Full Text Journal Articles by
Author Deepa R J Arachchillage

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Suveer Singh, Diana A Gorog, Ciara F Mahon, Bhavin Rawal, Thomas R Semple, Edward D Nicol, Deepa R J Arachchillage, Susanna Price, Sujal Desai, Carole A Ridge, Simon P G Padley, Saeed Mirsadraee,

Crit Care Med (Critical care medicine)
[2021, 49(11):e1190-e1191]

Cited: 0 times

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Optimal Tests to Minimise Bleeding and Ischaemic Complications in Patients on Extracorporeal Membrane Oxygenation.

Rahim Kanji, Christophe Vandenbriele, Deepa R J Arachchillage, Susanna Price, Diana Adrienne Gorog,

Patients supported with extracorporeal membrane oxygenation (ECMO) experience a very high frequency of bleeding and ischaemic complications, including stroke and systemic embolism. These patients require systemic anticoagulation, mainly with unfractionated heparin (UFH) to prevent clotting of the circuit and reduce the risk of arterial or venous thrombosis. Monitoring of UFH ... Read more >>

Thromb Haemost (Thrombosis and haemostasis)
[2021, :]

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The clinical course of COVID-19 in pregnant versus non-pregnant women requiring hospitalisation: results from the multicentre UK CA-COVID-19 study.

Christina Crossette-Thambiah, Phillip Nicolson, Indika Rajakaruna, Alexander Langridge, Zara Sayar, Maria R Perelta, Sarah Essex, Roderick Oakes, Philip Mounter, Sarah Lewis, Tina Dutt, Ian Scott, Nini Aung, Susie Shapiro, Mike Laffan, Deepa R J Arachchillage,

The impact of COVID-19 infection on pregnant women remains relatively unknown but the physiological changes of pregnancy and hypercoagulability of COVID-19 may further increase thrombotic risk. In this retrospective multicentre observational study, we report clinical characteristics and outcomes in 36 pregnant women requiring hospitalisation for COVID-19 compared to a propensity-matched ... Read more >>

Br J Haematol (British journal of haematology)
[2021, 195(1):85-89]

Cited: 0 times

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Prevalence of Thrombotic Complications in ICU-Treated Patients With Coronavirus Disease 2019 Detected With Systematic CT Scanning.

Saeed Mirsadraee, Diana A Gorog, Ciara F Mahon, Bhavin Rawal, Thomas R Semple, Edward D Nicol, Deepa R J Arachchillage, Anand Devaraj, Susanna Price, Sujal R Desai, Carole A Ridge, Suveer Singh, Simon P G Padley,

<h4>Objectives</h4>Severe coronavirus disease 2019 is associated with an extensive pneumonitis and frequent coagulopathy. We sought the true prevalence of thrombotic complications in critically ill patients with severe coronavirus disease 2019 on the ICU, with or without extracorporeal membrane oxygenation.<h4>Design</h4>We undertook a single-center, retrospective analysis of 72 critically ill patients with ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(5):804-815]

Cited: 4 times

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Role, Laboratory Assessment and Clinical Relevance of Fibrin, Factor XIII and Endogenous Fibrinolysis in Arterial and Venous Thrombosis.

Vassilios P Memtsas, Deepa R J Arachchillage, Diana A Gorog,

Diseases such as myocardial infarction, ischaemic stroke, peripheral vascular disease and venous thromboembolism are major contributors to morbidity and mortality. Procoagulant, anticoagulant and fibrinolytic pathways are finely regulated in healthy individuals and dysregulated procoagulant, anticoagulant and fibrinolytic pathways lead to arterial and venous thrombosis. In this review article, we discuss ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(3):]

Cited: 2 times

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Outcome of Major Hemorrhage at a Major Cardiothoracic Center in Patients with Activated Major Hemorrhage Protocol versus Nonactivated Protocol.

Kathryn W Chang, Steve Owen, Michaela Gaspar, Mike Laffan, Deepa R J Arachchillage,

This study aimed to determine the impact of major hemorrhage (MH) protocol (MHP) activation on blood administration and patient outcome at a UK major cardiothoracic center. MH was defined in patients (> 16 years) as those who received > 5 units of red blood cells (RBCs) in < 4 hours, or > 10 units in 24 hours. Data ... Read more >>

Semin Thromb Hemost (Seminars in thrombosis and hemostasis)
[2021, 47(1):74-83]

Cited: 0 times

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Efficacy and Safety of D-dimer, Weight, and Renal Function-Adjusted Thromboprophylaxis in Patients with Coronavirus Disease 2019 (COVID-19).

Deepa R J Arachchillage, Christine Shi, David Saliu, Peter Kozman, Emma Mi, Noora Buti, Elika Kashef, Susan J Copley, Carlos Gomez, Richard Leonard, Riaz Aziz, Abdul A Shlebak, Mike Laffan,

Semin Thromb Hemost (Seminars in thrombosis and hemostasis)
[2021, 47(4):436-441]

Cited: 3 times

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The heparin-von Willebrand factor interaction and conventional tests of haemostasis - the challenges in predicting bleeding in cardiopulmonary bypass.

Amita Ranger, Mihaela Gaspar, Amira Elkhatteb, Tim Jackson, Steve Fox, T C Aw, Lisa Vipond, Judy Cotterill, Arshad Ghori, Mike Laffan, Deepa R J Arachchillage,

Bleeding is a significant complication of cardiopulmonary bypass (CPB), despite routine anticoagulation monitoring. This is likely to be multifactorial. In this prospective, single-centre cohort study of 30 patients undergoing CPB surgery, our aim was to characterise the changes in von Willebrand factor (VWF) function, platelet interaction and the global coagulation ... Read more >>

Br J Haematol (British journal of haematology)
[2021, 192(6):1073-1081]

Cited: 0 times

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Frequency of Thrombocytopenia and Heparin-Induced Thrombocytopenia in Patients Receiving Extracorporeal Membrane Oxygenation Compared With Cardiopulmonary Bypass and the Limited Sensitivity of Pretest Probability Score.

Deepa R J Arachchillage, Mike Laffan, Sanjay Khanna, Christophe Vandenbriele, Farah Kamani, Maurizio Passariello, Alex Rosenberg, T C Aw, Winston Banya, Stephane Ledot, Brijesh V Patel,

<h4>Objectives</h4>To ascertain: 1) the frequency of thrombocytopenia and heparin-induced thrombocytopenia; 2) positive predictive value of the Pretest Probability Score in identifying heparin-induced thrombocytopenia; and 3) clinical outcome of heparin-induced thrombocytopenia in adult patients receiving venovenous- or venoarterial-extracorporeal membrane oxygenation, compared with cardiopulmonary bypass.<h4>Design</h4>A single-center, retrospective, observational cohort study from January ... Read more >>

Crit Care Med (Critical care medicine)
[2020, 48(5):e371-e379]

Cited: 2 times

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Red cell alloimmunisation in patients receiving veno-venous extracorporeal membrane oxygenation (VV-ECMO).

Deepa R J Arachchillage, Steve Owen, Maria Anievas, Mihaela Gaspar, Mike Laffan,

Intensive Care Med (Intensive care medicine)
[2020, 46(10):1932-1933]

Cited: 1 time

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Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia.

Deepa R J Arachchillage, Mike Laffan,

J Thromb Haemost (Journal of thrombosis and haemostasis : JTH)
[2020, 18(5):1233-1234]

Cited: 62 times

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Effect of direct-acting oral anticoagulants (DOACs) on bleeding and blood product usage in cardiac surgery compared to warfarin and controls.

Christopher Little, Richard Szydlo, T C Aw, Mike Laffan, Deepa R J Arachchillage,

In this retrospective, single-centre, observational study, we assessed (i) use of anticoagulant and antiplatelet (AP) therapy, (ii) the duration of direct-acting oral anticoagulant (DOAC) discontinuation, (iii) renal function and (iv) PT and APTT as predictors of bleeding and blood product usage; in adults (>18 years) undergoing major cardiac surgery from 01.01.2015 ... Read more >>

Br J Haematol (British journal of haematology)
[2020, 190(2):284-293]

Cited: 0 times

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What is the appropriate anticoagulation strategy for thrombotic antiphospholipid syndrome?

Deepa R J Arachchillage, Mike Laffan,

Antiphospholipid syndrome (APS) is an autoimmune prothrombotic disorder mediated by a heterogeneous group of autoantibodies collectively known as antiphospholipid antibodies (aPL). They include lupus anticoagulant (LA), IgG and IgM anticardiolipin antibodies (aCL) and anti-β2-glycoprotein I (anti-β2GPI) antibodies. It has been shown that those patients with all three aPL (triple positive) ... Read more >>

Br J Haematol (British journal of haematology)
[2020, 189(2):216-227]

Cited: 2 times

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Addendum to British Society for Haematology Guidelines on Investigation and Management of Antiphospholipid syndrome, 2012 (Br. J. Haematol. 2012; 157: 47-58): use of direct acting oral anticoagulants.

Deepa R J Arachchillage, Keith Gomez, Raza Alikhan, Julia A M Anderson, Will Lester, Mike Laffan, ,

Br J Haematol (British journal of haematology)
[2020, 189(2):212-215]

Cited: 5 times

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Limitations on point care APTT for monitoring of unfractionated heparin in intensive care patients.

Deepa R J Arachchillage, Lisa Vipond, Mike Laffan,

Thromb Res (Thrombosis research)
[2019, 181:124-126]

Cited: 0 times

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Apixaban enhances endogenous fibrinolysis in patients with atrial fibrillation.

Nikolaos Spinthakis, Ying Gue, Mohamed Farag, Manivannan Srinivasan, David Wellsted, Deepa R J Arachchillage, Gregory Y H Lip, Diana A Gorog,

<h4>Aims</h4>Approximately 20% of ischaemic stroke patients exhibit spontaneous arterial recanalization, attributable to endogenous fibrinolysis, which strongly relates to improved functional outcome. The impact of oral anticoagulants on endogenous fibrinolysis is unknown. Our aim was to test the hypothesis that apixaban enhances endogenous fibrinolysis in non-valvular atrial fibrillation (NVAF).<h4>Methods and results</h4>In ... Read more >>

Europace (Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology)
[2019, 21(9):1297-1306]

Cited: 3 times

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Reply to Comment on: Inherited Thrombophilia and Pregnancy Complications: Should We Test?

Deepa R J Arachchillage, Mike Makris,

Semin Thromb Hemost (Seminars in thrombosis and hemostasis)
[2019, 45(5):555-556]

Cited: 1 time

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Erratum: Inherited Thrombophilia and Pregnancy Complications: Should We Test?

Deepa R J Arachchillage, Mike Makris,

Semin Thromb Hemost (Seminars in thrombosis and hemostasis)
[2019, 45(1):e1]

Cited: 0 times

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Efficacy and safety of prothrombin complex concentrate in patients treated with rivaroxaban or apixaban compared to warfarin presenting with major bleeding.

Deepa R J Arachchillage, Sharon Alavian, Jessica Griffin, Kamala Gurung, Richard Szydlo, Nilanthi Karawitage, Mike Laffan,

This retrospective study investigated the efficacy and safety of prothrombin complex concentrates (PCCs) for management of major bleeding events (MBE) in 344 patients receiving the anticoagulants rivaroxaban, apixaban or warfarin during the period January 2016 to April 2018. Median (range) PCC dose was 2000 units (1000-4500). Intracranial haemorrhage (ICH) was the ... Read more >>

Br J Haematol (British journal of haematology)
[2019, 184(5):808-816]

Cited: 4 times

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Inherited Thrombophilia and Pregnancy Complications: Should We Test?

Deepa R J Arachchillage, Mike Makris,

Recurrent miscarriages and pregnancy-related complications cause significant stress to couples looking for successful pregnancy outcome as well as to health care professionals. There is conflicting evidence with respect to the presence and the strength of associations between inherited thrombophilia and these complications. A complete thrombophilia screen is expensive, and no ... Read more >>

Semin Thromb Hemost (Seminars in thrombosis and hemostasis)
[2019, 45(1):50-60]

Cited: 2 times

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Intracranial Hemorrhage and Early Mortality in Patients Receiving Extracorporeal Membrane Oxygenation for Severe Respiratory Failure.

Deepa R J Arachchillage, Maurizio Passariello, Michael Laffan, T C Aw, Leah Owen, Winston Banya, Richard Trimlett, Cliff Morgan, Brijesh V Patel, John Pepper, Stephane Ledot,

Intracranial hemorrhage (ICH) is a serious complication in patients receiving veno-venous extracorporeal membrane oxygenation (VV-ECMO) and is associated with high mortality. It is unknown whether ICH may be a consequence of the ECMO or of an underlying disease. The authors first aimed to assess the incidence of ICH at initiation ... Read more >>

Semin Thromb Hemost (Seminars in thrombosis and hemostasis)
[2018, 44(3):276-286]

Cited: 8 times

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Can Mean Platelet Volume Be Used as a Predictor of Vascular Disease? Problems and Pitfalls.

Deepa R J Arachchillage, Mike Laffan,

Semin Thromb Hemost (Seminars in thrombosis and hemostasis)
[2017, 43(6):599-608]

Cited: 1 time

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Pathogenesis and management of antiphospholipid syndrome.

Deepa R J Arachchillage, Mike Laffan,

Antiphospholipid antibodies are a heterogeneous group of autoantibodies that have clear associations with thrombosis and pregnancy morbidity, and which together constitute the 'antiphospholipid syndrome' (APS). However, the pathophysiology of these complications is not well understood and their heterogeneity suggests that more than one pathogenic process may be involved. Diagnosis remains ... Read more >>

Br J Haematol (British journal of haematology)
[2017, 178(2):181-195]

Cited: 21 times

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Direct Oral Anticoagulants and Women.

Hannah Cohen, Deepa R J Arachchillage, Jan Beyer-Westendorf, Saskia Middeldorp, Rezan A Kadir,

Direct oral anticoagulants (DOACs) provide an effective, safe, and convenient therapeutic alternative to warfarin and other vitamin K antagonists (VKAs), and are now established for a wide range of indications. The use of DOACs in women merits special consideration due to two main situations: first, in relation to fertility, pregnancy, ... Read more >>

Semin Thromb Hemost (Seminars in thrombosis and hemostasis)
[2016, 42(7):789-797]

Cited: 5 times

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Combined factor IIa and Xa inhibitor therapy for thrombosis whilst on therapeutic anticoagulant.

Deepa R J Arachchillage, Martin Besser, Rhona Maclean, Trevor Baglin, Joost J van Veen,

Thromb Res (Thrombosis research)
[2016, 143:137-140]

Cited: 1 time

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