, Christoffel Johannes Van Niekerk, Amin Al-Ahmad, J David Burkhardt, G Joseph Gallinghouse, Javier E Sanchez, Dhanunjaya Lakkireddy, Douglas N Gibson, Andrea Natale,

<h4>Objectives</h4>This study sought to report the incidence of device-related thrombosis (DRT) and thromboembolic (TE) events when an alternative to clopidogrel is prescribed in loss-of-function (LOF) allele carriers of the cytochrome P450 2C19 (CYP2C19) gene.<h4>Background</h4>LOF polymorphisms of the CYP2C19 gene are associated with reduced hepatic bioactivation of clopidogrel.<h4>Methods</h4>One thousand two Watchman ... Read more >>

JACC Clin Electrophysiol (JACC. Clinical electrophysiology)
[2021, :]

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Managing Atrial Fibrillation in Patients With Heart Failure and Reduced Ejection Fraction: A Scientific Statement From the American Heart Association.

Rakesh Gopinathannair, Lin Y Chen, Mina K Chung, William K Cornwell, Karen L Furie, Dhanunjaya R Lakkireddy, Nassir F Marrouche, Andrea Natale, Brian Olshansky, Jose A Joglar, ,

Atrial fibrillation and heart failure with reduced ejection fraction are increasing in prevalence worldwide. Atrial fibrillation can precipitate and can be a consequence of heart failure with reduced ejection fraction and cardiomyopathy. Atrial fibrillation and heart failure, when present together, are associated with worse outcomes. Together, these 2 conditions increase ... Read more >>

Circ Arrhythm Electrophysiol (Circulation. Arrhythmia and electrophysiology)
[2021, 14(6):HAE0000000000000078]

Cited: 2 times

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Early Implantable Cardioverter-Defibrillator After Acute Myocardial Infarction.

Kuldeep Shah, Siddharth Shah, Mohit K Turagam, Rahul Bhardwaj, Tahmeed Contractor, Ravi Mandapati, Andrea Natale, Dhanunjaya Lakkireddy, Jalaj Garg,

Am J Cardiol (The American journal of cardiology)
[2021, 152:170-172]

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Focal impulse and rotor modulation guided ablation versus pulmonary vein isolation for atrial fibrillation: A meta-analysis of head-to-head comparative studies.

Jorge Romero, Mohamed Gabr, Isabella Alviz, David Briceno, Juan Carlos Diaz, Daniel Rodriguez, Kavisha Patel, Dalvert Polanco, Chintan Trivedi, Sanghamitra Mohanty, Domenico Della Rocca, Dhanunjaya Lakkireddy, Andrea Natale, Luigi Di Biase,

<h4>Introduction</h4>Empirical pulmonary vein isolation (PVI) remains the cornerstone for catheter ablation of atrial fibrillation (AF). Various ablation strategies and modalities are continually tested with the aim of improving ablation outcomes. Although focal impulse and rotor modulation (FIRM)-guided ablation is currently used as an adjunct to PVI, evidence supporting this strategy ... Read more >>

J Cardiovasc Electrophysiol (Journal of cardiovascular electrophysiology)
[2021, 32(7):1822-1832]

Cited: 1 time

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Autoimmune dysautonomia secondary to chronic organophosphate exposure.

Sri Harsha Kanuri, Poojita Shivamurthy, Rawan Albadareen, Mehmet Ali Elbey, Rakesh Gopinathannair, Dhanunjaya Lakkireddy,

HeartRhythm Case Rep (HeartRhythm case reports)
[2021, 7(8):522-524]

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Epicardial access complications during electrophysiology procedures.

Jorge Romero, Kavisha Patel, Dhanunjaya Lakkireddy, Isabella Alviz, Alejandro Velasco, Daniel Rodriguez, Joseph Karpenos, Xiao-Dong Zhang, Andrea Natale, Luigi Di Biase,

<h4>Introduction</h4>Percutaneous epicardial access (EA) was first described more than two decades ago. Since its initial introduction, indications for its utilization in the field of electrophysiology have expanded dramatically.<h4>Discussion</h4>Epicardial mapping and ablation in patients with ventricular tachycardia is routinely performed in tertiary electrophysiology centers around the world. Although limited by lack ... Read more >>

J Cardiovasc Electrophysiol (Journal of cardiovascular electrophysiology)
[2021, 32(7):1985-1994]

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