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Author Denis Nonclercq

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Cytological analysis of integumentary and muscular adaptations in three sand-dwelling marine teleosts, Ammodytes tobianus (Ammodytidae), Gorgasia preclara (Congridae) and Heteroconger hassi (Congridae) (Teleostei; Actinopterygii).

Jérôme Canei, Arnaud Trupia, Denis Nonclercq,

Sandy bottoms are a ubiquitous environment found from sea bottoms to intertidal and freshwater zones. They are inhabited by many invertebrates and vertebrates which have developed morphological and physiological adaptations to sustain life under these particular conditions. Sandy habitats exhibit three potential constraints: abrasion, hypoxia and mechanical resistance. Here, three ... Read more >>

J. Fish Biol. (Journal of fish biology)
[2020, :]

Cited: 0 times

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Comparative study of the visual system of two psammophilic lizards (Scincus scincus &Eumeces schneideri).

Jérôme Canei, Carmen Burtea, Denis Nonclercq,

Sand deserts are common biotopes on the earth's surface. Some specialized vertebrate species have colonized these ecological habitats by living buried in the sand. Among these so called psammophilic species are the Scincidae sand dune living species Scincus scincus and Eumeces schneideri. These two skinks share a relatively similar behavioral ... Read more >>

Vision Res. (Vision research)
[2020, 171:17-30]

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Modulation of adiponectin receptors AdipoR1 and AdipoR2 by phage display-derived peptides in in vitro and in vivo models.

Deborah Crombez, Sébastien Delcambre, Denis Nonclercq, Luce Vander Elst, Sophie Laurent, Miriam Cnop, Robert N Muller, Carmen Burtea,

Type 2 diabetes (T2D) is often linked to metabolic syndrome, which assembles various risk factors related to obesity. Plasma levels of adiponectin are decreased in T2D and obese subjects. Aiming to develop a peptide able to bind adiponectin receptors and modulate their signalling pathways, a 12-amino acid sequence homologous in ... Read more >>

J Drug Target (Journal of drug targeting)
[2020, 28(7-8):831-851]

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Morphology and fibre-type distribution in the tongue of the Pogona vitticeps lizard (Iguania, Agamidae).

Leïla-Nastasia Zghikh, Emilie Vangysel, Denis Nonclercq, Alexandre Legrand, Bernard Blairon, Cécile Berri, Thierry Bordeau, Christophe Rémy, Carmen Burtéa, Stéphane J Montuelle, Vincent Bels,

Agamid lizards use tongue prehension for capturing all types of prey. The purpose of this study was to investigate the functional relationship between tongue structure, both surface and musculature, and function during prey capture in Pogona vitticeps. The lack of a detailed description of the distribution of fibre-types in the ... Read more >>

J. Anat. (Journal of anatomy)
[2014, 225(4):377-389]

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Protection of Wistar-Furth rats against postischaemic acute renal injury: role for nitric oxide and thromboxane?

Viginie Voisin, Anne-Emilie Declèves, Virginie Hubert, Vanessa Colombaro, Laetitia Giordano, Isabelle Habsch, Nadine Bouby, Denis Nonclercq, Nathalie Caron,

The Wistar-Furth (WF) rat strain is usually used in models of full major histocompatibility complex-mismatched kidney transplantation. Because these rats have been demonstrated to be resistant to several models of chronic kidney disease, the aim of the present study was to investigate their potential resistance to renal ischaemia-reperfusion (I/R) injury ... Read more >>

Clin. Exp. Pharmacol. Physiol. (Clinical and experimental pharmacology & physiology)
[2014, 41(11):911-920]

Cited: 4 times

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Involvement of CD74 in head and neck squamous cell carcinomas.

Nadège Kindt, Jérôme R Lechien, Denis Nonclercq, Guy Laurent, Sven Saussez,

While macrophage migration inhibitory factor (MIF) has been extensively studied in the context of inflammation and inflammatory disorders, less work has been devoted to its involvement in cancer, notably in neoplastic progression. In a previous study, we have found evidence that MIF plays a role in head and neck squamous ... Read more >>

J. Cancer Res. Clin. Oncol. (Journal of cancer research and clinical oncology)
[2014, 140(6):937-947]

Cited: 14 times

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Inhibition of hyaluronan is protective against renal ischaemia-reperfusion injury.

Vanessa Colombaro, Anne-Emilie Declèves, Inès Jadot, Virginie Voisin, Laetitia Giordano, Isabelle Habsch, Denis Nonclercq, Bruno Flamion, Nathalie Caron,

BACKGROUND: Ischaemia-reperfusion injury (IRI) to the kidney is a complex pathophysiological process that leads to acute renal failure and chronic dysfunction in renal allografts. It was previously demonstrated that during IRI, hyaluronan (HA) accumulates in the cortical and external medullary interstitium along with an increased expression of its main receptor, ... Read more >>

Nephrol. Dial. Transplant. (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association)
[2013, 28(10):2484-2493]

Cited: 11 times

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Pharmacological inhibition of macrophage migration inhibitory factor interferes with the proliferation and invasiveness of squamous carcinoma cells.

Nadège Kindt, Guy Laurent, Denis Nonclercq, Fabrice Journé, Ghanem Ghanem, Hugues Duvillier, Hans-Joachim Gabius, Jérôme Lechien, Sven Saussez,

Recent clinical observations and experimental studies of our group indicate that macrophage migration inhibitory factor (MIF) may contribute to tumor progression in head and neck squamous cell carcinomas (HNSCC). The present study was undertaken to examine the effects of the irreversible MIF inhibitor 4-iodo-6-phenylpyrimidine (4-IPP) on proliferation and invasiveness of ... Read more >>

Int. J. Oncol. (International journal of oncology)
[2013, 43(1):185-193]

Cited: 22 times

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Monoclonal antibody to CD31 (PECAM-1) inhibits tubular regeneration after ischemia reperfusion injury in the rat.

Xavier Valentini, Annabel Gossiaux, Nathalie Caron, Denis Nonclercq, Alexandre Legrand, Gérard Toubeau,

We used a rat model of renal ischemia (35 min) to test the potential involvement of platelet/endothelial cell adhesion molecule 1 (PECAM-1/CD31) in the process of S3 tubule regeneration.A monoclonal antibody specific for murine PECAM-1 was injected i.p. immediately after kidney reperfusion or 48 h post-ischemia. One day before ischemia, ... Read more >>

Nephron Exp. Nephrol. (Nephron. Experimental nephrology)
[2011, 118(3):e60-8]

Cited: 0 times

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Immunohistochemical localization of galectins-1 and -3 and monitoring of tissue galectin-binding sites during tubular regeneration after renal ischemia reperfusion in the rat.

David Vansthertem, Stéphanie Cludts, Denis Nonclercq, Annabel Gossiaux, Sven Saussez, Alexandre Legrand, Hans-Joachim Gabius, Gérard Toubeau,

Endogenous lectins act as effectors of cellular activities such as growth regulation, migration and adhesion. In this study, we report the histochemical detection of galectins and their binding sites in rat kidneys after ischemic injury (35 min) with regard to renal regeneration. In this context, we have shown in a ... Read more >>

Histol. Histopathol. (Histology and histopathology)
[2010, 25(11):1417-1429]

Cited: 10 times

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Expression of nestin, vimentin, and NCAM by renal interstitial cells after ischemic tubular injury.

David Vansthertem, Annabel Gossiaux, Anne-Emilie Declèves, Nathalie Caron, Denis Nonclercq, Alexandre Legrand, Gérard Toubeau,

This work explores the distribution of various markers expressed by interstitial cells in rat kidneys after ischemic injury (35 minutes) during regeneration of S3 tubules of outer stripe of outer medulla (OSOM). Groups of experimental animals (n = 4) were sacrificed every two hours during the first 24 hours post-ischemia ... Read more >>

J. Biomed. Biotechnol. (Journal of biomedicine & biotechnology)
[2010, 2010:193259]

Cited: 14 times

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Capacity of type I and II ligands to confer to estrogen receptor alpha an appropriate conformation for the recruitment of coactivators containing a LxxLL motif-Relationship with the regulation of receptor level and ERE-dependent transcription in MCF-7 cells.

Sandrine Bourgoin-Voillard, Dominique Gallo, Ioanna Laïos, Anny Cleeren, Latifa El Bali, Yves Jacquot, Denis Nonclercq, Guy Laurent, Jean-Claude Tabet, Guy Leclercq,

Estrogen receptor alpha (ERalpha) belongs to the superfamily of nuclear receptors and as such acts as a ligand-modulated transcription factor. Ligands elicit in ERalpha conformational changes leading to the recruitment of coactivators required for the transactivation of target genes via cognate response elements. In many cells, activated ERalpha also undergoes ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2010, 79(5):746-757]

Cited: 13 times

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Effect of fluorination on the pharmacological profile of 11beta isomers of fulvestrant in breast carcinoma cells.

Vangelis Agouridas, Emmanuel Magnier, Jean-Claude Blazejewski, Ioanna Laïos, Anny Cleeren, Denis Nonclercq, Guy Laurent, Guy Leclercq,

We describe the synthesis of an 11beta isomer 3 of the steroidal antiestrogen fulvestrant 2. Partial fluorination of the 11beta side chain in 3 leads to 4, which still shows strong antiproliferative activity on MCF-7 cells. However, unlike 2 and 3, compound 4 fails to down-regulate estrogen receptor alpha (ERalpha). ... Read more >>

J Med Chem (Journal of medicinal chemistry)
[2009, 52(3):883-887]

Cited: 3 times

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Label-retaining cells and tubular regeneration in postischaemic kidney.

David Vansthertem, Nathalie Caron, Anne-Emilie Declèves, Stéphanie Cludts, Annabel Gossiaux, Denis Nonclercq, Bruno Flamion, Alexandre Legrand, Gérard Toubeau,

BACKGROUND: In this study, we have examined rat kidneys after ischaemic injury (35 min) with regard to the dynamics of S3 tubule regeneration. METHODS: One day before ischaemia, each rat received four successive i.p. injections of BrdU (5-bromo-2'-deoxyuridine: 80 mg/kg) at 2 h intervals. Groups of experimental animals (n = ... Read more >>

Nephrol. Dial. Transplant. (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association)
[2008, 23(12):3786-3797]

Cited: 3 times

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Association between farnesoid X receptor expression and cell proliferation in estrogen receptor-positive luminal-like breast cancer from postmenopausal patients.

Fabrice Journe, Virginie Durbecq, Carole Chaboteaux, Ghizlane Rouas, Guy Laurent, Denis Nonclercq, Christos Sotiriou, Jean-Jacques Body, Denis Larsimont,

The farnesoid X receptor (FXR, NR1H4), a member of the nuclear receptor superfamily of ligand-dependent transcription factors, is normally produced in the liver and the gastrointestinal tract, where it acts as a bile acid sensor. It has been recently detected in breast cancer cell lines and tissue specimens. The expression ... Read more >>

Breast Cancer Res. Treat. (Breast cancer research and treatment)
[2009, 115(3):523-535]

Cited: 26 times

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Effects of (R,S)/(S,R)-4,5-bis(2-chloro-4-hydroxyphenyl)-2-imidazolines and (R,S)/(S,R)-2,3-bis(2-chloro-4-hydroxyphenyl)piperazines on estrogen receptor alpha level and transcriptional activity in MCF-7 cells.

Ioanna Laïos, Anny Cleeren, Guy Leclercq, Denis Nonclercq, Guy Laurent, Miriam Schlenk, Anja Wellner, Ronald Gust,

4,5-Diaryl-2-imidazolines (Im(s)) and 2,3-diarylpiperazines (Pip(s)) belong to the type II class of estrogens. These compounds enhance ERalpha-mediated transcription of ERE-driven reporter genes in MCF-7 cells but do not compete with [(3)H]estradiol (E(2)) for receptor binding, because of distinct anchoring modes. The present study examined whether the estrogenic action of Im(s) ... Read more >>

Biochem. Pharmacol. (Biochemical pharmacology)
[2007, 74(7):1029-1038]

Cited: 6 times

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Effect of nuclear export inhibition on estrogen receptor regulation in breast cancer cells.

Denis Nonclercq, Fabrice Journé, Ioanna Laïos, Carole Chaboteaux, Robert-Alain Toillon, Guy Leclercq, Guy Laurent,

We used the Crm1 inhibitor leptomycin B (LMB) to examine a possible involvement of nuclear export in estrogen receptor alpha (ER) level and function in MCF-7 breast carcinoma cells. As revealed by immunofluorescence microscopy and western blotting with anti-ER antibodies, LMB produced an accumulation of ER in cell nuclei. LMB ... Read more >>

J. Mol. Endocrinol. (Journal of molecular endocrinology)
[2007, 39(2):105-118]

Cited: 15 times

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Calmodulin-independent, agonistic properties of a peptide containing the calmodulin binding site of estrogen receptor alpha.

Dominique Gallo, Françoise Jacquemotte, Anny Cleeren, Ioanna Laïos, Samira Hadiy, Martin G Rowlands, Olivier Caille, Denis Nonclercq, Guy Laurent, Yves Jacquot, Guy Leclercq,

Calmodulin (CaM) contributes to estrogen receptor alpha (ER)-mediated transcription. In order to study the underlying mechanisms, we synthesized a peptide including the CaM binding site: ERalpha17p (P(295)-T(311)). This peptide inhibited ER-CaM association, unlike two analogs in which two amino acids required for CaM binding were substituted. Exposure of MCF-7 cells ... Read more >>

Mol. Cell. Endocrinol. (Molecular and cellular endocrinology)
[2007, 268(1-2):37-49]

Cited: 13 times

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Dynamics of hyaluronan, CD44, and inflammatory cells in the rat kidney after ischemia/reperfusion injury.

Anne-Emilie Declèves, Nathalie Caron, Denis Nonclercq, Alexandre Legrand, Gérard Toubeau, Ronald Kramp, Bruno Flamion,

Ischemia/reperfusion (I/R) injury in the kidney involves hemodynamic and cellular dysfunctions as well as leukocyte infiltration. Functional recovery occurs via cell proliferation and/or migration. To determine the roles of hyaluronan (HA) and its main receptor CD44 in renal postischemic processes, we compared their localization and expression with that of neutrophils, ... Read more >>

Int. J. Mol. Med. (International journal of molecular medicine)
[2006, 18(1):83-94]

Cited: 26 times

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Farnesol, a mevalonate pathway intermediate, stimulates MCF-7 breast cancer cell growth through farnesoid-X-receptor-mediated estrogen receptor activation.

Fabrice Journe, Guy Laurent, Carole Chaboteaux, Denis Nonclercq, Virginie Durbecq, Denis Larsimont, Jean-Jacques Body,

Farnesoid X receptor (FXR) is a metabolic nuclear receptor expressed in the liver and traditionally considered as a bile acid sensor. Yet, FXR has been recently demonstrated in other tissues and cells, such as the kidneys, the adrenals, and arterial smooth muscle cells. Immunohistochemical data reported in this study point ... Read more >>

Breast Cancer Res. Treat. (Breast cancer research and treatment)
[2008, 107(1):49-61]

Cited: 30 times

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Synthesis, structure, and estrogenic activity of 4-amino-3-(2-methylbenzyl)coumarins on human breast carcinoma cells.

Yves Jacquot, Ioanna Laïos, Anny Cleeren, Denis Nonclercq, Laurent Bermont, Bernard Refouvelet, Kamal Boubekeur, Alain Xicluna, Guy Leclercq, Guy Laurent,

A number of coumarins exhibit interesting pharmacological activities and are therefore of therapeutic use. We report here the synthesis and the structural analysis of new N-substituted 4-amino-3-(2-methylbenzyl)coumarins (compounds 8a-8e) that present structural analogies with estrothiazine and 11- or 7-substituted 17beta-estradiol. These derivatives were tested with respect to estrogenic activity on ... Read more >>

Bioorg. Med. Chem. (Bioorganic & medicinal chemistry)
[2007, 15(6):2269-2282]

Cited: 11 times

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Early expression of the Helicase-Like Transcription Factor (HLTF/SMARCA3) in an experimental model of estrogen-induced renal carcinogenesis.

Gaël Debauve, Denis Nonclercq, Fabrice Ribaucour, Murielle Wiedig, Cécile Gerbaux, Oberdan Leo, Guy Laurent, Fabrice Journé, Alexandra Belayew, Gérard Toubeau,

BACKGROUND: The Helicase-Like Transcription Factor (HLTF/SMARCA3) belongs to the family of SWI/SNF proteins that use the energy of ATP hydrolysis to remodel chromatin in a variety of cellular processes. Several SWI/SNF genes are disrupted in cancer, suggesting a role of tumor suppressor. Similarly, the HLTF gene was recently found to ... Read more >>

Mol. Cancer (Molecular cancer)
[2006, 5:23]

Cited: 9 times

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Towards functional glycomics by localization of binding sites for tissue lectins: lectin histochemical reactivity for galectins during diethylstilbestrol-induced kidney tumorigenesis in male Syrian hamster.

Sven Saussez, Francois Lorfevre, Denis Nonclercq, Guy Laurent, Sabine André, Fabrice Journé, Robert Kiss, Gérard Toubeau, Hans-Joachim Gabius,

Endogenous lectins act as effectors of cellular activities such as growth regulation, migration, and adhesion. Following their immunohistochemical localization in our previous study (Saussez et al. in Histochem Cell Biol 123:29-41, 2005) we purified several galectins and used them as tools for monitoring accessible binding sites. Herein, we report the ... Read more >>

Histochem. Cell Biol. (Histochemistry and cell biology)
[2006, 126(1):57-69]

Cited: 6 times

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Differential regulation of angiotensin II receptors during renal injury and compensatory hypertrophy in the rat.

Emma Joly, Denis Nonclercq, Nathalie Caron, Jeannine Mertens, Bruno Flamion, Gerard Toubeau, Ronald Kramp, Nadine Bouby,

1. The renin-angiotensin system may be involved in the compensatory adaptations occurring after the reduction of renal mass and during the consecutive changes leading to chronic renal failure. We therefore investigated the regulation of angiotensin II receptors in two models of renal hypertrophy in the rat: hypertrophy following uninephrectomy (UNx) ... Read more >>

Clin. Exp. Pharmacol. Physiol. (Clinical and experimental pharmacology & physiology)
[2005, 32(4):241-248]

Cited: 9 times

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Ligand-independent and agonist-mediated degradation of estrogen receptor-alpha in breast carcinoma cells: evidence for distinct degradative pathways.

Denis Nonclercq, Fabrice Journé, Jean-Jacques Body, Guy Leclercq, Guy Laurent,

Molecular chaperones and co-chaperones, such as heat-shock proteins (Hsp's), play a pivotal role in the adequate folding and the stability of steroid hormone receptors. As shown by immunofluorescence staining and immunoblot analysis, the Hsp90 inhibitor radicicol induced a rapid (within hours) depletion of estrogen receptor-alpha (ER) in MCF-7 and IBEP-2 ... Read more >>

Mol. Cell. Endocrinol. (Molecular and cellular endocrinology)
[2004, 227(1-2):53-65]

Cited: 11 times

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