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Early Hemoglobin Status as a Predictor of Long-Term Mortality for Sepsis Patients in Intensive Care Units.

Desheng Qi, Milin Peng,

<h4>Objectives</h4>It is still not clear what influences hemoglobin has on the outcomes of patients with sepsis. The intention of this research is to investigate the impact of early hemoglobin levels on clinical outcomes for sepsis.<h4>Methods</h4>In this single-center, cohort study, each patient was put into one of four groups dependent on ... Read more >>

Shock (Shock (Augusta, Ga.))
[2021, 55(2):215-223]

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Transcriptomics and flow cytometry reveals the cytotoxicity of aflatoxin B1 and aflatoxin M1 in bovine mammary epithelial cells.

Kuntan Wu, Sifan Jia, Jiacai Zhang, Cong Zhang, Shuai Wang, Shahid Ali Rajput, Lvhui Sun, Desheng Qi,

Aflatoxin is a known mycotoxin that pollutes various grains widely in the environment. Aflatoxin B<sub>1</sub> (AFB<sub>1</sub>) and Aflatoxin M<sub>1</sub> (AFM<sub>1</sub>) have been shown to induce cytotoxicity in many cells, yet their effects on mammary epithelial cells remain unclear. In this study, we examined the toxicity and the effects of AFB<sub>1</sub> ... Read more >>

Ecotoxicol Environ Saf (Ecotoxicology and environmental safety)
[2020, 209:111823]

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The Complete Genome of Probiotic Lactobacillus sakei Derived from Plateau Yak Feces.

Kun Li, Juanjuan Liu, Zhibo Zeng, Muhammad Fakhar-E-Alam Kulyar, Yaping Wang, Aoyun Li, Zeeshan Ahmad Bhutta, Amjad Islam Aqib, Muhammad Shahzad, Jiakui Li, Desheng Qi,

Probiotic bacteria are receiving increased attention due to the potential benefits to their hosts. Plateau yaks have resistance against diseases and stress, which is potentially related to their inner probiotics. To uncover the potential functional genes of yak probiotics, we sequenced the whole genome of <i>Lactobacillus sakei</i> (<i>L. sakei</i>). The ... Read more >>

Genes (Basel) (Genes)
[2020, 11(12):]

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Effects of Dietary Cottonseed Oil and Cottonseed Meal Supplementation on Liver Lipid Content, Fatty Acid Profile and Hepatic Function in Laying Hens.

Ao Yang, Cong Zhang, Beiyu Zhang, Zhiyun Wang, Luoyi Zhu, Yang Mu, Shuai Wang, Desheng Qi,

Antinutrients, such as cyclopropene fatty acids (CPFAs) and free gossypol (FG), present together in cottonseed have caused numerous adverse effects on liver health and egg quality of laying hens, which are both likely to be related to a disturbance in lipid metabolism. This experiment employed a 3 × 3 factorial ... Read more >>

Animals (Basel) (Animals : an open access journal from MDPI)
[2021, 11(1):]

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Targeted isolation of 1,1-diphenyl-2-picrylhydrazyl inhibitors from Saxifraga atrata using medium- and high- pressure liquid chromatography combined with online high performance liquid chromatography-1,1-diphenyl-2- picrylhydrazyl detection.

Yangzom Dawa, Yurong Du, Qi Wang, Chengbiao Chen, Denglang Zou, Desheng Qi, Jianbin Ma, Jun Dang,

Traditional Tibetan medicine (TTM) is a valuable source of novel therapeutic lead molecules inspired by natural products (NPs). The health benefits of Saxifraga atrata are well documented in TTM, but reports on its chemical composition are limited, most likely due to the complicated purification process. Herein, target separation and identification ... Read more >>

J Chromatogr A (Journal of chromatography. A)
[2021, 1635:461690]

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Effects of Short Chain Fatty Acids (SCFAs) Modulation on Potentially Diarrhea Causing Pathogens in Yaks Through Metagenomics Sequencing

Kun Li, Zhibo Zeng, Juanjuan Liu, Lulu Pei, Yaping Wang, Aoyun Li, Muhammad Fakhar-e-Alam Kulyar, Muhammad Shahzad, Desheng Qi, JIAKUI LI,

Yaks are of great importance on the plateau; however, an emerging endemic diarrheal disease during the last few years is posing a great threat to the health of these animals. Yaks have special gut microbiotal community and short-chain fatty acids (SCFAs) which are not only the principle nutrient substrates of ... Read more >>

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Enhanced local cancer therapy using a CA4P and CDDP co-loaded polypeptide gel depot.

Shuangjiang Yu, Shu Wei, Liang Liu, Desheng Qi, Jiayu Wang, Guojun Chen, Wanying He, Chaoliang He, Xuesi Chen, Zhen Gu,

Cancer combination therapy based on drug co-delivery systems provides an effective strategy for enhancing treatment efficacy and reducing side effects. In this work, a new strategy through co-delivery of combretastatin A4 disodium phosphate (CA4P) and cisplatin (CDDP) was developed for the local treatment of colon cancer, through an in situ ... Read more >>

Biomater Sci (Biomaterials science)
[2019, 7(3):860-866]

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Effects of dietary cadmium supplementation on production performance, cadmium residue in eggs, and hepatic damage in laying hens.

Can Tao, Beiyu Zhang, Xiaotian Wei, Man Zhao, Zhangjian Sun, Shuai Wang, Jiwen Bi, Desheng Qi, Lvhui Sun, Niya Zhang,

This study was conducted to investigate the adverse effects of cadmium (Cd) on the production performance, serum biochemistry, liver antioxidant status, histopathology, and egg residue in laying hens. A total of 72 healthy Hy-Line brown laying hens at 40-week-old were randomly assigned to four diets containing 0 (control diet), 15, ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2020, 27(26):33103-33111]

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Heavy Metal Content in Feedstuffs and Feeds in Hubei Province, China.

Can Tao, Xiaotian Wei, Beiyu Zhang, Man Zhao, Shuai Wang, Zhangjian Sun, Desheng Qi, Lvhui Sun, Shahid Ali Rajput, Niya Zhang,

ABSTRACT:Heavy metal pollution threatens the health and life of animals and humans through the food chain. This study was performed to survey the heavy metal contamination in feedstuffs and feeds in Hubei Province, People's Republic of China, from 2012 to 2016. Samples were analyzed for cadmium (306 samples), mercury (117 ... Read more >>

J Food Prot (Journal of food protection)
[2020, 83(5):762-766]

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Sodium Butyrate Protects the Intestinal Barrier by Modulating Intestinal Host Defense Peptide Expression and Gut Microbiota after a Challenge with Deoxynivalenol in Weaned Piglets.

Shuai Wang, Cong Zhang, Jiacheng Yang, Xu Wang, Kuntan Wu, Beiyu Zhang, Jiacai Zhang, Ao Yang, Shahid Ali Rajput, Desheng Qi,

This study aims to determine whether sodium butyrate (SB) could antagonize deoxynivalenol (DON)-induced intestinal epithelial dysfunction. In a four-week feeding trial, twenty-eight barrows were randomly divided into four treatments: (1) uncontaminated basal diet (control); (2) 4 mg/kg DON-contaminated diet (DON); (3) basal diet supplemented with 0.2% SB (SB); and (4) ... Read more >>

J Agric Food Chem (Journal of agricultural and food chemistry)
[2020, 68(15):4515-4527]

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Effect of new onset of jaundice on outcomes in patients with sepsis: A population-based propensity score-matched study

Desheng Qi, Fuxing Deng, Yuhang Ai, Lina Zhang, Shuangping Zhao, Daomiao Xu, Milin Peng,

<h4>Background: </h4> Although jaundice have been associated with mortality in critically ill patients, yet no data from large studies demonstrates its effect in sepsis. The aim of the study is to investigate the impact of jaundice on outcomes in septic patients.Methods Propensity-matched analysis of cohort database from Medical Information Mart ... Read more >>

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Early hemoglobin status is predictive of outcomes and long-term mortality of sepsis

Desheng Qi, Milin Peng,

<h4>Background: </h4> Hemoglobin change plays a critical role in progress of sepsis. However, the contribution of hemoglobin change to outcomes of patients with sepsis is still unknown. The aim of our study is to investigate the effect of early hemoglobin level within 48h after admission to Intensive Care Unit (ICU) ... Read more >>

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Early liver injury is closely related to organ failure of sepsis

Milin Peng, Yuhang Ai, Lina Zhang, Shuangping Zhao, Zhiyong Liu, Haisong Zhang, Xiaolei Zhang, Desheng Qi,

<h4>Background: </h4> s: Sepsis induced organ failure is main cause of mortality in intensive care units (ICU), however, the impact of early liver injury on clinical ending of sepsis is not clear and has not been discussed in context of clinical research on sepsis before. Our study aimed at the ... Read more >>

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The effect of dietary supplementation with Clostridium butyricum on the growth performance, immunity, intestinal microbiota and disease resistance of tilapia (Oreochromis niloticus).

Hongqin Li, Ying Zhou, Huayun Ling, Li Luo, Desheng Qi, Lin Feng,

This study was conducted to assess the effects of dietary Clostridium butyricum on the growth, immunity, intestinal microbiota and disease resistance of tilapia (Oreochromis niloticus). Three hundreds of tilapia (56.21 ± 0.81 g) were divided into 5 groups and fed a diet supplemented with C. butyricum at 0, 1 x ... Read more >>

PLoS One (PloS one)
[2019, 14(12):e0223428]

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Deoxynivalenol Inhibits Porcine Intestinal Trefoil Factors Expression in Weanling Piglets and IPEC-J2 Cells.

Shuai Wang, Cong Zhang, Xu Wang, Jiacheng Yang, Kuntan Wu, Jiacai Zhang, Beiyu Zhang, Ao Yang, Desheng Qi,

Trefoil factors (TFFs) are regulatory peptides playing critical roles in mucosal repair and protection against a variety of insults within the gastrointestinal tract. This work aimed to explore the effects of deoxynivalenol (DON) on intestinal TFFs expression using in vivo and in vitro models. In an animal trial, twenty-four 28-d-old ... Read more >>

Toxins (Basel) (Toxins)
[2019, 11(11):]

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The paradoxical effects of progesterone on the eggshell quality of laying hens.

Jiacai Zhang, Zhiyun Wang, Xu Wang, Lvhui Sun, Shahid Ali Rajput, Desheng Qi,

This study demonstrates the effects of progesterone on eggshell quality and ultrastructure by injecting progesterone into laying hens 2 and 5 h post-oviposition, respectively. Progesterone injected 2 h post-oviposition (P<sub>4</sub>-2 h) improved eggshell quality with a significant decrease (P < 0.01) in the thickness of the mammillary layer and a significant increase (P < 0.01) in ... Read more >>

J Struct Biol (Journal of structural biology)
[2020, 209(2):107430]

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The differences of gonadal hormones and uterine transcriptome during shell calcification of hens laying hard or weak-shelled eggs.

Jiacai Zhang, Yanan Wang, Cong Zhang, Mingxin Xiong, Shahid Ali Rajput, Yun Liu, Desheng Qi,

<h4>Background</h4>Eggshell breaking strength is critical to reduce egg breaking rate and avoid economic loss. The process of eggshell calcification initiates with the egg entering the uterus and lasts about 18 h. It follows a temporal sequence corresponding to the initiation, growth and termination periods of shell calcification. During each period of ... Read more >>

BMC Genomics (BMC genomics)
[2019, 20(1):707]

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The effects of dietary cottonseed meal and oil supplementation on laying performance and egg quality of laying hens.

Yang Mu, Luo-Yi Zhu, Ao Yang, Xin Gao, Niya Zhang, Lvhui Sun, Desheng Qi,

Cottonseed meal (CSM) and cottonseed oil (CSO), two cottonseed products, are rich in protein and lipids, respectively, but their use is limited by antinutritional factors in the products. This study investigated the effect of different dietary levels of CSM and CSO supplementation on the laying performance and egg quality of ... Read more >>

Food Sci Nutr (Food science & nutrition)
[2019, 7(7):2436-2447]

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Potential Link between Gut Microbiota and Deoxynivalenol-Induced Feed Refusal in Weaned Piglets.

Shuai Wang, Jiacheng Yang, Beiyu Zhang, Lei Zhang, Kuntan Wu, Ao Yang, Chong Li, Yanan Wang, Jiacai Zhang, Desheng Qi,

This study investigated the potential link between gut microbiota and deoxynivalenol (DON)-induced feed refusal. A total of 24 barrows were randomly divided into one of three diets containing 0.61 (control diet), 1.28, or 2.89 mg DON/kg feed for 28 days. Dietary exposure to DON at 2.89 mg/kg significantly decreased the ... Read more >>

J Agric Food Chem (Journal of agricultural and food chemistry)
[2019, 67(17):4976-4986]

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DNA barcodes and their characteristic diagnostic sites analysis of Schizothoracinae fishes in Qinghai province.

Ting Wang, Desheng Qi, Shihao Sun, Zhonghao Liu, Yurong Du, Songchang Guo, Jianbin Ma,

The Qinghai-Tibetan Plateau (QTP), the source and upper reaches of many Asian rivers, are crisscrossed by rivers and dotted with lakes. Schizothoracinae fishes, species native to the QTP, are distributed widely through these rivers and lakes. Over the past decades, ecological protection has become increasingly intense. The rapid acquisition of ... Read more >>

Mitochondrial DNA A DNA Mapp Seq Anal (Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis)
[2019, 30(4):592-601]

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Proanthocyanidins Alleviates AflatoxinB₁-Induced Oxidative Stress and Apoptosis through Mitochondrial Pathway in the Bursa of Fabricius of Broilers.

Shahid Ali Rajput, Cong Zhang, Yue Feng, Xiao Tian Wei, Mahmoud Mohamed Khalil, Imran Rashid Rajput, Dost Muhammad Baloch, Aftab Shaukat, Nasir Rajput, Hammad Qamar, Mubashar Hassan, Desheng Qi,

Aflatoxin B₁ (AFB₁) is a serious threat to the poultry industry. Proanthocyanidins (PCs) demonstrates a broad range of biological, pharmacological, therapeutic, and chemoprotective properties. The aim of this study was to investigate the ameliorative effects of PCs against AFB₁-induced histopathology, oxidative stress, and apoptosis via the mitochondrial pathway in the ... Read more >>

Toxins (Basel) (Toxins)
[2019, 11(3):]

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Grape Seed Proanthocyanidin Extract Alleviates AflatoxinB₁-Induced Immunotoxicity and Oxidative Stress via Modulation of NF-κB and Nrf2 Signaling Pathways in Broilers.

Shahid Ali Rajput, Lvhui Sun, Ni-Ya Zhang, Mahmoud Mohamed Khalil, Zhao Ling, Li Chong, Shuai Wang, Imran Rashid Rajput, Dost Muhammad Bloch, Farhan Anwar Khan, Aftab Shaukat, Desheng Qi,

Aflatoxin B₁ (AFB₁) is a widely spread mycotoxin contaminates food and feed, causing severe oxidative stress damages and immunotoxicity. Grape seed proanthocyanidin (GSPE), a natural antioxidant with wide range of pharmacological and medicinal properties. The goal of the present study was to investigate the protective effects of GSPE against AFB₁-induced ... Read more >>

Toxins (Basel) (Toxins)
[2019, 11(1):]

Cited: 4 times

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Effects of dietary cottonseed oil and cottonseed meal supplementation on the structure, nutritional composition of egg yolk and gossypol residue in eggs.

Luoyi Zhu, Ao Yang, Yang Mu, Niya Zhang, Lvhui Sun, Shahid Ali Rajput, Desheng Qi,

The aim of this study was to evaluate the effects of dietary non-gossypol cottonseed oil (CSO) or cottonseed meal (CSM) and their interactions on the texture properties, structure, nutritional composition, and edible safety of egg yolk. A total of 162 24-wk-old Hy-line Brown laying hens were randomly allocated into 9 ... Read more >>

Poult Sci (Poultry science)
[2019, 98(1):381-392]

Cited: 3 times

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Refined cottonseed oil as a replacement for soybean oil in broiler diet.

Ao Yang, Ming Qi, Xu Wang, Shuai Wang, Lvhui Sun, Desheng Qi, Luoyi Zhu, Yongzhi Duan, Xin Gao, Shahid Ali Rajput, Niya Zhang,

With the shortage of common vegetable fat sources, such as soybean oil (SBO), it is urgent to find alternative oil sources for broiler producers. The objective of this study was to evaluate the potential of refined cottonseed oil (CSO) as a replacement for SBO in broiler diets. A total of ... Read more >>

Food Sci Nutr (Food science & nutrition)
[2019, 7(3):1027-1034]

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A molecular phylogeny of Schizothoracinae (Teleostei: Cypriniformes: Cyprinidae) based on 12 protein-coding mitochondrial genes and RAG1 gene analysis

Yurong Du, Ting Wang, Delin Qi, Desheng Qi, Weilin Li, Jiangbin Zhong, Juan Chen, Songchang Guo, Jianbin Ma,

The ever-increasing interest in the investigation of origin and speciation of schizothoracine fishes can be dated to 20th century. However, molecular phylogeny of Schizothoracinae and their phylogenetic relationships, as well as the divergence times still remain controversial. In this study, two DNA sets consisting of 12 protein-coding mitochondrial genes from ... Read more >>

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