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Author Dengchao Cao

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Vascular smooth muscle cell-specific miRNA-214 knockout inhibits angiotensin II-induced hypertension through upregulation of Smad7.

Youyou Li, Hongxing Li, Wenjuan Xing, Jianwei Li, Ruikai Du, Dengchao Cao, Yinbo Wang, Xueyi Yang, Guohui Zhong, Yinlong Zhao, Weijia Sun, Caizhi Liu, Xingcheng Gao, Yeheng Li, Zizhong Liu, Xiaoyan Jin, Dingsheng Zhao, Yingjun Tan, Yanqing Wang, Shujuan Liu, Min Yuan, Jinping Song, Yan-Zhong Chang, Feng Gao, Shukuan Ling, Yingxian Li,

Vascular remodeling is a prominent trait during the development of hypertension, attributable to the phenotypic transition of vascular smooth muscle cells (VSMCs). Increasing studies demonstrate that microRNA plays an important role in this process. Here, we surprisingly found that smooth muscle cell-specific miR-214 knockout (miR-214 cKO) significantly alleviates angiotensin II ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(11):e21947]

Cited: 0 times

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miR-214 stimulated by IL-17A regulates bone loss in patients with ankylosing spondylitis.

Zizhong Liu, Feng Huang, Gui Luo, Yiwen Wang, Ruikai Du, Weijia Sun, Jianwei Li, Xinxin Yuan, Dengchao Cao, Yuheng Li, Caizhi Liu, Shuai Liang, Xiaoyan Jin, Shukuan Ling, Deqing Wang, Yingxian Li,

<h4>Objective</h4>Bone loss is common in AS, and miR-214 plays an important role in regulating bone formation. The aim of this study was to investigate the effect of miR-214, the production of which is stimulated by IL-17A, on bone loss in AS.<h4>Methods</h4>Peripheral blood was obtained from 32 patients with AS and ... Read more >>

Rheumatology (Oxford) (Rheumatology (Oxford, England))
[2020, 59(5):1159-1169]

Cited: 3 times

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Alteration of calcium signalling in cardiomyocyte induced by simulated microgravity and hypergravity.

Caizhi Liu, Guohui Zhong, Yuezhang Zhou, Yuchen Yang, Yingjun Tan, Yuheng Li, Xingcheng Gao, Weijia Sun, Jianwei Li, Xiaoyan Jin, Dengchao Cao, Xinxin Yuan, Zizhong Liu, Shuai Liang, Youyou Li, Ruikai Du, Yinlong Zhao, Jianqi Xue, Dingsheng Zhao, Jinping Song, Shukuan Ling, Yingxian Li,

<h4>Objectives</h4>Cardiac Ca<sup>2+</sup> signalling plays an essential role in regulating excitation-contraction coupling and cardiac remodelling. However, the response of cardiomyocytes to simulated microgravity and hypergravity and the effects on Ca<sup>2+</sup> signalling remain unknown. Here, we elucidate the mechanisms underlying the proliferation and remodelling of HL-1 cardiomyocytes subjected to rotation-simulated microgravity and ... Read more >>

Cell Prolif (Cell proliferation)
[2020, 53(3):e12783]

Cited: 3 times

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Effects of spaceflight on the composition and function of the human gut microbiota.

Zizhong Liu, Gui Luo, Ruikai Du, Weijia Sun, Jianwei Li, Haiyun Lan, Pu Chen, Xinxin Yuan, Dengchao Cao, Yuheng Li, Caizhi Liu, Shuai Liang, Xiaoyan Jin, Ruifu Yang, Yujing Bi, Yanping Han, Ping Cao, Wei Zhao, Shukuan Ling, Yingxian Li,

Interaction between humans and the gut microbiota is important for human physiology. Here, the gut microbiota was analyzed via metagenomic sequencing, and the fluctuations in the gut microbiota under the conditions of spaceflight were characterized. The composition and function of the gut microbiota were substantially affected by spaceflight; however, individual ... Read more >>

Gut Microbes (Gut microbes)
[2020, 11(4):807-819]

Cited: 5 times

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The mechanosensitive Piezo1 channel is required for bone formation.

Weijia Sun, Shaopeng Chi, Yuheng Li, Shukuan Ling, Yingjun Tan, Youjia Xu, Fan Jiang, Jianwei Li, Caizhi Liu, Guohui Zhong, Dengchao Cao, Xiaoyan Jin, Dingsheng Zhao, Xingcheng Gao, Zizhong Liu, Bailong Xiao, Yingxian Li,

Mechanical load of the skeleton system is essential for the development, growth, and maintenance of bone. However, the molecular mechanism by which mechanical stimuli are converted into osteogenesis and bone formation remains unclear. Here we report that Piezo1, a bona fide mechanotransducer that is critical for various biological processes, plays ... Read more >>

Elife (eLife)
[2019, 8:]

Cited: 36 times

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Hematopoietic stem cells and lineage cells undergo dynamic alterations under microgravity and recovery conditions.

Dengchao Cao, Jinping Song, Shukuan Ling, Shuaishuai Niu, Liang Lu, Zhengzhi Cui, Yuheng Li, Shanshan Hao, Guohui Zhong, Zhihong Qi, Weijia Sun, Xinxin Yuan, Hongxing Li, Dingsheng Zhao, Xiaoyan Jin, Caizhi Liu, Xiaorui Wu, Guanghan Kan, Hongqing Cao, Youmin Kang, Shuyang Yu, Yingxian Li,

Spaceflight leads to health risks including bone demineralization, skeletal muscle atrophy, cardiovascular dysfunction, and disorders of almost all physiologic systems. However, the impacts of microgravity on blood lineage cells and hematopoietic stem cells (HSCs) in vivo are largely unknown. In this study, we analyzed peripheral blood samples from 6 astronauts ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2019, 33(6):6904-6918]

Cited: 6 times

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Lrp5 and Lrp6 are required for maintaining self-renewal and differentiation of hematopoietic stem cells.

Juanjuan Liu, Zhengzhi Cui, Fang Wang, Yingpeng Yao, Guotao Yu, Jingjing Liu, Dengchao Cao, Shuaishuai Niu, Menghao You, Zhen Sun, Di Lian, Tianyan Zhao, Youmin Kang, Yaofeng Zhao, Hai-Hui Xue, Shuyang Yu,

Hematopoietic stem cells (HSCs) have the capacity for self-renewal to maintain the HSCs' pool and the ability for multilineage differentiation, which are responsible for sustained production of multiple blood lineages. The regulation of HSC development is controlled precisely by complex signal networks and hematopoietic microenvironment, which has been termed the ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2019, 33(4):5615-5625]

Cited: 7 times

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Panax quinquefolium saponin attenuates cardiac remodeling induced by simulated microgravity.

Huiyuan Sun, Shukuan Ling, Dingsheng Zhao, Yang Li, Guohui Zhong, Ming Guo, Yuheng Li, Lin Yang, Jianpeng Du, Yuezhang Zhou, Jianwei Li, Shuai Liang, Yanqing Wang, Xingcheng Gao, Yating Zhang, Dengchao Cao, Caizhi Liu, Xiaoyan Jin, Zizhong Liu, Weijia Sun, Xiaorui Wu, Jinping Song, Yingxian Li, Dazhuo Shi,

<h4>Background</h4>Cardiac atrophy and reduced cardiac distensibility have been reported following space flight. Cardiac function is correspondingly regulated in response to changes in loading conditions. Panax quinquefolium saponin (PQS) improves ventricular remodeling after acute myocardial infarction by alleviating endoplasmic reticulum stress and Ca<sup>2+</sup>overload. However, whether PQS can ameliorate cardiac atrophy following ... Read more >>

Phytomedicine (Phytomedicine : international journal of phytotherapy and phytopharmacology)
[2019, 56:83-93]

Cited: 2 times

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Myocardial CKIP-1 Overexpression Protects from Simulated Microgravity-Induced Cardiac Remodeling.

Shukuan Ling, Yuheng Li, Guohui Zhong, Yongjun Zheng, Qing Xu, Dingsheng Zhao, Weijia Sun, Xiaoyan Jin, Hongxing Li, Jianwei Li, Huiyuan Sun, Dengchao Cao, Jinping Song, Caizhi Liu, Xinxin Yuan, Xiaorui Wu, Yinlong Zhao, Zizhong Liu, Qi Li, Yingxian Li,

Human cardiovascular system has adapted to Earth's gravity of 1G. The microgravity during space flight can induce cardiac remodeling and decline of cardiac function. At present, the mechanism of cardiac remodeling induced by microgravity remains to be disclosed. Casein kinase-2 interacting protein-1 (CKIP-1) is an important inhibitor of pressure-overload induced ... Read more >>

Front Physiol (Frontiers in physiology)
[2018, 9:40]

Cited: 5 times

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Simulated Microgravity and Recovery-Induced Remodeling of the Left and Right Ventricle.

Guohui Zhong, Yuheng Li, Hongxing Li, Weijia Sun, Dengchao Cao, Jianwei Li, Dingsheng Zhao, Jinping Song, Xiaoyan Jin, Hailin Song, Xinxin Yuan, Xiaorui Wu, Qi Li, Qing Xu, Guanghan Kan, Hongqing Cao, Shukuan Ling, Yingxian Li,

Physiological adaptations to microgravity involve alterations in cardiovascular systems. These adaptations result in cardiac remodeling and orthostatic hypotension. However, the response of the left ventricle (LV) and right ventricle (RV) following hindlimb unloading (HU) and hindlimb reloading (HR) is not clear and the underlying mechanism remains to be understood. In ... Read more >>

Front Physiol (Frontiers in physiology)
[2016, 7:274]

Cited: 3 times

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