Full Text Journal Articles by
Author Davut Sinan Kaplan

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The effect of tramadol on oxidative stress total antioxidant levels in rats with renal ischemia-reperfusion injury.

Elzem Şen, Davut Sinan Kaplan, Zehra Bozdağ, Mustafa Örkmez, Ayşe Mızrak, Haluk Şen, Ömer Bayrak,

OBJECTIVE:To evaluate the protective effect of tramadol on renal tissue in rats with induced renal ischemia-reperfusion injury (I/R injury), and its effects on oxidative stress. MATERIAL AND METHODS:Thirty adult, male Wistar rats weighing 250-300 g were selected as subjects. Rats were randomized into 3 groups: group 1, sham; group 2, ... Read more >>

Turk J Urol (Turkish journal of urology)
[2020, 46(5):388-392]

Cited: 0 times

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Colostrum immunoglobulins and oxidative capacity may be affected by infant sex and maternal age and parity

Davut Sinan Kaplan, Cahit Bağcı, Mustafa Örkmez, Özge Kömürcü Karuserci, Seyhan Sucu, Hakim Çelik, Seyithan Taysı,

Background/aim:The aims of this study were to determine the levels of the total antioxidant status (TAS), the total oxidant status (TOS), the oxidative stress index (OSI), and the concentration of ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2019, 49(1):87-92]

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Nigella sativa oil and thymoquinone reduce oxidative stress in the brain tissue of rats exposed to total head irradiation.

Elif Demir, Seyithan Taysi, Hasan Ulusal, Davut Sinan Kaplan, Kadir Cinar, Mehmet Tarakcioglu,

Purpose: To evaluate the antioxidant and radio-protective effects of Nigella sativa oil (NSO) and thymoquinone (TQ) on radiation-induced oxidative stress in brain tissue.Materials and methods: Fifty-four Sprague-Dawley rats were divided into six groups to test the radio-protective effectiveness of Nigella sativa oil and thymoquine administered by either orogastric tube or ... Read more >>

Int J Radiat Biol (International journal of radiation biology)
[2020, 96(2):228-235]

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Studying the effect of large neutral amino acid supplements on oxidative stress in phenylketonuric patients.

Burcu Kumru, Burcu Ozturk Hismi, Davut Sinan Kaplan, Hakim Celik,

Background Oxidative stress may be one of the causes responsible for mental retardation in phenylketonuria (PKU) patients. Phenylalanine (Phe) reduces antioxidant defense and promotes oxidative stress by causing increase in reactive oxygen-nitrogen species. Our study aimed to investigate the effect of different treatments (amino acid mixture/large neutral amino acid [LNAA] ... Read more >>

J Pediatr Endocrinol Metab (Journal of pediatric endocrinology & metabolism : JPEM)
[2019, 32(3):269-274]

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Relationship of fibroblast growth factor 21, sirtuin 1, visfatin, and regulators in children with short stature.

Davut Sinan Kaplan, Asuman Canak, Emregul Isık, Mustafa Orkmez, Burcu Kumru,

Fibroblast growth factor 21 (FGF21) is mainly secreted by the liver. It is a factor that is not fully understood in relation to growth. Sirtuin 1 (SIRT1) is a deacetylase protein. It is thought that may have an effect on the release and function of GH and IGF-1. Visfatin is ... Read more >>

Growth Factors (Growth factors (Chur, Switzerland))
[2018, 36(3-4):172-177]

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Effect of Blood Phenylalanine Levels on Oxidative Stress in Classical Phenylketonuric Patients.

Burcu Kumru, Davut Sinan Kaplan, Burcu Oztürk Hismi, Hakim Celik,

Mental retardation, which occurs in phenylketonuric patients, is associated with increased levels of phenylalanine, increased oxidative stress, and an imbalance of amino acids in the brain. Recent studies have shown that oxidative stress plays a role in the pathogenesis of phenylketonuria. In this work, we aimed to compare the influence ... Read more >>

Cell Mol Neurobiol (Cellular and molecular neurobiology)
[2018, 38(5):1033-1038]

Cited: 1 time

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The effects of bupivacaine combined with different adjuvants on block onset and duration and on ion channel expressions (SCN9A, TRPM) in sciatic nerve block in rats.

Nurgül Dolu, Levent Şahin, Davut Sinan Kaplan, Tuncer Demir, Hasan Şimşek, Mehrican Şahin, Beyhan Cengiz,

BACKGROUND/AIM:The objective of this experimental study was to examine the effects of epinephrine, dexmedetomidine, and clonidine added as adjuvants to bupivacaine on block onset and effect times, as well as the effects on the Na+ and Ca+2 channel gene expressions, which may indicate cell damage in the sciatic nerve cell ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2016, 46(3):926-935]

Cited: 1 time

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Assessment of expressions of Bcl-XL, b-FGF, Bmp-2, Caspase-3, PDGFR-α, Smad1 and TGF-β1 genes in a rat model of lung ischemia/reperfusion.

Hasan Şimşek, Şeniz Demiryürek, Tuncer Demir, Hüsne Didem Atabay, Ali Osman Çeribasi, Recep Bayraktar, Davut Sinan Kaplan, Serdar Öztuzcu, Beyhan Cengiz,

OBJECTIVES:Ischemia is described as organs and tissues are destitute of oxygen due to decreased arterial or venous blood flow. Many mechanisms play role in cell death happened as a consequence of a new blood flow is needed for both cell regeneration and to clean toxic metabolites during ischemia and later. ... Read more >>

Iran J Basic Med Sci (Iranian journal of basic medical sciences)
[2016, 19(2):209-214]

Cited: 1 time

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Palosuran treatment effective as bosentan in the treatment model of pulmonary arterial hypertension.

Yavuz Pehlivan, Recep Dokuyucu, Tuncer Demir, Davut Sinan Kaplan, Ibrahim Koc, Mustafa Orkmez, Ibrahim Halil Turkbeyler, Ali Osman Ceribasi, Ediz Tutar, Seyithan Taysi, Bunyamin Kisacik, Ahmet Mesut Onat,

Pulmonary arterial hypertension (PAH) is a progressive and fatal disorder that any valuable advance in the management of diseases has crucial importance. The present study aimed to compare the Endothelin1 (ET1) inhibitor bosentan which is regarded as standard therapy with different dose regimens of palosuran which is urotensin-II (UII) inhibitor ... Read more >>

Inflammation (Inflammation)
[2014, 37(4):1280-1288]

Cited: 2 times

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The role of hepcidin and its related genes (BMP6, GDF-15, and HJV) in rats exposed to ischemia and reperfusion.

Recep Dokuyucu, Tuncer Demir, Yumrutaş Onder, Ayşe Binnur Erbağci, Mustafa Orkmez, Abdulkadir Yasir Bahar, Recep Bayraktar, Ibrahim Bozgeyik, Davut Sinan Kaplan, Beyhan Cengiz, Beyhan Cengiz Bağci,

BACKGROUND/AIM: To determine the roles of hepcidin and its related genes in a renal ischemia/reperfusion model. MATERIALS AND METHODS: A total of 20 Wistar albino rats were equally divided into 2 groups: Group I was the control group and Group II was the ischemia and reperfusion (I/R) group (60 min ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2014, 44(4):576-581]

Cited: 1 time

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Evaluation of TRPM (transient receptor potential melastatin) genes expressions in myocardial ischemia and reperfusion.

Tuncer Demir, Onder Yumrutas, Beyhan Cengiz, Seniz Demiryurek, Hatice Unverdi, Davut Sinan Kaplan, Recep Bayraktar, Nadide Ozkul, Cahit Bagcı,

In the present study, the expression levels of TRPM1, TRPM2, TRPM3, TRPM4, TRPM5, TRPM6, TRPM7, and TRPM8 genes were evaluated in heart tissues after ischemia/reperfusion (IR). For this study, 30 albino male Wistar rats were equally divided into three groups as follows: Group 1: control group (n:10), Group II: ischemia ... Read more >>

Mol. Biol. Rep. (Molecular biology reports)
[2014, 41(5):2845-2849]

Cited: 9 times

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Effectiveness of palosuran in bleomycin-induced experimental scleroderma.

Tuncer Demir, Ibrahim Turkbeyler, Davut Sinan Kaplan, Yavuz Pehlivan, Mustafa Orkmez, Ediz Tutar, Seyithan Taysi, Bunyamin Kisacik, Ahmet Mesut Onat, Cahit Bagcı,

Systemic sclerosis (SSc) is a disease characterized by skin and internal organ involvement. There is progressive accumulation of extracellular matrix components in the skin and involved organs. Tissue fibrosis is the prominent reason for mortality, and still, there is no satisfactory treatment. The aim of this study was to evaluate ... Read more >>

Inflammation (Inflammation)
[2013, 36(1):75-79]

Cited: 1 time

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Urotensin inhibition with palosuran could be a promising alternative in pulmonary arterial hypertension.

Ahmet Mesut Onat, Yavuz Pehlivan, Ibrahim Halil Turkbeyler, Tuncer Demir, Davut Sinan Kaplan, Ali Osman Ceribasi, Mustafa Orkmez, Ediz Tutar, Seyithan Taysi, Mehmet Sayarlioglu, Bunyamin Kisacik,

Pulmonary arterial hypertension (PAH) is a progressive and a life-threatening disease with its high morbidity and mortality ratios. On searching for new shining targets in pathogenesis, we noticed, in our previous studies, urotensin-II (UII) in systemic sclerosis with potent angiogenic and pro-fibrotic features. Owing to the mimicking properties of UII ... Read more >>

Inflammation (Inflammation)
[2013, 36(2):405-412]

Cited: 4 times

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Investigation of the esophageal Rho-kinase expression in patients with Barrett's esophagus.

Seniz Demiryürek, Irfan Koruk, Zehra Bozdag, Esma Ozkara, Davut Sinan Kaplan, Serdar Oztuzcu, Ali Cetinkaya, Belgin Alasehirli, Abdullah Tuncay Demiryürek,

The mechanisms responsible for the malignant transformation in Barrett's esophagus (BE) are still poorly understood. The authors have evaluated the role of Rho-kinase (ROCK1 and ROCK2) expressions in patients with BE. All patients underwent upper gastrointestinal system endoscopy, which was confirmed histologically. Real-time PCR revealed no marked change in gene ... Read more >>

Ultrastruct Pathol (Ultrastructural pathology)
[2013, 37(4):284-289]

Cited: 2 times

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Preliminary study of efficacy of hyaluronic acid on caustic esophageal burns in an experimental rat model.

Muazez Cevik, Tuncer Demir, Cetin Ali Karadag, Muzaffer Aydin Ketani, Hakim Celik, Davut Sinan Kaplan, Mehmet Emin Boleken,

BACKGROUND: The aim of this study was to investigate the effectiveness of hyaluronic acid on the prevention of esophageal damage and stricture formation after experimental caustic (alkaline) esophageal injury in rats. MATERIALS AND METHODS: Twenty-one Wistar albino rats were randomly divided into three groups. A caustic esophageal burn was created ... Read more >>

J Pediatr Surg (Journal of pediatric surgery)
[2013, 48(4):716-723]

Cited: 2 times

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The efficiency of a urotensin II antagonist in an experimental lung fibrosis model.

Ahmet Mesut Onat, Ibrahim Halil Turkbeyler, Yavuz Pehlivan, Tuncer Demir, Davut Sinan Kaplan, Seyithan Taysi, Ali Osman Ceribasi, Ediz Tutar, Bunyamin Kisacik,

Pulmonary fibrosis is a chronic disease. Urotensin II (U-II) is a new peptide with angiogenic and profibrotic features. Therefore, we aim to evaluate the antagonism of U-II with palosuran in an animal model and plan to measure U-II, endothelin-1 (ET-1), and transforming growth factor-β1 (TGF-β1) and their association with lung ... Read more >>

Inflammation (Inflammation)
[2012, 35(3):1138-1143]

Cited: 9 times

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Prolidase could act as a diagnosis and treatment mediator in lung fibrosis.

Ibrahim Türkbeyler, Tuncer Demir, Yavuz Pehlivan, Davut Sinan Kaplan, Ali Osman Ceribasi, Mustafa Orkmez, Nurten Aksoy, Seyithan Taysi, Bunyamin Kisacik, Ahmet Mesut Onat,

Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease with unknown etiology and pathogenesis. With high mortality risks, most of the IPF cases emerged after a damage of alveolar epithelium, where this situation stimulates the over expression of matrix components. Inflammatory process observed as a reaction to emerged damage. Prolidase ... Read more >>

Inflammation (Inflammation)
[2012, 35(5):1747-1752]

Cited: 6 times

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