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Author Deanna L Benson

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Non-Motor Symptoms of Parkinson's Disease: The Neurobiology of Early Psychiatric and Cognitive Dysfunction.

Ayan Hussein, Christopher A Guevara, Pamela Del Valle, Swati Gupta, Deanna L Benson, George W Huntley,

Parkinson's disease (PD) is a progressive neurodegenerative disorder that has been recognized for over 200 years by its clinically dominant motor system impairment. There are prominent non-motor symptoms as well, and among these, psychiatric symptoms of depression and anxiety and cognitive impairment are common and can appear earlier than motor ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :10738584211011979]

Cited: 0 times

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Mitochondrial localization and moderated activity are key to murine erythroid enucleation.

Raymond Liang, Vijay Menon, Jiajing Qiu, Tasleem Arif, Santosh Renuse, Miao Lin, Roberta Nowak, Boris Hartmann, Nikos Tzavaras, Deanna L Benson, Jerry E Chipuk, Miguel Fribourg, Akhilesh Pandey, Velia Fowler, Saghi Ghaffari,

Mammalian red blood cells (RBCs), which primarily contain hemoglobin, exemplify an elaborate maturation process, with the terminal steps of RBC generation involving extensive cellular remodeling. This encompasses alterations of cellular content through distinct stages of erythroblast maturation that result in the expulsion of the nucleus (enucleation) followed by the loss ... Read more >>

Blood Adv (Blood advances)
[2021, 5(10):2490-2504]

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LRRK2 mutation alters behavioral, synaptic, and nonsynaptic adaptations to acute social stress.

Christopher A Guevara, Bridget A Matikainen-Ankney, Nebojsa Kezunovic, Katherine LeClair, Alexander P Conway, Caroline Menard, Meghan E Flanigan, Madeline Pfau, Scott J Russo, Deanna L Benson, George W Huntley,

Parkinson's disease (PD) risk is increased by stress and certain gene mutations, including the most prevalent PD-linked mutation <i>LRRK2</i>-G2019S. Both PD and stress increase risk for psychiatric symptoms, yet it is unclear how PD-risk genes alter neural circuitry in response to stress that may promote psychopathology. Here we show significant ... Read more >>

J Neurophysiol (Journal of neurophysiology)
[2020, 123(6):2382-2389]

Cited: 3 times

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Origins of Parkinson's Disease in Brain Development: Insights From Early and Persistent Effects of LRRK2-G2019S on Striatal Circuits.

George W Huntley, Deanna L Benson,

Late-onset Parkinson's disease (PD) is dominated clinically and experimentally by a focus on dopamine neuron degeneration and ensuing motor system abnormalities. There are, additionally, a number of non-motor symptoms - including cognitive and psychiatric - that can appear much earlier in the course of the disease and also significantly impair ... Read more >>

Front Neurosci (Frontiers in neuroscience)
[2020, 14:265]

Cited: 1 time

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Cyfip1 Regulates SynGAP1 at Hippocampal Synapses.

Abhishek Sahasrabudhe, Fatema Begum, Christopher A Guevara, Chenel Morrison, Kuangfu Hsiao, Nebojsa Kezunovic, Ozlem Bozdagi-Gunal, Deanna L Benson,

In humans, copy number variations in <i>CYFIP1</i> appear to have sweeping physiological and structural consequences in the brain, either producing or altering the severity of intellectual disability, autism, and schizophrenia. Independently, <i>SynGAP1</i> haploinsufficiency produces intellectual disability and, frequently, autism. Cyfip1 inhibits protein translation and promotes actin polymerization, and SynGAP1 is ... Read more >>

Front Synaptic Neurosci (Frontiers in synaptic neuroscience)
[2020, 12:581714]

Cited: 1 time

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Are we listening to everything the PARK genes are telling us?

Deanna L Benson, George W Huntley,

The cardinal motor symptoms that define Parkinson's disease (PD) clinically have been recognized for over 200 years. That these symptoms arise following the loss of dopamine neurons in the substantia nigra has been known for the last 50. These long-established facts have fueled a broadly held expectation that degenerating dopaminergic neurons ... Read more >>

J Comp Neurol (The Journal of comparative neurology)
[2019, 527(9):1527-1540]

Cited: 2 times

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Functional and behavioral consequences of Parkinson's disease-associated LRRK2-G2019S mutation.

Deanna L Benson, Bridget A Matikainen-Ankney, Ayan Hussein, George W Huntley,

<i>LRRK2</i> mutation is the most common inherited, autosomal dominant cause of Parkinson's disease (PD) and has also been observed in sporadic cases. Most mutations result in increased LRRK2 kinase activity. LRRK2 is highly expressed in brain regions that receive dense, convergent innervation by dopaminergic and glutamatergic axons, and its levels ... Read more >>

Biochem Soc Trans (Biochemical Society transactions)
[2018, 46(6):1697-1705]

Cited: 4 times

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Parkinson's Disease-Linked LRRK2-G2019S Mutation Alters Synaptic Plasticity and Promotes Resilience to Chronic Social Stress in Young Adulthood.

Bridget A Matikainen-Ankney, Nebojsa Kezunovic, Caroline Menard, Meghan E Flanigan, Yue Zhong, Scott J Russo, Deanna L Benson, George W Huntley,

The G2019S mutation in leucine-rich repeat kinase 2 (<i>LRRK2</i>) is a prevalent cause of late-onset Parkinson's disease, producing psychiatric and motor symptoms, including depression, that are indistinguishable from sporadic cases. Here we tested how this mutation impacts depression-related behaviors and associated synaptic responses and plasticity in mice expressing a <i>Lrrk2</i>-G2019S ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2018, 38(45):9700-9711]

Cited: 15 times

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Quantitative Whole-mount Immunofluorescence Analysis of Cardiac Progenitor Populations in Mouse Embryos.

Evan Bardot, Nikos Tzavaras, Deanna L Benson, Nicole C Dubois,

The use of ever-advancing imaging techniques has contributed broadly to our increased understanding of embryonic development. Pre-implantation development and organogenesis are two areas of research that have benefitted greatly from these advances, due to the high quality of data that can be obtained directly from imaging pre-implantation embryos or ex ... Read more >>

J Vis Exp (Journal of visualized experiments : JoVE)
[2017, (128):]

Cited: 0 times

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Visualizing and Characterizing Semaphorin Endocytic Events Using Quantum Dot-Conjugated Proteins.

Ioana Carcea, Deanna L Benson,

Neurons can endocytose soluble semaphorins to either initiate or interrupt signaling at the cell membrane. Depending on the cell type and even on the specific subcellular domain, the endocytic process will differ in intensity, speed, and modality, and will subsequently facilitate diverse actions of semaphorin molecules. Therefore, in order to ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2017, 1493:277-286]

Cited: 0 times

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Altered Development of Synapse Structure and Function in Striatum Caused by Parkinson's Disease-Linked LRRK2-G2019S Mutation.

Bridget A Matikainen-Ankney, Nebojsa Kezunovic, Roxana E Mesias, Yuan Tian, Frances M Williams, George W Huntley, Deanna L Benson,

<h4>Unlabelled</h4>Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) can cause Parkinson's disease (PD), and the most common disease-associated mutation, G2019S, increases kinase activity. Because LRRK2 expression levels rise during synaptogenesis and are highest in dorsal striatal spiny projection neurons (SPNs), we tested the hypothesis that the LRRK2-G2019S mutation ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2016, 36(27):7128-7141]

Cited: 39 times

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Erratum. The granin VGF promotes genesis of secretory vesicles, and regulates circulating catecholamine levels and blood pressure.

Samira Fargali, Angelo L Garcia, Masato Sadahiro, Cheng Jiang, William G Janssen, Wei-Jye Lin, Valeria Cogliani, Alice Elste, Steven Mortillo, Cheryl Cero, Britta Veitenheimer, Gallia Graiani, Giulio M Pasinetti, Sushil K Mahata, John W Osborn, George W Huntley, Greg R Phillips, Deanna L Benson, Alessandro Bartolomucci, Stephen R Salton,

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2015, 29(6):2679]

Cited: 0 times

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Maturation of cortical circuits requires Semaphorin 7A.

Ioana Carcea, Shekhar B Patil, Alfred J Robison, Roxana Mesias, Molly M Huntsman, Robert C Froemke, Joseph D Buxbaum, George W Huntley, Deanna L Benson,

Abnormal cortical circuits underlie some cognitive and psychiatric disorders, yet the molecular signals that generate normal cortical networks remain poorly understood. Semaphorin 7A (Sema7A) is an atypical member of the semaphorin family that is GPI-linked, expressed principally postnatally, and enriched in sensory cortex. Significantly, SEMA7A is deleted in individuals with ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2014, 111(38):13978-13983]

Cited: 13 times

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Role for NUP62 depletion and PYK2 redistribution in dendritic retraction resulting from chronic stress.

Yayoi Kinoshita, Richard G Hunter, Jason D Gray, Roxana Mesias, Bruce S McEwen, Deanna L Benson, D Stave Kohtz,

Genetic evidence suggests cell-type-specific functions for certain nucleoporins, and gene expression profiling has revealed that nucleoporin p62 (NUP62) transcripts are decreased in the prefrontal cortex of major depressives. Chronic stress, which can precipitate depression, induces changes in the architecture and plasticity of apical dendrites that are particularly evident in the ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2014, 111(45):16130-16135]

Cited: 16 times

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Axonal cap-dependent translation regulates presynaptic p35.

Kuangfu Hsiao, Ozlem Bozdagi, Deanna L Benson,

Axonal growth cones synthesize proteins during development and in response to injury in adult animals. Proteins locally translated in axons are used to generate appropriate responses to guidance cues, contribute to axon growth, and can serve as retrograde messengers. In addition to growth cones, mRNAs and translational machinery are also ... Read more >>

Dev Neurobiol (Developmental neurobiology)
[2014, 74(3):351-364]

Cited: 9 times

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N-cadherin regulates molecular organization of excitatory and inhibitory synaptic circuits in adult hippocampus in vivo.

Jessica S Nikitczuk, Shekhar B Patil, Bridget A Matikainen-Ankney, Joseph Scarpa, Matthew L Shapiro, Deanna L Benson, George W Huntley,

N-Cadherin and β-catenin form a transsynaptic adhesion complex required for spine and synapse development. In adulthood, N-cadherin mediates persistent synaptic plasticity, but whether the role of N-cadherin at mature synapses is similar to that at developing synapses is unclear. To address this, we conditionally ablated N-cadherin from excitatory forebrain synapses ... Read more >>

Hippocampus (Hippocampus)
[2014, 24(8):943-962]

Cited: 22 times

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Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies.

Paul Davies, Kelly M Hinkle, Nour N Sukar, Bryan Sepulveda, Roxana Mesias, Geidy Serrano, Dario R Alessi, Thomas G Beach, Deanna L Benson, Charles L White, Rita M Cowell, Sonal S Das, Andrew B West, Heather L Melrose,

Missense mutations in LRRK2 (leucine-rich repeat kinase 2) are a major cause of PD (Parkinson's disease). Several antibodies against LRRK2 have been developed, but results using these polyclonal antibodies have varied widely leading to conflicting conclusions. To address this challenge, the Michael J. Fox Foundation for Parkinson's Research generated a ... Read more >>

Biochem J (The Biochemical journal)
[2013, 453(1):101-113]

Cited: 51 times

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Short- and long-term effects of LRRK2 on axon and dendrite growth.

Bryan Sepulveda, Roxana Mesias, Xianting Li, Zhenyu Yue, Deanna L Benson,

Mutations in leucine-rich repeat kinase 2 (LRRK2) underlie an autosomal-dominant form of Parkinson's disease (PD) that is clinically indistinguishable from idiopathic PD. The function of LRRK2 is not well understood, but it has become widely accepted that LRRK2 levels or its kinase activity, which is increased by the most commonly ... Read more >>

PLoS One (PloS one)
[2013, 8(4):e61986]

Cited: 29 times

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Anesthetics interfere with axon guidance in developing mouse neocortical neurons in vitro via a γ-aminobutyric acid type A receptor mechanism.

C David Mintz, Kendall M S Barrett, Sarah C Smith, Deanna L Benson, Neil L Harrison,

<h4>Background</h4>The finding that exposure to general anesthetics (GAs) in childhood may increase rates of learning disabilities has raised a concern that anesthetics may interfere with brain development. The generation of neuronal circuits, a complex process in which axons follow guidance cues to dendritic targets, is an unexplored potential target for ... Read more >>

Anesthesiology (Anesthesiology)
[2013, 118(4):825-833]

Cited: 37 times

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Anesthetics interfere with the polarization of developing cortical neurons.

Cyrus David Mintz, Sarah C Smith, Kendall M S Barrett, Deanna L Benson,

Numerous studies from the clinical and preclinical literature indicate that general anesthetic agents have toxic effects on the developing brain, but the mechanism of this toxicity is still unknown. Previous studies have focused on the effects of anesthetics on cell survival, dendrite elaboration, and synapse formation, but little attention has ... Read more >>

J Neurosurg Anesthesiol (Journal of neurosurgical anesthesiology)
[2012, 24(4):368-375]

Cited: 24 times

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Synapse adhesion: a dynamic equilibrium conferring stability and flexibility.

Deanna L Benson, George W Huntley,

Cell adhesion molecules (CAMs) linked to cytoskeleton generate stable cell-cell junctions. Cadherins provide a canonical example, but paradoxically, they participate in a multitude of transient and regulatable interactions. Their extracellular binding generates weak adhesion that is modified by clustering; interactions with F-actin are regulated, can be transient, and can alter ... Read more >>

Curr Opin Neurobiol (Current opinion in neurobiology)
[2012, 22(3):397-404]

Cited: 28 times

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Flotillin-mediated endocytic events dictate cell type-specific responses to semaphorin 3A.

Ioana Carcea, Avi Ma'ayan, Roxana Mesias, Bryan Sepulveda, Stephen R Salton, Deanna L Benson,

Cortical efferents growing in the same environment diverge early in development. The expression of particular transcription factors dictates the trajectories taken, presumably by regulating responsiveness to guidance cues via cellular mechanisms that are not yet known. Here, we show that cortical neurons that are dissociated and grown in culture maintain ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2010, 30(45):15317-15329]

Cited: 32 times

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Building and remodeling synapses.

Deanna L Benson, George W Huntley,

Synaptic junctions are generated by adhesion proteins that bridge the synaptic cleft to firmly anchor pre- and postsynaptic membranes. Several cell adhesion molecule (CAM) families localize to synapses, but it is not yet completely understood how each synaptic CAM family contributes to synapse formation and/or structure, and whether or how ... Read more >>

Hippocampus (Hippocampus)
[2012, 22(5):954-968]

Cited: 15 times

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Requirement for protein synthesis at developing synapses.

Joseph Sebeo, Kuangfu Hsiao, Ozlem Bozdagi, Dani Dumitriu, Yongchao Ge, Qiang Zhou, Deanna L Benson,

Activity and protein synthesis act cooperatively to generate persistent changes in synaptic responses. This forms the basis for enduring memory in adults. Activity also shapes neural circuits developmentally, but whether protein synthesis plays a congruent function in this process is poorly understood. Here, we show that brief periods of global ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2009, 29(31):9778-9793]

Cited: 25 times

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ERM proteins regulate growth cone responses to Sema3A.

C David Mintz, Ioana Carcea, Daniel G McNickle, Tracey C Dickson, Yongchao Ge, Stephen R J Salton, Deanna L Benson,

Axonal growth cones initiate and sustain directed growth in response to cues in their environment. A variety of events such as receptor internalization, kinase activation, and actin rearrangement can be stimulated by guidance cues and are essential for mediating targeted growth cone behavior. Surprisingly little is known about how such ... Read more >>

J Comp Neurol (The Journal of comparative neurology)
[2008, 510(4):351-366]

Cited: 26 times

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