Full Text Journal Articles by
Author Deeksha Malhan

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Mortality, Risk Factors and Risk Assessment after Periprosthetic Femoral Fractures-A Retrospective Cohort Study.

Thaqif El Khassawna, Gero Knapp, Nadja Scheibler, Deeksha Malhan, Nike Walter, Christoph Biehl, Volker Alt, Christian Heiss, Markus Rupp,

Periprosthetic femoral fracture (PFF) is a devastating complication. Here, the authors aimed to determine the influence of the timing of surgery as a risk factor for mortality and poor postoperative outcome in patients suffering from PFF. A retrospective descriptive analysis of patients treated for PFF between January 2010 and March ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(19):]

Cited: 0 times

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DXA reference values of the humanoid sheep model in preclinical studies.

Christoph Biehl, Jakob Schmitt, Sabine Stoetzel, Deeksha Malhan, Fathi Hassan, Gero Knapp, Christian Heiss, Thaqif El Khassawna,

<h4>Background</h4>Merino land sheep are a popular pre-clinical large animal model in research on systemic skeletal diseases such as osteoporosis. Interpretation of studies is difficult because many reference parameters are missing or not established. This study aims to determine the reference parameters of the skeletal system (peak bone mass = PBM, ... Read more >>

PeerJ (PeerJ)
[2021, 9:e11183]

Cited: 0 times

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Large Animal Model of Osteoporotic Defect Healing: An Alternative to Metaphyseal Defect Model.

Markus Rupp, Christoph Biehl, Deeksha Malhan, Fathi Hassan, Sameh Attia, Sebastian Rosch, Annemarie B Schäfer, Erin McMahon, Marian Kampschulte, Christian Heiss, Thaqif El Khassawna,

Osteoporosis is a common metabolic disorder diagnosed by lower bone density and higher risk of fracture. Fragility fractures because of osteoporosis are associated with high mortality rate. Deep understanding of fracture healing in osteoporosis is important for successful treatment. Therefore, the FDA approved the use of small and large animal ... Read more >>

Life (Basel) (Life (Basel, Switzerland))
[2021, 11(3):]

Cited: 0 times

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An Optimal Time for Treatment-Predicting Circadian Time by Machine Learning and Mathematical Modelling.

Janina Hesse, Deeksha Malhan, Müge Yalҫin, Ouda Aboumanify, Alireza Basti, Angela Relógio,

Tailoring medical interventions to a particular patient and pathology has been termed personalized medicine. The outcome of cancer treatments is improved when the intervention is timed in accordance with the patient's internal time. Yet, one challenge of personalized medicine is how to consider the biological time of the patient. Prerequisite ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(11):]

Cited: 2 times

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Is Biofeedback through an Intra-Aural Device an Effective Method to Treat Bruxism? Case Series and Initial Experience.

Kira Pfeiffer, Thaqif El Khassawna, Deeksha Malhan, Christine Langer, Barbara Sommer, Mohamed Mekhemar, Hans-Peter Howaldt, Sameh Attia,

Biofeedback was reported as an effective concept for bruxism treatment, through increasing patient's awareness of the habit. During bruxing both ear canals become tighter, therefore, an in-ear device can provide biofeedback. The in-ear device is fitted to the ear canal in physiological status, during bruxing the ear-canal tightens resulting in ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 18(1):]

Cited: 2 times

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Oral Rehabilitation of Hypodontia Patients Using an Endosseous Dental Implant: Functional and Aesthetic Results.

Sameh Attia, Heidrun Schaaf, Thaqif El Khassawna, Deeksha Malhan, Katharina Mausbach, Hans-Peter Howaldt, Philipp Streckbein,

Hypodontia often leads to limited bone availability of the alveolar ridges. Oral rehabilitation of severe hypodontia patients is challenging. In this retrospective study, we evaluated the functional and aesthetic results after dental implants in hypodontia patients, corroborated by Albrektsson implant success criteria. Over a period of 15 years (2000-2015), a ... Read more >>

J Clin Med (Journal of clinical medicine)
[2019, 8(10):]

Cited: 5 times

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Do Systemic Factors Influence the Fate of Nonunions to Become Atrophic? A Retrospective Analysis of 162 Cases.

Markus Rupp, Stefanie Kern, Thaqif El Khassawna, Abdullah Ismat, Deeksha Malhan, Volker Alt, Christian Heiss, Michael J Raschke,

<h4>Introduction</h4>Nonunions are a challenge for orthopedic surgeons. In hypertrophic nonunions, improvement of mechanical stability usually is the satisfactory treatment, whereas in atrophic nonunions improvement of the biological environment is most important. However, scientific evidence revealed that "avital" nonunions are not avascular and fibrous tissue contains cells with osteogenic potential. To ... Read more >>

Biomed Res Int (BioMed research international)
[2019, 2019:6407098]

Cited: 2 times

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An Optimized Approach to Perform Bone Histomorphometry.

Deeksha Malhan, Matthias Muelke, Sebastian Rosch, Annemarie B Schaefer, Felix Merboth, David Weisweiler, Christian Heiss, Ignacio Arganda-Carreras, Thaqif El Khassawna,

Bone histomorphometry allows quantitative evaluation of bone micro-architecture, bone formation, and bone remodeling by providing an insight to cellular changes. Histomorphometry plays an important role in monitoring changes in bone properties because of systemic skeletal diseases like osteoporosis and osteomalacia. Besides, quantitative evaluation plays an important role in fracture healing ... Read more >>

Front Endocrinol (Lausanne) (Frontiers in endocrinology)
[2018, 9:666]

Cited: 7 times

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A tissue-based approach to selection of reference genes for quantitative real-time PCR in a sheep osteoporosis model.

Felix Schulze, Deeksha Malhan, Thaqif El Khassawna, Christian Heiss, Anja Seckinger, Dirk Hose, Angela Rösen-Wolff,

<h4>Background</h4>In order to better understand the multifactorial nature of osteoporosis, animal models are utilized and compared to healthy controls. Female sheep are well established as a model for osteoporosis induced by ovariectomy, calcium and vitamin D low diet, application of steroids, or a combination of these treatments. Transcriptional studies can ... Read more >>

BMC Genomics (BMC genomics)
[2017, 18(1):975]

Cited: 9 times

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Nonsurgical Clinical Management of Periapical Lesions Using Calcium Hydroxide-Iodoform-Silicon-Oil Paste.

Qusai Al Khasawnah, Fathi Hassan, Deeksha Malhan, Markus Engelhardt, Diaa Eldin S Daghma, Dima Obidat, Katrin S Lips, Thaqif El Khassawna, Christian Heiss,

<h4>Background</h4>The study aim is to avoid tooth extraction by nonsurgical treatment of periapical lesion. It assesses healing progress in response to calcium hydroxide-iodoform-silicon oil paste (CHISP). Numeric Pain Rating Scale was used to validate the approach. Furthermore, CHISP was used to treat cystic lesions secondary to posttraumatic avulsion of permanent ... Read more >>

Biomed Res Int (BioMed research international)
[2018, 2018:8198795]

Cited: 1 time

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A New Clinically Relevant T-Score Standard to Interpret Bone Status in a Sheep Model.

Christian Heiss, Stefanie Kern, Deeksha Malhan, Wolfgang Böcker, Markus Engelhardt, Diaa Eldin S Daghma, Sabine Stoetzel, Jakob Schmitt, Matthias Ivo, Vivien Kauschke, Katrin S Lips, Kamen Tushtev, Kurosch Rezwan, Thaqif El Khassawna,

BACKGROUND Osteoporosis is diagnosed by bone loss using a radiological parameter called T-score. Preclinical studies use DXA to evaluate bone status were the T-score is referenced on bone mineral density (BMD) values of the same animals before treatment. Clinically, the reference BMD represents values of an independent group of healthy ... Read more >>

Med Sci Monit Basic Res (Medical science monitor basic research)
[2017, 23:326-335]

Cited: 5 times

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Computational segmentation of collagen fibers in bone matrix indicates bone quality in ovariectomized rat spine.

Diaa Eldin S Daghma, Deeksha Malhan, Paul Simon, Sabine Stötzel, Stefanie Kern, Fathi Hassan, Katrin Susanne Lips, Christian Heiss, Thaqif El Khassawna,

Bone loss varies according to disease and age and these variations affect bone cells and extracellular matrix. Osteoporosis rat models are widely investigated to assess mechanical and structural properties of bone; however, bone matrix proteins and their discrepant regulation of diseased and aged bone are often overlooked. The current study ... Read more >>

J Bone Miner Metab (Journal of bone and mineral metabolism)
[2018, 36(3):297-306]

Cited: 6 times

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Osteocyte Regulation of Receptor Activator of NF-κB Ligand/Osteoprotegerin in a Sheep Model of Osteoporosis.

Thaqif El Khassawna, Felix Merboth, Deeksha Malhan, Wolfgang Böcker, Diaa E S Daghma, Sabine Stoetzel, Stefanie Kern, Fathi Hassan, Dirk Rosenbaum, Judith Langenstein, Natali Bauer, Anja Schlagenhauf, Angela Rösen-Wolff, Felix Schulze, Markus Rupp, Dirk Hose, Anja Secklinger, Anita Ignatius, Hans-Joachim Wilke, Katrin S Lips, Christian Heiss,

Osteoporosis induction in a sheep model by steroid administration combined with ovariectomy recapitulates decreased bone formation and substandard matrix mineralization in patients. Recently, the role of osteocytes has been frequently addressed, with focus on their role in osteoclastogenesis. However, the quantification of receptor activator of NF-κB ligand (RANKL) and osteoprotegerin ... Read more >>

Am J Pathol (The American journal of pathology)
[2017, 187(8):1686-1699]

Cited: 5 times

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T Lymphocytes Influence the Mineralization Process of Bone.

Thaqif El Khassawna, Alessandro Serra, Christian H Bucher, Ansgar Petersen, Claudia Schlundt, Ireen Könnecke, Deeksha Malhan, Sebastian Wendler, Hanna Schell, Hans-Dieter Volk, Katharina Schmidt-Bleek, Georg N Duda,

Bone is a unique organ able to regenerate itself after injuries. This regeneration requires the local interplay between different biological systems such as inflammation and matrix formation. Structural reconstitution is initiated by an inflammatory response orchestrated by the host immune system. However, the individual role of T cells and B ... Read more >>

Front Immunol (Frontiers in immunology)
[2017, 8:562]

Cited: 15 times

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Genome wide gene expression analyses of Arabidopsis shoot stem cell niche cell populations.

Deeksha Malhan, Shivani Bhatia, Ram Kishor Yadav,

The shoot apical meristem (SAM) of higher plants harbors stem cells at their tips. In the SAM, stem cell niches maintain the pluripotent nature of these cell types in the central zone (CZ) and allow them to enter in to differentiation pathways either in the peripheral zone (PZ) or rib ... Read more >>

Plant Signal Behav (Plant signaling & behavior)
[2015, 10(4):e1011937]

Cited: 0 times

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