Full Text Journal Articles by
Author Denes V Agoston

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Targeting the Cerebrovascular System: Next-Generation Biomarkers and Treatment for Mild Traumatic Brain Injury.

Tamara L Baker, Denes V Agoston, Rhys D Brady, Brendan Major, Stuart J McDonald, Richelle Mychasiuk, David K Wright, Glenn R Yamakawa, Mujun Sun, Sandy R Shultz,

The diagnosis, prognosis, and treatment of mild traumatic brain injuries (mTBIs), such as concussions, are significant unmet medical issues. The kinetic forces that occur in mTBI adversely affect the cerebral vasculature, making cerebrovascular injury (CVI) a pathophysiological hallmark of mTBI. Given the importance of a healthy cerebrovascular system in overall ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :10738584211012264]

Cited: 0 times

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The Known Unknowns: An Overview of the State of Blood-based Protein Biomarkers of Mild Traumatic Brain Injury.

Stuart John McDonald, Sandy R Shultz, Denes V Agoston,

Blood-based protein biomarkers have revolutionized several fields of medicine by enabling molecular level diagnosis, as well as monitoring disease progression and treatment efficacy. Traumatic brain injury (TBI) so far has benefitted only moderately from using protein biomarkers to improve injury outcome. Due to its complexity and dynamic nature, TBI, especially ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2021, :]

Cited: 0 times

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Identification of clinically relevant biomarkers of epileptogenesis - a strategic roadmap.

Michele Simonato, Denes V Agoston, Amy Brooks-Kayal, Chris Dulla, Brandy Fureman, David C Henshall, Asla Pitkänen, William H Theodore, Roy E Twyman, Firas H Kobeissy, Kevin K Wang, Vicky Whittemore, Karen S Wilcox,

Onset of many forms of epilepsy occurs after an initial epileptogenic insult or as a result of an identified genetic defect. Given that the precipitating insult is known, these epilepsies are, in principle, amenable to secondary prevention. However, development of preventive treatments is difficult because only a subset of individuals ... Read more >>

Nat Rev Neurol (Nature reviews. Neurology)
[2021, 17(4):231-242]

Cited: 3 times

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Influence of Blood-Brain Barrier Integrity on Brain Protein Biomarker Clearance in Severe Traumatic Brain Injury: A Longitudinal Prospective Study.

Caroline Lindblad, David W Nelson, Frederick A Zeiler, Ari Ercole, Per Hamid Ghatan, Henrik von Horn, Mårten Risling, Mikael Svensson, Denes V Agoston, Bo-Michael Bellander, Eric Peter Thelin,

Brain protein biomarker clearance to blood in traumatic brain injury (TBI) is not fully understood. The aim of this study was to analyze the effect that a disrupted blood-brain barrier (BBB) had on biomarker clearance. Seventeen severe TBI patients admitted to Karolinska University Hospital were prospectively included. Cerebrospinal fluid (CSF) ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2020, 37(12):1381-1391]

Cited: 8 times

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A novel rat model of heterotopic ossification after polytrauma with traumatic brain injury.

Rhys D Brady, Michael Z Zhao, Ker R Wong, Pablo M Casilla-Espinosa, Glenn R Yamakawa, Ryan C Wortman, Mujun Sun, Brian L Grills, Richelle Mychasiuk, Terence J O'Brien, Denes V Agoston, Peter V S Lee, Stuart J McDonald, Dale L Robinson, Sandy R Shultz,

Neurological heterotopic ossification (NHO) is characterized by abnormal bone growth in soft tissue and joints in response to injury to the central nervous system. The ectopic bone frequently causes pain, restricts mobility, and decreases the quality of life for those affected. NHO commonly develops in severe traumatic brain injury (TBI) ... Read more >>

Bone (Bone)
[2020, 133:115263]

Cited: 2 times

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Repeated mild traumatic brain injuries induce persistent changes in plasma protein and magnetic resonance imaging biomarkers in the rat.

David K Wright, Rhys D Brady, Alaa Kamnaksh, Jack Trezise, Mujun Sun, Stuart J McDonald, Richelle Mychasiuk, Scott C Kolbe, Meng Law, Leigh A Johnston, Terence J O'Brien, Denes V Agoston, Sandy R Shultz,

A single mild traumatic brain injury (mTBI) typically causes only transient symptoms, but repeated mTBI (RmTBI) is associated with cumulative and chronic neurological abnormalities. Clinical management of mTBI is challenging due to the heterogeneous, subjective and transient nature of symptoms, and thus would be aided by objective biomarkers. Promising biomarkers ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):14626]

Cited: 5 times

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How to Translate Time: The Temporal Aspects of Rodent and Human Pathobiological Processes in Traumatic Brain Injury.

Denes V Agoston, Robert Vink, Adel Helmy, Mårten Risling, David Nelson, Mayumi Prins,

Traumatic brain injury (TBI) triggers multiple pathobiological responses with differing onsets, magnitudes, and durations. Identifying the therapeutic window of individual pathologies is critical for successful pharmacological treatment. Dozens of experimental pharmacotherapies have been successfully tested in rodent models, yet all of them (to date) have failed in clinical trials. The ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2019, 36(11):1724-1737]

Cited: 5 times

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Modelling traumatic brain injury and posttraumatic epilepsy in rodents.

Rhys D Brady, Pablo M Casillas-Espinosa, Denes V Agoston, Edward H Bertram, Alaa Kamnaksh, Bridgette D Semple, Sandy R Shultz,

Posttraumatic epilepsy (PTE) is one of the most debilitating and understudied consequences of traumatic brain injury (TBI). It is challenging to study the effects, underlying pathophysiology, biomarkers, and treatment of TBI and PTE purely in human patients for a number of reasons. Rodent models can complement human PTE studies as ... Read more >>

Neurobiol Dis (Neurobiology of disease)
[2019, 123:8-19]

Cited: 12 times

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A Comparative Study of Two Blast-Induced Traumatic Brain Injury Models: Changes in Monoamine and Galanin Systems Following Single and Repeated Exposure.

Lizan Kawa, Alaa Kamnaksh, Joseph B Long, Ulf P Arborelius, Tomas Hökfelt, Denes V Agoston, Mårten Risling,

Repeated mild blast-induced traumatic brain injury (rmbTBI), caused by recurrent exposure to low levels of explosive blast, is a significant concern for military health systems. However, the pathobiology of rmbTBI is currently poorly understood. Animal models are important tools to identify the molecular changes of rmbTBI, but comparisons across different ... Read more >>

Front Neurol (Frontiers in neurology)
[2018, 9:479]

Cited: 4 times

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Repeated mild blast exposure in young adult rats results in dynamic and persistent microstructural changes in the brain.

Alexandra Badea, Alaa Kamnaksh, Robert J Anderson, Evan Calabrese, Joseph B Long, Denes V Agoston,

A history of mild traumatic brain injury (mTBI), particularly repeated mTBI (rmTBI), has been identified as a risk factor for late-onset neurodegenerative conditions. The mild and transient nature of early symptoms often impedes diagnosis in young adults who are disproportionately affected by mTBIs. A proportion of the affected population will ... Read more >>

Neuroimage Clin (NeuroImage. Clinical)
[2018, 18:60-73]

Cited: 10 times

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Big Data in traumatic brain injury; promise and challenges.

Denes V Agoston, Dianne Langford,

Traumatic brain injury (TBI) is a spectrum disease of overwhelming complexity, the research of which generates enormous amounts of structured, semi-structured and unstructured data. This resulting big data has tremendous potential to be mined for valuable information regarding the "most complex disease of the most complex organ". Big data analyses ... Read more >>

Concussion (Concussion (London, England))
[2017, 2(4):CNC45]

Cited: 6 times

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Understanding the complexities of traumatic brain injury: A big data approach to a big disease.

Denes V Agoston,

Behav Brain Res (Behavioural brain research)
[2018, 340:172-173]

Cited: 2 times

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How to Translate Time? The Temporal Aspect of Human and Rodent Biology.

Denes V Agoston,

Front Neurol (Frontiers in neurology)
[2017, 8:92]

Cited: 30 times

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Great insight created by tiny holes; celebrating 40 years of brain micropunch technique.

Dénes V Ágoston,

Ideggyogy Sz (Ideggyogyaszati szemle)
[2014, 67(9-10):355-357]

Cited: 0 times

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Biofluid biomarkers of traumatic brain injury.

Denes V Agoston, Andrew Shutes-David, Elaine R Peskind,

<h4>Primary objective</h4>The purpose of this paper is to review the clinical and research utility and applications of blood, cerebrospinal fluid (CSF), and cerebral microdialysis biomarkers in traumatic brain injury (TBI).<h4>Research design</h4>Not applicable.<h4>Methods and procedures</h4>A selective review was performed on these biofluid biomarkers in TBI.<h4>Main outcome and results</h4>Neurofilament heavy chain protein ... Read more >>

Brain Inj (Brain injury)
[2017, 31(9):1195-1203]

Cited: 51 times

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Behavioral, blood, and magnetic resonance imaging biomarkers of experimental mild traumatic brain injury.

David K Wright, Jack Trezise, Alaa Kamnaksh, Ramsey Bekdash, Leigh A Johnston, Roger Ordidge, Bridgette D Semple, Andrew J Gardner, Peter Stanwell, Terence J O'Brien, Denes V Agoston, Sandy R Shultz,

Repeated mild traumatic brain injuries (mTBI) may lead to serious neurological consequences, especially if re-injury occurs within the period of increased cerebral vulnerability (ICV) triggered by the initial insult. MRI and blood proteomics might provide objective measures of pathophysiological changes in mTBI, and indicate when the brain is no longer ... Read more >>

Sci Rep (Scientific reports)
[2016, 6:28713]

Cited: 35 times

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Editorial: When Physics Meets Biology; Biomechanics and Biology of Traumatic Brain Injury.

Denes V Agoston, Mattias K Sköld,

Front Neurol (Frontiers in neurology)
[2016, 7:91]

Cited: 3 times

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The effect of concomitant peripheral injury on traumatic brain injury pathobiology and outcome.

Stuart J McDonald, Mujun Sun, Denes V Agoston, Sandy R Shultz,

<h4>Background</h4>Traumatic injuries are physical insults to the body that are prevalent worldwide. Many individuals involved in accidents suffer injuries affecting a number of extremities and organs, otherwise known as multitrauma or polytrauma. Traumatic brain injury is one of the most serious forms of the trauma-induced injuries and is a leading ... Read more >>

J Neuroinflammation (Journal of neuroinflammation)
[2016, 13(1):90]

Cited: 40 times

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Modeling the Neurobehavioral Consequences of Blast-Induced Traumatic Brain Injury Spectrum Disorder and Identifying Related Biomarkers

Denes V Agoston, Alaa Kamnaksh,

Blast induced traumatic brain injury (bTBI) has become the most common type of military head injuries affecting close to 500,000 service members. bTBI is a spectrum disorder ranging from the severe form that is frequently comorbid with polytrauma to the mild form that shares symptoms and/or comorbid with post-traumatic stress ... Read more >>

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The Temporal Pattern of Changes in Serum Biomarker Levels Reveals Complex and Dynamically Changing Pathologies after Exposure to a Single Low-Intensity Blast in Mice.

Farid Ahmed, Stefan Plantman, Ibolja Cernak, Denes V Agoston,

Time-dependent changes in blood-based protein biomarkers can help identify the -pathological processes in blast-induced traumatic brain injury (bTBI), assess injury severity, and monitor disease progression. We obtained blood from control and injured mice (exposed to a single, low-intensity blast) at 2-h, 1-day, 1-week, and 1-month post-injury. We then determined the ... Read more >>

Front Neurol (Frontiers in neurology)
[2015, 6:114]

Cited: 30 times

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Bench-to-Bedside and Bedside Back to the Bench; Seeking a Better Understanding of the Acute Pathophysiological Process in Severe Traumatic Brain Injury.

Denes V Agoston,

Despite substantial investments, traumatic brain injury (TBI) remains one of the major disorders that lack specific pharmacotherapy. To a substantial degree, this situation is due to lack of understanding of the pathophysiological process of the disease. Experimental TBI research offers controlled, rapid, and cost-effective means to identify the pathophysiology but ... Read more >>

Front Neurol (Frontiers in neurology)
[2015, 6:47]

Cited: 11 times

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Great insight created by tiny holes; celebrating 40 years of brain micropunch technique.

Denes V Agoston,

Front Neuroanat (Frontiers in neuroanatomy)
[2014, 8:61]

Cited: 1 time

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Diffusion tensor imaging reveals acute subcortical changes after mild blast-induced traumatic brain injury.

Alaa Kamnaksh, Matthew D Budde, Erzsebet Kovesdi, Joseph B Long, Joseph A Frank, Denes V Agoston,

Mild blast-induced traumatic brain injury (mbTBI) poses special diagnostic challenges due to its overlapping symptomatology with other neuropsychiatric conditions and the lack of objective outcome measures. Diffusion tensor imaging (DTI) can potentially provide clinically relevant information toward a differential diagnosis. In this study, we aimed to determine if single and ... Read more >>

Sci Rep (Scientific reports)
[2014, 4:4809]

Cited: 24 times

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The terminal pathway of the complement system is activated in focal penetrating but not in mild diffuse traumatic brain injury.

Elham Rostami, Johan Davidsson, Andrea Gyorgy, Denes V Agoston, Mårten Risling, Bo-Michael Bellander,

The complement system plays an important role in the inflammatory response activated by many central nervous system disorders. However, its significance in traumatic diffuse traumatic axonal injury (TAI) is not fully known. Here we analyze the complement activity in two rat models of traumatic brain injury (TBI); a focal penetration ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2013, 30(23):1954-1965]

Cited: 6 times

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Long-term consequences of single and multiple mild blast exposure on select physiological parameters and blood-based biomarkers.

Farid A Ahmed, Alaa Kamnaksh, Erzsebet Kovesdi, Joseph B Long, Denes V Agoston,

Mild traumatic brain injury (mTBI), especially when it is repeated (rmTBI), can lead to progressive degenerative diseases and lasting neuropsychiatric abnormalities. To better understand the long-term pathobiological changes in mTBI and rmTBI, we exposed rats to single or repeated (5 total; administered on consecutive days) mild blast overpressure, monitored changes ... Read more >>

Electrophoresis (Electrophoresis)
[2013, 34(15):2229-2233]

Cited: 24 times

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