Full Text Journal Articles by
Author Dean A Fergusson

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Identifying sex-specific differences in the carotid revascularisation literature: findings from a scoping review.

Vignan Yogendrakumar, Michel Shamy, Brian Dewar, Dean A Fergusson, Dar Dowlatshahi, Candyce Hamel, Sophia Gocan, Mark Fedyk, Jean-Louis Mas, Peter Rothwell, Virginia Howard, Olena Bereznyakova, ,

<h4>Objective</h4>No systematic review of the literature has dedicated itself to looking at the management of symptomatic carotid stenosis in female patients. In this scoping review, we aimed to identify all randomised controlled trials (RCTs) that reported sex-specific outcomes for patients who underwent carotid revascularisation, and determine whether sufficient information is ... Read more >>

Stroke Vasc Neurol (Stroke and vascular neurology)
[2021, :]

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Performance Feedback May Not Improve Radical Prostatectomy Outcomes: The Surgical Report Card (SuRep) Study.

Ravi M Kumar, Dean A Fergusson, Luke T Lavallée, Ilias Cagiannos, Christopher Morash, Michael Horrigan, Ranjeeta Mallick, Dawn Stacey, Michael Fung-Kee Fung, David Sands, Rodney H Breau,

<h4>Introduction</h4>Oncologic, urinary, and sexual outcomes are important to patients receiving prostate cancer surgery. The objective of this study was to determine if providing surgical report cards (SuRep) to surgeons resulted in improved patient outcomes.<h4>Methods</h4>A prospective before-and-after study was conducted at The Ottawa Hospital. 422 consecutive patients undergoing radical prostatectomy were ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001764]

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Factors contributing to fidelity in a pilot trial of individualized resistant starches for pediatric inflammatory bowel disease: a fidelity study protocol.

Gisell Castillo, David R Mack, Manoj M Lalu, Ruth Singleton, Dean A Fergusson, Alain Stintzi, Megan Harrison, Justin Presseau,

<h4>Background</h4>The consumption of resistant starches is a promising adjuvant therapy for patients with inflammatory bowel disease. Rigorous evaluation of resistant starches in this setting depends on the intervention being delivered, received, and enacted as intended, that is, with fidelity. As part of a planned pilot trial, participants will be randomized ... Read more >>

Pilot Feasibility Stud (Pilot and feasibility studies)
[2021, 7(1):75]

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Navigating choice in the face of uncertainty: using a theory informed qualitative approach to identifying potential patient barriers and enablers to participating in an early phase chimeric antigen receptor T (CAR-T) cell therapy trial.

Gisell Castillo, Manoj M Lalu, Sarah Asad, Madison Foster, Natasha Kekre, Dean A Fergusson, Terry Hawrysh, Harold Atkins, Kednapa Thavorn, Joshua Montroy, Stuart Schwartz, Robert A Holt, Raewyn Broady, Justin Presseau,

<h4>Objectives</h4>Bench to bedside translation of groundbreaking treatments like chimeric antigen receptor T (CAR-T) cell therapy depends on patient participation in early phase trials. Unfortunately, many novel therapies fail to be adequately evaluated due to low recruitment rates, which slows patient access to emerging treatments. Using the Theoretical Domains Framework (TDF), ... Read more >>

BMJ Open (BMJ open)
[2021, 11(3):e043929]

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Effects of implementing Pressure Ulcer Prevention Practice Guidelines (PUPPG) in the prevention of pressure ulcers among hospitalised elderly patients: a systematic review protocol.

Amos Wung Buh, Hassan Mahmoud, Wenjun Chen, Matthew D F McInnes, Dean A Fergusson,

<h4>Introduction</h4>Pressure ulcers are serious and potentially life-threatening problems across all age groups and across all medical specialties and care settings. The hospitalised elderly population is the most common group to develop pressure ulcers. This study aims to systematically review studies implementing pressure ulcer prevention strategies recommended in the Pressure Ulcer ... Read more >>

BMJ Open (BMJ open)
[2021, 11(3):e043042]

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Variation in prophylactic tranexamic acid administration among anesthesiologists and surgeons in orthopedic surgery: a retrospective cohort study.

Brett L Houston, Dean A Fergusson, Jamie Falk, Robert Ariano, Donald S Houston, Emily Krupka, Anna Blankstein, Iris Perelman, Rodney H Breau, Daniel I McIsaac, Emily Rimmer, Allan Garland, Alan Tinmouth, Robert Balshaw, Alexis F Turgeon, Eric Jacobsohn, Eric Bohm, Ryan Zarychanski,

<h4>Purpose</h4>Tranexamic acid (TXA) reduces red blood cell transfusion in various orthopedic surgeries, yet the degree of practice variation in its use among anesthesiologists and surgeons has not been described. To target future knowledge transfer and implementation strategies, and to better understand determinants of variability in prophylactic TXA use, our primary ... Read more >>

Can J Anaesth (Canadian journal of anaesthesia = Journal canadien d'anesthesie)
[2021, :]

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Rationalisations for women-only randomised controlled trials in conditions that affect both sexes: a scoping review protocol.

Ainsley Matthewson, Olena Bereznyakova, Brian Dewar, Alexandra Davis, Mark Fedyk, Vignan Yogendrakumar, Dean A Fergusson, Sophia Gocan, Dar Dowlatshahi, Robert Fahed, Michel Shamy,

<h4>Introduction</h4>Women have historically been under-represented in randomised controlled trials (RCTs), including many landmark RCTs that established standards of care. In light of this fact, some modern researchers are calling for replication of earlier landmark trials with women only. This approach is ethically concerning, in that it would require some enrolled ... Read more >>

BMJ Open (BMJ open)
[2021, 11(2):e043370]

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Adjuvant melatonin for the prevention of recurrence and mortality following lung cancer resection (AMPLCaRe): A randomized placebo controlled clinical trial.

Dugald Seely, Mark Legacy, Rebecca C Auer, Anna Fazekas, Edita Delic, Caitlin Anstee, Leonard Angka, Michael A Kennedy, Lee-Hwa Tai, Tinghua Zhang, Donna E Maziak, Farid M Shamji, R Sudhir Sundaresan, Sebastien Gilbert, P James Villeneuve, Ahmad S Ashrafi, Richard Inculet, Kazuhiro Yasufuku, Thomas K Waddell, Christian Finley, Yaron Shargall, Madelaine Plourde, Dean A Fergusson, Tim Ramsay, Andrew J E Seely,

<h4>Background</h4>Despite curative intent resection in patients with non-small cell lung cancer (NSCLC), recurrence leading to mortality remains too common. Melatonin has shown promise for the treatment of patients with lung cancer; however, its effect following cancer resection has not been studied. We evaluated if melatonin taken after complete resection reduces ... Read more >>

EClinicalMedicine (EClinicalMedicine)
[2021, 33:100763]

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Pragmatic, double-blind, randomised trial evaluating the impact of red blood cell donor sex on recipient mortality in an academic hospital population: the innovative Trial Assessing Donor Sex (iTADS) protocol.

Dean A Fergusson, Michael Chassé, Alan Tinmouth, Jason P Acker, Shane English, Alan J Forster, Steven Hawken, Nadine Shehata, Kednapa Thavorn, Kumanan Wilson, Angie Tuttle, Iris Perelman, Nancy Cober, Heather Maddison, Melanie Tokessy,

<h4>Introduction</h4>With over 1 million units of blood transfused each year in Canada, their use has a significant clinical and economic impact on our health system. Adequate screening of blood donors is important to ensure the safety and clinical benefit of blood products. Some adverse transfusion reactions have been shown to ... Read more >>

BMJ Open (BMJ open)
[2021, 11(2):e049598]

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Direct oral anticoagulants in treatment of cerebral venous thrombosis: a systematic review.

Gauruv Bose, Justin Graveline, Vignan Yogendrakumar, Risa Shorr, Dean A Fergusson, Gregoire Le Gal, Jonathan Coutinho, Marcelo Mendonça, Miguel Viana-Baptista, Simon Nagel, Dar Dowlatshahi,

<h4>Objectives</h4>Current guidelines do not recommend direct oral anticoagulants (DOACs) to treat cerebral venous thrombosis (CVT) despite their benefits over standard therapy. We performed a systematic review to summarise the published experience of DOAC therapy in CVT.<h4>Data sources</h4>MEDLINE, Embase and COCHRANE databases up to 18 November 2020.<h4>Eligibility criteria</h4>All published articles of ... Read more >>

BMJ Open (BMJ open)
[2021, 11(2):e040212]

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Preoperative Anemia in Primary Arthroplasty Patients-Prevalence, Influence on Outcome, and the Effect of Treatment.

Adrian Bailey, Isabel Eisen, Antony Palmer, , Paul E Beaulé, Dean A Fergusson, George Grammatopoulos,

<h4>Background</h4>This study aims to: 1) Determine the prevalence of preoperative anemia in arthroplasty; 2) Assess whether preoperative anemia is associated with inferior outcomes; and 3) Ascertain whether optimization in a dedicated blood management program (BMP) is associated with improved outcomes.<h4>Methods</h4>All primary arthroplasties performed at an academic, tertiary-care, arthroplasty center between ... Read more >>

J Arthroplasty (The Journal of arthroplasty)
[2021, :]

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Surrogate Humane Endpoints in Small Animal Models of Acute Lung Injury: A Modified Delphi Consensus Study of Researchers and Laboratory Animal Veterinarians.

Ryan McGinn, Dean A Fergusson, Duncan J Stewart, Arnold S Kristof, Carly C Barron, Bernard Thebaud, Lauralyn McIntyre, Dawn Stacey, Mark Liepmann, Aurore Dodelet-Devillers, Haibo Zhang, Richard Renlund, Elliot Lilley, Gregory P Downey, Earl G Brown, Lucie Côté, Claudia C Dos Santos, Alison E Fox-Robichaud, Sabah N A Hussain, John G Laffey, Mingyao Liu, Jenna MacNeil, Holly Orlando, Salman T Qureshi, Patricia V Turner, Brent W Winston, Manoj M Lalu, ,

<h4>Objectives</h4>In many jurisdictions, ethical concerns require surrogate humane endpoints to replace death in small animal models of acute lung injury. Heterogenous selection and reporting of surrogate endpoints render interpretation and generalizability of findings between studies difficult. We aimed to establish expert-guided consensus among preclinical scientists and laboratory animal veterinarians on ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(2):311-323]

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Do androgen-directed therapies improve outcomes in prostate cancer patients undergoing radical prostatectomy? A systematic review and meta-analysis.

Ameeta L Nayak, Anathea S Flaman, Ranjeeta Mallick, Luke T Lavallée, Dean A Fergusson, Ilias Cagiannos, Chris Morash, Rodney H Breau,

<h4>Introduction</h4>Approximately 50% of patients with non-metastatic prostate cancer are treated with radical prostatectomy. While some men will be cured with surgery alone, a substantial proportion will experience cancer recurrence. Androgen-directed therapy (ADT) is an effective adjuvant therapy for patients treated with prostate radiation. Comparatively, the efficacy of ADT in surgical ... Read more >>

Can Urol Assoc J (Canadian Urological Association journal = Journal de l'Association des urologues du Canada)
[2021, :]

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Interventions to prevent anastomotic leak after esophageal surgery: a systematic review and meta-analysis.

Emma J M Grigor, Suha Kaaki, Dean A Fergusson, Donna E Maziak, Andrew J E Seely,

<h4>Background</h4>Anastomotic leakage (AL) is a common and serious complication following esophagectomy. We aimed to provide an up-to-date review and critical appraisal of the efficacy and safety of all previous interventions aiming to reduce AL risk.<h4>Methods</h4>We searched MEDLINE and Embase from 1946 to January 2019 for randomized controlled trials (RCTs) evaluating interventions to ... Read more >>

BMC Surg (BMC surgery)
[2021, 21(1):42]

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Neuroprotection by Remote Ischemic Conditioning in Rodent Models of Focal Ischemia: a Systematic Review and Meta-Analysis.

Allyson J Ripley, Matthew S Jeffers, Matthew W McDonald, Joshua Montroy, Angela Dykes, Dean A Fergusson, Gergely Silasi, Manoj M Lalu, Dale Corbett,

Remote ischemic conditioning (RIC) is a promising neuroprotective therapy for ischemic stroke. Preclinical studies investigating RIC have shown RIC reduced infarct volume, but clinical trials have been equivocal. Therefore, the efficacy of RIC in reducing infarct volume and quality of current literature needs to be evaluated to identify knowledge gaps ... Read more >>

Transl Stroke Res (Translational stroke research)
[2021, :]

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Intraoperative Red Blood Cell Transfusion Decision-Making: A systematic Review of Guidelines.

Laura Baker, Lily Park, Richard Gilbert, Hilalion Ahn, Andre Martel, Tori Lenet, Alexandra Davis, Daniel I McIsaac, Alan Tinmouth, Dean A Fergusson, Guillaume Martel,

<h4>Objectives</h4>The objective of this work was to carry out a systematic review of clinical practice guidelines (CPGs) pertaining to intraoperative red blood cell (RBC) transfusions, in terms of indications, decision-making, and supporting evidence base.<h4>Summary background data</h4>Red blood cell (RBC) transfusions are common during surgery and there is evidence of wide ... Read more >>

Ann Surg (Annals of surgery)
[2020, :]

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Hypothermia During Partial Nephrectomy for Patients with Renal Tumors: A Randomized Controlled Trial.

Rodney H Breau, Dean A Fergusson, Greg Knoll, Kristen McAlpine, Christopher Morash, Sonya Cnossen, Luke T Lavallée, Ranjeeta Mallick, Antonio Finelli, Michael A S Jewett, Bradley C Leibovich, Jonathan A Cook, Anil Kapoor, Frederic Pouliot, Jonathan Izawa, Ricardo Rendon, Ilias Cagiannos,

<h4>Purpose</h4>Surgeons induce renal hypothermia during partial nephrectomy to preserve kidney function, without strong evidence of benefit. This trial examined the effectiveness and safety of renal hypothermia during partial nephrectomy.<h4>Materials and methods</h4>We conducted a parallel randomized controlled trial of hypothermia versus no hypothermia (control group) during partial nephrectomy at 6 academic ... Read more >>

J Urol (The Journal of urology)
[2020, :101097JU0000000000001517]

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Validation of the International Classification of Disease 10th Revision Codes for Kidney Transplant Rejection and Failure.

David Massicotte-Azarniouch, Manish M Sood, Dean A Fergusson, Greg A Knoll,

<h4>Background</h4>Clinical research requires that diagnostic codes captured from routinely collected health administrative data accurately identify individuals with a disease.<h4>Objective</h4>In this study, we validated the International Classification of Disease 10th Revision (ICD-10) definition for kidney transplant rejection (T86.100) and for kidney transplant failure (T86.101).<h4>Design</h4>Retrospective cohort study.<h4>Setting</h4>A large, regional transplantation center in ... Read more >>

Can J Kidney Health Dis (Canadian journal of kidney health and disease)
[2020, 7:2054358120977390]

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A patient-focused, theory-guided approach to survey design identified barriers to and drivers of clinical trial participation.

Jamie C Brehaut, Kelly Carroll, Justin Presseau, Dawn P Richards, Jenn Gordon, Angèle Bénard, Natasha Hudek, Ian D Graham, Dean A Fergusson, Susan Marlin,

<h4>Objectives</h4>Despite clear evidence showing that many clinical trials fail or are delayed because of poor patient recruitment, there is surprisingly little empirically supported guidance for trialists seeking to optimize their trial recruitment strategies. We propose that the challenges of recruitment can be better understood and addressed by thinking of research ... Read more >>

J Clin Epidemiol (Journal of clinical epidemiology)
[2021, 132:106-115]

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Endoscopic polypectomy performed in clinic for chronic rhinosinusitis with nasal polyps: study protocol for the EPIC multicentre randomised controlled trial.

Shaun Kilty, Kednapa Thavorn, Arif Janjua, John Lee, Kristian MacDonald, Eric Meen, Damian Micomonaco, Brian Rotenberg, Leigh J Sowerby, Marc Tewfik, Susan Adams, Hubert Frenette, Andrea Lasso, Dean A Fergusson,

<h4>Introduction</h4>Chronic rhinosinusitis (CRS) is common, with a Canadian prevalence of 5%, and associated with significant morbidity. Understandably, CRS impairs workplace productivity but that productivity substantially increases following surgical treatment. CRS with nasal polyps (CRSwNP), the most common type of CRS, is usually treated with a combination of medications and endoscopic ... Read more >>

BMJ Open (BMJ open)
[2020, 10(12):e042413]

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The effects of resistant starches on inflammatory bowel disease in preclinical and clinical settings: a systematic review and meta-analysis.

Joshua Montroy, Rania Berjawi, Manoj M Lalu, Eyal Podolsky, Cayden Peixoto, Levent Sahin, Alain Stintzi, David Mack, Dean A Fergusson,

<h4>Background</h4>Inflammatory bowel disease (IBD) is a debilitating chronic disease with limited treatment options. Resistant starches may represent a novel treatment for IBD. However, its efficacy and safety remain unclear. Our objective was to perform a systematic review to summarize the preclinical and clinical effects of resistant starch, which may help ... Read more >>

BMC Gastroenterol (BMC gastroenterology)
[2020, 20(1):372]

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Combination Tests in the Diagnosis of Chronic Periprosthetic Joint Infection: Systematic Review and Development of a Stepwise Clinical Decision-Making Tool.

Hesham Abdelbary, Wei Cheng, Nadera Ahmadzai, Alberto V Carli, Beverley J Shea, Brian Hutton, Dean A Fergusson, Paul E Beaulé,

<h4>Background</h4>Our objective was to identify combination tests used to diagnose chronic periprosthetic joint infection (PJI) and develop a stepwise decision-making tool to facilitate diagnosis.<h4>Methods</h4>We conducted a systematic review of existing combinations of serum, synovial, and tissue-based tests for diagnosing chronic PJI after hip or knee replacement. This work is an ... Read more >>

J Bone Joint Surg Am (The Journal of bone and joint surgery. American volume)
[2020, 102(Suppl 2):114-124]

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Partnering with patients to get better outcomes with chimeric antigen receptor T-cell therapy: towards engagement of patients in early phase trials.

Madison Foster, Dean A Fergusson, Terry Hawrysh, Justin Presseau, Natasha Kekre, Stuart Schwartz, Gisell Castillo, Sarah Asad, Grace Fox, Harold Atkins, Kednapa Thavorn, Joshua Montroy, Robert A Holt, Zarah Monfaredi, Manoj M Lalu,

<h4>Aim</h4>Though patient engagement in clinical research is growing, recent reports suggest few clinical trials report on such activities. To address this gap, we describe our approach to patient engagement in the development of a clinical trial protocol to assess a new immunotherapy for blood cancer (chimeric antigen receptor T-cell therapy, CAR-T ... Read more >>

Res Involv Engagem (Research involvement and engagement)
[2020, 6:61]

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Prevention of post-cardiac surgery vitamin D deficiency in children with congenital heart disease: a pilot feasibility dose evaluation randomized controlled trial.

James Dayre McNally, Katie O'Hearn, Dean A Fergusson, Jane Lougheed, Dermot R Doherty, Gyaandeo Maharajh, Hope Weiler, Glenville Jones, Ali Khamessan, Stephanie Redpath, Pavel Geier, Lauralyn McIntyre, Margaret L Lawson, Tara Girolamo, Kusum Menon, ,

<h4>Background</h4>The vast majority of children undergoing cardiac surgery have low vitamin D levels post-operative, which may contribute to greater illness severity and worse clinical outcomes. Prior to the initiation of a large phase III clinical trial focused on clinical outcomes, studies are required to evaluate the feasibility of the study ... Read more >>

Pilot Feasibility Stud (Pilot and feasibility studies)
[2020, 6:159]

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Mind the evidence gap: The need for trials in the prevention and management of perioperative anemia in noncardiac surgery.

Dean A Fergusson, Manoj M Lalu,

Transfusion (Transfusion)
[2020, 60(10):2168-2170]

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