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Author Davis Ryman

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Safety and efficacy of tilavonemab in progressive supranuclear palsy: a phase 2, randomised, placebo-controlled trial.

Günter U Höglinger, Irene Litvan, Nuno Mendonca, Deli Wang, Hui Zheng, Beatrice Rendenbach-Mueller, Hoi-Kei Lon, Ziyi Jin, Nahome Fisseha, Kumar Budur, Michael Gold, Davis Ryman, Hana Florian, ,

<h4>Background</h4>Progressive supranuclear palsy is a neurodegenerative disorder associated with tau protein aggregation. Tilavonemab (ABBV-8E12) is a monoclonal antibody that binds to the N-terminus of human tau. We assessed the safety and efficacy of tilavonemab for the treatment of progressive supranuclear palsy.<h4>Methods</h4>We did a phase 2, multicentre, randomised, placebo-controlled, double-blind study ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2021, 20(3):182-192]

Cited: 0 times

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Prader-Willi-Like Phenotype Caused by an Atypical 15q11.2 Microdeletion.

Qiming Tan, Kathryn J Potter, Lisa Cole Burnett, Camila E Orsso, Mark Inman, Davis C Ryman, Andrea M Haqq,

We report a 17-year-old boy who met most of the major Prader-Willi syndrome (PWS) diagnostic criteria, including infantile hypotonia and poor feeding followed by hyperphagia, early-onset morbid obesity, delayed development, and characteristic facial features. However, unlike many children with PWS, he had spontaneous onset of puberty and reached a tall ... Read more >>

Genes (Basel) (Genes)
[2020, 11(2):]

Cited: 2 times

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Efficacy and safety of levodopa-carbidopa intestinal gel from a study in Japanese, Taiwanese, and Korean advanced Parkinson's disease patients.

Miho Murata, Masahito Mihara, Kazuko Hasegawa, Beomseok Jeon, Chon-Haw Tsai, Noriko Nishikawa, Tomoko Oeda, Masayuki Yokoyama, Weining Z Robieson, Davis Ryman, Susan Eaton, Krai Chatamra, Janet Benesh,

In a previous multinational, randomized, double-blind, double-dummy study, levodopa-carbidopa intestinal gel (LCIG) was tolerable and significantly improved 'off' time in advanced Parkinson's disease (PD) patients. However, efficacy and safety in the Asian population has not yet been demonstrated. In this open-label study, efficacy and safety of LCIG were assessed in ... Read more >>

NPJ Parkinsons Dis (NPJ Parkinson's disease)
[2016, 2:16020]

Cited: 5 times

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Neurological manifestations of autosomal dominant familial Alzheimer's disease: a comparison of the published literature with the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS).

Mengxuan Tang, Davis C Ryman, Eric McDade, Mateusz S Jasielec, Virginia D Buckles, Nigel J Cairns, Anne M Fagan, Alison Goate, Daniel S Marcus, Chengjie Xiong, Ricardo F Allegri, Jasmeer P Chhatwal, Adrian Danek, Martin R Farlow, Nick C Fox, Bernardino Ghetti, Neill R Graff-Radford, Christopher Laske, Ralph N Martins, Colin L Masters, Richard P Mayeux, John M Ringman, Martin N Rossor, Stephen P Salloway, Peter R Schofield, John C Morris, Randall J Bateman, ,

<h4>Background</h4>Autosomal dominant familial Alzheimer's disease (ADAD) is a rare disorder with non-amnestic neurological symptoms in some clinical presentations. We aimed to compile and compare data from symptomatic participants in the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS) with those reported in the literature to estimate the prevalences of non-amnestic neurological ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2016, 15(13):1317-1325]

Cited: 22 times

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Cerebral amyloidosis associated with cognitive decline in autosomal dominant Alzheimer disease.

Fen Wang, Brian A Gordon, Davis C Ryman, Shengmei Ma, Chengjie Xiong, Jason Hassenstab, Alison Goate, Anne M Fagan, Nigel J Cairns, Daniel S Marcus, Eric McDade, John M Ringman, Neill R Graff-Radford, Bernardino Ghetti, Martin R Farlow, Reisa Sperling, Steve Salloway, Peter R Schofield, Colin L Masters, Ralph N Martins, Martin N Rossor, Mathias Jucker, Adrian Danek, Stefan Förster, Christopher A S Lane, John C Morris, Tammie L S Benzinger, Randall J Bateman, ,

<h4>Objective</h4>To investigate the associations of cerebral amyloidosis with concurrent cognitive performance and with longitudinal cognitive decline in asymptomatic and symptomatic stages of autosomal dominant Alzheimer disease (ADAD).<h4>Methods</h4>Two hundred sixty-three participants enrolled in the Dominantly Inherited Alzheimer Network observational study underwent neuropsychological evaluation as well as PET scans with Pittsburgh compound ... Read more >>

Neurology (Neurology)
[2015, 85(9):790-798]

Cited: 16 times

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Factors associated with the onset and persistence of post-lumbar puncture headache.

Andrés E Monserrate, Davis C Ryman, Shengmei Ma, Chengjie Xiong, James M Noble, John M Ringman, John C Morris, Adrian Danek, Felix Müller-Sarnowski, David B Clifford, Eric M McDade, William S Brooks, David G Darby, Colin L Masters, Philip S J Weston, Martin R Farlow, Neill R Graff-Radford, Stephen P Salloway, Anne M Fagan, Angela Oliver, Randall J Bateman, ,

<h4>Importance</h4>This study assesses factors associated with the most common adverse event following lumbar puncture.<h4>Objective</h4>To identify factors associated with the risk, onset, and persistence of post-dural puncture headache (PDPH).<h4>Design, setting, and participants</h4>We performed univariate and multivariable analyses of 338 lumbar punctures in the Dominantly Inherited Alzheimer Network observational study using linear ... Read more >>

JAMA Neurol (JAMA neurology)
[2015, 72(3):325-332]

Cited: 17 times

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Symptom onset in autosomal dominant Alzheimer disease: a systematic review and meta-analysis.

Davis C Ryman, Natalia Acosta-Baena, Paul S Aisen, Thomas Bird, Adrian Danek, Nick C Fox, Alison Goate, Peter Frommelt, Bernardino Ghetti, Jessica B S Langbaum, Francisco Lopera, Ralph Martins, Colin L Masters, Richard P Mayeux, Eric McDade, Sonia Moreno, Eric M Reiman, John M Ringman, Steve Salloway, Peter R Schofield, Reisa Sperling, Pierre N Tariot, Chengjie Xiong, John C Morris, Randall J Bateman, ,

<h4>Objective</h4>To identify factors influencing age at symptom onset and disease course in autosomal dominant Alzheimer disease (ADAD), and develop evidence-based criteria for predicting symptom onset in ADAD.<h4>Methods</h4>We have collected individual-level data on ages at symptom onset and death from 387 ADAD pedigrees, compiled from 137 peer-reviewed publications, the Dominantly Inherited ... Read more >>

Neurology (Neurology)
[2014, 83(3):253-260]

Cited: 141 times

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Medial medullary infarction with central sparing.

Davis C Ryman, Yo-El S Ju,

A 35-year-old woman had cardiac arrest requiring treatment with a left ventricular assist device. After regaining consciousness, examination revealed upbeating nystagmus, otherwise normal bulbar function, left arm dysmetria, and numbness periorally and in areas she described as "a turtleneck of numbness with a T-shirt of sensation" (figure 1). ... Read more >>

Neurology (Neurology)
[2013, 81(23):2054-2055]

Cited: 0 times

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Genetic loci modulating amyloid-beta levels in a mouse model of Alzheimer's disease.

Davis Ryman, Yuan Gao, Bruce T Lamb,

Genetic studies have demonstrated very high heritability for Alzheimer's disease (AD) risk in humans; however, these genetic contributions have proven extremely challenging to map in large studies of AD patients. Processing of the amyloid precursor protein (APP) to produce amyloid-beta (Abeta) peptide is increasingly believed to be of central importance ... Read more >>

Neurobiol Aging (Neurobiology of aging)
[2008, 29(8):1190-1198]

Cited: 19 times

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Genetic and environmental modifiers of Alzheimer's disease phenotypes in the mouse.

Davis Ryman, Bruce T Lamb,

As a group, strains of laboratory mice carrying Alzheimer's disease (AD)-related transgenes are currently the most widely studied animal models of AD. Many AD mouse models carrying the same or similar transgene constructs demonstrate strikingly different phenotypic responses to transgene expression, mimicking the apparent genetic complexity of AD pathogenesis seen ... Read more >>

Curr Alzheimer Res (Current Alzheimer research)
[2006, 3(5):465-473]

Cited: 23 times

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