Full Text Journal Articles by
Author David Zurakowski

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Rhythmic Change of Cortical Hemodynamic Signals Associated with Ongoing Nociception in Awake and Anesthetized Individuals: An Exploratory Functional Near Infrared Spectroscopy Study.

Ke Peng, Keerthana Deepti Karunakaran, Arielle Lee, Andrea Gomez-Morad, Robert Labadie, Arielle Mizrahi-Arnaud, Delany Berry, Barry Kussman, David Zurakowski, Lyle Micheli, Lino Becerra, David Borsook,

<h4>Background</h4>Patients undergoing surgical procedures are vulnerable to repetitive evoked or ongoing nociceptive barrage. Using functional near infrared spectroscopy, the authors aimed to evaluate the cortical hemodynamic signal power changes during ongoing nociception in healthy awake volunteers and in surgical patients under general anesthesia. The authors hypothesized that ongoing nociception to ... Read more >>

Anesthesiology (Anesthesiology)
[2021, 135(5):877-892]

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Infant study of hemispheric asymmetry after long-gap esophageal atresia repair.

Mackenzie S Kagan, Chandler R L Mongerson, David Zurakowski, Russell W Jennings, Dusica Bajic,

Previous studies have demonstrated that infants are typically born with a left-greater-than-right forebrain asymmetry that reverses throughout the first year of life. We hypothesized that critically ill term-born and premature patients following surgical and critical care for long-gap esophageal atresia (LGEA) would exhibit alteration in expected forebrain asymmetry. Term-born (n = 13) ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2021, :]

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Endothelial GNAQ p.R183Q Increases ANGPT2 (Angiopoietin-2) and Drives Formation of Enlarged Blood Vessels.

Lan Huang, Colette Bichsel, Alexis Norris, Jeremy Thorpe, Jonathan Pevsner, Sanda Alexandrescu, Anna Pinto, David Zurakowski, Robin J Kleiman, Mustafa Sahin, Arin K Greene, Joyce Bischoff,

Capillary malformation (CM) occurs sporadically and is associated with Sturge-Weber syndrome. The somatic mosaic mutation in GNAQ (c.548G>A, p.R183Q) is enriched in endothelial cells (ECs) in skin CM and Sturge-Weber syndrome brain CM. Our goal was to investigate how the mutant Gαq (G-protein αq subunit) alters EC signaling and disrupts ... Read more >>

Arterioscler Thromb Vasc Biol (Arteriosclerosis, thrombosis, and vascular biology)
[2021, :ATVBAHA121316651]

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rAAV-Mediated sox9 Overexpression Improves the Repair of Osteochondral Defects in a Clinically Relevant Large Animal Model Over Time In Vivo and Reduces Perifocal Osteoarthritic Changes.

Cliff Lange, Henning Madry, Jagadeesh K Venkatesan, Gertrud Schmitt, Susanne Speicher-Mentges, David Zurakowski, Michael D Menger, Matthias W Laschke, Magali Cucchiarini,

<h4>Background</h4>Gene transfer of the transcription factor SOX9 with clinically adapted recombinant adeno-associated virus (rAAV) vectors offers a powerful tool to durably enhance the repair process at sites of osteochondral injuries and counteract the development of perifocal osteoarthritis (OA) in the adjacent articular cartilage.<h4>Purpose</h4>To examine the ability of an rAAV <i>sox9</i> ... Read more >>

Am J Sports Med (The American journal of sports medicine)
[2021, :3635465211049414]

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Phenotyping respiratory decompensation following definitive closure of the patent ductus arteriosus in preterm infants.

Craig R Wheeler, Daniel Gagner, Holly Stephens, Amelia Kraus, David Zurakowski, Kevin G Friedman, Juan C Ibla, Ryan Callahan, Diego Porras, Philip T Levy,

<h4>Objective</h4>To identify risk factors associated with high-frequency ventilation (HFV) following definitive closure of the patent ductus arteriosus (PDA).<h4>Methods</h4>We performed a retrospective study of premature infants (<37 weeks) who were mechanically ventilated before and after surgical or transcatheter PDA closure. Primary outcome was HFV requirement within 24 h of procedure. Logistic regression ... Read more >>

J Perinatol (Journal of perinatology : official journal of the California Perinatal Association)
[2021, :]

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DTI and MTR Measures of Nerve Fiber Integrity in Pediatric Patients With Ankle Injury.

Scott A Holmes, Anastasia Karapanagou, Steven J Staffa, David Zurakowski, Ronald Borra, Laura E Simons, Christine Sieberg, Alyssa Lebel, David Borsook,

Acute peripheral nerve injury can lead to chronic neuropathic pain. Having a standardized, non-invasive method to evaluate pathological changes in a nerve following nerve injury would help with diagnostic and therapeutic assessments or interventions. The accurate evaluation of nerve fiber integrity after injury may provide insight into the extent of ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2021, 9:656843]

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A role for abdominal ultrasound in discriminating suspected necrotizing enterocolitis in congenital heart disease patients.

Stefanie P Lazow, Sarah A Tracy, Judy A Estroff, Richard B Parad, Ilse M Castro-Aragon, Alan M Fujii, Steven J Staffa, David Zurakowski, Catherine Chen,

<h4>Purpose</h4>We evaluated the diagnostic utility of abdominal ultrasound (AUS), an adjunct to abdominal X-ray (AXR), for necrotizing enterocolitis (NEC) in congenital heart disease (CHD) patients.<h4>Methods</h4>86 patients with suspected NEC from 2009 to 2018 were classified as with CHD (n = 18) if they required cardiac intervention versus without CHD (n = 68). Clinical and ... Read more >>

Pediatr Surg Int (Pediatric surgery international)
[2021, :]

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Impact of Cardiopulmonary Bypass on Neurogenesis and Cortical Maturation.

Zaenab Dhari, Camille Leonetti, Stephen Lin, Arianna Prince, James Howick, David Zurakowski, Paul C Wang, Richard A Jonas, Nobuyuki Ishibashi,

<h4>Objective</h4>Neurodevelopmental delays and frontal lobe cortical dysmaturation are widespread among children with congenital heart disease (CHD). The subventricular zone (SVZ) is the largest pool of neural stem/progenitor cells in the postnatal brain. Our aim is to determine the effects of cardiopulmonary bypass (CPB) on neurogenesis and cortical maturation in piglets ... Read more >>

Ann Neurol (Annals of neurology)
[2021, :]

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Statistical Development and Validation of Clinical Prediction Models.

Steven J Staffa, David Zurakowski,

<h4>Summary</h4>Clinical prediction models in anesthesia and surgery research have many clinical applications including preoperative risk stratification with implications for clinical utility in decision-making, resource utilization, and costs. It is imperative that predictive algorithms and multivariable models are validated in a suitable and comprehensive way in order to establish the robustness ... Read more >>

Anesthesiology (Anesthesiology)
[2021, 135(3):396-405]

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Comparing standard and non-standard videolaryngoscopes in children: methodological issues. Response to Br J Anaesth 2021; 127: e52-e4.

James Peyton, John Fiadjoe, Mary L Stein, Raymond Park, Steven Staffa, David Zurakowski, Pete Kovatsis,

Br J Anaesth (British journal of anaesthesia)
[2021, 127(5):e172-e173]

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Predictors of anti-reflux procedure failure in complex esophageal atresia patients.

Kyle Thompson, Benjamin Zendejas, Ali Kamran, Wendy Jo Svetanoff, Jay Meisner, David Zurakowski, Steven J Staffa, Peter Ngo, Michael Manfredi, Jessica L Yasuda, Russell W Jennings, C Jason Smithers, Thomas E Hamilton,

<h4>Background</h4>Anti-reflux procedures (ARP) in esophageal atresia (EA) patients can be challenging and prone to failure. These challenges become more evident with increasing complexity of EA. We sought to determine predictors of ARP failure in complex EA patients.<h4>Methods</h4>Single-institution retrospective review of complex EA patients (e.g. long-gap EA, esophageal strictures, hiatal hernia, ... Read more >>

J Pediatr Surg (Journal of pediatric surgery)
[2021, :]

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Predictors of Neurological Outcome Following Infant Cardiac Surgery Without Deep Hypothermic Circulatory Arrest.

Agnieszka Kosiorek, Mary T Donofrio, David Zurakowski, Justus G Reitz, Lauren Tague, Jonathan Murnick, Roland Axt-Fliedner, Catherine Limperopoulos, Can Yerebakan, Jessica L Carpenter,

The aim of this study is to describe the clinical characteristics, perioperative course and neuroimaging abnormalities of infants with congenital heart disease (CHD) undergoing heart surgery without deep hypothermic circulatory arrest (DHCA) and identify variables associated with neurological outcome. Infants with CHD undergoing open-heart surgery without DHCA between 2009 and ... Read more >>

Pediatr Cardiol (Pediatric cardiology)
[2021, :]

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Renal 99mTc-DMSA pharmacokinetics in pediatric patients.

Donika Plyku, Michael Ghaly, Ye Li, Justin L Brown, Shannon O'Reilly, Kitiwat Khamwan, Alison B Goodkind, Briana Sexton-Stallone, Xinhua Cao, David Zurakowski, Frederic H Fahey, S Ted Treves, Wesley E Bolch, Eric C Frey, George Sgouros,

<sup>99m</sup>Tc-DMSA is one of the most commonly used pediatric nuclear medicine imaging agents. Nevertheless, there are no pharmacokinetic (PK) models for <sup>99m</sup>Tc-DMSA in children, and currently available pediatric dose estimates for <sup>99m</sup>Tc-DMSA use pediatric S values with PK data derived from adults. Furthermore, the adult PK data were collected in ... Read more >>

EJNMMI Phys (EJNMMI physics)
[2021, 8(1):53]

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Nutrition delivery and growth outcomes in infants with long-gap esophageal atresia who undergo the Foker process.

Amanda W Harrington, Jane Riebold, Kayla Hernandez, Steven J Staffa, Wendy Jo Svetanoff, David Zurakowski, Thomas Hamilton, Russell Jennings, Nilesh M Mehta, Benjamin Zendejas,

<h4>Background</h4>Predictors of growth outcomes in patients with long-gap esophageal atresia (LGEA) are not known. We examined nutrition and growth in-hospital and post-discharge in LGEA patients who underwent the Foker Process (FP).<h4>Methods</h4>Single-center, retrospective cohort study of infants with LGEA undergoing primary (non-rescue) FP from 2014 to 2020. Weight-for-age z scores (WAZ, ... Read more >>

J Pediatr Surg (Journal of pediatric surgery)
[2021, :]

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Unselected CD117 expression in amniotic and placental mesenchymal stem cells.

Stefanie P Lazow, Ina Kycia, Sarah A Tracy, David Zurakowski, Dario O Fauza,

J Pediatr Surg (Journal of pediatric surgery)
[2021, :]

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Time to achieve delivery of nutrition targets is associated with clinical outcomes in critically ill children.

Lori J Bechard, Steven J Staffa, David Zurakowski, Nilesh M Mehta,

<h4>Background</h4>Optimal nutrition in critically ill children involves a complex interplay between the doses, route, and timing of macronutrient delivery.<h4>Objectives</h4>We aimed to examine the association between the time to achieve delivery of 60% of the prescribed energy and protein targets and clinical outcomes in mechanically ventilated children.<h4>Methods</h4>We conducted a prospective, observational ... Read more >>

Am J Clin Nutr (The American journal of clinical nutrition)
[2021, :]

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The Liver Retransplantation Risk Score: a prognostic model for survival after adult liver retransplantation.

Isabel M A Brüggenwirth, Maureen J M Werner, René Adam, Wojciech G Polak, Vincent Karam, Michael A Heneghan, Arianeb Mehrabi, Jürgen L Klempnauer, Andreas Paul, Darius F Mirza, Johann Pratschke, Mauro Salizzoni, Daniel Cherqui, Michael Allison, Olivier Soubrane, Steven J Staffa, David Zurakowski, Robert J Porte, Vincent E de Meijer, ,

High-risk combinations of recipient and graft characteristics are poorly defined for liver retransplantation (reLT) in the current era. We aimed to develop a risk model for survival after reLT using data from the European Liver Transplantation Registry, followed by internal and external validation. From 2006 to 2016, 85 067 liver transplants ... Read more >>

Transpl Int (Transplant international : official journal of the European Society for Organ Transplantation)
[2021, 34(10):1928-1937]

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Patch augmentation of small ascending aorta during stage I procedure reduces the risk of morbidity and mortality.

David M Hoganson, Breanna L Piekarski, Luis G Quinonez, John J Kheir, Aditya K Kaza, David Zurakowski, Sitaram M Emani, Chris W Baird,

<h4>Objectives</h4>Hypoplastic left heart syndrome (HLHS) with aortic atresia (AA) patients are prone to coronary insufficiency due to a small ascending aorta. Prophylactic patch augmentation of the small ascending aorta during the stage I procedure (S1P) may reduce the risk of coronary insufficiency as marked by ventricular dysfunction, need for extracorporeal ... Read more >>

Eur J Cardiothorac Surg (European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery)
[2021, :]

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Virtual reality prototype for binocular therapy in older children and adults with amblyopia.

Abdelrahman M Elhusseiny, Kaila Bishop, Steven J Staffa, David Zurakowski, David G Hunter, Iason S Mantagos,

<h4>Purpose</h4>To evaluate the best-corrected visual acuity and stereoacuity gains in children >7 years of age and adults with unilateral amblyopia treated with a prototype virtual reality-based binocular amblyopia therapy.<h4>Methods</h4>In this randomized, double masked, cross-in clinical trial, patients at Boston Children's Hospital with unilateral anisometropic and/or strabismic amblyopia and history of prior ... Read more >>

J AAPOS (Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus)
[2021, 25(4):217.e1-217.e6]

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Synergy in Nanomedicine: What It Is Not, and What It Might Be.

Steven J Staffa, Daniel S Kohane, David Zurakowski,

Interactions between nanoformulations delivering two or more drugs-or a drug and some other therapeutic modality-are often described as synergistic. In fact, synergy is a specific term of art, with important therapeutic implications. The term is often misused in the nanoscience literature. Here we discuss what synergy is and an approach ... Read more >>

Nano Lett (Nano letters)
[2021, 21(13):5457-5460]

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Outcomes of a multicomponent safe surgery intervention in Tanzania's Lake Zone: a prospective, longitudinal study.

Shehnaz Alidina, Gopal Menon, Steven J Staffa, Sakshie Alreja, David Barash, Erin Barringer, Monica Cainer, Isabelle Citron, Amanda DiMeo, Edwin Ernest, Laura Fitzgerald, Hiba Ghandour, Magdalena Gruendl, Audustino Hellar, Desmond T Jumbam, Adam Katoto, Lauren Kelly, Steve Kisakye, Salome Kuchukhidze, Tenzing Lama, William Lodge Ii, Erastus Maina, Fabian Massaga, Adelina Mazhiqi, John G Meara, Stella Mshana, Ian Nason, Chase Reynolds, Cheri Reynolds, Hannington Segirinya, Dorcas Simba, Victoria Smith, Christopher Strader, Meaghan Sydlowski, Leopold Tibyehabwa, Florian Tinuga, Alena Troxel, Mpoki Ulisubisya, John Varallo, Taylor Wurdeman, Noor Zanial, David Zurakowski, Ntuli Kapologwe, Sarah Maongezi,

<h4>Background</h4>Evidence-based strategies for improving surgical quality and patient outcomes in low-resource settings are a priority.<h4>Objective</h4>To evaluate the impact of a multicomponent safe surgery intervention (Safe Surgery 2020) on (1) adherence to safety practices, teamwork and communication, and documentation in patient files, and (2) incidence of maternal sepsis, postoperative sepsis, and ... Read more >>

Int J Qual Health Care (International journal for quality in health care : journal of the International Society for Quality in Health Care)
[2021, 33(2):]

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Predictors of progression in radiation-induced versus nonradiation-induced pediatric meningiomas: a large single-institution surgical experience.

Mohammed A Fouda, Emily L Day, David Zurakowski, R Michael Scott, Edward R Smith, Karen J Marcus, Katie P Fehnel,

<h4>Objective</h4>The goal in this study was to outline unique differences between radiation-induced and nonradiation-induced pediatric meningiomas and to identify independent risk factors of tumor recurrence/progression.<h4>Methods</h4>This is a retrospective cohort study of all pediatric meningiomas diagnosed and surgically treated at the authors' institution between 1993 and 2017. Multivariable Cox regression was ... Read more >>

J Neurosurg Pediatr (Journal of neurosurgery. Pediatrics)
[2021, :1-7]

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Magnetic Resonance Imaging Features and Clinical Findings in Pediatric Idiopathic Intracranial Hypertension: A Case-Control Study.

Aubrey L Gilbert, Jennifer Vaughn, Sarah Whitecross, Caroline D Robson, David Zurakowski, Gena Heidary,

The purpose of this study is to identify salient magnetic resonance imaging (MRI) findings of pediatric IIH, to determine the relevance of these findings with regard to disease pathogenesis, and to relate these findings to the clinical presentation towards identification of risk factors of disease. A retrospective, a case-control study ... Read more >>

Life (Basel) (Life (Basel, Switzerland))
[2021, 11(6):]

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Burnout Rate and Risk Factors among Anesthesiologists in the United States.

Anoushka M Afonso, Joshua B Cadwell, Steven J Staffa, David Zurakowski, Amy E Vinson,

<h4>Background</h4>Physician burnout, widespread across medicine, is linked to poorer physician quality of life and reduced quality of care. Data on prevalence of and risk factors for burnout among anesthesiologists are limited. The objective of the current study was to improve understanding of burnout in anesthesiologists, identify workplace and personal factors ... Read more >>

Anesthesiology (Anesthesiology)
[2021, 134(5):683-696]

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Abdominal ultrasound findings contribute to a multivariable predictive risk score for surgical necrotizing enterocolitis: A pilot study.

Stefanie P Lazow, Sarah A Tracy, Steven J Staffa, Judy A Estroff, Richard B Parad, Ilse M Castro-Aragon, Alan M Fujii, David Zurakowski, Catherine Chen,

<h4>Background</h4>Abdominal ultrasound (AUS) is a promising adjunct to abdominal x-ray (AXR) for evaluating necrotizing enterocolitis (NEC). We developed a multivariable risk score incorporating AUS to predict surgical NEC.<h4>Methods</h4>83 patients were evaluated by AXR and AUS for suspected NEC. A subset had surgical NEC. Multivariate logistic regression determined predictors of surgical ... Read more >>

Am J Surg (American journal of surgery)
[2021, :]

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