Full Text Journal Articles by
Author Dereck Salisbury

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Exercise Dose and Aerobic Fitness Response in Alzheimer's Dementia in the FIT-AD Trial.

Dereck Salisbury, Michelle A Mathiason, Fang Yu,

The purpose of this study was to examine the effects of a 6-month cycling aerobic exercise intervention on cardiorespiratory fitness and the dose-response relationship in community-dwelling older adults with mild-to-moderate Alzheimer's dementia. The FIT-AD trial was a single blind, 2-parallel group, pilot randomized controlled trial. The aerobic exercise group participated ... Read more >>

Int J Sports Med (International journal of sports medicine)
[2021, :]

Cited: 0 times

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Efficacy of simultaneous aerobic exercise and cognitive training in subjective cognitive decline: study protocol for randomized controlled trial of the Exergames Study.

Dereck Salisbury, Tom Plocher, Fang Yu,

<h4>Background</h4>Subjective cognitive decline (SCD) is an early manifestation of Alzheimer's disease (AD) and offers a therapeutic window where interventions have strong potential to prevent or delay the progression of AD. Aerobic exercise and cognitive training represent two promising interventions for AD prevention, but their synergistic effect has yet to be ... Read more >>

Trials (Trials)
[2021, 22(1):14]

Cited: 0 times

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Cognitive Effects of Aerobic Exercise in Alzheimer's Disease: A Pilot Randomized Controlled Trial.

Fang Yu, David M Vock, Lin Zhang, Dereck Salisbury, Nathaniel W Nelson, Lisa S Chow, Glenn Smith, Terry R Barclay, Maurice Dysken, Jean F Wyman,

<h4>Background</h4>Aerobic exercise has shown inconsistent cognitive effects in older adults with Alzheimer's disease (AD) dementia.<h4>Objective</h4>To examine the immediate and longitudinal effects of 6-month cycling on cognition in older adults with AD dementia.<h4>Methods</h4>This randomized controlled trial randomized 96 participants (64 to cycling and 32 to stretching for six months) and followed ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2021, 80(1):233-244]

Cited: 2 times

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Factors Predicting the Onset of Amnestic Mild Cognitive Impairment or Alzheimer's Dementia in Persons With Subjective Cognitive Decline.

Sangwoo Ahn, Michelle A Mathiason, Dereck Salisbury, Fang Yu,

The objective of the current retrospective cohort study was to identify vascular and/or neuropsychiatric risk factors predicting clinical progression in persons with subjective cognitive decline (SCD). Information on 1,525 persons with SCD (mean age = 73.8 [SD = 8.1] years) was obtained from the National Alzheimer's Coordinating Center. Clinical progression ... Read more >>

J Gerontol Nurs (Journal of gerontological nursing)
[2020, 46(8):28-36]

Cited: 1 time

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Adherence and exercise mode in supervised exercise therapy for peripheral artery disease.

Kristin M Elgersma, Rebecca J L Brown, Dereck L Salisbury, Laurissa Stigen, Lois Gildea, Kayla Larson, Erica N Schorr, Laura N Kirk, Diane Treat-Jacobson,

Supervised exercise therapy (SET) is a first-line treatment for people with peripheral artery disease (PAD). However, data on patient adherence to SET are limited. In addition, while intermittent treadmill exercise has been widely tested, no studies have investigated recumbent total body stepping (step-ex). We examined whether exercise mode (treadmill walking ... Read more >>

J Vasc Nurs (Journal of vascular nursing : official publication of the Society for Peripheral Vascular Nursing)
[2020, 38(3):108-117]

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Inter-individual differences in the responses to aerobic exercise in Alzheimer's disease: Findings from the FIT-AD trial.

Fang Yu, Dereck Salisbury, Michelle A Mathiason,

<h4>Background</h4>Despite the strong evidence of aerobic exercise as a disease-modifying treatment for Alzheimer's disease (AD) in animal models, its effects on cognition are inconsistent in human studies. A major contributor to these findings is inter-individual differences in the responses to aerobic exercise, which was well documented in the general population ... Read more >>

J Sport Health Sci (Journal of sport and health science)
[2021, 10(1):65-72]

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A Comparison of Cardiopulmonary Exercise Testing and Field Walking Tests in Community-Dwelling Older Adults With Mild-to-Moderate Alzheimer's Dementia.

Dereck L Salisbury, Fang Yu,

The purpose of this study was to investigate the relationships among peak exercise parameters on 6-min walk test, shuttle walk test, and laboratory-based cardiopulmonary exercise testing in persons with Alzheimer's dementia. This study is a cross-sectional analysis of the baseline data of 90 participants (age 77.1 [6.6] years, 43% female) ... Read more >>

J Aging Phys Act (Journal of aging and physical activity)
[2020, :1]

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Inter-Individual Differences in Exercise Responses in Alzheimer’s Disease

Fang Yu, Dereck Salisbury, Michelle Mathiason,

Abstract Aerobic exercise is widely supported as a disease-modifying treatment for Alzheimer’s disease (AD) in animal models; however, its effects on cognition have been mixed in human studies, which may be attributable to inter-individual differences in aerobic fitness and cognitive responses to aerobic exercise. This study evaluated inter-individual differences in ... Read more >>

Innov Aging (Innovation in aging)
[2020, 4(Suppl 1):188-188]

Cited: 0 times

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Establishing Reference Cardiorespiratory Fitness Parameters in Alzheimer's Disease.

Dereck Salisbury, Fang Yu,

Evidence is growing for aerobic exercise training as a viable means to attenuate cognitive losses associated with Alzheimer's disease. The mechanism of action for aerobic exercise's cognitive benefits is likely enhanced cardiorespiratory fitness and its response to incremental aerobic exercise have been incompletely evaluated in Alzheimer's disease. The aim of ... Read more >>

Sports Med Int Open (Sports medicine international open)
[2020, 4(1):E1-E7]

Cited: 1 time

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Developing an Exergame Intervention to Prevent Alzheimer’s Disease

Fang Yu, Dereck Salisbury, Tom Plocher,

Abstract Delaying the onset of Alzheimer’s Disease by five years could save the U.S. ~$89 billion by 2030. Aerobic exercise and cognitive training are two promising interventions for AD prevention and the two together may have a synergistic cognitive effect than either alone. The purposes of this study were to ... Read more >>

Innov Aging (Innovation in aging)
[2020, 4(Suppl 1):849-849]

Cited: 0 times

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RELATIONSHIP OF CARDIOPULMONARY EXERCISE TESTING AND FIELD WALKING TESTS IN MILD-MODERATE ALZHEIMER’S DEMENTIA

Dereck L Salisbury, Fang Yu,

Abstract The purpose of this study was to investigate relationships among peak exercise parameters on 6-minute walk (6MWT) and shuttle walk tests (SWT), and laboratory-based cardiopulmonary exercise testing (CPET). These relationships have been established in cardiopulmonary patient populations, but not in community-dwelling older adults with mild-moderate Alzheimer’s dementia (AD). This ... Read more >>

Innov Aging (Innovation in aging)
[2019, 3(Suppl 1):S611-S611]

Cited: 0 times

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A case study of recumbent cross-training in supervised exercise therapy for peripheral artery disease (PAD).

Rebecca J L Brown, Dereck L Salisbury, Diane Treat-Jacobson,

J Vasc Nurs (Journal of vascular nursing : official publication of the Society for Peripheral Vascular Nursing)
[2019, 37(3):223-224]

Cited: 0 times

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Implementation of Supervised Exercise Therapy for Patients With Symptomatic Peripheral Artery Disease: A Science Advisory From the American Heart Association.

Diane Treat-Jacobson, Mary M McDermott, Joshua A Beckman, Marsha A Burt, Mark A Creager, Jonathan K Ehrman, Andrew W Gardner, Ryan J Mays, Judith G Regensteiner, Dereck L Salisbury, Erica N Schorr, M Eileen Walsh, ,

Patients with lower-extremity peripheral artery disease (PAD) have greater functional impairment, faster functional decline, increased rates of mobility loss, and poorer quality of life than people without PAD. Supervised exercise therapy (SET) improves walking ability, overall functional status, and health-related quality of life in patients with symptomatic PAD. In 2017, ... Read more >>

Circulation (Circulation)
[2019, 140(13):e700-e710]

Cited: 5 times

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Experience Implementing Supervised Exercise Therapy for Peripheral Artery Disease.

Dereck L Salisbury, Mary O Whipple, Marsha Burt, Rebecca Brown, Ryan J Mays, Mark Bakken, Diane Treat-Jacobson,

<h4>Background</h4>Supervised exercise therapy (SET) is a cornerstone of treatment for improving walking distance for individuals with symptomatic peripheral artery disease and claudication. High quality randomized controlled trials have documented the efficacy of SET as a claudication treatment and led to the recent Centers for Medicare and Medicaid decision to cover ... Read more >>

J Clin Exerc Physiol (Journal of clinical exercise physiology)
[2019, 8(1):1-12]

Cited: 2 times

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Efficacy and mechanisms of combined aerobic exercise and cognitive training in mild cognitive impairment: study protocol of the ACT trial.

Fang Yu, Feng Vankee Lin, Dereck L Salisbury, Krupa N Shah, Lisa Chow, David Vock, Nathaniel W Nelson, Anton P Porsteinsson, Clifford Jack,

<h4>Background</h4>Developing non-pharmacological interventions with strong potential to prevent or delay the onset of Alzheimer's disease (AD) in high-risk populations is critical. Aerobic exercise and cognitive training are two promising interventions. Aerobic exercise increases aerobic fitness, which in turn improves brain structure and function, while cognitive training improves selective brain function ... Read more >>

Trials (Trials)
[2018, 19(1):700]

Cited: 4 times

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Measurement of peripheral blood flow in patients with peripheral artery disease: Methods and considerations.

Dereck L Salisbury, Rebecca Jl Brown, Ulf G Bronas, Laura N Kirk, Diane Treat-Jacobson,

Peripheral artery disease (PAD) is a manifestation of generalized atherosclerosis which results in hemodynamic compromise of oxygen and substrate delivery to the lower extremity skeletal muscles. Hemodynamic assessments are vital in PAD diagnosis and in the evaluation of strategies aimed at treating claudication (i.e. exercise training, revascularization, and pharmacological agents). ... Read more >>

Vasc Med (Vascular medicine (London, England))
[2018, 23(2):163-171]

Cited: 1 time

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Translation of an evidence-based therapeutic exercise program for patients with peripheral artery disease.

Dereck L Salisbury, Mary O Whipple, Marsha Burt, Rebecca J L Brown, Alan Hirsch, Christopher Foley, Diane Treat-Jacobson,

The purpose of this study was to implement and evaluate quality outcomes including referral, enrollment, and completion rates of a new peripheral artery disease (PAD)-specific supervised exercise therapy (SET) program within a preexisting clinical exercise wellness program and to evaluate the clinical effectiveness and patient-centered outcomes derived from 12 weeks of ... Read more >>

J Vasc Nurs (Journal of vascular nursing : official publication of the Society for Peripheral Vascular Nursing)
[2018, 36(1):23-33]

Cited: 3 times

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Determination of Aerobic Capacity via Cycle Ergometer Exercise Testing in Alzheimer's Disease.

Ulf G Bronas, Dereck Salisbury, Kaitlin Kelly, Arthur Leon, Lisa Chow, Fang Yu,

<h4>Background</h4>Older adults with Alzheimer's disease (AD) may be unable to perform treadmill testing due to balance issues. We investigated whether older adults with AD could successfully complete a peak cycle ergometer test.<h4>Methods</h4>Peak oxygen consumption (peak [Formula: see text]) assessed via a cycle ergometer test in 44 participants with AD (age ... Read more >>

Am J Alzheimers Dis Other Demen (American journal of Alzheimer's disease and other dementias)
[2017, 32(8):500-508]

Cited: 3 times

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Reactive oxygen and nitrogen species: impact on endothelial dysfunction.

Dereck Salisbury, Ulf Bronas,

<h4>Background</h4>Reactive oxygen and nitrogen species, known as free radicals, play a key role in the etiology and progression of atherosclerotic cardiovascular disease by creating vascular oxidative stress.<h4>Purpose</h4>This review will discuss current biological research about the enzymatic and nonenzymatic sources of oxidative stress, free radical chemistry, and how it pertains to ... Read more >>

Nurs Res (Nursing research)
[2015, 64(1):53-66]

Cited: 31 times

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Inflammation and immune system contribution to the etiology of atherosclerosis: mechanisms and methods of assessment.

Dereck Salisbury, Ulf Bronas,

<h4>Background</h4>Immune system activation and inflammation are intricately involved in the development and progression of atherosclerosis.<h4>Purpose</h4>The purposes of this review are to (a) discuss effects of inflammation and the immune system across the lifespan of atherosclerotic plaque, (b) review current recommended testing techniques for assessing inflammation using blood and within the ... Read more >>

Nurs Res (Nursing research)
[2014, 63(5):375-385]

Cited: 24 times

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