Full Text Journal Articles by
Author Dequina Nicholas

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aPC/PAR1 confers endothelial anti-apoptotic activity via a discrete, β-arrestin-2-mediated SphK1-S1PR1-Akt signaling axis.

Olivia Molinar-Inglis, Cierra A Birch, Dequina Nicholas, Lennis Orduña-Castillo, Metztli Cisneros-Aguirre, Anand Patwardhan, Buxin Chen, Neil J Grimsey, Luisa J Coronel, Huilan Lin, Patrick K Gomez Menzies, Mark A Lawson, Hemal H Patel, JoAnn Trejo,

Endothelial dysfunction is associated with vascular disease and results in disruption of endothelial barrier function and increased sensitivity to apoptosis. Currently, there are limited treatments for improving endothelial dysfunction. Activated protein C (aPC), a promising therapeutic, signals via protease-activated receptor-1 (PAR1) and mediates several cytoprotective responses, including endothelial barrier stabilization ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(49):]

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aPC/PAR1 confers endothelial anti-apoptotic activity via a discrete β-arrestin-2 mediated SphK1-S1PR1-Akt signaling axis

Olivia Molinar-Inglis, Cierra Birch, Dequina Nicholas, Metzli Cisneros-Aguirre, Anand Patwardhan, Buxin Chen, Neil Grimsey, Patrick Gomez-Menzies, Huilan Lin, Luisa Coronel, Mark Lawson, Hemal Patel, JoAnn Trejo,

Endothelial dysfunction is associated with multiple vascular diseases and lacks effective treatments. Activated Protein C (aPC) is a promising biotherapeutic that signals via protease-activated receptor-1 (PAR1) to promote diverse cytoprotective responses, including endothelial barrier stabilization, anti-inflammatory and anti-apoptotic activities, which is facilitated by co-receptors. We showed that aPC-activated PAR1 signals ... Read more >>

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MON-009 GLUT1-Mediated Glycolysis Facilitates GnRH-Induced Secretion of Luteinizing Hormone

Dequina Nicholas, Vashti Knight, Karen Tonsfeldt, Tomohiro Terasaka, Olivia Molinar-Inglis, Shannon Brooke Zoe Stephens, Joann Trejo, Alexander S Kauffman, Pamela L Mellon, Mark A Lawson,

Abstract Reproduction requires intensive energy expenditure, and energy availability impacts the function of the reproductive endocrine HPG-axis. Accordingly, the reproductive axis is suppressed during hypoglycemia. Circulating blood glucose can directly interact with gonadotropes within the highly vascular pituitary. Therefore, it is possible that gonadotropes may sense energy availability via the ... Read more >>

J Endocr Soc (Journal of the Endocrine Society)
[2020, 4(Suppl 1):]

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Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation.

Leena P Bharath, Madhur Agrawal, Grace McCambridge, Dequina A Nicholas, Hatice Hasturk, Jing Liu, Kai Jiang, Rui Liu, Zhenheng Guo, Jude Deeney, Caroline M Apovian, Jennifer Snyder-Cappione, Gregory S Hawk, Rebecca M Fleeman, Riley M F Pihl, Katherine Thompson, Anna C Belkina, Licong Cui, Elizabeth A Proctor, Philip A Kern, Barbara S Nikolajczyk,

Age is a non-modifiable risk factor for the inflammation that underlies age-associated diseases; thus, anti-inflammaging drugs hold promise for increasing health span. Cytokine profiling and bioinformatic analyses showed that Th17 cytokine production differentiates CD4<sup>+</sup> T cells from lean, normoglycemic older and younger subjects, and mimics a diabetes-associated Th17 profile. T cells from ... Read more >>

Cell Metab (Cell metabolism)
[2020, 32(1):44-55.e6]

Cited: 65 times

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En Balance: The Contribution of Physical Activity to the Efficacy of Spanish Diabetes Education of Hispanic Americans with Type 2 Diabetes.

Dequina A Nicholas, Lorena M Salto, Kristen Lavelle, Joy Wilson, W Lawrence Beeson, Anthony Firek, William H R Langridge, Zaida Cordero-MacIntyre, Marino De Leon,

<h4>Purpose</h4><i>En Balance</i>, a culturally sensitive diabetes education program, improves glycemic control in Hispanics with type 2 diabetes. The program emphasized diet, physical activity, and other factors important for glycemic control. However, the individual contributions of these education factors are unclear. The purpose of this study is to assess the contribution ... Read more >>

J Diabetes Res (Journal of diabetes research)
[2020, 2020:4826704]

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Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes.

Dequina A Nicholas, Elizabeth A Proctor, Madhur Agrawal, Anna C Belkina, Stephen C Van Nostrand, Leena Panneerseelan-Bharath, Albert R Jones, Forum Raval, Blanche C Ip, Min Zhu, Jose M Cacicedo, Chloe Habib, Nestor Sainz-Rueda, Leah Persky, Patrick G Sullivan, Barbara E Corkey, Caroline M Apovian, Philip A Kern, Douglas A Lauffenburger, Barbara S Nikolajczyk,

Mechanisms that regulate metabolites and downstream energy generation are key determinants of T cell cytokine production, but the processes underlying the Th17 profile that predicts the metabolic status of people with obesity are untested. Th17 function requires fatty acid uptake, and our new data show that blockade of CPT1A inhibits Th17-associated ... Read more >>

Cell Metab (Cell metabolism)
[2019, 30(3):447-461.e5]

Cited: 25 times

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SAT-177 GLUT1-Mediated Glucose Metabolism Is Necessary for GnRH-Induced Gonadotrope Secretion of LH and Is Increased by Androgen

Dequina Nicholas, Vashti Knight, Tomohiro Terasaka, Jeong in Choi, Oscar Muñoz, Pamela Mellon, Mark Lawson,

Abstract Women with polycystic ovary syndrome (PCOS) have a high prevalence of metabolic comorbidities including dyslipidemia, metabolic syndrome, and type 2 diabetes mellitus. However, the impact of systemic metabolic dysregulation on reproduction is not completely understood. In particular, women with PCOS have elevated androgen as well as elevated blood glucose, ... Read more >>

J Endocr Soc (Journal of the Endocrine Society)
[2019, 3(Suppl 1):]

Cited: 0 times

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Advances in the quantification of mitochondrial function in primary human immune cells through extracellular flux analysis.

Dequina Nicholas, Elizabeth A Proctor, Forum M Raval, Blanche C Ip, Chloe Habib, Eleni Ritou, Tom N Grammatopoulos, Devin Steenkamp, Hans Dooms, Caroline M Apovian, Douglas A Lauffenburger, Barbara S Nikolajczyk,

Numerous studies show that mitochondrial energy generation determines the effectiveness of immune responses. Furthermore, changes in mitochondrial function may regulate lymphocyte function in inflammatory diseases like type 2 diabetes. Analysis of lymphocyte mitochondrial function has been facilitated by introduction of 96-well format extracellular flux (XF96) analyzers, but the technology remains ... Read more >>

PLoS One (PloS one)
[2017, 12(2):e0170975]

Cited: 20 times

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Correction to "Barriers to Obtaining Sera and Tissue Specimens of African-American Women for the Advancement of Cancer Research".

Katherine J Strissel, Dequina A Nicholas, Myriam Castagne-Charlotin, Naomi Ko, Gerald V Denis,

[This corrects the article DOI: 10.4137/CMWH.S34698.]. ... Read more >>

Clin Med Insights Womens Health (Clinical medicine insights. Women's health)
[2016, 9:35]

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BET bromodomain proteins and epigenetic regulation of inflammation: implications for type 2 diabetes and breast cancer.

Dequina A Nicholas, Guillaume Andrieu, Katherine J Strissel, Barbara S Nikolajczyk, Gerald V Denis,

Chronic inflammation drives pathologies associated with type 2 diabetes (T2D) and breast cancer. Obesity-driven inflammation may explain increased risk and mortality of breast cancer with T2D reported in the epidemiology literature. Therapeutic approaches to target inflammation in both T2D and cancer have so far fallen short of the expected improvements ... Read more >>

Cell Mol Life Sci (Cellular and molecular life sciences : CMLS)
[2017, 74(2):231-243]

Cited: 6 times

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Barriers to Obtaining Sera and Tissue Specimens of African-American Women for the Advancement of Cancer Research.

Katherine J Strissel, Dequina A Nicholas, Myriam Castagne-Charlotin, Naomi Ko, Gerald V Denis,

African-American women, a historically understudied and underserved group, have increased risk for triple-negative breast cancer and obesity-associated disease. Obesity-associated metabolic diseases share a common link of low grade chronic inflammation, but not all obese women have metabolic disturbances or are inflamed. One goal of our ongoing research is to identify ... Read more >>

Clin Med Insights Womens Health (Clinical medicine insights. Women's health)
[2016, 9(Suppl 1):57-61]

Cited: 3 times

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Chimeric Vaccine Stimulation of Human Dendritic Cell Indoleamine 2, 3-Dioxygenase Occurs via the Non-Canonical NF-κB Pathway.

Nan-Sun Kim, Jacques C Mbongue, Dequina A Nicholas, Grace E Esebanmen, Juli J Unternaehrer, Anthony F Firek, William H R Langridge,

A chimeric protein vaccine composed of the cholera toxin B subunit fused to proinsulin (CTB-INS) was shown to suppress type 1 diabetes onset in NOD mice and upregulate biosynthesis of the tryptophan catabolic enzyme indoleamine 2, 3-dioxygenase (IDO1) in human dendritic cells (DCs). Here we demonstrate siRNA inhibition of the ... Read more >>

PLoS One (PloS one)
[2016, 11(2):e0147509]

Cited: 10 times

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B cells shed light on diminished vaccine responses in obesity.

Dequina A Nicholas, Barbara S Nikolajczyk,

Obesity (Silver Spring) (Obesity (Silver Spring, Md.))
[2016, 24(3):551]

Cited: 2 times

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Identification of Anti-Long Chain Saturated Fatty Acid IgG Antibodies in Serum of Patients with Type 2 Diabetes.

Dequina A Nicholas, Lorena M Salto, Ava M Boston, Nan Sun Kim, Marco Larios, W Lawrence Beeson, Anthony F Firek, Carlos A Casiano, William H R Langridge, Zaida Cordero-MacIntyre, Marino De Leon,

High levels of serum long chain saturated fatty acids (LCSFAs) have been associated with inflammation in type 2 diabetes. Dietary SFAs can promote inflammation, the secretion of IgG antibodies, and secretion of the proinflammatory cytokine IL-1β. This study characterizes anti-LCSFA IgG antibodies from patients with type 2 diabetes. Serum samples ... Read more >>

Mediators Inflamm (Mediators of inflammation)
[2015, 2015:196297]

Cited: 3 times

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The Role of Indoleamine 2, 3-Dioxygenase in Immune Suppression and Autoimmunity.

Jacques C Mbongue, Dequina A Nicholas, Timothy W Torrez, Nan-Sun Kim, Anthony F Firek, William H R Langridge,

Indoleamine 2, 3-dioxygenase (IDO) is the first and rate limiting catabolic enzyme in the degradation pathway of the essential amino acid tryptophan. By cleaving the aromatic indole ring of tryptophan, IDO initiates the production of a variety of tryptophan degradation products called "kynurenines" that are known to exert important immuno-regulatory ... Read more >>

Vaccines (Basel) (Vaccines)
[2015, 3(3):703-729]

Cited: 105 times

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Autoantigen based vaccines for type 1 diabetes.

Dequina Nicholas, Oludare Odumosu, William H R Langridge,

Type 1 diabetes is an organ-specific autoimmune disease caused by chronic inflammation (insulitis), which damages the insulin producing β-cells of the pancreatic Islets of Langerhans. Dendritic cells (DCs) are generally the first cells of the immune system to process β-cell autoantigens and, by promoting autoreactivity, play a major role in ... Read more >>

Discov Med (Discovery medicine)
[2011, 11(59):293-301]

Cited: 11 times

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AB toxins: a paradigm switch from deadly to desirable.

Oludare Odumosu, Dequina Nicholas, Hiroshi Yano, William Langridge,

To ensure their survival, a number of bacterial and plant species have evolved a common strategy to capture energy from other biological systems. Being imperfect pathogens, organisms synthesizing multi-subunit AB toxins are responsible for the mortality of millions of people and animals annually. Vaccination against these organisms and their toxins ... Read more >>

Toxins (Basel) (Toxins)
[2010, 2(7):1612-1645]

Cited: 27 times

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