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Prognostic Factors Associated With Development of Venous Thromboembolism in Critically Ill Patients-A Systematic Review and Meta-Analysis.

Alexandre Tran, Shannon M Fernando, Bram Rochwerg, Deborah J Cook, Mark A Crowther, Robert A Fowler, Waleed Alhazzani, Deborah M Siegal, Lana A Castellucci, Ryan Zarychanski, Shane W English, Kwadwo Kyeremanteng, Marc Carrier,

<h4>Objective</h4>To identify prognostic factors for the development of venous thromboembolism in the ICU.<h4>Data sources</h4>We searched MEDLINE, EMBASE, and Cochrane CENTRAL from inception to March 1, 2021.<h4>Study selection</h4>We included English-language studies describing prognostic factors associated with the development of venous thromboembolism among critically ill patients.<h4>Data extraction</h4>Two authors performed data extraction and ... Read more >>

Crit Care Med (Critical care medicine)
[2021, :]

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Clinical Research: From Case Reports to International Multicenter Clinical Trials.

Simon Finfer, Deborah Cook, Flavia R Machado, Anders Perner,

Crit Care Med (Critical care medicine)
[2021, 49(11):1866-1882]

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How can we increase participation in pandemic research in Canada?

Jennifer L Y Tsang, Robert Fowler, Deborah J Cook, Huiting Ma, Alexandra Binnie,

Can J Anaesth (Canadian journal of anaesthesia = Journal canadien d'anesthesie)
[2021, :]

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Restricted visitation policies in acute care settings during the COVID-19 pandemic: a scoping review.

Stephana J Moss, Karla D Krewulak, Henry T Stelfox, Sofia B Ahmed, Melanie C Anglin, Sean M Bagshaw, Karen E A Burns, Deborah J Cook, Christopher J Doig, Alison Fox-Robichaud, Robert Fowler, Laura Hernández, Michelle E Kho, Maia Kredentser, Kira Makuk, Srinivas Murthy, Daniel J Niven, Kendiss Olafson, Ken Kuljit S Parhar, Scott B Patten, Oleksa G Rewa, Bram Rochwerg, Bonnie Sept, Andrea Soo, Krista Spence, Sean Spence, Sharon Straus, Andrew West, Jeanna Parsons Leigh, Kirsten M Fiest,

<h4>Background</h4>Restricted visitation policies in acute care settings because of the COVID-19 pandemic have negative consequences. The objective of this scoping review is to identify impacts of restricted visitation policies in acute care settings, and describe perspectives and mitigation approaches among patients, families, and healthcare professionals.<h4>Methods</h4>We searched Medline, Embase, PsycINFO, Healthstar, ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):347]

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End-of-Life Care During the Coronavirus Disease 2019 Pandemic: The 3 Wishes Program.

Thanh H Neville, Danielle K Bear, Yuhan Kao, Xueqing Sherry Xu, Kristen Hjelmhaug, Desiree Quebral, Natalie Sanaee, Jessica Hainje, Genevieve Arriola, Maria Carmela Granone, Elizabeth White, Apurva Chaturvedi, Shuyi Yu, France Clarke, Deborah J Cook,

Patient- and family-centered end-of-life care can be difficult to achieve in light of visitation restrictions and infection-prevention measures. We evaluated how the 3 Wishes Program evolved to allow continued provision of compassionate end-of-life care for critically ill patients during the coronavirus disease 2019 pandemic.<h4>Design</h4>This is a prospective observational study where ... Read more >>

Crit Care Explor (Critical care explorations)
[2021, 3(10):e549]

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Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial.

, Lise J Estcourt, Alexis F Turgeon, Zoe K McQuilten, Bryan J McVerry, Farah Al-Beidh, Djillali Annane, Yaseen M Arabi, Donald M Arnold, Abigail Beane, Philippe Bégin, Wilma van Bentum-Puijk, Lindsay R Berry, Zahra Bhimani, Janet E Birchall, Marc J M Bonten, Charlotte A Bradbury, Frank M Brunkhorst, Meredith Buxton, Jeannie L Callum, Michaël Chassé, Allen C Cheng, Matthew E Cove, James Daly, Lennie Derde, Michelle A Detry, Menno De Jong, Amy Evans, Dean A Fergusson, Matthew Fish, Mark Fitzgerald, Claire Foley, Herman Goossens, Anthony C Gordon, Iain B Gosbell, Cameron Green, Rashan Haniffa, Heli Harvala, Alisa M Higgins, Thomas E Hills, Veronica C Hoad, Christopher Horvat, David T Huang, Cara L Hudson, Nao Ichihara, Emma Laing, Abigail A Lamikanra, François Lamontagne, Patrick R Lawler, Kelsey Linstrum, Edward Litton, Elizabeth Lorenzi, Sheila MacLennan, John Marshall, Daniel F McAuley, John F McDyer, Anna McGlothlin, Shay McGuinness, Gail Miflin, Stephanie Montgomery, Paul R Mouncey, Srinivas Murthy, Alistair Nichol, Rachael Parke, Jane C Parker, Nicole Priddee, Damian F J Purcell, Luis F Reyes, Peter Richardson, Nancy Robitaille, Kathryn M Rowan, Jennifer Rynne, Hiroki Saito, Marlene Santos, Christina T Saunders, Ary Serpa Neto, Christopher W Seymour, Jon A Silversides, Alan A Tinmouth, Darrell J Triulzi, Anne M Turner, Frank van de Veerdonk, Timothy S Walsh, Erica M Wood, Scott Berry, Roger J Lewis, David K Menon, Colin McArthur, Ryan Zarychanski, Derek C Angus, Steve A Webb, David J Roberts, Manu Shankar-Hari,

<h4>Importance</h4>The evidence for benefit of convalescent plasma for critically ill patients with COVID-19 is inconclusive.<h4>Objective</h4>To determine whether convalescent plasma would improve outcomes for critically ill adults with COVID-19.<h4>Design, setting, and participants</h4>The ongoing Randomized, Embedded, Multifactorial, Adaptive Platform Trial for Community-Acquired Pneumonia (REMAP-CAP) enrolled and randomized 4763 adults with suspected or ... Read more >>

JAMA (JAMA)
[2021, :]

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Impact of restricted visitation policies in hospitals on patients, family members and healthcare providers during the COVID-19 pandemic: a scoping review protocol.

Stephana J Moss, Henry T Stelfox, Karla D Krewulak, Sofia Ahmed, Melanie C Anglin, Sean M Bagshaw, Tavish Barnes, Karen E A Burns, Deborah J Cook, Sarah Crowe, Christopher J Doig, Nadine Foster, Alison Fox-Robichaud, Robert Fowler, Maia Kredenster, Srinivas Murthy, Daniel Niven, Kendiss Olafson, Ken Kuljit S Parhar, Scott B Patten, Oleska Rewa, Bram Rochwerg, Bonnie G Sept, Andrea Soo, Krista Spence, Sean Spence, Sharon E Straus, Andrew West, Jeanna Parsons Leigh, Kirsten M Fiest,

<h4>Introduction</h4>Flexible visitation policies in hospitals are an important component of care that contributes to reduced stress and increased satisfaction among patients and their family members. Early evidence suggests restricted visitation policies enacted in hospitals during the COVID-19 pandemic are having unintended consequences on patients, family members and healthcare providers. There ... Read more >>

BMJ Open (BMJ open)
[2021, 11(9):e048227]

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Effect of Esophageal Pressure-Guided Positive End-Expiratory Pressure on Survival from Acute Respiratory Distress Syndrome: A Risk-Based and Mechanistic Reanalysis of the EPVent-2 Trial.

Todd Sarge, Elias Baedorf-Kassis, Valerie Banner-Goodspeed, Victor Novack, Stephen H Loring, Michelle N Gong, Deborah Cook, Daniel Talmor, Jeremy R Beitler, ,

<h4>Rationale</h4>In acute respiratory distress syndrome (ARDS), the effect of positive end-expiratory pressure (PEEP) may depend on the extent to which multiorgan dysfunction contributes to risk of death, and the precision with which PEEP is titrated to attenuate atelectrauma without exacerbating overdistension.<h4>Objective</h4>To evaluate whether multiorgan dysfunction and lung mechanics modified treatment ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2021, :]

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Venous Thromboembolism Prophylaxis in Critically Ill Adults: A Systematic Review and Network Meta-analysis.

Shannon M Fernando, Alexandre Tran, Wei Cheng, Behnam Sadeghirad, Yaseen M Arabi, Deborah J Cook, Morten Hylander Møller, Sangeeta Mehta, Robert A Fowler, Karen E A Burns, Philip S Wells, Marc Carrier, Mark A Crowther, Damon C Scales, Shane W English, Kwadwo Kyeremanteng, Salmaan Kanji, Michelle E Kho, Bram Rochwerg,

<h4>Background</h4>Critically ill adults are at increased risk of VTE, including DVT, and pulmonary embolism. Various agents exist for venous thromboprophylaxis in this population.<h4>Research question</h4>What is the comparative efficacy and safety of prophylaxis agents for prevention of VTE in critically ill adults?<h4>Study design and methods</h4>Systematic review and network meta-analysis of randomized ... Read more >>

Chest (Chest)
[2021, :]

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Effect of Probiotics on Incident Ventilator-Associated Pneumonia in Critically Ill Patients: A Randomized Clinical Trial.

Jennie Johnstone, Maureen Meade, François Lauzier, John Marshall, Erick Duan, Joanna Dionne, Yaseen M Arabi, Diane Heels-Ansdell, Lehana Thabane, Daphnee Lamarche, Michael Surette, Nicole Zytaruk, Sangeeta Mehta, Peter Dodek, Lauralyn McIntyre, Shane English, Bram Rochwerg, Tim Karachi, William Henderson, Gordon Wood, Daniel Ovakim, Margaret Herridge, John Granton, M Elizabeth Wilcox, Alberto Goffi, Henry T Stelfox, Daniel Niven, John Muscedere, François Lamontagne, Frédérick D'Aragon, Charles St-Arnaud, Ian Ball, Dave Nagpal, Martin Girard, Pierre Aslanian, Emmanuel Charbonney, David Williamson, Wendy Sligl, Jan Friedrich, Neill K Adhikari, François Marquis, Patrick Archambault, Kosar Khwaja, Arnold Kristof, James Kutsogiannis, Ryan Zarychanski, Bojan Paunovic, Brenda Reeve, François Lellouche, Paul Hosek, Jennifer Tsang, Alexandra Binnie, Sébastien Trop, Osama Loubani, Richard Hall, Robert Cirone, Steve Reynolds, Paul Lysecki, Eyal Golan, Rodrigo Cartin-Ceba, Robert Taylor, Deborah Cook, ,

<h4>Importance</h4>Growing interest in microbial dysbiosis during critical illness has raised questions about the therapeutic potential of microbiome modification with probiotics. Prior randomized trials in this population suggest that probiotics reduce infection, particularly ventilator-associated pneumonia (VAP), although probiotic-associated infections have also been reported.<h4>Objective</h4>To evaluate the effect of Lactobacillus rhamnosus GG on ... Read more >>

JAMA (JAMA)
[2021, 326(11):1024-1033]

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End-of-life transitions for family member on the solid tumour oncology ward: the 3 Wishes Project.

Gwenyth Day, Danielle Bear, Marilyn Swinton, Daniel Karlin, Peter Phung, Kelly McCann, Allegra Bell, Rayna McParlane, Maria Carmela Granone, Deborah J Cook, Thanh H Neville,

<h4>Objectives</h4>Although death is not uncommon for hospitalised patients with cancer, there are few interventions in oncology that are designed to create a dignified, compassionate end-of-life (EOL) experience for patients and families. The 3 Wishes Project (3WP), a programme in which clinicians elicit and implement final wishes for dying patients, has ... Read more >>

BMJ Support Palliat Care (BMJ supportive & palliative care)
[2021, :]

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Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19.

, , , Patrick R Lawler, Ewan C Goligher, Jeffrey S Berger, Matthew D Neal, Bryan J McVerry, Jose C Nicolau, Michelle N Gong, Marc Carrier, Robert S Rosenson, Harmony R Reynolds, Alexis F Turgeon, Jorge Escobedo, David T Huang, Charlotte A Bradbury, Brett L Houston, Lucy Z Kornblith, Anand Kumar, Susan R Kahn, Mary Cushman, Zoe McQuilten, Arthur S Slutsky, Keri S Kim, Anthony C Gordon, Bridget-Anne Kirwan, Maria M Brooks, Alisa M Higgins, Roger J Lewis, Elizabeth Lorenzi, Scott M Berry, Lindsay R Berry, Aaron W Aday, Farah Al-Beidh, Djillali Annane, Yaseen M Arabi, Diptesh Aryal, Lisa Baumann Kreuziger, Abi Beane, Zahra Bhimani, Shailesh Bihari, Henny H Billett, Lindsay Bond, Marc Bonten, Frank Brunkhorst, Meredith Buxton, Adrian Buzgau, Lana A Castellucci, Sweta Chekuri, Jen-Ting Chen, Allen C Cheng, Tamta Chkhikvadze, Benjamin Coiffard, Todd W Costantini, Sophie de Brouwer, Lennie P G Derde, Michelle A Detry, Abhijit Duggal, Vladimír Džavík, Mark B Effron, Lise J Estcourt, Brendan M Everett, Dean A Fergusson, Mark Fitzgerald, Robert A Fowler, Jean P Galanaud, Benjamin T Galen, Sheetal Gandotra, Sebastian García-Madrona, Timothy D Girard, Lucas C Godoy, Andrew L Goodman, Herman Goossens, Cameron Green, Yonatan Y Greenstein, Peter L Gross, Naomi M Hamburg, Rashan Haniffa, George Hanna, Nicholas Hanna, Sheila M Hegde, Carolyn M Hendrickson, R Duncan Hite, Alexander A Hindenburg, Aluko A Hope, James M Horowitz, Christopher M Horvat, Kristin Hudock, Beverley J Hunt, Mansoor Husain, Robert C Hyzy, Vivek N Iyer, Jeffrey R Jacobson, Devachandran Jayakumar, Norma M Keller, Akram Khan, Yuri Kim, Andrei L Kindzelski, Andrew J King, M Margaret Knudson, Aaron E Kornblith, Vidya Krishnan, Matthew E Kutcher, Michael A Laffan, Francois Lamontagne, Grégoire Le Gal, Christine M Leeper, Eric S Leifer, George Lim, Felipe Gallego Lima, Kelsey Linstrum, Edward Litton, Jose Lopez-Sendon, Jose L Lopez-Sendon Moreno, Sylvain A Lother, Saurabh Malhotra, Miguel Marcos, Andréa Saud Marinez, John C Marshall, Nicole Marten, Michael A Matthay, Daniel F McAuley, Emily G McDonald, Anna McGlothlin, Shay P McGuinness, Saskia Middeldorp, Stephanie K Montgomery, Steven C Moore, Raquel Morillo Guerrero, Paul R Mouncey, Srinivas Murthy, Girish B Nair, Rahul Nair, Alistair D Nichol, Brenda Nunez-Garcia, Ambarish Pandey, Pauline K Park, Rachael L Parke, Jane C Parker, Sam Parnia, Jonathan D Paul, Yessica S Pérez González, Mauricio Pompilio, Matthew E Prekker, John G Quigley, Natalia S Rost, Kathryn Rowan, Fernanda O Santos, Marlene Santos, Mayler Olombrada Santos, Lewis Satterwhite, Christina T Saunders, Roger E G Schutgens, Christopher W Seymour, Deborah M Siegal, Delcio G Silva, Manu Shankar-Hari, John P Sheehan, Aneesh B Singhal, Dayna Solvason, Simon J Stanworth, Tobias Tritschler, Anne M Turner, Wilma van Bentum-Puijk, Frank L van de Veerdonk, Sean van Diepen, Gloria Vazquez-Grande, Lana Wahid, Vanessa Wareham, Bryan J Wells, R Jay Widmer, Jennifer G Wilson, Eugene Yuriditsky, Fernando G Zampieri, Derek C Angus, Colin J McArthur, Steven A Webb, Michael E Farkouh, Judith S Hochman, Ryan Zarychanski,

<h4>Background</h4>Thrombosis and inflammation may contribute to the risk of death and complications among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation may improve outcomes in noncritically ill patients who are hospitalized with Covid-19.<h4>Methods</h4>In this open-label, adaptive, multiplatform, controlled trial, we randomly assigned patients who were hospitalized with ... Read more >>

N Engl J Med (The New England journal of medicine)
[2021, 385(9):790-802]

Cited: 17 times

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Helmet non-invasive ventilation compared to facemask non-invasive ventilation and high flow nasal cannula in acute respiratory failure: a systematic review and meta-analysis.

Dipayan Chaudhuri, Rehman Jinah, Karen E A Burns, Federico Angriman, Bruno Ferreyro, Laveena Munshi, Ewan Goligher, Damon Scales, Deborah J Cook, Tommaso Mauri, Bram Rochwerg,

<h4>Background</h4>Although small randomised controlled trials (RCTs) and observational studies have examined helmet non-invasive ventilation (NIV), uncertainty remains regarding its role. We conducted a systematic review and meta-analysis to examine the effect of helmet NIV compared to facemask NIV or high flow nasal cannula (HFNC) in acute respiratory failure.<h4>Methods</h4>We searched multiple ... Read more >>

Eur Respir J (The European respiratory journal)
[2021, :]

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Moral Distress and Other Wellness Measures in Canadian Critical Care Physicians.

Peter M Dodek, Elaine O Cheung, Karen E A Burns, Claudio M Martin, Patrick M Archambault, Francois Lauzier, Aimee J Sarti, Sangeeta Mehta, Alison E Fox-Robichaud, Andrew J E Seely, Christopher Parshuram, Daniel Garros, Davinia E Withington, Deborah J Cook, Dominique Piquette, Franco A Carnevale, J Gordon Boyd, James Downar, D James Kutsogiannis, Michael Chassé, Patricia Fontela, Robert A Fowler, Sean Bagshaw, Sonny Dhanani, Srinivas Murthy, Paige Gehrke, Tomoko Fujii,

<b>Rationale:</b> Understanding the magnitude of moral distress and its associations may point to solutions. <b>Objectives:</b> To understand the magnitude of moral distress and other measures of wellness in Canadian critical care physicians, to determine any associations among these measures, and to identify potentially modifiable factors. <b>Methods:</b> This was an online ... Read more >>

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2021, 18(8):1343-1351]

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Diversity of Authors of Publications From the Canadian Critical Care Trials Group.

Sangeeta Mehta, Nanki Ahluwalia, Kiyan Heybati, Karen E A Burns, Sawayra Owais, Deborah J Cook, ,

<h4>Objectives</h4>Diverse perspectives improve the quality of scholarly initiatives. The demographic and professional diversity of scientists who contribute to critical care research and publications has not been described for the Canadian Critical Care Trials Group. Our objective was to describe the diversity of authors of publications from the Canadian Critical Care ... Read more >>

Crit Care Med (Critical care medicine)
[2021, :]

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Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19.

, , , Ewan C Goligher, Charlotte A Bradbury, Bryan J McVerry, Patrick R Lawler, Jeffrey S Berger, Michelle N Gong, Marc Carrier, Harmony R Reynolds, Anand Kumar, Alexis F Turgeon, Lucy Z Kornblith, Susan R Kahn, John C Marshall, Keri S Kim, Brett L Houston, Lennie P G Derde, Mary Cushman, Tobias Tritschler, Derek C Angus, Lucas C Godoy, Zoe McQuilten, Bridget-Anne Kirwan, Michael E Farkouh, Maria M Brooks, Roger J Lewis, Lindsay R Berry, Elizabeth Lorenzi, Anthony C Gordon, Tania Ahuja, Farah Al-Beidh, Djillali Annane, Yaseen M Arabi, Diptesh Aryal, Lisa Baumann Kreuziger, Abi Beane, Zahra Bhimani, Shailesh Bihari, Henny H Billett, Lindsay Bond, Marc Bonten, Frank Brunkhorst, Meredith Buxton, Adrian Buzgau, Lana A Castellucci, Sweta Chekuri, Jen-Ting Chen, Allen C Cheng, Tamta Chkhikvadze, Benjamin Coiffard, Aira Contreras, Todd W Costantini, Sophie de Brouwer, Michelle A Detry, Abhijit Duggal, Vladimír Džavík, Mark B Effron, Heather F Eng, Jorge Escobedo, Lise J Estcourt, Brendan M Everett, Dean A Fergusson, Mark Fitzgerald, Robert A Fowler, Joshua D Froess, Zhuxuan Fu, Jean P Galanaud, Benjamin T Galen, Sheetal Gandotra, Timothy D Girard, Andrew L Goodman, Herman Goossens, Cameron Green, Yonatan Y Greenstein, Peter L Gross, Rashan Haniffa, Sheila M Hegde, Carolyn M Hendrickson, Alisa M Higgins, Alexander A Hindenburg, Aluko A Hope, James M Horowitz, Christopher M Horvat, David T Huang, Kristin Hudock, Beverley J Hunt, Mansoor Husain, Robert C Hyzy, Jeffrey R Jacobson, Devachandran Jayakumar, Norma M Keller, Akram Khan, Yuri Kim, Andrei Kindzelski, Andrew J King, M Margaret Knudson, Aaron E Kornblith, Matthew E Kutcher, Michael A Laffan, Francois Lamontagne, Grégoire Le Gal, Christine M Leeper, Eric S Leifer, George Lim, Felipe Gallego Lima, Kelsey Linstrum, Edward Litton, Jose Lopez-Sendon, Sylvain A Lother, Nicole Marten, Andréa Saud Marinez, Mary Martinez, Eduardo Mateos Garcia, Stavroula Mavromichalis, Daniel F McAuley, Emily G McDonald, Anna McGlothlin, Shay P McGuinness, Saskia Middeldorp, Stephanie K Montgomery, Paul R Mouncey, Srinivas Murthy, Girish B Nair, Rahul Nair, Alistair D Nichol, Jose C Nicolau, Brenda Nunez-Garcia, John J Park, Pauline K Park, Rachael L Parke, Jane C Parker, Sam Parnia, Jonathan D Paul, Mauricio Pompilio, John G Quigley, Robert S Rosenson, Natalia S Rost, Kathryn Rowan, Fernanda O Santos, Marlene Santos, Mayler O Santos, Lewis Satterwhite, Christina T Saunders, Jake Schreiber, Roger E G Schutgens, Christopher W Seymour, Deborah M Siegal, Delcio G Silva, Aneesh B Singhal, Arthur S Slutsky, Dayna Solvason, Simon J Stanworth, Anne M Turner, Wilma van Bentum-Puijk, Frank L van de Veerdonk, Sean van Diepen, Gloria Vazquez-Grande, Lana Wahid, Vanessa Wareham, R Jay Widmer, Jennifer G Wilson, Eugene Yuriditsky, Yongqi Zhong, Scott M Berry, Colin J McArthur, Matthew D Neal, Judith S Hochman, Steven A Webb, Ryan Zarychanski,

<h4>Background</h4>Thrombosis and inflammation may contribute to morbidity and mortality among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation would improve outcomes in critically ill patients with Covid-19.<h4>Methods</h4>In an open-label, adaptive, multiplatform, randomized clinical trial, critically ill patients with severe Covid-19 were randomly assigned to a pragmatically defined ... Read more >>

N Engl J Med (The New England journal of medicine)
[2021, 385(9):777-789]

Cited: 23 times

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Community implementation of the 3 Wishes Project: an observational study of a compassionate end-of-life care initiative for critically ill patients.

Brenda K Reeve, Brittany B Dennis, William Dechert, Barbara Longo, Diane Heels-Ansdell, Alison Scholes, France J Clarke, John R K Arthur, Deborah J Cook,

<h4>Background</h4>The 3 Wishes Project (3WP) promotes a personalized dying experience by eliciting and facilitating individualized terminal wishes for patients, families and the clinicians caring for them. We aimed to evaluate the adaptability of the 3WP to a community intensive care unit (ICU), and to describe the patients cared for with ... Read more >>

CMAJ Open (CMAJ open)
[2021, 9(3):E757-E764]

Cited: 0 times

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Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial.

Yaseen M Arabi, Anthony C Gordon, Lennie P G Derde, Alistair D Nichol, Srinivas Murthy, Farah Al Beidh, Djillali Annane, Lolowa Al Swaidan, Abi Beane, Richard Beasley, Lindsay R Berry, Zahra Bhimani, Marc J M Bonten, Charlotte A Bradbury, Frank M Brunkhorst, Meredith Buxton, Adrian Buzgau, Allen Cheng, Menno De Jong, Michelle A Detry, Eamon J Duffy, Lise J Estcourt, Mark Fitzgerald, Rob Fowler, Timothy D Girard, Ewan C Goligher, Herman Goossens, Rashan Haniffa, Alisa M Higgins, Thomas E Hills, Christopher M Horvat, David T Huang, Andrew J King, Francois Lamontagne, Patrick R Lawler, Roger Lewis, Kelsey Linstrum, Edward Litton, Elizabeth Lorenzi, Salim Malakouti, Daniel F McAuley, Anna McGlothlin, Shay Mcguinness, Bryan J McVerry, Stephanie K Montgomery, Susan C Morpeth, Paul R Mouncey, Katrina Orr, Rachael Parke, Jane C Parker, Asad E Patanwala, Kathryn M Rowan, Marlene S Santos, Christina T Saunders, Christopher W Seymour, Manu Shankar-Hari, Steven Y C Tong, Alexis F Turgeon, Anne M Turner, Frank Leo Van de Veerdonk, Ryan Zarychanski, Cameron Green, Scott Berry, John C Marshall, Colin McArthur, Derek C Angus, Steven A Webb, ,

<h4>Purpose</h4>To study the efficacy of lopinavir-ritonavir and hydroxychloroquine in critically ill patients with coronavirus disease 2019 (COVID-19).<h4>Methods</h4>Critically ill adults with COVID-19 were randomized to receive lopinavir-ritonavir, hydroxychloroquine, combination therapy of lopinavir-ritonavir and hydroxychloroquine or no antiviral therapy (control). The primary endpoint was an ordinal scale of organ support-free days. Analyses ... Read more >>

Intensive Care Med (Intensive care medicine)
[2021, 47(8):867-886]

Cited: 2 times

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Evolution Over Time of Ventilatory Management and Outcome of Patients With Neurologic Disease.

Eva E Tejerina, Paolo Pelosi, Chiara Robba, Oscar Peñuelas, Alfonso Muriel, Deisy Barrios, Fernando Frutos-Vivar, Konstantinos Raymondos, Bin Du, Arnaud W Thille, Fernando Ríos, Marco González, Lorenzo Del-Sorbo, Maria Del Carmen Marín, Bruno Valle Pinheiro, Marco Antonio Soares, Nicolas Nin, Salvatore M Maggiore, Andrew Bersten, Pravin Amin, Nahit Cakar, Gee Young Suh, Fekri Abroug, Manuel Jibaja, Dimitros Matamis, Amine Ali Zeggwagh, Yuda Sutherasan, Antonio Anzueto, Andrés Esteban, ,

<h4>Objectives</h4>To describe the changes in ventilator management over time in patients with neurologic disease at ICU admission and to estimate factors associated with 28-day hospital mortality.<h4>Design</h4>Secondary analysis of three prospective, observational, multicenter studies.<h4>Setting</h4>Cohort studies conducted in 2004, 2010, and 2016.<h4>Patients</h4>Adult patients who received mechanical ventilation for more than 12 hours.<h4>Interventions</h4>None.<h4>Measurements ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(7):1095-1106]

Cited: 0 times

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An environmental scan of visitation policies in Canadian intensive care units during the first wave of the COVID-19 pandemic.

Kirsten M Fiest, Karla D Krewulak, Carmen Hiploylee, Sean M Bagshaw, Karen E A Burns, Deborah J Cook, Robert A Fowler, Maia S Kredentser, Daniel J Niven, Kendiss Olafson, Ken Kuljit S Parhar, Scott B Patten, Alison E Fox-Robichaud, Oleksa G Rewa, Bram Rochwerg, Krista L Spence, Sharon E Straus, Sean Spence, Andrew West, Henry T Stelfox, Jeanna Parsons Leigh, ,

<h4>Purpose</h4>In response to the rapid spread of SARS-CoV-2, hospitals in Canada enacted temporary visitor restrictions to limit the spread of COVID-19 and preserve personal protective equipment supplies. This study describes the extent, variation, and fluctuation of Canadian adult intensive care unit (ICU) visitation policies before and during the first wave ... Read more >>

Can J Anaesth (Canadian journal of anaesthesia = Journal canadien d'anesthesie)
[2021, 68(10):1474-1484]

Cited: 0 times

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Bereavement interventions to support informal caregivers in the intensive care unit: a systematic review.

Stephana J Moss, Krista Wollny, Therese G Poulin, Deborah J Cook, Henry T Stelfox, Amanda Roze des Ordons, Kirsten M Fiest,

<h4>Background</h4>Informal caregivers of critically ill patients in intensive care unit (ICUs) experience negative psychological sequelae that worsen after death. We synthesized outcomes reported from ICU bereavement interventions intended to improve informal caregivers' ability to cope with grief.<h4>Data sources</h4>MEDLINE, EMBASE, CINAHL and PsycINFO from inception to October 2020.<h4>Study selection</h4>Randomized controlled trials ... Read more >>

BMC Palliat Care (BMC palliative care)
[2021, 20(1):66]

Cited: 0 times

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Suicide and self-harm in adult survivors of critical illness: population based cohort study.

Shannon M Fernando, Danial Qureshi, Manish M Sood, Michael Pugliese, Robert Talarico, Daniel T Myran, Margaret S Herridge, Dale M Needham, Bram Rochwerg, Deborah J Cook, Hannah Wunsch, Robert A Fowler, Damon C Scales, O Joseph Bienvenu, Kathryn M Rowan, Magdalena Kisilewicz, Laura H Thompson, Peter Tanuseputro, Kwadwo Kyeremanteng,

<h4>Objective</h4>To analyse the association between survival from critical illness and suicide or self-harm after hospital discharge.<h4>Design</h4>Population based cohort study using linked and validated provincial databases.<h4>Setting</h4>Ontario, Canada between January 2009 and December 2017 (inclusive).<h4>Participants</h4>Consecutive adult intensive care unit (ICU) survivors (≥18 years) were included. Linked administrative databases were used to compare ... Read more >>

BMJ (BMJ (Clinical research ed.))
[2021, 373:n973]

Cited: 0 times

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Health-Related Quality-of-Life and Cost Utility Analyses in Critical Care: A Systematic Review.

Vincent I Lau, Feng Xie, John Basmaji, Deborah J Cook, Robert Fowler, Michel Kiflen, Emily Sirotich, Alla Iansavichene, Sean M Bagshaw, M Elizabeth Wilcox, François Lamontagne, Niall Ferguson, Bram Rochwerg,

<h4>Objectives</h4>Cost utility analyses compare the costs and health outcome of interventions, with a denominator of quality-adjusted life year, a generic health utility measure combining both quality and quantity of life. Cost utility analyses are difficult to compare when methods are not standardized. It is unclear how cost utility analyses are ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(4):575-588]

Cited: 0 times

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Scale-up and sustainability of a personalized end-of-life care intervention: a longitudinal mixed-methods study.

Alyson Takaoka, Benjamin Tam, Meredith Vanstone, France J Clarke, Neala Hoad, Marilyn Swinton, Feli Toledo, Anne Boyle, Anne Woods, Erick H Duan, Diane Heels-Ansdell, Lily Waugh, Mark Soth, Jill Rudkowski, Waleed Alhazzani, Dan Perri, Tania Ligori, Roman Jaeschke, Nicole Zytaruk, Deborah J Cook,

<h4>Background</h4>Scaling-up and sustaining healthcare interventions can be challenging. Our objective was to describe how the 3 Wishes Project (3WP), a personalized end-of-life intervention, was scaled-up and sustained in an intensive care unit (ICU).<h4>Methods</h4>In a longitudinal mixed-methods study from January 12,013 - December 31, 2018, dying patients and families were invited ... Read more >>

BMC Health Serv Res (BMC health services research)
[2021, 21(1):218]

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Ventilator Weaning and Discontinuation Practices for Critically Ill Patients.

Karen E A Burns, Leena Rizvi, Deborah J Cook, Gerald Lebovic, Peter Dodek, Jesús Villar, Arthur S Slutsky, Andrew Jones, Farhad N Kapadia, David J Gattas, Scott K Epstein, Paolo Pelosi, Kallirroi Kefala, Maureen O Meade, ,

<h4>Importance</h4>Although most critically ill patients receive invasive mechanical ventilation (IMV), few studies have characterized how IMV is discontinued in practice.<h4>Objective</h4>To describe practice variation in IMV discontinuation internationally, associations between initial discontinuation events and outcomes, and factors associated with the use of select discontinuation strategies and failed initial spontaneous breathing trials ... Read more >>

JAMA (JAMA)
[2021, 325(12):1173-1184]

Cited: 1 time

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