Full Text Journal Articles by
Author Deepa Chand

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Pattern of Laboratory Parameters and Management of Secondary Hyperparathyroidism in Countries of Europe, Asia, the Middle East, and North America.

Mario Cozzolino, Eugeniy Shilov, Zuo Li, Masafumi Fukagawa, Saeed M G Al-Ghamdi, Ronald Pisoni, Brian Bieber, Bhadrish Vallabh, Deepa H Chand,

INTRODUCTION:This analysis explored laboratory mineral and bone disorder parameters and management of secondary hyperparathyroidism in patients undergoing hemodialysis in Belgium, Canada, China, France, Germany, Italy, Japan, Russia, Saudi Arabia, Spain, Sweden, the UK, and the USA. METHODS:Analyses used demographic, medication, and laboratory data collected in the prospective Dialysis Outcomes and ... Read more >>

Adv Ther (Advances in therapy)
[2020, 37(6):2748-2762]

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Risk Behaviors in Teens with Chronic Kidney Disease: A Study from the Midwest Pediatric Nephrology Consortium.

Nianzhou Xiao, Adrienne Stolfi, Rossana Malatesta-Muncher, Reshma Bholah, Amy Kogon, Angelica Eddington, Deepa Chand, Larry A Greenbaum, Coral Hanevold, Cheryl L Tran, Aftab Chishti, Keefe Davis, Robyn Matloff, Robert Woroniecki, Colleen Klosterman, Kera Luckritz, Abiodun Omoloja,

Introduction:There is a paucity of information about risk behaviors in adolescents with chronic kidney disease (CKD). We designed this study to assess the prevalence of risk behaviors among teens with CKD in the United States and to investigate any associations between risk behavior and patient or disease characteristics. Methods:After informed ... Read more >>

Int J Nephrol (International journal of nephrology)
[2019, 2019:7828406]

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Renal replacement therapy in the management of intoxications in children: recommendations from the Pediatric Continuous Renal Replacement Therapy (PCRRT) workgroup.

Rupesh Raina, Manpreet K Grewal, Martha Blackford, Jordan M Symons, Michael J G Somers, Christoph Licht, Rajit K Basu, Sidharth Kumar Sethi, Deepa Chand, Gaurav Kapur, Mignon McCulloch, Arvind Bagga, Vinod Krishnappa, Hui-Kim Yap, Marcelo de Sousa Tavares, Timothy E Bunchman, Michelle Bestic, Bradley A Warady, Maria Díaz-González de Ferris,

BACKGROUND:Intentional or unintentional ingestions among children and adolescents are common. There are a number of ingestions amenable to renal replacement therapy (RRT). METHODS:We systematically searched PubMed/Medline, Embase, and Cochrane databases for literature regarding drugs/intoxicants and treatment with RRT in pediatric populations. Two experts from the PCRRT (Pediatric Continuous Renal Replacement ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2019, 34(11):2427-2448]

Cited: 0 times

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Catheter Craze Continues for Pediatric Hemodialysis Vascular Access: The Need to Move From Catheter First to Catheter Last.

Rudolph P Valentini, Deepa H Chand,

Am. J. Kidney Dis. (American journal of kidney diseases : the official journal of the National Kidney Foundation)
[2019, 74(2):155-157]

Cited: 0 times

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Pediatric intradialytic hypotension: recommendations from the Pediatric Continuous Renal Replacement Therapy (PCRRT) Workgroup.

Rupesh Raina, Stephanie Lam, Hershita Raheja, Vinod Krishnappa, Daljit Hothi, Andrew Davenport, Deepa Chand, Gaurav Kapur, Franz Schaefer, Sidharth Kumar Sethi, Mignon McCulloch, Arvind Bagga, Timothy Bunchman, Bradley A Warady,

Intradialytic hypotension (IDH) is a common adverse event resulting in premature interruption of hemodialysis, and consequently, inadequate fluid and solute removal. IDH occurs in response to the reduction in blood volume during ultrafiltration and subsequent poor compensatory mechanisms due to abnormal cardiac function or autonomic or baroreceptor failure. Pediatric patients ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2019, 34(5):925-941]

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Low-Dose Methotrexate for the Prevention of Atherosclerotic Events.

Paul M Ridker, Brendan M Everett, Aruna Pradhan, Jean G MacFadyen, Daniel H Solomon, Elaine Zaharris, Virak Mam, Ahmed Hasan, Yves Rosenberg, Erin Iturriaga, Milan Gupta, Michelle Tsigoulis, Subodh Verma, Michael Clearfield, Peter Libby, Samuel Z Goldhaber, Roger Seagle, Cyril Ofori, Mohammad Saklayen, Samuel Butman, Narendra Singh, Michel Le May, Olivier Bertrand, James Johnston, Nina P Paynter, Robert J Glynn, ,

BACKGROUND:Inflammation is causally related to atherothrombosis. Treatment with canakinumab, a monoclonal antibody that inhibits inflammation by neutralizing interleukin-1β, resulted in a lower rate of cardiovascular events than placebo in a previous randomized trial. We sought to determine whether an alternative approach to inflammation inhibition with low-dose methotrexate might provide similar ... Read more >>

N. Engl. J. Med. (The New England journal of medicine)
[2019, 380(8):752-762]

Cited: 29 times

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Hemodialysis in neonates and infants: A systematic review.

Rupesh Raina, Prashanth Vijayaraghavan, Gaurav Kapur, Sidharth Kumar Sethi, Vinod Krishnappa, Deepak Kumar, Timothy E Bunchman, Shari D Bolen, Deepa Chand,

Hemodialysis (HD) in neonates and infants poses unique challenges due to high risks of mortality attributable to obligatory small blood flow volumes. Although HD is often necessary in neonates, its effectiveness and feasibility are poorly understood. The aim of this review is to describe in detail the few studies reporting ... Read more >>

Semin Dial (Seminars in dialysis)
[2018, 31(3):289-299]

Cited: 1 time

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Mycophenolate mofetil-related leukopenia in children and young adults following kidney transplantation: Influence of genes and drugs.

Charles D Varnell, Tsuyoshi Fukuda, Cassie L Kirby, Lisa J Martin, Barry L Warshaw, Hiren P Patel, Deepa H Chand, Gina-Marie Barletta, Scott K Van Why, Rene G VanDeVoorde, Donald J Weaver, Amy Wilson, Priya S Verghese, Alexander A Vinks, Larry A Greenbaum, Jens Goebel, David K Hooper,

MMF is commonly prescribed following kidney transplantation, yet its use is complicated by leukopenia. Understanding the genetics mediating this risk will help clinicians administer MMF safely. We evaluated 284 patients under 21 years of age for incidence and time course of MMF-related leukopenia and performed a candidate gene association study comparing ... Read more >>

Pediatr Transplant (Pediatric transplantation)
[2017, 21(7):]

Cited: 1 time

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Recommended Clinical Trial End Points for Dialysis Catheters.

Michael Allon, Deborah J Brouwer-Maier, Kenneth Abreo, Kevin M Baskin, Kay Bregel, Deepa H Chand, Andrea M Easom, Leonard Mermel, Michele H Mokrzycki, Priti R Patel, Prabir Roy-Chaudhury, Surendra Shenoy, Rudolph P Valentini, Haimanot Wasse,

Central venous catheters are used frequently in patients on hemodialysis as a bridge to a permanent vascular access. They are prone to frequent complications, including catheter-related bloodstream infection, catheter dysfunction, and central vein obstruction. There is a compelling need to develop new drugs or devices to prevent central venous catheter ... Read more >>

Clin J Am Soc Nephrol (Clinical journal of the American Society of Nephrology : CJASN)
[2018, 13(3):495-500]

Cited: 2 times

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Dialysis in Children and Adolescents: The Pediatric Nephrology Perspective.

Deepa H Chand, Sarah Swartz, Shamir Tuchman, Rudolph P Valentini, Michael J G Somers,

The care of children with end-stage renal disease (ESRD) is highly specialized and often poorly understood by nonpediatric providers and facility/institution administrators. As such, this position paper has been created to offer provider, facility, and institutional guidance regarding the components of care necessary for children receiving dialysis. Key differences between ... Read more >>

Am. J. Kidney Dis. (American journal of kidney diseases : the official journal of the National Kidney Foundation)
[2017, 69(2):278-286]

Cited: 3 times

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Pediatric Hypertension: Are Pediatricians Following Guidelines?

Neil D Patel, Andrew Newburn, Michael E Brier, Deepa H Chand,

The National Heart, Lung, and Blood Institute recommends that children older than 3 years seen in the medical setting have their blood pressure (BP) measured. The authors aimed to determine whether BPs are measured at well-child visits and whether elevated readings are recognized. A retrospective chart review of 3- to ... Read more >>

J Clin Hypertens (Greenwich) (Journal of clinical hypertension (Greenwich, Conn.))
[2016, 18(12):1230-1234]

Cited: 3 times

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Overview of C3 Glomerulopathy.

Vimal Master Sankar Raj, Roberto Gordillo, Deepa H Chand,

C3 glomerulopathy is an umbrella term, which includes several rare forms of glomerulonephritis (GN) with underlying defects in the alternate complement cascade. A common histological feature noted in all these GN is dominant C3 deposition in the glomerulus. In this review, we will provide an overview of the complement system ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2016, 4:45]

Cited: 0 times

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In vivo heat inactivation of serum can distinguish false positive cross matches in renal transplants.

Alyssa A Riley, Lynne Klingman, Michael E Brier, Deepa H Chand,

Renal transplants have traditionally been performed despite positive cross match if results are presumptively due to IgM antibodies. False positives have been distinguishable from true positives by dithiothreitol or dithioerythritol treatment to inactivate IgM antibodies. Heat inactivation, which renders the antibodies inactive, is an alternative to chemical amelioration.We retrospectively evaluated ... Read more >>

Int J Artif Organs (The International journal of artificial organs)
[2016, 39(2):63-67]

Cited: 0 times

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HLA-DQA1 and PLCG2 Are Candidate Risk Loci for Childhood-Onset Steroid-Sensitive Nephrotic Syndrome.

Rasheed A Gbadegesin, Adebowale Adeyemo, Nicholas J A Webb, Larry A Greenbaum, Asiri Abeyagunawardena, Shenal Thalgahagoda, Arundhati Kale, Debbie Gipson, Tarak Srivastava, Jen-Jar Lin, Deepa Chand, Tracy E Hunley, Patrick D Brophy, Arvind Bagga, Aditi Sinha, Michelle N Rheault, Joanna Ghali, Kathy Nicholls, Elizabeth Abraham, Halima S Janjua, Abiodun Omoloja, Gina-Marie Barletta, Yi Cai, David D Milford, Catherine O'Brien, Atif Awan, Vladimir Belostotsky, William E Smoyer, Alison Homstad, Gentzon Hall, Guanghong Wu, Shashi Nagaraj, Delbert Wigfall, John Foreman, Michelle P Winn, ,

Steroid-sensitive nephrotic syndrome (SSNS) accounts for >80% of cases of nephrotic syndrome in childhood. However, the etiology and pathogenesis of SSNS remain obscure. Hypothesizing that coding variation may underlie SSNS risk, we conducted an exome array association study of SSNS. We enrolled a discovery set of 363 persons (214 South ... Read more >>

J. Am. Soc. Nephrol. (Journal of the American Society of Nephrology : JASN)
[2015, 26(7):1701-1710]

Cited: 35 times

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Gaining the Patient Reported Outcomes Measurement Information System (PROMIS) perspective in chronic kidney disease: a Midwest Pediatric Nephrology Consortium study.

David T Selewski, Susan F Massengill, Jonathan P Troost, Larysa Wickman, Kassandra L Messer, Emily Herreshoff, Corinna Bowers, Maria E Ferris, John D Mahan, Larry A Greenbaum, Jackie MacHardy, Gaurav Kapur, Deepa H Chand, Jens Goebel, Gina Marie Barletta, Denis Geary, David B Kershaw, Cynthia G Pan, Rasheed Gbadegesin, Guillermo Hidalgo, Jerome C Lane, Jeffrey D Leiser, Peter X Song, David Thissen, Yang Liu, Heather E Gross, Darren A DeWalt, Debbie S Gipson,

Chronic kidney disease is a persistent chronic health condition commonly seen in pediatric nephrology programs. Our study aims to evaluate the sensitivity of the Patient Reported Outcomes Measurement Information System (PROMIS) pediatric instrument to indicators of disease severity and activity in pediatric chronic kidney disease.This cross sectional study included 233 ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2014, 29(12):2347-2356]

Cited: 13 times

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Tobacco exposure in children and adolescents with chronic kidney disease: parental behavior and knowledge. A study from the Midwest Pediatric Nephrology Consortium.

Abiodun Omoloja, Adrienne Stolfi, Deepa Chand, Benjamin Laskin, Debbie Gipson, Hiren Patel, Jane Anne Smith, Aftab Chishti,

AIM:The incidence of cardiovascular disease (CVD) in children with chronic kidney disease (CKD) is high. Exposure to second hand smoke (SHS) is a known risk factor for CVD. Due to a recent report of high incidence of SHS in children with CKD, we sought to investigate via questionnaire the smoking ... Read more >>

Clin. Nephrol. (Clinical nephrology)
[2014, 81(5):307-312]

Cited: 1 time

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Barriers, biases, and beliefs about arteriovenous fistula placement in children: a survey of the International Pediatric Fistula First Initiative (IPFFI) within the Midwest Pediatric Nephrology Consortium (MWPNC).

Deepa H Chand, Denis Geary, Hiren Patel, Larry A Greenbaum, Corina Nailescu, Michael E Brier, Rudolph P Valentini,

There has been recent emphasis on increased arteriovenous fistula (AVF) use and decreased central venous catheter use in hemodialysis (HD) patients. The International Pediatric Fistula First Initiative was founded via collaborative effort with the Midwest Pediatric Nephrology Consortium to alert nephrologists, surgeons, and dialysis staff to consider fistulae as the ... Read more >>

Hemodial Int (Hemodialysis international. International Symposium on Home Hemodialysis)
[2015, 19(1):100-107]

Cited: 5 times

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The quality of cardiovascular disease care for adolescents with kidney disease: a Midwest Pediatric Nephrology Consortium study.

David K Hooper, Jason C Williams, Adam C Carle, Sandra Amaral, Deepa H Chand, Maria E Ferris, Hiren P Patel, Christoph Licht, Gina-Marie Barletta, Veronica Zitterman, Mark Mitsnefes, Uptal D Patel,

Cardiovascular disease is the leading cause of increased mortality for adolescents with advanced kidney disease. The quality of preventive cardiovascular care may impact long-term outcomes for these patients.We reviewed the records of 196 consecutive adolescents from eight centers with pre-dialysis chronic kidney disease, on dialysis or with a kidney transplant, ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2013, 28(6):939-949]

Cited: 9 times

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Gaining the PROMIS perspective from children with nephrotic syndrome: a Midwest pediatric nephrology consortium study.

Debbie S Gipson, David T Selewski, Susan F Massengill, Larysa Wickman, Kassandra L Messer, Emily Herreshoff, Corinna Bowers, Maria E Ferris, John D Mahan, Larry A Greenbaum, Jackie MacHardy, Gaurav Kapur, Deepa H Chand, Jens Goebel, Gina Marie Barletta, Denis Geary, David B Kershaw, Cynthia G Pan, Rasheed Gbadegesin, Guillermo Hidalgo, Jerome C Lane, Jeffrey D Leiser, Brett W Plattner, Peter X Song, David Thissen, Yang Liu, Heather E Gross, Darren A DeWalt,

Nephrotic syndrome (NS) represents a common disease in pediatric nephrology typified by a relapsing and remitting course and characterized by the presence of edema that can significantly affect the health-related quality of life in children and adolescents. The PROMIS pediatric measures were constructed to be publically available, efficient, precise, and ... Read more >>

Health Qual Life Outcomes (Health and quality of life outcomes)
[2013, 11:30]

Cited: 17 times

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Chronic kidney disease, pediatric nephrologists, and tobacco counseling: perceptions and practice patterns. A study from the Midwest Pediatric Nephrology Consortium.

Karen Bruner, Deepa Chand, Hiren Patel, Adrienne Stolfi, Abiodun Omoloja,

We sought to identify practice patterns of pediatric nephrologists for tobacco counseling, because of a high incidence of secondhand smoke exposure and tobacco use in adolescents with chronic kidney disease. Counseling was minimal for several reasons, thus increasing the risk for heart disease inherent in children with chronic kidney disease. ... Read more >>

J. Pediatr. (The Journal of pediatrics)
[2011, 159(1):155-157.e1]

Cited: 2 times

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Influenza vaccine after pediatric kidney transplant: a Midwest Pediatric Nephrology Consortium study.

Corina Nailescu, Xiyan Xu, Hong Zhou, Henrietta Hall, Amy C Wilson, Jeffrey D Leiser, Deepa H Chand, Rudolph P Valentini, Diane Hebert, John D Mahan,

The main aim of this study was to compare the response to trivalent inactivated influenza vaccine in children who received a kidney transplant and were on steroid-free versus steroid-based immunosuppression. Groups: 1. Kidney transplant recipients on steroid-free immunosuppression (n=27); 2. Kidney transplant recipients on steroid-based immunosuppression (n=39); 3. Healthy controls ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2011, 26(3):459-467]

Cited: 14 times

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A comparison of laboratory values in pediatric hemodialysis patients: does day of the week matter?

Christina Nguyen, Dale Bednarz, Michael E Brier, Abubakr Imam, Deepa H Chand,

The National Kidney Foundation Dialysis Outcomes Quality Initiative (NKF-K/DOQI) guidelines recommend the delivered dose of hemodialysis (HD) be measured no less than monthly by checking Kt/V (K is effective urea clearance, t is minute and V is urea distribution). To date, no studies have explored whether the day of the ... Read more >>

Nephrol. Dial. Transplant. (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association)
[2012, 27(2):816-819]

Cited: 0 times

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Administration of a pediatric dialysis unit: the basics.

Deepa H Chand,

In the current era of dialysis care, the nephrologist must be prepared to perform multiple functions beyond the delivery of patient care. One potential role that the nephrologist may assume is the medical director of a dialysis facility. The medical director is responsible for the unit functions on several levels. ... Read more >>

Ren Fail (Renal failure)
[2010, 32(1):10-13]

Cited: 0 times

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Cigarette smoking and second-hand smoking exposure in adolescents with chronic kidney disease: a study from the Midwest Pediatric Nephrology Consortium.

Abiodun Omoloja, Deepa Chand, Larry Greenbaum, Amy Wilson, Veronica Bastian, Maria Ferris, John Bernert, Adrienne Stolfi, Hiren Patel,

BACKGROUND: Smoking and second-hand smoking [SHS] cause significant cardiovascular mortality and morbidity. In healthy individuals and adults with chronic kidney disease [CKD], cigarette smoking is associated with albuminuria, increased risk for CKD, increased graft loss and progression of renal insufficiency. In children, SHS has been associated with higher blood pressure ... Read more >>

Nephrol. Dial. Transplant. (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association)
[2011, 26(3):908-913]

Cited: 6 times

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A vascular access team can increase AV fistula creation in pediatric ESRD patients: a single center experience.

Deepa H Chand, Dale Bednarz, Matthew Eagleton, Leonard Krajewski,

The National Kidney Foundation Dialysis Outcomes Quality Initiative (NKF-DOQI) recommends the use of a permanent vascular access for pediatric hemodialysis (HD) patients; however, central venous catheters are the most common vascular access used among children. In children receiving HD, central venous catheters, while suboptimal, are the most common vascular access ... Read more >>

Semin Dial (Seminars in dialysis)
[2009, 22(6):679-683]

Cited: 11 times

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