Full Text Journal Articles by
Author Debora Salerno

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Hepatitis B protein HBx binds the DLEU2 lncRNA to sustain cccDNA and host cancer-related gene transcription.

Debora Salerno, Letizia Chiodo, Vincenzo Alfano, Oceane Floriot, Grazia Cottone, Alexia Paturel, Matteo Pallocca, Marie-Laure Plissonnier, Safaa Jeddari, Laura Belloni, Mirjam Zeisel, Massimo Levrero, Francesca Guerrieri,

OBJECTIVE:The HBV HBx regulatory protein is required for transcription from the covalently closed circular DNA (cccDNA) minichromosome and affects the epigenetic control of both viral and host cellular chromatin. DESIGN:We explored, in relevant cellular models of HBV replication, the functional consequences of HBx interaction with DLEU2, a long non-coding RNA ... Read more >>

Gut (Gut)
[2020, :]

Cited: 0 times

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Inducing and Characterizing Vesicular Steatosis in Differentiated HepaRG Cells.

Silvia Di Cocco, Laura Belloni, Abigail D G Nunn, Debora Salerno, Silvia Piconese, Massimo Levrero, Natalia Pediconi,

Hepatic steatosis represents a metabolic dysfunction that results from an accumulation of triglyceride-containing lipid droplets in hepatocytes. Excessive fat accumulation leads to non-alcoholic fatty liver disease (NAFLD),  which is potentially reversible and may evolve into non-alcoholic steatohepatitis (NASH) and eventually cirrhosis and hepatocellular carcinoma (HCC). The molecular mechanisms linking lipid ... Read more >>

J Vis Exp (Journal of visualized experiments : JoVE)
[2019, (149):]

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EZH2, JMJD3, and UTX epigenetically regulate hepatic plasticity inducing retro-differentiation and proliferation of liver cells.

Natalia Pediconi, Debora Salerno, Leonardo Lupacchini, Annapaola Angrisani, Giovanna Peruzzi, Enrico De Smaele, Massimo Levrero, Laura Belloni,

Modification of histones by lysine methylation plays a role in many biological processes, and it is dynamically regulated by several histone methyltransferases and demethylases. The polycomb repressive complex contains the H3K27 methyltransferase EZH2 and controls dimethylation and trimethylation of H3K27 (H3K27me2/3), which trigger gene suppression. JMJD3 and UTX have been ... Read more >>

Cell Death Dis (Cell death & disease)
[2019, 10(7):518]

Cited: 2 times

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Targeting a phospho-STAT3-miRNAs pathway improves vesicular hepatic steatosis in an in vitro and in vivo model.

Laura Belloni, Silvia Di Cocco, Francesca Guerrieri, Abigail D G Nunn, Silvia Piconese, Debora Salerno, Barbara Testoni, Claudio Pulito, Federica Mori, Matteo Pallocca, Andrea Sacconi, Elisa Vivoli, Fabio Marra, Sabrina Strano, Giovanni Blandino, Massimo Levrero, Natalia Pediconi,

Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease. Although genetic predisposition and epigenetic factors contribute to the development of NAFLD, our understanding of the molecular mechanism involved in the pathogenesis of the disease is still emerging. Here we investigated a possible role of a microRNAs-STAT3 ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):13638]

Cited: 2 times

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Impaired IFN-α-mediated signal in dendritic cells differentiates active from latent tuberculosis.

Stefania Parlato, Teresa Chiacchio, Debora Salerno, Linda Petrone, Luciano Castiello, Giulia Romagnoli, Irene Canini, Delia Goletti, Lucia Gabriele,

Individuals exposed to Mycobacterium tuberculosis (Mtb) may be infected and remain for the entire life in this condition defined as latent tuberculosis infection (LTBI) or develop active tuberculosis (TB). Among the multiple factors governing the outcome of the infection, dendritic cells (DCs) play a major role in dictating antibacterial immunity. ... Read more >>

PLoS ONE (PloS one)
[2018, 13(1):e0189477]

Cited: 5 times

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3D Microfluidic model for evaluating immunotherapy efficacy by tracking dendritic cell behaviour toward tumor cells.

Stefania Parlato, Adele De Ninno, Rosa Molfetta, Elena Toschi, Debora Salerno, Arianna Mencattini, Giulia Romagnoli, Alessandra Fragale, Lorenzo Roccazzello, Maria Buoncervello, Irene Canini, Enrico Bentivegna, Mario Falchi, Francesca Romana Bertani, Annamaria Gerardino, Eugenio Martinelli, Corrado Natale, Rossella Paolini, Luca Businaro, Lucia Gabriele,

Immunotherapy efficacy relies on the crosstalk within the tumor microenvironment between cancer and dendritic cells (DCs) resulting in the induction of a potent and effective antitumor response. DCs have the specific role of recognizing cancer cells, taking up tumor antigens (Ags) and then migrating to lymph nodes for Ag (cross)-presentation ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):1093]

Cited: 22 times

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Correction: IL6 Inhibits HBV Transcription by Targeting the Epigenetic Control of the Nuclear cccDNA Minichromosome.

Gianna Aurora Palumbo, Cecilia Scisciani, Natalia Pediconi, Leonardo Lupacchini, Dulce Alfaiate, Francesca Guerrieri, Ludovica Calvo, Debora Salerno, Silvia Di Cocco, Massimo Levrero, Laura Belloni,

PLoS ONE (PloS one)
[2015, 10(12):e0145555]

Cited: 0 times

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Sir2 is involved in the transcriptional modulation of NHP6A in Saccharomyces cerevisiae.

Ambra Ciuffetta, Debora Salerno, Giorgio Camilloni, Sabrina Venditti,

The Sir proteins, namely Sir2, 3 and 4, have roles related to heterochromatin, but genome-wide studies have revealed their presence at many euchromatic loci, although the functional meaning of this is still not clear. Nhp6a is an abundant HMG-like protein in yeast, which has a role in transcription by modulating ... Read more >>

Biochem. Biophys. Res. Commun. (Biochemical and biophysical research communications)
[2015, 461(1):42-46]

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IFN-α regulates Blimp-1 expression via miR-23a and miR-125b in both monocytes-derived DC and pDC.

Stefania Parlato, Roberto Bruni, Paola Fragapane, Debora Salerno, Cinzia Marcantonio, Paola Borghi, Paola Tataseo, Anna Rita Ciccaglione, Carlo Presutti, Giulia Romagnoli, Irene Bozzoni, Filippo Belardelli, Lucia Gabriele,

Type I interferon (IFN-I) have emerged as crucial mediators of cellular signals controlling DC differentiation and function. Human DC differentiated from monocytes in the presence of IFN-α (IFN-α DC) show a partially mature phenotype and a special capability of stimulating CD4+ T cell and cross-priming CD8+ T cells. Likewise, plasmacytoid ... Read more >>

PLoS ONE (PloS one)
[2013, 8(8):e72833]

Cited: 15 times

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