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Author Davide Caimmi

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Handling of allergen immunotherapy in the COVID-19 pandemic: An ARIA-EAACI statement.

Ludger Klimek, Marek Jutel, Cezmi Akdis, Jean Bousquet, Mübeccel Akdis, Claus Bachert, Ioana Agache, Ignacio Ansotegui, Anna Bedbrook, Sinthia Bosnic-Anticevich, Giorgio W Canonica, Tomas Chivato, Alvaro A Cruz, Wiencyslawa Czarlewski, Stefano Del Giacco, Hui Du, Joao A Fonseca, Yadong Gao, Tari Haahtela, Karin Hoffmann-Sommergruber, Juan-Carlos Ivancevich, Nikolai Khaltaev, Edward F Knol, Piotr Kuna, Desiree Larenas-Linnemann, Erik Melen, Joaquim Mullol, Robert Naclerio, Ken Ohta, Yoshitaka Okamoto, Liam O'Mahony, Gabrielle L Onorato, Nikos G Papadopoulos, Ruby Pawankar, Oliver Pfaar, Boleslaw Samolinski, Jurgen Schwarze, Sanna Toppila-Salmi, Mohamed H Shamji, Maria Teresa Ventura, Arunas Valiulis, Arzu Yorgancioglu, Paolo Matricardi, Torsten Zuberbier, ,

The current COVID-19 pandemic influences many areas of social life, medical treatments and the way allergy is performed. Allergen-specific immunotherapy (AIT) is one of the most important treatment options for IgE-mediated allergies and is based on immunological effects on the diseased patient. ... Read more >>

Allergy (Allergy)
[2020, :]

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How molecular allergology can shape the management of allergic airways diseases.

Davide Caimmi, Enrica Manca, Elena Carboni, Pascal Demoly,

PURPOSE OF REVIEW:In allergy, personalized medicine passes through the assessment of molecular allergens sensitization profiles. Such technique may help to better diagnose and treat patients suffering from allergic respiratory diseases. RECENT FINDINGS:Different laboratory tests are available today to assess sensitization to molecular allergens, from singleplex assays, to unspecific, screening multiplex ... Read more >>

Curr Opin Allergy Clin Immunol (Current opinion in allergy and clinical immunology)
[2020, 20(2):149-154]

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Intranasal corticosteroids in allergic rhinitis in COVID-19 infected patients: An ARIA-EAACI statement.

Jean Bousquet, Cezmi Akdis, Marek Jutel, Claus Bachert, Ludger Klimek, Ioana Agache, Ignacio J Ansotegui, Anna Bedbrook, Sinthia Bosnic-Anticevich, Giorgio W Canonica, Tomas Chivato, Alvaro A Cruz, Wienia Czarlewski, Stefano Del Giacco, Hui Du, Joao A Fonseca, Yadong Gao, Tari Haahtela, Karin Hoffmann-Sommergruber, Juan C Ivancevich, Nikolai Khaltaev, Edward F Knol, Piotr Kuna, Desiree Larenas-Linnemann, Joaquim Mullol, Robert Naclerio, Ken Ohta, Y Okamoto, Liam O'Mahony, Gabrielle L Onorato, Nikos G Papadopoulos, Oliver Pfaar, Boleslaw Samolinski, Jürgen Schwarze, Sanna Toppila-Salmi, Maria Teresa Ventura, Arunas Valiulis, Arzu Yorgancioglu, Torsten Zuberbier, ,

Allergy (Allergy)
[2020, :]

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May Failure to Thrive in Infants Be a Clinical Marker for the Early Diagnosis of Cow's Milk Allergy?

Lucia Diaferio, Davide Caimmi, Maria Carmen Verga, Valentina Palladino, Lorenzo Trovè, Paola Giordano, Elvira Verduci, Vito Leonardo Miniello,

Objectives-Failure to thrive (FTT) in infants is characterized by growth failure. Although, cow's milk allergy (CMA) may have an impact on growth and leads to FTT, data are still limited. We focused on FTT as a possible clinical marker for an early diagnosis of CMA. The aim of the present ... Read more >>

Nutrients (Nutrients)
[2020, 12(2):]

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Oral corticosteroids and asthma in children: Practical considerations.

Maria De Filippo, Evangéline Clark, Anouchka Fillard, Lucia Diaferio, Davide Caimmi,

Corticosteroids (CS) are among the most prescribed drugs in pediatrics. In allergy, CS are prescribed for several different conditions. If CS show clear benefits when adequately prescribed, CS are also associated with several side effects, well known by pediatricians. As for asthma exacerbations, the oral route is always the preferred ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, 31 Suppl 24:43-45]

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Real-Life Safety and Effectiveness of Lumacaftor-Ivacaftor in Patients with Cystic Fibrosis.

Pierre-Régis Burgel, Anne Munck, Isabelle Durieu, Raphaël Chiron, Laurent Mely, Anne Prevotat, Marlene Murris-Espin, Michele Porzio, Michel Abely, Philippe Reix, Christophe Marguet, Julie Macey, Isabelle Sermet-Gaudelus, Harriet Corvol, Stéphanie Bui, Lydie Lemonnier, Clémence Dehillotte, Jennifer Da Silva, Jean-Louis Paillasseur, Dominique Hubert, ,

Rationale: Lumacaftor-ivacaftor is a CFTR (cystic fibrosis transmembrane conductance regulator) modulator combination recently approved for patients with cystic fibrosis (CF) homozygous for the Phe508del mutation.Objectives: To evaluate the safety and effectiveness of lumacaftor-ivacaftor in adolescents (≥12 yr) and adults (≥18 yr) in a real-life postapproval setting.Methods: The study was conducted ... Read more >>

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2020, 201(2):188-197]

Cited: 1 time

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Protocols for drug allergy desensitization in children.

Lucia Diaferio, Mattia Giovannini, Evangéline Clark, Riccardo Castagnoli, Davide Caimmi,

Introduction: When a drug hypersensitivity reaction is proven, desensitization protocols allow the reintroduction of the molecule in patients for whom such therapy is essential. Through drug desensitization (DDS), a temporary immune tolerance is maintained for the single course of a specific therapy. In pediatrics, indications for such a procedure include ... Read more >>

Expert Rev Clin Immunol (Expert review of clinical immunology)
[2020, 16(1):91-100]

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Response to commentary by Drs. Poncet and Sénéchal.

Caroline Klingebiel, Yannick Chantran, Pascal Demoly, Pol-André Apoil, Davide Paolo Caimmi, Joëlle Birnbaum, Marion Gouitaa, Isabelle Cabon-Boudard, Stéphane Guez, Jean-Luc Bourrain, Sylvie Leroy, Thierry Bourrier, Agnès Aferiat-Derome, Anne Sarrat, Jonas Lidholm, Joana Vitte,

Clin. Exp. Allergy (Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology)
[2019, 49(8):1167-1168]

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Skin tests are important in children with β-lactam hypersensitivity, but may be reduced in number.

Lucia Diaferio, Anca Mirela Chiriac, Maria Chiara Leoni, Riccardo Castagnoli, Silvia Caimmi, Vito Leonardo Miniello, Pascal Demoly, Davide Caimmi,

BACKGROUND:There is no perfect agreement on how to perform an allergy workup in suspected beta-lactam (BL)-allergic children, since skin test (ST)-induced pain is often a limitation. The aim of the study was to assess the possibility of reducing the number of ST in children when performing a complete allergy workup ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2019, 30(4):462-468]

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Discriminating severe seasonal allergic rhinitis. Results from a large nation-wide database.

Davide Caimmi, Nour Baiz, Shreosi Sanyal, Soutrik Banerjee, Pascal Demoly, Isabella Annesi-Maesano,

Allergic rhinitis (AR) is a chronic disease affecting a large amount of the population. To optimize treatment and disease management, it is crucial to detect patients suffering from severe forms. Several tools have been used to classify patients according to severity: standardized questionnaires, visual analogue scales (VAS) and cluster analysis. ... Read more >>

PLoS ONE (PloS one)
[2018, 13(11):e0207290]

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SIAIP position paper: provocation challenge to antibiotics and non-steroidal anti-inflammatory drugs in children.

Carlo Caffarelli, Fabrizio Franceschini, Davide Caimmi, Francesca Mori, Lucia Diaferio, Dora Di Mauro, Carla Mastrorilli, Stefania Arasi, Simona Barni, Paolo Bottau, Silvia Caimmi, Fabio Cardinale, Pasquale Comberiati, Giuseppe Crisafulli, Lucia Liotti, Umberto Pelosi, Francesca Saretta, Gianluigi Marseglia, Marzia Duse, Francesco Paravati,

Drug hypersensitivity reactions (DHRs) in childhood are mainly caused by betalactam or non-betalactam antibiotics, and non-steroidal anti-inflammatory drugs (NSAIDs). Laboratory tests for identifying children who are allergic to drugs have low diagnostic accuracy and predictive value. The gold standard to diagnose DHR is represented by the drug provocation test (DPT), ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2018, 44(1):147]

Cited: 9 times

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Characteristics of NSAID-induced hypersensitivity reactions in childhood.

Ozlem Cavkaytar, George du Toit, Davide Caimmi,

Non-steroidal anti-inflammatory drugs (NSAIDs) are available as over-the-counter drugs, and they are commonly used in children for their antipyretic, analgesic, and anti-inflammatory effects. NSAIDs are among the most frequently reported drugs associated with hypersensitivity reactions and even with anaphylaxis. A complete evaluation of the patients based on reported clinical manifestations, ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2019, 30(1):25-35]

Cited: 2 times

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Electronic Clinical Decision Support System for allergic rhinitis management: MASK e-CDSS.

Anne-Lise Courbis, Ruth Brigid Murray, Sylvie Arnavielhe, Davide Caimmi, Anna Bedbrook, Michiel Van Eerd, Govert De Vries, Gerard Dray, Ioana Agache, Mario Morais-Almeida, Claus Bachert, Karl Christian Bergmann, Sinthia Bosnic-Anticevich, Jan Brozek, Caterina Bucca, Paulo Camargos, Giorgio Walter Canonica, Warner Carr, Thomas Casale, Joao A Fonseca, Tari Haahtela, Omer Kalayci, Ludger Klimek, Piotr Kuna, Violeta Kvedariene, Desiree Larenas Linnemann, Phil Lieberman, Joaquim Mullol, Robyn Ohehir, Nikolaos Papadopoulos, David Price, Dermot Ryan, Boleslaw Samolinski, F Estelle Simons, Peter Tomazic, Massimo Triggiani, Arunas Valiulis, Erkka Valovirta, Martin Wagenmann, Magnus Wickman, Arzu Yorgancioglu, Jean Bousquet,

BACKGROUND:Allergic rhinitis (AR) management has changed in recent years following the switch from the concept of disease severity to the concept of disease control, publication of the AR clinical decision support system (CDSS) and development of mobile health (m-health) tools for patients (eg Allergy Diary). The Allergy Diary Companion app ... Read more >>

Clin. Exp. Allergy (Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology)
[2018, 48(12):1640-1653]

Cited: 4 times

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Dynamic changes of DNA methylation and lung disease in cystic fibrosis: lessons from a monogenic disease.

Milena Magalhães, Jörg Tost, Fanny Pineau, Isabelle Rivals, Florence Busato, Nathan Alary, Laurent Mely, Sylvie Leroy, Marlène Murris, Davide Caimmi, Mireille Claustres, Raphaël Chiron, Albertina De Sario,

AIM:To assess whether DNA methylation levels account for the noninherited phenotypic variations observed among cystic fibrosis (CF) patients. PATIENTS & METHODS:Using the 450 K BeadChip, we profiled DNA methylation in nasal epithelial cells collected from 32 CF patients and 16 controls. RESULTS:We detected substantial DNA methylation differences up to 55% (median ... Read more >>

Epigenomics (Epigenomics)
[2018, 10(8):1131-1145]

Cited: 0 times

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Positive Effect of Liposomal Amikacin for Inhalation on Mycobacterium abcessus in Cystic Fibrosis Patients.

Davide Caimmi, Nicolas Martocq, Delphine Trioleyre, Catherine Guinet, Sylvain Godreuil, Thomas Daniel, Raphael Chiron,

Mycobacterium abscessus is difficult to eradicate. At the Montpellier CF Center, we prescribed liposomal amikacin for inhalation to 5 patients with M abscessus infection. The 3 patients who completed the treatment did not have any respiratory exacerbation, showed negative cultures for M abscessus in their sputum, and stabilized their spirometric ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2018, 5(3):ofy034]

Cited: 2 times

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Filaggrin mutations and Molluscum contagiosum skin infection in patients with atopic dermatitis.

Sara Manti, Maria Amorini, Caterina Cuppari, Annamaria Salpietro, Francesca Porcino, Salvatore Leonardi, Michele Miraglia Del Giudice, Gianluigi Marseglia, Davide Paolo Caimmi, Carmelo Salpietro,

Although mutations in the filaggrin (FLG) gene have been reported to predispose patients with atopic dermatitis (AD) skin infection susceptibility, to date, the data reported in the literature are still controversial.To evaluate the role of FLG polymorphisms expression and risk of developing a concomitant Molluscum contagiosum sustained skin infection in ... Read more >>

Ann. Allergy Asthma Immunol. (Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology)
[2017, 119(5):446-451]

Cited: 4 times

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Specific IgE and skin prick tests to diagnose allergy to fresh and baked cow's milk according to age: a systematic review.

Barbara Cuomo, Giovanni Cosimo Indirli, Annamaria Bianchi, Stefania Arasi, Davide Caimmi, Arianna Dondi, Stefania La Grutta, Valentina Panetta, Maria Carmen Verga, Mauro Calvani,

The diagnosis of IgE-mediated cow's milk allergy is often based on anamnesis, and on specific IgE (sIgE) levels and/or Skin Prick Tests (SPT), which have both a good sensitivity but a low specificity, often causing positive results in non-allergic subjects. Thus, oral food challenge is still the gold standard test ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2017, 43(1):93]

Cited: 6 times

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Risk factors for developing food-induced bronchospasm during oral food challenge.

Marie Lagreula, Anca-Mirela Chiriac, Maria Chiara Leoni, Pascal Demoly, Davide Caimmi,

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2017, 28(6):598-602]

Cited: 1 time

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Neuroendocrine cell hyperplasia of infancy: an unusual cause of hypoxemia in children.

Silvia Caimmi, Amelia Licari, Davide Caimmi, Anna Rispoli, Eugenio Baraldi, Fiorella Calabrese, Gian Luigi Marseglia,

Childhood interstitial lung disease (chILD) is a heterogeneous group of rare disorders characterized by abnormal imaging findings, impaired gas exchange; and is associated with substantial morbidity and mortality. Neuroendocrine cell hyperplasia (NEHI) is a unique sub-group, which is more prevalent in infants and children younger than 2 years of age, and ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2016, 42(1):84]

Cited: 1 time

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MACVIA clinical decision algorithm in adolescents and adults with allergic rhinitis.

Jean Bousquet, Holger J Schünemann, Peter W Hellings, Sylvie Arnavielhe, Claus Bachert, Anna Bedbrook, Karl-Christian Bergmann, Sinthia Bosnic-Anticevich, Jan Brozek, Moises Calderon, G Walter Canonica, Thomas B Casale, Niels H Chavannes, Linda Cox, Henry Chrystyn, Alvaro A Cruz, Ronald Dahl, Giuseppe De Carlo, Pascal Demoly, Phillipe Devillier, Gérard Dray, Monica Fletcher, Wytske J Fokkens, Joao Fonseca, Sandra N Gonzalez-Diaz, Lawrence Grouse, Thomas Keil, Piotr Kuna, Désirée Larenas-Linnemann, Karin C Lodrup Carlsen, Eli O Meltzer, Jaoquim Mullol, Antonella Muraro, Robert N Naclerio, Susanna Palkonen, Nikolaos G Papadopoulos, Giovanni Passalacqua, David Price, Dermot Ryan, Boleslaw Samolinski, Glenis K Scadding, Aziz Sheikh, François Spertini, Arunas Valiulis, Erkka Valovirta, Samantha Walker, Magnus Wickman, Arzu Yorgancioglu, Tari Haahtela, Torsten Zuberbier, ,

The selection of pharmacotherapy for patients with allergic rhinitis (AR) depends on several factors, including age, prominent symptoms, symptom severity, control of AR, patient preferences, and cost. Allergen exposure and the resulting symptoms vary, and treatment adjustment is required. Clinical decision support systems (CDSSs) might be beneficial for the assessment ... Read more >>

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2016, 138(2):367-374.e2]

Cited: 30 times

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Phenotypical characterization of children with hypersensitivity reactions to NSAIDs.

Mathias Cousin, Anca Chiriac, Nicolas Molinari, Pascal Demoly, Davide Caimmi,

Non-steroidal anti-inflammatory drugs (NSAIDs) are the main cause of drug-induced hypersensitivity in children. Many classifications have been proposed, focusing on adults. So far, no large study has deeply investigated a pediatric cohort. The aim of the present study was to describe a population of NSAID hypersensitive patients reporting a reaction ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2016, 27(7):743-748]

Cited: 10 times

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A model for active and healthy ageing with a rare genetic disease: cystic fibrosis.

Raphael Chiron, Davide Caimmi, Arunas Valiulis, Isabelle Durieu, Patrick Tejedor, Yam Le Cam, Mathieu Boudes, Oliver Jonquet, Timo Strandberg, Jean-Pierre Michel, Esteban de Manuel Keenoy, Pascal Demoly, Jacques Mercier, Radolphe Bourret, Jean Bousquet, ,

Eur. Respir. J. (The European respiratory journal)
[2016, 47(3):714-719]

Cited: 2 times

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Rhinovirus-associated pulmonary exacerbations show a lack of FEV1 improvement in children with cystic fibrosis.

Mathias Cousin, Nicolas Molinari, Vincent Foulongne, Davide Caimmi, Isabelle Vachier, Michel Abely, Raphael Chiron,

BACKGROUND:Respiratory viral infections lead to bronchial inflammation in patients with cystic fibrosis, especially during pulmonary exacerbations. The aim of this study was to determine the impact of viral-associated pulmonary exacerbations in children with cystic fibrosis and failure to improve forced expiratory volume in 1 s (FEV1 ) after an appropriate treatment. ... Read more >>

Influenza Other Respir Viruses (Influenza and other respiratory viruses)
[2016, 10(2):109-112]

Cited: 10 times

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Allergen Immunotherapy Outcomes and Unmet Needs: A Critical Review.

Davide Caimmi, Moises A Calderon, Jean Bousquet, Pascal Demoly,

Allergen immunotherapy (AIT) has been evaluated throughout several studies over the last years. A position paper from the European Academy of Allergy and Clinical Immunology highlighted the total combined symptoms score as the method to record the primary end point in AIT studies for allergic rhinitis, but this score still ... Read more >>

Immunol Allergy Clin North Am (Immunology and Allergy Clinics of North America)
[2016, 36(1):181-189]

Cited: 2 times

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[The reference site of the European Innovation Partnership on Active and Healthy Aging MACVIA-LR (the fight against chronic diseases for an active and healthy aging in Languedoc-Roussillon)].

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Presse Med (Presse medicale (Paris, France : 1983))
[2015, 44 Suppl 1:S6-22]

Cited: 1 time

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