Full Text Journal Articles by
Author Dennis S Chi

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Rectosigmoid resection by gynecologic oncologists versus colorectal surgeons: as long as it catches the mouse, does the color of the cat matter?

Suk Joon Chang, Christina Fotopoulou, Robert E Bristow, Dennis S Chi, William A Cliby,

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(3):e51]

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Frailty based on the memorial Sloan Kettering Frailty Index is associated with surgical decision making, clinical trial participation, and overall survival among older women with ovarian cancer.

Olga T Filippova, Amy L Tin, Joanne Alonso, Andrew J Vickers, William P Tew, Ginger J Gardner, Yukio Sonoda, Kara Long Roche, Oliver Zivanovic, Dennis S Chi, Armin Shahrokni,

<h4>Objectives</h4>To determine whether the Memorial Sloan Kettering Frailty Index (MSK-FI) is associated with decision-making in older women surgically treated for advanced-stage ovarian cancer.<h4>Methods</h4>We retrospectively applied the MSK-FI to women ≥70 years with newly diagnosed advanced-stage ovarian cancer surgically treated at our institution from 01/2001-05/2017. MSK-FI components, including 10 comorbidities and functional ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, :]

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Molecular characterization of high-grade serous ovarian cancers occurring in younger and older women.

Olga T Filippova, Pier Selenica, Fresia Pareja, Mahsa Vahdatinia, Yingjie Zhu, Xin Pei, Nadeem Riaz, Kara Long Roche, Dennis S Chi, Nadeem R Abu-Rustum, Lora H Ellenson, Jorge S Reis-Filho, Dmitriy Zamarin, Britta Weigelt,

<h4>Objectives</h4>To determine if the mutational landscapes and genomic features of homologous recombination DNA repair defects (HRD) vary between younger and older patients with high-grade serous ovarian cancer (HGSOC).<h4>Methods</h4>Younger and older women were defined as bottom and top age quartiles, respectively. HGSOCs from 15 younger (median 49 years, range 35-53) and 15 ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, :]

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Minimally invasive repair of a left diaphragm hernia after debulking surgery for advanced ovarian cancer.

Sarah Ehmann, Bernard Park, Dennis S Chi,

Eighty percent of women with ovarian cancer have advanced disease (FIGO stage III or IV) at the time of diagnoses and require extensive upper abdominal surgery to obtain complete gross resection (Minig et al., 2015, Eisenhauer et al., 2006). A diaphragmatic hernia is defined as abdominal contents bulging into the ... Read more >>

Gynecol Oncol Rep (Gynecologic oncology reports)
[2021, 36:100713]

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Standing on the shoulders of giants: Mentorship advice from leaders in the field.

Teresa K L Boitano, Dennis S Chi, Larry J Copeland, J Michael Straughn,

This commentary is presenting opinions and advice on mentorship in the field of gynecologic oncology. Eleven academic gynecologic oncologists from across the country were interviewed and their thoughts about mentorship were recorded with recurring themes and ideas described in this commentary. Trust, respect, and mutual agreement on expectations were all ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, :]

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Prophylactic Negative Pressure Wound Therapy After Laparotomy for Gynecologic Surgery: A Randomized Controlled Trial.

Mario M Leitao, Qin C Zhou, Maria B Schiavone, Renee A Cowan, Evan S Smith, Alexia Iasonos, Mitchell Veith, Michael Rafizadeh, Katherine Curran, Bhavani Ramesh, Kaity Chang, Dennis S Chi, Yukio Sonoda, Amy K Brown, Jonathan A Cosin, Nadeem R Abu-Rustum, Martin A Martino, Jennifer J Mueller, Kara Long Roche, Elizabeth L Jewell, Vance Broach, Nicholas C Lambrou, John P Diaz, Oliver Zivanovic,

<h4>Objective</h4>To estimate the effectiveness of prophylactic negative pressure wound therapy in patients undergoing laparotomy for gynecologic surgery.<h4>Methods</h4>We conducted a randomized controlled trial. Eligible, consenting patients, regardless of body mass index (BMI), who were undergoing laparotomy for presumed gynecologic malignancy were randomly allocated to standard gauze or negative pressure wound therapy. ... Read more >>

Obstet Gynecol (Obstetrics and gynecology)
[2021, 137(2):334-341]

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Exploring the clinical significance of serous tubal intraepithelial carcinoma associated with advanced high-grade serous ovarian cancer: A Memorial Sloan Kettering Team Ovary Study.

Thomas Boerner, Henry S Walch, Bastien Nguyen, Alexia Iasonos, Qin C Zhou, Nikolaus Schultz, M Herman Chui, Rachel N Grisham, William P Tew, Roisin E O'Cearbhaill, Carol Aghajanian, Oliver Zivanovic, Nadeem R Abu-Rustum, Ginger J Gardner, Yukio Sonoda, Dennis S Chi, Kara Long Roche,

<h4>Objective</h4>To evaluate the clinical significance and genomic associations of concurrent serous tubal intraepithelial carcinoma (STIC) with high-grade serous carcinoma (HGSC) of the ovary in women undergoing primary debulking surgery (PDS).<h4>Methods</h4>All patients who underwent PDS for HGSC between 01/2015 and 12/2018 were captured in a prospectively maintained institutional database. Patients were ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, 160(3):696-703]

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Acute pericarditis after transabdominal cardiophrenic lymph node dissection and pericardotomy during ovarian cancer debulking surgery: A case report.

Dib Sassine, Dimitrios Nasioudis, Kathryn Miller, Rebecca Chang, Derman Basaran, Evan S Smith, Sarah Ehmann, Dennis S Chi,

•Complete gross resection as part of debulking surgery is crucial in advanced ovarian cancer.•Supradiaphragmatic lymph node resection may prolong survival in patients with ovarian cancer.•We report acute pericarditis after supradiaphragmatic lymph node resection and pericardotomy. ... Read more >>

Gynecol Oncol Rep (Gynecologic oncology reports)
[2021, 35:100683]

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Advanced ovarian cancer and cytoreductive surgery: Independent validation of a risk-calculator for perioperative adverse events.

Alli M Straubhar, Jennifer L Wolf, Ms Qin C Zhou, Alexia Iasonos, Stephanie Cham, Jason D Wright, Kara Long Roche, Dennis S Chi, Oliver Zivanovic,

<h4>Objective</h4>To independently validate a published risk-calculator for adverse perioperative outcomes in patients with epithelial ovarian cancer undergoing debulking surgery at a high-volume surgical center.<h4>Methods</h4>Using our institution's curated prospective ovarian cancer database, we identified patients with epithelial ovarian cancer who underwent a debulking procedure from 7/2015 to 5/2019, to be used ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, 160(2):438-444]

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Surgical ovarian suppression for adjuvant treatment in hormone receptor positive breast cancer in premenopausal patients.

Anton Oseledchyk, Mary L Gemignani, Qin C Zhou, Alexia Iasonos, Rahmi Elahjji, Zara Adamou, Noah Feit, Shari B Goldfarb, Kara Long Roche, Yukio Sonoda, Deborah J Goldfrank, Dennis S Chi, Sally S Saban, Vance Broach, Nadeem R Abu-Rustum, Jeanne Carter, Mario Leitao, Oliver Zivanovic,

<h4>Objective</h4>Ovarian suppression is recommended to complement endocrine therapy in premenopausal women with breast cancer and high-risk features. It can be achieved by either medical ovarian suppression or therapeutic bilateral salpingo-oophorectomy. Our objective was to evaluate characteristics of patients with stage I-III hormone receptor positive primary breast cancer who underwent bilateral ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2021, 31(2):222-231]

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Why was GOG-0213 a negative trial?

Sarah Ehmann, Oliver Zivanovic, Dennis S Chi,

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(1):e19]

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Survival outcomes of acute normovolemic hemodilution in patients undergoing primary debulking surgery for advanced ovarian cancer: A Memorial Sloan Kettering Cancer Center Team Ovary study.

Thomas Boerner, Edward Tanner, Olga Filippova, Qin C Zhou, Alexia Iasonos, William P Tew, Roisin E O'Cearbhaill, Rachel N Grisham, Ginger J Gardner, Yukio Sonoda, Nadeem R Abu-Rustum, Oliver Zivanovic, Kara Long Roche, Anoushka M Afonso, Mary Fischer, Dennis S Chi,

<h4>Objective</h4>To describe oncologic outcomes after using acute normovolemic hemodilution (ANH) to reduce requirement for allogenic red blood cell transfusions (ABT) in patients undergoing primary debulking surgery (PDS) for advanced ovarian cancer.<h4>Methods</h4>We performed a post-hoc analysis of a recent prospective trial investigating the safety and feasibility of ANH during PDS for ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, 160(1):51-55]

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Update on the role of surgery in the management of advanced epithelial ovarian cancer.

Alli Straubhar, Dennis S Chi, Kara Long Roche,

Surgical cytoreduction and platinum/taxane-based chemotherapy are the cornerstones of the management of advanced ovarian cancer; however, the optimal timing and order of these interventions remain a topic of debate. Interpreting the available data, specifically regarding the role of neoadjuvant chemotherapy in the primary setting and surgical cytoreduction in the recurrent ... Read more >>

Clin Adv Hematol Oncol (Clinical advances in hematology & oncology : H&O)
[2020, 18(11):723-731]

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Pre-operative neoadjuvant chemotherapy cycles and survival in newly diagnosed ovarian cancer: what is the optimal number? A Memorial Sloan Kettering Cancer Center Team Ovary study.

Ying L Liu, Qin C Zhou, Alexia Iasonos, Dennis S Chi, Oliver Zivanovic, Yukio Sonoda, Ginger Gardner, Vance Broach, Roisin O'Cearbhaill, Jason A Konner, Rachel Grisham, Carol A Aghajanian, Nadeem R Abu-Rustum, William Tew, Kara Long Roche,

<h4>Objective</h4>Although trials of neoadjuvant chemotherapy in ovarian cancer use 3 neoadjuvant cycles, real-world practice varies. We sought to evaluate the influence of increasing pre-operative cycles on survival, accounting for surgical outcomes.<h4>Methods</h4>We identified 199 women with newly diagnosed ovarian cancer recommended for neoadjuvant chemotherapy who underwent interval debulking surgery from July ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2020, 30(12):1915-1921]

Cited: 2 times

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Genomic Alterations as Potential Therapeutic Targets in Extramammary Paget's Disease of the Vulva.

Marina Stasenko, Gowtham Jayakumaran, Renee Cowan, Vance Broach, Dennis S Chi, Anthony Rossi, Travis J Hollman, Ahmet Zehir, Nadeem R Abu-Rustum, Mario M Leitao,

<h4>Purpose</h4>To identify genomic alterations as potential therapeutic targets in extramammary Paget disease (EMPD) of the vulva.<h4>Methods</h4>We identified all patients with primary vulvar EMPD who were treated at our institution and underwent paired tumor-normal massively parallel sequencing of 410-468 cancer-related genes (MSK-IMPACT assay). EMPD of the vulva samples sequenced from 2014 ... Read more >>

JCO Precis Oncol (JCO precision oncology)
[2020, 4:]

Cited: 1 time

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Role of delayed interval debulking for persistent residual disease after more than 5 cycles of chemotherapy for primary advanced ovarian cancer. An international multicenter study.

Helmut Plett, Olga T Filippova, Annalisa Garbi, Stefan Kommoss, Mikkel Rosendahl, Carrie Langstraat, Saurabh Phadnis, Mustafa Zelal Muallem, Thaïs Baert, Dennis S Chi, Giovanni Damiano Aletti, Florin-Andrei Taran, Jan Philipp Ramspott, Oliver Zivanovic, Andreas du Bois, Yukio Sonoda, Ginger Gardner, Alexander Traut, Kara Long Roche, Philipp Harter,

<h4>Background</h4>Standard of care in patients with advanced ovarian cancer (AOC) is upfront surgery followed by chemotherapy. Neoadjuvant chemotherapy (NACT) and interval debulking surgery (IDS) is an alternative in selected patients. Most data exist with IDS following 3-4 cycles chemotherapy, however, some patients experience a delay of IDS. So far, the impact ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2020, 159(2):434-441]

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Video-assisted thoracic surgery in the primary management of advanced ovarian carcinoma with moderate to large pleural effusions: A Memorial Sloan Kettering Cancer Center Team Ovary Study.

Thomas Boerner, Olga T Filippova, Andrew J Chi, Alexia Iasonos, Qin C Zhou, Kara Long Roche, Oliver Zivanovic, Bernard J Park, James Huang, David R Jones, Nadeem R Abu-Rustum, Ginger Gardner, Yukio Sonoda, Dennis S Chi,

<h4>Objectives</h4>We assessed the utility of video-assisted thoracic surgery (VATS) in defining extent of intrathoracic disease in advanced ovarian carcinoma with moderate-to-large pleural effusions.<h4>Methods</h4>Beginning in 2001, VATS was performed on all patients with suspected advanced ovarian carcinoma and moderate-to-large pleural effusions, evaluating for macroscopic intrathoracic disease. The algorithm recommended primary debulking ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2020, 159(1):66-71]

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Electronic patient-reported symptom monitoring in patients recovering from ambulatory minimally invasive gynecologic surgery: A prospective pilot study.

Oliver Zivanovic, Ling Y Chen, Andrew Vickers, Alli Straubhar, Raymond Baser, Mitchell Veith, Nate Aiken, Jeanne Carter, Katherine Curran, Brett Simon, Jennifer Mueller, Elizabeth Jewell, Dennis S Chi, Yukio Sonoda, Nadeem R Abu-Rustum, Mario M Leitao,

<h4>Objective</h4>To evaluate the feasibility of an electronic symptom-tracking platform for patients recovering from ambulatory surgery.<h4>Method</h4>We assessed user response to an electronic system designed to self-report symptoms. Endpoints included compliance, postoperative symptoms, patient satisfaction. An 8-item symptom inventory (pain, nausea, vomiting, shortness of breath, fever, swelling, discharge, redness) was developed and ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2020, 159(1):187-194]

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Comparison of minimally invasive versus open surgery in the treatment of endometrial carcinosarcoma.

Silvana Pedra Nobre, Jennifer J Mueller, Ginger J Gardner, Kara Long Roche, Carol L Brown, Robert A Soslow, Kaled M Alektiar, Yukio Sonoda, Vance A Broach, Elizabeth L Jewell, Oliver Zivanovic, Dennis S Chi, Nadeem R Abu-Rustum, Mario M Leitao,

<h4>Objective</h4>The aim of this study was to compare perioperative and oncologic outcomes between minimally invasive and open surgery in the treatment of endometrial carcinosarcoma.<h4>Methods</h4>We retrospectively identified all patients with newly diagnosed endometrial carcinosarcoma who underwent primary surgery via any approach at our institution from January 2009 to January 2018. Patients ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2020, 30(8):1162-1168]

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Hematologic changes after splenectomy for ovarian cancer debulking surgery, and association with infection and venous thromboembolism.

Olga T Filippova, Sun Woo Kim, Renee A Cowan, Andrew J Chi, Alexia Iasonos, Qin C Zhou, Vance Broach, Oliver Zivanovic, Kara Long Roche, Yukio Sonoda, Ginger Gardner, Dennis S Chi,

<h4>Introduction</h4>The spleen plays a role in the immune and coagulative responses, yet a splenectomy may be required during ovarian cancer surgery to achieve complete cytoreduction. The aim of the study was to correlate hematologic changes with the development of infection and venous thromboembolism in patients undergoing splenectomy.<h4>Methods</h4>This single-institution retrospective review ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2020, 30(8):1183-1188]

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Delays from neoadjuvant chemotherapy to interval debulking surgery and survival in ovarian cancer.

Ying L Liu, Qin C Zhou, Alexia Iasonos, Olga T Filippova, Dennis S Chi, Oliver Zivanovic, Yukio Sonoda, Ginger Gardner, Vance Broach, Roisin OCearbhaill, Jason A Konner, Carol A Aghajanian, Kara Long, William Tew,

<h4>Introduction</h4>Delays from primary surgery to chemotherapy are associated with worse survival in ovarian cancer, however the impact of delays from neoadjuvant chemotherapy to interval debulking surgery is unknown. We sought to evaluate the association of delays from neoadjuvant chemotherapy to interval debulking with survival.<h4>Methods</h4>Patients with a diagnosis of stage III/IV ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2020, 30(10):1554-1561]

Cited: 1 time

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A multimodality triage algorithm to improve cytoreductive outcomes in patients undergoing primary debulking surgery for advanced ovarian cancer: A Memorial Sloan Kettering Cancer Center team ovary initiative.

Alli M Straubhar, Olga T Filippova, Renee A Cowan, Yulia Lakhman, Debra M Sarasohn, Ines Nikolovski, Jean M Torrisi, Weining Ma, Nadeem R Abu-Rustum, Ginger J Gardner, Yukio Sonoda, Oliver Zivanovic, Dennis S Chi, Kara Long Roche,

<h4>Objective</h4>To describe outcomes using a multimodal algorithm to triage patients with advanced epithelial ovarian cancer (EOC) to primary debulking surgery (PDS) versus neoadjuvant chemotherapy (NACT).<h4>Methods</h4>All patients with EOC treated at our institution from 04/2015-08/2018 were identified. We included patients without contraindication to PDS who underwent prospective calculation of a Resectability ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2020, 158(3):608-613]

Cited: 1 time

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Practical guidelines for triage to neoadjuvant chemotherapy in advanced ovarian cancer: Big risk, big reward…or too much risk?

Kara Long Roche, Dennis S Chi,

Gynecol Oncol (Gynecologic oncology)
[2020, 157(3):561-562]

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Ovarian Cancer After Prophylactic Salpingectomy in a Patient With Germline BRCA1 Mutation.

Nicole Lugo Santiago, Evan Smith, Mary Cox, Carrie S Wan, Nana E Tchabo, Ibraheem Awowole, Vance Broach, Dennis S Chi,

<h4>Background</h4>Women with germline BRCA1 or BRCA2 mutations have a lifetime risk of ovarian cancer of up to 46%. Opportunistic salpingectomy has been advocated as a risk-reducing strategy owing to increasing recognition of tubal origin, yet evidence of efficacy in this high-risk population is limited.<h4>Case</h4>This is the case of a woman ... Read more >>

Obstet Gynecol (Obstetrics and gynecology)
[2020, 135(6):1270-1274]

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Unraveling tumor-immune heterogeneity in advanced ovarian cancer uncovers immunogenic effect of chemotherapy.

Alejandro Jiménez-Sánchez, Paulina Cybulska, Katherine LaVigne Mager, Simon Koplev, Oliver Cast, Dominique-Laurent Couturier, Danish Memon, Pier Selenica, Ines Nikolovski, Yousef Mazaheri, Yonina Bykov, Felipe C Geyer, Geoff Macintyre, Lena Morrill Gavarró, Ruben M Drews, Michael B Gill, Anastasios D Papanastasiou, Ramon E Sosa, Robert A Soslow, Tyler Walther, Ronglai Shen, Dennis S Chi, Kay J Park, Travis Hollmann, Jorge S Reis-Filho, Florian Markowetz, Pedro Beltrao, Hebert Alberto Vargas, Dmitriy Zamarin, James D Brenton, Alexandra Snyder, Britta Weigelt, Evis Sala, Martin L Miller,

In metastatic cancer, the degree of heterogeneity of the tumor microenvironment (TME) and its molecular underpinnings remain largely unstudied. To characterize the tumor-immune interface at baseline and during neoadjuvant chemotherapy (NACT) in high-grade serous ovarian cancer (HGSOC), we performed immunogenomic analysis of treatment-naive and paired samples from before and after ... Read more >>

Nat Genet (Nature genetics)
[2020, 52(6):582-593]

Cited: 9 times

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